原著論文
2017
The Pluripotent Stem-Cell Marker Alkaline Phosphatase is Highly Expressed in Refractory Glioblastoma with DNA Hypomethylation..
Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N.
Neurosurgery. 2017 Feb 1;80(2):248-256.
2016
Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands.
Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T.
FEBS J. 2016 Nov;283(21):3931-3940.
Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior.
Fukuda M, Takatori A, Nakamura Y, Suganami A, Hoshino T, Tamura Y, Nakagawara A.
Neurochem Int.2016 Jul;97:42-8.
Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells.
Arai MA, Ishikawa N, Tanaka M, Uemura K, Sugimitsu N, Suganami A, Tamura Y, Koyano T, Kowithayakornd T, Ishibashi M.
Chem. Sci. 2016, 7, 1514-1520.
2015
Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.
Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y.
Int J Pharm. 2015 Oct 23. pii: S0378-5173(15)30271-4.
Effect of photodynamic therapy on local muscle treatment in a rat muscle injury model: a controlled trial.
Inage K, Sakuma Y, Yamauchi K, Suganami A, Orita S, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Takahashi K, Ohtori S, Tamura Y.
J Orthop Surg Res. 2015 Apr 18;10(1):50.
Treatment of near-infrared photodynamic therapy using a liposomally formulated indocyanine green derivative for squamous cell carcinoma.
Maruyama T, Akutsu Y, Suganami A, Tamura Y, Fujito H, Ouchi T, Akanuma N, Isozaki Y, Takeshita N, Hoshino I, Uesato M, Toyota T, Hayashi H, Matsubara H.
PLoS One. 2015 Apr 7;10(4):e0122849.
Detection of peritoneal dissemination with near-infrared fluorescence laparoscopic imaging using a liposomal formulation of a synthesized indocyanine green liposomal derivative.
Hoshino I, Maruyama T, Fujito H, Tamura Y, Suganami A, Hayashi H, Toyota T, Akutsu Y, Murakami K, Isozaki Y, Akanuma N, Takeshita N, Toyozumi T, Komatsu A, Matsubara H.
Anticancer Res. 2015 Mar;35(3):1353-9.
Longitudinal evaluation of local muscle conditions in a rat model of gastrocnemius muscle injury using an in vivo imaging system.
Inage K, Sakuma Y, Yamauchi K, Suganami A, Orita S, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Takahashi K, Ohtori S, Tamura Y.
J Orthop Res. 2015 Mar 2.
2014
Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice.
Qin W, Akutsu Y, Andocs G, Suganami A, Hu X, Yusup G, Komatsu-Akimoto A, Hoshino I, Hanari N, Mori M, Isozaki Y, Akanuma N, Tamura Y, Matsubara H.
Oncol Rep. 2014 Dec;32(6):2373-9.
Aurora kinase A is a possible target of OSU‑03012 to destabilize MYC family proteins.
Silva A, Wang J, Lomahan S, Tran TA, Grenlin L, Suganami A, Tamura Y, Ikegaki N.
Oncol Rep. 2014 Sep;32(3):901-5.
Structure based functional distinction between Cln1 and Cln2 depends on the ubiquitin-proteasome pathway.
Suganami A, Takase N, Sugiyama H, Virtudazo EV, Kawamoto S, Tamura Y.
J. Proteomics Bioinform. 2014 May; 7:102-107.
Chemical and Biological Properties of ICG-Lipo.
Suganami A, Toyota T, Okazaki S, Hayashi H, Okamoto Y, Tamura Y.
JJSLSM 2014 ;35(1):39-45.
Outcome from Photodynamic Therapy with Phospholipid-Conjugated Indocyanine Green for Animal Spontaneous Deep-Seated Occurring Tumors.
Okamoto Y, Ohsaki T, Azuma K, Itoh N, Tsuka1T, Imagawa T, Suganami A, Tamura Y.
JJSLSM 2014 ;35(1):46-50.
Non-deep-seated primary CNS lymphoma – therapeutic responses and a molecular signature.
Iwadate Y, Suganami A, Ikegami S, Shinozaki N, Matsutani T, Tamura Y, Saeki N, Yamanaka R.
J. Neurooncol. 2014 Apr;117(2):261-8.
Near-infrared-fluorescence imaging of lymph nodes by using liposomally formulated indocyanine green derivatives.
Toyota T, Fujito H, Suganami A, Ouchi T, Ohishi A, Aoki A, Onoue K, Muraki Y, Madono T, Fujinami M, Tamura Y, Hayashi H.
Bioorg Med Chem. 2014 Jan 15;22(2):721-7.
Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma.
Nakamura Y, Suganami A, Fukuda M, Hasan MK, Yokochi T, Takatori A, Satoh S, Hoshino T, Tamura Y, Nakagawara A.
Cancer Med. 2014 Feb;3(1):25-35.
2013
Prediction of the interaction between spermidine and the G-G mismatch containing acceptor stem in tRNA(Ile): Molecular modeling, density functional theory, and molecular dynamics study.
Hayashi Y, Sugiyama H, Suganami A, Higashi K, Kashiwagi K, Igarashi K, Kawauchi S, Tamura Y.
Biochem Biophys Res Commun. 2013 Nov 29;441(4):999-1004.
  Affinity maturation of a CDR3-grafted VHH using in silico analysis and surface plasmon resonance.
Inoue H, Suganami A, Ishida I, Tamura Y, Maeda Y.
J Biochem. 2013 Oct;154(4):325-32.
 
2012
  Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe.
Suganami A, Toyota T, Okazaki S, Saito K, Miyamoto K, Akutsu Y, Kawahira H, Aoki A, Muraki Y, Madono T, Hayashi H, Matsubara H, Omatsu T, Shirasawa H, Tamura Y.
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7481-5.
  Structural Changes of Regulatory Domain Heterodimer of N-Methyl-D-aspartate Receptor Subunits GluN1 and GluN2B through the Binding of Spermine and Ifenprodil.
Tomitori H, Suganami A, Saiki R, Mizuno S, Yoshizawa Y, Masuko T, Tamura Y, Nishimura K, Toida T, Williams K, Kashiwagi K, Igarashi K
J Pharmacol Exp Ther. 2012 Oct;343(1):82-90.
雑誌の表紙に採択されました 
  Interleukin 6 mediates production of interleukin 10 in metastatic melanoma.
Terai M, Eto M, Young GD, Berd D, Mastrangelo MJ, Tamura Y, Harigaya K, Sato T.
Cancer Immunol Immunother. 2012 Feb;61(2):145-55.
  2011
  Towards understanding cell cycle control in Cryptococcus neoformans: structure-function relationship of G1 and G1/S cyclins homologue CnCln1.
Virtudazo EV, Suganami A, Tamura Y, Kawamoto S.
Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):217-21.
  Mastermind-like 1 (MamL1)/Mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M.
Development. 2011 Dec;138(23):5235-46.
  Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy.
Sato T, Terai M, Tamura Y, Alexeev V, Mastrangelo MJ, Selvan SR.
Immunol Res. 2011 Dec;51(2-3):170-82.
  Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma.
Kagaya A, Shimada H, Shiratori T, Kuboshima M, Nakashima-Fujita K, Yasuraoka M, Nishimori T, Kurei S, Hachiya T, Murakami A, Tamura Y, Nomura F, Ochiai T, Matsubara H, Takiguchi M, Hiwasa T.
Proteome Sci. 2011 Jun 23;9(1):31.
2010
Target validation and ligand development for a pathogenic fungal profilin, using a knock-down strain of pathogenic yeast Candida glabrata and structure-based ligand design.
Ueno K, Tamura Y, Chibana H.
Yeast. 2010 Jul;27(7):369-78.
Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin.
Nakamura H, Wakita S, Suganami A, Tamura Y, Hanada K, Murayama T.
J Lipid Res. 2010 Apr;51(4):720-8.
Identification of acrolein-conjugated protein in plasma of patients with brain infarction.
Yoshida M, Higashi K, Jin L, Machi Y, Suzuki T, Masuda A, Dohmae N, Suganami A, Tamura Y, Nishimura K, Toida T, Tomitori H, Kashiwagi K, Igarashi K.
Biochem Biophys Res Commun. 2010 Jan 8;391(2):1234-9.
2009
Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential.
Terai M, Tamura Y, Alexeev V, Ohtsuka E, Berd D, Mastrangelo MJ, Sato T.
Cancer Immunol Immunother. 2009 Aug;58(8):1307-17.
Screening of SMG7-Binding Peptides by Combination of Phage Display and Docking Simulation Analysis.
Zahed M, Suzuki T, Suganami A, Sugiyama H, Harada K, Takiguchi M, Tamura Y, Suzuki N.
Protein Pept Lett. 2009;16(3):301-5.
Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells.
Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, Kimura S, Yokoyama S, Takano Y, Kikuchi T, Sato N.
Biochem Biophys Res Commun. 2009 Feb 13;379(3):765-70.
Insight into estrogenicity of phytoestrogens using in silico simulation.
Sugiyama H, Kumamoto T, Suganami A, Nakanishi W, Sowa Y, Takiguchi M, Ishikawa T, Tamura Y.
Biochem Biophys Res Commun. 2009 Jan 30;379(1):139-44.
2008
Selective structural change by spermidine in the bulged-out region of double-stranded RNA and its effect on RNA function.
Higashi K, Terui Y, Suganami A, Tamura Y, Nishimura K, Kashiwagi K, Igarashi K.
J Biol Chem.
2008 Nov 21;283(47):32989-94.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
Shimizu M, Nakamura H, Hirabayashi T, Suganami A, Tamura Y, Murayama T.
Cell Signal.
2008 May;20(5):815-24.
DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo.
Chattergoon MA, Muthumani K, Tamura Y, Ramanathan M, Shames JP, Saulino V, Robinson TM, Montaner LJ, Weiner DB.
Mol Ther. 2008 Feb;16(2):419-26.
~2007
Biological heterogeneity of the peptide-binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis.
Maeda H, Sahara H, Mori Y, Torigo T, Kamiguchi K, Tamura Y, Tamura Y, Hirata K, Sato N.
J Biol Chem. 2007 Sep 14;282(37):26956-62.
Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver.
Ishihara A, Matsumoto E, Horikawa K, Kudo T, Sakao E, Nemoto A, Iwase K, Sugiyama H, Tamura Y, Shibata S, Takiguchi M.
J Biol Rhythms.
2007 Aug;22(4):324-34.
Inhibition of hemoglobin S polymerization in vitro by a novel 15-mer EF-helix beta73 histidine-containing peptide.
Akbar MG, Tamura Y, Ding M, Ding H, Rosenblatt MM, Reddy KS, Surrey S, Adachi K.
Biochemistry.
2006 Jul 11;45(27):8358-67.
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.
Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB.
J Immunol. 2005 Jul 1;175(1):112-23.
Computational evaluation of the specific interaction between cation and mismatch base pair.
Sugiyama H, Adachi N, Kawauchi S, Kozasa T, Katayama T, Torigoe H, Ono A, Tamura Y.
Nucleic Acids Symp Ser (Oxf). 2005;(49):215-6.
Oligodeoxynucleotides having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines form stable hairpins.
Yamamoto Y, Shuto S, Tamura Y, Kodama T, Hoshika S, Ichikawa S, Ueno Y, Ohtsuka E, Komatsu Y, Matsuda A.
Biochemistry. 2004 Jul 13;43(27):8690-9.
著書
「インドシアニングリーン修飾リポソームを用いたがん治療:基礎と臨床」
岡本芳晴, 菅波晃子, 田村 裕.
ファルマシア. 2015 51(11): 1042-46. The Pharmaceutical Society of Japan
「インドシアニングリーン修飾リポソームを用いたがん治療〜基礎編」
菅波晃子, 齋藤謙悟, 堀田行久, 森本 稔, 岡本芳晴, 白澤 浩, 田村 裕.
infoVets. 2015 18(2): 34-38.
 
特許
「新規化合物及びこれを有効成分とする抗ウイルス剤」
特願2014-264513号
白澤 浩,荒井 孝義,田村 裕,齋藤 謙悟,菅波 晃子,大野 吉史,柳澤 章,松本 祥治,根本 哲宏,渡辺 旺嗣
 
「神経変性疾患治療剤」
特願2013−066352号・PCT/JP2014/058005
中川原 章,田村 裕,中村 洋子,菅波 晃子,福田 真佑
 
「抗癌剤」
特許第6045828号 特願2012−155889号
中川原 章,田村 裕,星野 忠次,中村 洋子,菅波 晃子
 
「抗癌剤」
特許第6013029号 特願2012−119973号
中川原 章,田村 裕,星野 忠次,中村 洋子,菅波 晃子
 
「近赤外線の波長特性を利用した非侵襲性医療装置」
特願2012−103379号
岡本芳晴,田村 裕,菅波晃子,豊田太郎,林 秀樹,真殿智行,松原久裕
 
「抗癌剤」
特許第5955531号 特願2011−243013号
中川原 章,田村 裕,星野 忠次,中村 洋子,菅波 晃子
 
「リポソーム複合体」
特許第5979385号 特願2011-223273号・PCT/JP2012/076259
岡本 芳晴,田村 裕,菅波 晃子,林 秀樹,真殿 智行,松原 久裕,豊田 太郎
 
「リンパ節イメージング用蛍光プローブ」
特開2017-75937 特願2010-124252号・PCT/JP2011/003069・TW100119156
林 秀樹,藤浪 眞紀,豊田 太郎,田村 裕,青木 陽,村木 裕,尾上 和貴
 
「血液細胞の凍結保存剤」
特願2009-270830号
大須賀 敏明,清水 直美,中世古 知昭,田村 裕,浅井 隆善,高梨 美乃子
 
「デコリン由来ペプチド」
特許 第4560612号
瀧口 正樹,町田 雅之,田村 裕,日和佐 隆樹,下出 真義
 
「分子設計装置、分子設計方法及びプログラム」
特許5339111号
田村 裕,星野 忠次,藤 秀義,安達 統衛,塩原 紀行,杉山 肇
 
「生物学情報統合装置、生物学情報統合方法及び生物学情報統合プログラム」
特願2004-37337, PCT/JP2005/002055
大塚榮子,田村裕,天野直己,倉井龍太郎
 
「データベース及び解析サービスの操作統合システム、その方法、及びそのプログラム」
特許 第4543166号
大塚 栄子,田村 裕,天野 直己
 
「抗体医薬」
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