With the basic principle, “For smiles of patients and their families,” we are working on research with the objective of contributing to the “Development and enhancement of medical treatment” by the “Discovery of useful drugs to treat refractory or rare diseases.” We have established a “Logical Drug Discovery System” using computers. Based on this technology, we have constructing immunoadhesins, combining the extracellular domain of human interleukin 10 receptor 1 (IL-10R1) with the Fc regions of human IgG1 heavy chain and investigated the their capability of blocking the biological activities of human IL-10. Furthermore, we have developing “peptide drugs,” which can control the function of epidermal growth factor receptor (EGFR: a membrane protein associated with the functional recovery in patients with diseases like lung cancer or spinal cord injury). Yutaka TAMURA　　　 Copyright(C)　2009- Dept. of Bioinfor., Chiba Univ. All Rights Reserved.