２０２２ Indocyanine green conjugated phototheranostic nanoparticle for photodiagnosis and photodynamic therapy. Shinoda K, Suganami A, Moriya Y, Yamashita M, Tanaka T, Suzuki AS, Suito H, Akutsu Y, Saito K, Shinozaki Y, Isojima K, Nakamura N, Miyauchi Y, Shirasawa H, Matsubara H, Okamoto Y, Nakayama T, Tamura Y. Photodiagnosis Photodyn Ther. 2022 Sep;39:103041. Inhibitory effects and gene expression analysis of chemotherapeutic photodynamic therapy by using a liposomally formulated indocyanine green derivative. Okamoto Y, Ishizuka M, Sumiyama F, Kosaka H, Suganami A, Tamura Y, Sekimoto M, Kaibori M. Shirasawa H. Photodiagnosis Photodyn Ther. 2022 Sep;39:102961. ２０２１ Role of Blood Stasis Syndrome of Kampo Medicine in the Early Pathogenic Stage of Atherosclerosis: A Retrospective Cross-Sectional Study. Morita A, Namiki T, Nakaguchi T, Murai K, Watanabe Y, Nakamura M, Kawasaki Y, Shiko Y, Tamura Y, Suganami A, Murakami A, Yagi A, Okamoto H, Hirasaki Y. Evid Based Complement Alternat Med. 2021 May 26;2021:5557392. The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD 2 or PGE 2. Okura I, Hasuoka N, Senoo K, Suganami A, Fukushima K, Regan JW, Mashimo M, Murayama T, Tamura Y, Fujino H. Pharmacol Rep.2021 Mar 30. CCL299, a Benzimidazole Derivative Induces G1 Phase Arrest and Apoptosis in Cancer Cells. Ohno Y, Yi R, Suganami A, Tamura Y, Matsumoto A, Matsumoto S, Saito K, Shirasawa H. Anticancer Res.2021 Feb;41(2):699-706. ２０２０ Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina. Arai MA, Makita Y, Yamaguchi Y, Kawano H, Suganami A, Tamura Y, Ishibashi M. Sci Rep.2020 Dec 8;10(1):21433. CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells. Yi R, Ohno Y, Tian Z, Guo S, Chen W, Ma X, Win NN, Li Q, Vahed M, Saito K, Nakamoto S, Suganami A, Isegawa N, Yoshida K, Harada S, Tamura Y, Nishida A, Shirasawa H. Oncol Rep.2020 Dec;44(6):2770-2782. A Novel Chiral Compound CCL441 Induces Mitotic Arrest and Apoptosis in Hepatoblastoma HepG2 Cells. Guo S, Ohno Y, Tsubosaka A, Vahed M, Yi R, Ma X, Li Q, Saito K, Nakamoto S, Muroyama R, Suganami A, Tamura Y, Tsuchida A, Arai T, and Shirasawa H. Am. J. Res. Med. Sci..2020, 5,1-5. Photohyperthermal therapy using liposomally formulated indocyanine green for feline nasal lymphoma: A case report. Yamashita M, Mayama M, Suganami A, Azuma K, Tsuka T, Ito N, Imagawa T, Tamura Y, Okamoto Y. Mol Clin Oncol.2020 Oct;13(4):37. 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling. Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. J Biol Chem.2020 Sep 18;295(38):13338-13352. Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods. Arai MA, Morita K, Kawano H, Makita Y, Hashimoto M, Suganami A, Tamura Y, Sadhu SK, Ahmed F, Ishibashi M. Sci Rep.2020 Jan 28;10(1):1381. Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice. Hirano KI, Suganami A, Tamura Y, Yagita H, Habu S, Kitagawa M, Sato T, Hozumi K. Elife.2020 Jan 16;9:e50979. 　 ２０１９ Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model. Shibata S, Shinozaki N, Suganami A, Ikegami S, Kinoshita Y, Hasegawa R, Kentaro H, Okamoto Y, Aoki I, Tamura Y, Iwadate Y. Oncotarget.2019 Jan 4;10(2):175-183. Novel Chiral Chalcone Analogs that Induce M Phase Arrest and Apoptosis in HeLa Cells. Chen W, Yi R, Vahed M, Ohno M, Tian Z, Guo S, Ma X, Win NN, Li Q, Tsubosaka A, Saito K, Nakamoto S, Suganami A, Tamura Y, Arai T and Shirasawa H. Medicinal Chemistry.2019 9(6) 74-82. ２０１８ Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion. Ito C, Yamatoya K, Yoshida K, Fujimura L, Sugiyama H, Suganami A, Tamura Y, Hatano M, Miyado K, Toshimori K. Reproduction.2018 Dec;156(6):579-590. GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition. Arai MA, Ochi F, Makita Y, Chiba T, Higashi K, Suganami A, Tamura Y, Toida T, Iwama A, Sadhu SK, Ahmed F, Ishibashi M. ACS Chem Biol.2018 Sep 21;13(9):2551-2559. Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression. Win NN, Kanda T, Nakamoto S, Moriyama M, Jiang X, Suganami A, Tamura Y, Okamoto H, Shirasawa H. Int J Med Sci. 2018 Jul 30;15(11):1153-1159. Synthesis and Evaluation of Fuligocandin B Derivatives with Activity for Overcoming TRAIL Resistance. Arai MA, Masuda A, Suganami A, Tamura Y, Ishibashi M. Chem Pharm Bull (Tokyo).2018;66(8):810-817. ２０１７ PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. Araki Y, Suganami A, Endo S, Masuda Y, Fukushima K, Regan JW, Murayama T, Tamura Y, Fujino H. FEBS Lett.2017 Nov;591(22):3771-3780. Low-dose hyperthermia enhances the antitumor effects of chemotherapy in squamous cell carcinoma. Hu X, Akutsu Y, Suganami A, Qin W, Hanari N, Murakam K, Kano M, Usui A, Suito H, Takahashi M, Matsumoto Y, Otsuta R, Tamura Y, Matsubara H. Dis Esophagus.2017 Jul 1;30(7):1-7. Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Seira N, Yanagisawa N, Suganami A, Honda T, Wasai M, Regan JW, Fukushima K, Yamaguchi N, Tamura Y, Arai T, Murayama T, Fujino H. Biol Pharm Bull.2017;40(10):1806-1812. The Pluripotent Stem-Cell Marker Alkaline Phosphatase is Highly Expressed in Refractory Glioblastoma with DNA Hypomethylation.. Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N. Neurosurgery. 2017 Feb 1;80(2):248-256. ２０１６ Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T. FEBS J. 2016 Nov;283(21):3931-3940. Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior. Fukuda M, Takatori A, Nakamura Y, Suganami A, Hoshino T, Tamura Y, Nakagawara A. Neurochem Int.2016 Jul;97:42-8. Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells. Arai MA, Ishikawa N, Tanaka M, Uemura K, Sugimitsu N, Suganami A, Tamura Y, Koyano T, Kowithayakornd T, Ishibashi M. Chem. Sci. 2016, 7, 1514-1520. ２０１５ Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection. Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y. Int J Pharm. 2015 Oct 23. pii: S0378-5173(15)30271-4. Effect of photodynamic therapy on local muscle treatment in a rat muscle injury model: a controlled trial. Inage K, Sakuma Y, Yamauchi K, Suganami A, Orita S, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Takahashi K, Ohtori S, Tamura Y. J Orthop Surg Res. 2015 Apr 18;10(1):50. Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma. Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H. PLoS One. 2015 Apr 7;10(4):e0122849. Detection of peritoneal dissemination with near-infrared fluorescence laparoscopic imaging using a liposomal formulation of a synthesized indocyanine green liposomal derivative. Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H. Anticancer Res. 2015 Mar;35(3):1353-9. Longitudinal evaluation of local muscle conditions in a rat model of gastrocnemius muscle injury using an in vivo imaging system. Inage K, Sakuma Y, Yamauchi K, Suganami A, Orita S, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Takahashi K, Ohtori S, Tamura Y. J Orthop Res. 2015 Mar 2. ２０１４ Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice. Qin W, Akutsu Y, Andocs G, Suganami A, Hu X, Yusup G, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Isozaki Y, Akanuma N, Tamura Y, Matsubara H. Oncol Rep. 2014 Dec;32(6):2373-9. Aurora kinase A is a possible target of OSU‑03012 to destabilize MYC family proteins. Silva A, Wang J, Lomahan S, Tran TA, Grenlin L, Suganami A, Tamura Y, Ikegaki N. Oncol Rep. 2014 Sep;32(3):901-5. Structure based functional distinction between Cln1 and Cln2 depends on the ubiquitin-proteasome pathway. Suganami A, Takase N, Sugiyama H, Virtudazo EV, Kawamoto S, Tamura Y. J. Proteomics Bioinform. 2014 May; 7:102-107. Chemical and Biological Properties of ICG-Lipo. Suganami A, Toyota T, Okazaki S, Hayashi H, Okamoto Y, Tamura Y. JJSLSM 2014 ;35(1):39-45. Outcome from Photodynamic Therapy with Phospholipid-Conjugated Indocyanine Green for Animal Spontaneous Deep-Seated Occurring Tumors. Okamoto Y, Ohsaki T, Azuma K, Itoh N, Tsuka1T, Imagawa T, Suganami A, Tamura Y. JJSLSM 2014 ;35(1):46-50. Non-deep-seated primary CNS lymphoma – therapeutic responses and a molecular signature. Iwadate Y, Suganami A, Ikegami S, Shinozaki N, Matsutani T, Tamura Y, Saeki N, Yamanaka R. J. Neurooncol. 2014 Apr;117(2):261-8. Near-infrared-fluorescence imaging of lymph nodes by using liposomally formulated indocyanine green derivatives. Toyota T, Fujito H, Suganami A, Ouchi T, Ohishi A, Aoki A, Onoue K, Muraki Y, Madono T, Fujinami M, Tamura Y, Hayashi H. Bioorg Med Chem. 2014 Jan 15;22(2):721-7. Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. Nakamura Y, Suganami A, Fukuda M, Hasan MK, Yokochi T, Takatori A, Satoh S, Hoshino T, Tamura Y, Nakagawara A. Cancer Med. 2014 Feb;3(1):25-35. ２０１３ Prediction of the interaction between spermidine and the G-G mismatch containing acceptor stem in tRNA(Ile): Molecular modeling, density functional theory, and molecular dynamics study. Hayashi Y, Sugiyama H, Suganami A, Higashi K, Kashiwagi K, Igarashi K, Kawauchi S, Tamura Y. Biochem Biophys Res Commun. 2013 Nov 29;441(4):999-1004. Affinity maturation of a CDR3-grafted VHH using in silico analysis and surface plasmon resonance. Inoue H, Suganami A, Ishida I, Tamura Y, Maeda Y. J Biochem. 2013 Oct;154(4):325-32. 　 ２０１２ Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe. Suganami A, Toyota T, Okazaki S, Saito K, Miyamoto K, Akutsu Y, Kawahira H, Aoki A, Muraki Y, Madono T, Hayashi H, Matsubara H, Omatsu T, Shirasawa H, Tamura Y. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7481-5. Structural Changes of Regulatory Domain Heterodimer of N-Methyl-D-aspartate Receptor Subunits GluN1 and GluN2B through the Binding of Spermine and Ifenprodil. Tomitori H, Suganami A, Saiki R, Mizuno S, Yoshizawa Y, Masuko T, Tamura Y, Nishimura K, Toida T, Williams K, Kashiwagi K, Igarashi K. J Pharmacol Exp Ther. 2012 Oct;343(1):82-90. Selected for the cover image of the volume. Interleukin 6 mediates production of interleukin 10 in metastatic melanoma. Terai M, Eto M, Young GD, Berd D, Mastrangelo MJ, Tamura Y, Harigaya K, Sato T. Cancer Immunol Immunother. 2012 Feb;61(2):145-55. ２０１１ Towards understanding cell cycle control in Cryptococcus neoformans: structure-function relationship of G1 and G1/S cyclins homologue CnCln1. Virtudazo EV, Suganami A, Tamura Y, Kawamoto S. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):217-21. Mastermind-like 1 (MamL1)/Mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M. Development. 2011 Dec;138(23):5235-46. Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy. Sato T, Terai M, Tamura Y, Alexeev V, Mastrangelo MJ, Selvan SR. Immunol Res. 2011 Dec;51(2-3):170-82. Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. Kagaya A, Shimada H, Shiratori T, Kuboshima M, Nakashima-Fujita K, Yasuraoka M, Nishimori T, Kurei S, Hachiya T, Murakami A, Tamura Y, Nomura F, Ochiai T, Matsubara H, Takiguchi M, Hiwasa T. Proteome Sci. 2011 Jun 23;9(1):31. ２０１０ Target validation and ligand development for a pathogenic fungal profilin, using a knock-down strain of pathogenic yeast Candida glabrata and structure-based ligand design. Ueno K, Tamura Y, Chibana H. Yeast. 2010 Jul;27(7):369-78. Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin. Nakamura H, Wakita S, Suganami A, Tamura Y, Hanada K, Murayama T. J Lipid Res. 2010 Apr;51(4):720-8. Identification of acrolein-conjugated protein in plasma of patients with brain infarction. Yoshida M, Higashi K, Jin L, Machi Y, Suzuki T, Masuda A, Dohmae N, Suganami A, Tamura Y, Nishimura K, Toida T, Tomitori H, Kashiwagi K, Igarashi K. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1234-9. ２００９ Screening of SMG7-Binding Peptides by Combination of Phage Display and Docking Simulation Analysis. Zahed M, Suzuki T, Suganami A, Sugiyama H, Harada K, Takiguchi M, Tamura Y, Suzuki N. Protein Pept Lett. 2009;16(3):301-5. Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential. Terai M, Tamura Y, Alexeev V, Ohtsuka E, Berd D, Mastrangelo MJ, Sato T. Cancer Immunol Immunother. 2009 Aug;58(8):1307-17. Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells. Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, Kimura S, Yokoyama S, Takano Y, Kikuchi T, Sato N. Biochem Biophys Res Commun. 2009 Feb 13;379(3):765-70. Insight into estrogenicity of phytoestrogens using in silico simulation. Sugiyama H, Kumamoto T, Suganami A, Nakanishi W, Sowa Y, Takiguchi M, Ishikawa T, Tamura Y. Biochem Biophys Res Commun. 2009 Jan 30;379(1):139-44. ２００８ Selective structural change by spermidine in the bulged-out region of double-stranded RNA and its effect on RNA function. Higashi K, Terui Y, Suganami A, Tamura Y, Nishimura K, Kashiwagi K, Igarashi K. J Biol Chem. 2008 Nov 21;283(47):32989-94. Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha. Shimizu M, Nakamura H, Hirabayashi T, Suganami A, Tamura Y, Murayama T. Cell Signal. 2008 May;20(5):815-24. DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo. Chattergoon MA, Muthumani K, Tamura Y, Ramanathan M, Shames JP, Saulino V, Robinson TM, Montaner LJ, Weiner DB. Mol Ther. 2008 Feb;16(2):419-26. ～２００７ Biological heterogeneity of the peptide-binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis. Maeda H, Sahara H, Mori Y, Torigo T, Kamiguchi K, Tamura Y, Tamura Y, Hirata K, Sato N. J Biol Chem. 2007 Sep 14;282(37):26956-62. Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver. Ishihara A, Matsumoto E, Horikawa K, Kudo T, Sakao E, Nemoto A, Iwase K, Sugiyama H, Tamura Y, Shibata S, Takiguchi M. J Biol Rhythms. 2007 Aug;22(4):324-34. Inhibition of hemoglobin S polymerization in vitro by a novel 15-mer EF-helix beta73 histidine-containing peptide. Akbar MG, Tamura Y, Ding M, Ding H, Rosenblatt MM, Reddy KS, Surrey S, Adachi K. Biochemistry. 2006 Jul 11;45(27):8358-67. Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB. J Immunol. 2005 Jul 1;175(1):112-23. Computational evaluation of the specific interaction between cation and mismatch base pair. Sugiyama H, Adachi N, Kawauchi S, Kozasa T, Katayama T, Torigoe H, Ono A, Tamura Y. Nucleic Acids Symp Ser (Oxf). 2005;(49):215-6. Oligodeoxynucleotides having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines form stable hairpins. Yamamoto Y, Shuto S, Tamura Y, Kodama T, Hoshika S, Ichikawa S, Ueno Y, Ohtsuka E, Komatsu Y, Matsuda A. Biochemistry. 2004 Jul 13;43(27):8690-9. Copyright(C)　2009- Dept. of Bioinfor., Chiba Univ. All Rights Reserved.