研 究 論 文

PUBLICATION LIST

青字は教室元在籍者あるいは現在籍者)

2016

Fujita T, Yoshioka K, Umezawa H, Tanaka K, Naito Y, Nakayama T, Hatano M,Tatsumi K, Kasuya Y. Role of CD69 in the pathogenesis of elastase-induced pulmonary inflammationand emphysema. Biochem Biophys Rep. in press, 2016.

Song D, Nishiyama M, Kimura S: Potent inhibition of angiotensin AT1 receptor signaling by RGS8: Importance of the C terminal third exon part of its RGS domain. J Recept Signal Transduct. 36(5):478-487, 2016.

Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, Fukamizu A: Severe hypomyelination and developmental defects are caused in mice lacking protein arginine methyltransferase 1 (PRMT1) in the central nervous system. J Biol Chem, 291(5):2237-2245, 2016.

2015

Kim J, Park K, Ishida J, Kako K, Hamada J, Kani S, Takeuchi M, Namiki K, Fukui H, Fukuhara S, Hibi M, Kobayashi M, Kanaho Y, Kasuya Y, Mochizuki N, Fukamizu A: PRMT8 as a phospholipase regulates Purkinje cell dendritic arbors and motor coordination. Science Advances, Dec 4;1(11):e1500615, 2015 (doi: 10.1126/sciadv.1500615), 2015.

Kobayashi T, Tanaka K, Fujita T, Umezawa H, Amano H, Yoshioka K, Naito Y, Hatano M, Kimura S, Tatsumi K, Kasuya Y: Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis. Respiratory Research, 2015 Aug 20;16:99 (14 pages). doi: 10.1186/s12931-015-0261-z.

Yoshioka K, Namiki K, Sudo T, Kasuya Y: p38alpha controls self-renewal and fate decision of neurosphere-forming cells in adult hippocampus. FEBS Open Bio, 5:437-44, 2015.

2014

Emoto N, Kasuya Y, Yanagisawa M: The Second Tomoh Masaki Award (2013). Life Sci, 118(2):87-90, 2014.

Naito Y, Yoshioka K, Tanaka K, Tatsumi K, Kimura S, Kasuya Y: Endothelin B receptor-mediated encephalopathic events in mouse sepsis model.
Life Sci, 118(2):340-346, 2014.

Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y: Endothelin regulates function of IL-17-producing T cell subset. Life Sci. 118(2):244-247, 2014.

Tanaka K, Fujita T, Umezawa H, Namiki K, Yoshioka K, Hagihara M, Sudo T, Kimura S, Tatsumi K, Kasuya Y: Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis. Laboratory Investigation, 94(11):1247-1259, 2014.

Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y: p38 Mitogen-Activated Protein Kinase Accelerates Emphysema in Mouse Model of Chronic Obstructive Pulmonary Disease. J Recept Signal Transduct. 34(4):299-306, 2014.

2013

Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R: Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agricultural and Food Chemistry, 61:128-136, 2013.

Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S: Chapter 239, In silico search for biologically active peptides. in "Handbook of the Biologically Active Peptides", 2nd edition, edited by Kastin AJ, Academic Press, pp1743-1748, 2013.

2012

Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, Kasuya Y: Mechanism for p38alpha-mediated experimental autoimmune encephalomyelitis. J. Biol. Chem. 287(29): 24228-24238, 2012.

Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Matsunaga H, Iwamura C, Nakayama T, Tatsumi K: Role of CD69 in acute lung injury. Life Sci. 90(17-18): 657-665, 2012.

Sakurai K, Lee EY, Morita A, Kimura S, Kawamura K, Kasamatsu A, Shiiba M, Yabe Y, Yokote K, Miki T: Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive sweetener. J. Diabetes Invest. 3(2):156-163, 2012.

2011

Tsuyusaki J, Kuroda F, Kasuya Y, Ishizaki S, Yamauchi K, Sugimoto H, Kono T, Iwamura C, Nakayama T and Tatsumi K. Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice. J . Recept. Signal Transduct. 31(6):434-439, 2011.

Yamauchi K, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Ishizaki S, Matsunaga H, Iwamura C, Nakayama T, Tatsumi K: Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir. Res. Oct 5;12:131., 2011.

Tanaka Y, Takahashi H, Shibata S, Namiki K, Kimura S, Koike K, Kasuya Y: Functional analysis of guinea pig beta1-adrenoceptor. J. Receptor Signal Transduct. 31(6):395-401, 2011.

Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S: Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2: Roles of its N-terminal domain. Cellular Signalling 23(6):1041-1049, 2011.

2010

Tokuhara N*, Namiki K*, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y: N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis J. Biol. Chem. 285(43):33294-33306, 2010. (*The first two authors contributed equally to this work)

2009 

Miyamoto N, Namiki K, Tokuhara N, Uesugi M, Takahashi E, Kuromitsu J, Kasuya Y: The utilization of gene targeting models during in preclinical study of drug discovery process -Example of phenotypic and functional analysis of Cacna1b gene product- Curr. Pharmaceut. Biotech. 10(2):261-267, 2009.

2008

Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol. Cell 32(2):221-231, 2008.

Asada S, Ikeda A, Nagao R, Hama H, Sudo T, Fukamizu A, Kasuya Y, Kishi T: Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase. Int. J. Mol. Med, 22(1): 95-104, 2008.

Furuya M, Ishida J, Inaba S, Kasuya Y, Kimura S, Nemori R, Fukamizu A: Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension. Laboratory Investigation, 88(4): 416-429, 2008.

2007

Furuya M, Suyama T, Usui H, Kasuya Y, Nishiyama M, Tanaka N, Ishiwata I, Nagai Y, Shozu M, Kimura S: Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis. Human Pathol. 38(11):1676-87, 2007.

Hasegawa M, Furuya M, Kasuya Y, Nishiyama.M, Sugiura T. Nikaido T, .Momota Y, Ichinose M, Kimura S: The dynamics of CD151 might be crucial in carcinoma-stroma interaction by controlling integrins expression, adhesion strength and proteolytic activities. Laboratory Investigation. 87(9): 882-892, 2007.

Moroi K, Nishiyama M, Kawabata S, Ichiba H, Yajima T, Kimura S: Phosphorylation of Ser166 in RGS5 by protein kinase C causes loss of RGS function. Life Sci. 81(1): 40-50, 2007.

Namiki K, Nakamura A, Furuya M, Mizuhashi S, Matsuo Y, Tokuhara N, Sudo T, Hama H, Kuwaki T, Yano S, Kimura S, Kasuya Y: Involvement of p38a mitgen-activated protein kinase in kainate-induced seizure and neuronal cell damage. J Receptor Signal Transduct. 27(2-3): 99-111, 2007.

Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Kako K, Kishi T, Kasuya Y, Fukamizu A: Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cellular Signalling, 19(3):519-527, 2007.

2006

Matsuo Y*, Amano S*, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y: Involvement of p38alpha mitgen-activayed protein kinase in lung metastasis of tumor cells. J. Biol. Chem. 281, 36767-36775, 2006. (*The first two authors contributed equally to the work.)

Iemitsu M, Maeda S, Jesmin S, Otsuki T, Kasuya Y, Miyauchi T: Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. J Applied Physiol. 101(1), 151-63, 2006.

2005

Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H: Pathophysiology of Tumor Neovascularization. Vasc. Health Risk Management, I (4), 277-290, 2005.

Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT: RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc. Natl. Acad. Sci. USA 102:15030-15035, 2005.

Hashimoto Y, Ishida J, Yamamoto R, Fujiwara K, Asada S, Kasuya Y, Mochizuki N, Fukamizu A: G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility. Int. J. Mol. Med. 16, 787-792, 2005.

Momota Y, Suzuki N, Kasuya Y, Kobayashi T, Mizoguchi M, Yokoyama F, Nomizu M, Shinkai H, Iwasaki T, Utani A: Lamininホア3 LG4 module induces keratinocyte migration: Involvement of matrix metalloproteinase-9. J. Receptors Signal Transduction 25, 1-17, 2005.

Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A: Neurochondrin negatively regulates CaMKII phosphorylation and nervous system specific gene disruption results in epileptic seizure. J. Biol. Chem. 280, 20503-20508, 2005.

Suyama T, Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ichikawa T, Ueda T, Nikaido T, Ito H, Ishikura H: Up-Regulation of IFN-γ-Inducible Chemokine I-TAC and Mig, and Their Receptor CXCR3 in Human Renal Cell Carcinoma. Cancer 103, 258-67, 2005.

2004

Sakurai K, Matsuo Y, Sudoh T, Takuwa Y, Kimura S, Kasuya Y: Role of p38 mitogen-activated protein kinase in thrombus formation. J. Receptors Signal Transduction 24, 283-296, 2004.

Amano S, Tatsumi K, Tanabe N, Kasahara Y, Kurosu K, Takiguchi Y, Kasuya Y, Kimura S, Kuriyama T: Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension. Respirology 9, 184-189, 2004.

Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, Sugaya T, Matsuzaki H, Yamamoto R, Shiota N, Okunishi H, Kihara M, Umemura S, Sugiyama F, Yagami K, Kasuya Y, Mochizuki N, and Fukamizu A: Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo. J. Biol. Chem. 279, 26274-26279, 2004.

Furuya M, Nishiyama M, Kimura S, Suyama T, Naya Y, Ito H, Nikaido T, Ishikura H: Expression of a Regulator of G Protein Signaling, RGS5 in Angiogenic Vessels of Human Renal Cell Carcinoma. J. Pathology 203, 551-558, 2004.

Asada S, Takanami-Ohnishi Y, Zhou J, Hama H, Fukamizu A, Kimura S, Goto K, Kasuya Y: Cytodifferentiation enhances Erk activation induced by endothelin-1 in promary cultured astrocytes. J. Cardiovasc. Pharmacol. 44 (Suppl.1), S307-S312, 2004.

Irukayama-Tomobe Y, Miyauchi T, Kasuya Y, Sakai S, Goto K, Yamaguchi I: Activation of peroxisome proliferator-activated receptor-α (PPAR-α) decreases endothelin-1-induced p38 mitogen-activated protein kinase (MAPK) activation in cardiomyocytes. J. Cardiovasc. Pharmacol. 44 (Suppl.1), S358-S361, 2004.

Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I: Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway. Circulation 109, 904-910, 2004.

2003

Utani A, Momota Y, Endo H, Kasuya Y, Beck K, Suzuki N, Nomizu M, Shinkai H : Lamininα3 LG4 module induces matrix metalloproteinase-1 (MMP-1) through MAPK signaling. J. Biol. Chem. 278, 34483-34490, 2003.

Kayaba Y, Nakamura A, Kasuya Y, Ohuchi T, Yanagisawa M, Komuro I, Fukuda Y, Kuwaki T: Attenuated defense response and low basal blood pressure in orexin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R581-R593, 2003.

Sato M, Moroi K, Nishiyama M, Zhou J, Usui H, Kasuya Y, Fukuda M, Kohara Y, Komuro I, Kimura S: Characterization of a novel C. elegans RGS protein with a C2 domain - Evidence for interaction between C2 domain and Galfaq subunit -. Life Sci. 73, 917-932, 2003.

2002

Takanami-Ohnishi Y*, Amano S*, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y: Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J. Biol. Chem. 277, 37896-37903, 2002. (*The first two authors contributed equally to the work.)

2001

Takanami-Ohnishi Y, Asada S, Tsunoda H, Fukamizu A, Goto K, Yoshikawa H, Kubo T, Sudo T, Kimura S, Kasuya Y : Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition. Biochem. Biophs. Res. Commun. 288, 1155-1161, 2001.

Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S : Characterization of RGS5 in regulation of G protein-coupled receptor signaling. Life Sci. 68: 1457-1469, 2001.

2000

Maruyama M, Sudo T, Kasuya Y, Siga T, Hu BR, Osada H: Immunolocalization of p38 MAPK in mouse brain. Brain Res. 887: 350-358, 2000.

Homma S, OppenheimRW, Yaginuma H, Kimura S: Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Dev. Biol. 217: 121-137, 2000.

Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai K, Nishijo N, Shigematsu Y, Horiguchi H, Kasuya Y, Sugiyama F, Yagami K, Murakami K, Fukamizu A: Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J. Biol. Chem. 275: 5-8, 2000.

Usui H, Nishiyama M, Moroi K, Shibasaki T, Zhou J, Ishida J, Fukamizu A, Haga T, Sekiya S, Kimura S: RGS domain in the amino-terminus of G protein-coupled receptor kinase-2 inhibits Gq-mediated signaling. Int. J. Mol. Med. 5: 335-340, 2000.

Kurihara Y, Kurihara H, Morita H, Cao WH, Ling GY, Kumada M, Kimura S, Nagai R, Yazaki Y, Kuwaki T: Role of endothelin-1 in stress response in the central nervous system. Am. J. Physiol. 279: R515-R521, 2000.

 

1999

Kakinuma Y, Hama H, Kasuya Y, Fukamizu A: A new aspect of renin-angiotensin system (RAS) in central nervous system -RAS indispensable for maintaining function of Astrocytes-. Recent Research Developments in Neurochemistry 2: 473-493, 1999.

Gonda K, Okamoto H, Takuwa N, Yatomi Y, Okazaki H, Sakurai T, Kimura S, Sillard R, Harii K, Takuwa Y: The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. Biochem. J. 337: 67-75, 1999.

Yamamoto T, Nozaki-Taguchi N, Sakashita Y, Kimura S: Nociceptin/Orphanin FQ: Role in nociceptive information processing. Prog. Neurobiol. 57: 527-535, 1999.

Shibasaki T, Moroi K, Nishiyama M, Zhou J, Sakamoto A, Masaki T, Ito K, Haga T, Kimura S: Characterization of the carboxyl-terminal truncated endothelin B receptor coexpressed with G protein-coupled receptor kinase 2. Biochem. Mol. Biol. Int. 47: 569-577, 1999.

Namiki S, Kaneda F, Ikegami M, Arai T, Fujimori K, Asada S, Hama H, Kasuya Y, Goto K: Bis-N-nitroso-caged nitric oxides: photochemistry and biological performance test by rat aorta vasorelaxation. Bioorg. Med. Chem. 7: 1695-1702, 1999.

Le-Niculescu H, Bonfoco E, Kasuya Y, Claret F-X, Green DR, Karin M: Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19: 751-763, 1999.

Asada S, Kasuya Y, Hama H, Masaki T, Goto K: Cytodifferentiation potentiates aFGF-induced p21(ras)/Erk signaling pathway in rat cultured astrocytes. Biochem. Biophys. Res. Commun. 260: 441-445,1999.

Ishida J, Asada S, Daitoku H, Fujiwara K, Kon Y, Sugaya T, Murakami K, Nakajima T, Kasuya Y, Fukamizu A: Expression and characterization of mouse angiotensin II type 1a receptor tagging hemagglutinin epitope in cultured cells. Int. J. Mol. Med. 3: 263-270, 1999.

 

1998

Tanaka H, Moroi K, Iwai J, Takahashi H, Ohnuma N, Hori S, Takimoto M, Nishiyama M, Masaki T, Yanagisawa M, Sekiya S, Kimura S: Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization. J. Biol. Chem. 273: 11378-11383, 1998.

Moroi K, Ozaki N, Kadota T, Kadota K: Characterization of [3H]5-hydroxytryptamine and [3H]spiperone binding sites in clathrin-coated vesicles from bovine brain. Brain Res. 794: 291-298, 1998.

Uesugi M, Kasuya Y, Hayashi K, Goto K: SB209670, a potent endothelin receptor antagonist, prevents axonal degeneration after spinal cord injury. Brain Res. 786: 235-239, 1998. 

 

1997

Yamamoto T, Nozaki-Taguchi N, Kimura S:Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test. Neurosci. 81: 249-254, 1997.

Yamamoto T, Nozaki-Taguchi N, Kimura S: Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw. Brain Res. 754: 329-332, 1997.

Yamamoto T, Nozaki-Taguchi N, Kimura S: Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci. Lett. 224: 107-110, 1997.

Mizuguchi T, Nishiyama M, Moroi K, Tanaka H, Saito T, Masuda Y, Masaki T, de Wit D, Yanagisawa M, Kimura S: Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse. Br. J. Pharmacol. 120: 1427-1430, 1997.

Wei S, Kasuya Y, Yanagisawa M, Kimura S, Masaki T, Goto K: Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery. Eur. J. Pharmacol. 321: 307-314, 1997.

Hohki G, Terada N, Hamano N, Kitaura M, Nakajima T, Yoshie O, Ikeda T, Kimura S, Konno A: The effects of eotaxin on the surface adhesion molecules of endothelial cells and on eosinophil adhesion to microvascular endothelial cells. Biochem. Biophys. Res. Commun. 241: 136-141, 1997.

Hama H, Kasuya Y, Sakurai T, Yamada G, Suzuki N, Masaki T, Goto K: Role of Endothelin-1 in Astrocyte Responses after Acute Brain Damage. J. Neurosci. Res. 47: 590-602, 1997.

Ozawa F, Kasuya Y, Hama H, Asada S, Inada T, Masaki T, Goto K: Microtubule dynamics regulates the level of endothelin-B receptor in rat cultured astrocytes. J. Neurochem. 69: 562-569, 1997.

Koyama K, Kasuya Y, Koyama K, Goto K: Nitric oxide-mediated vasorelaxation induced by sodium polyoxyethylene laurylether sulfate. Toxicol. Appl. Pharmacol. 145: 294-300, 1997.

Goto K, Hama H, Kasuya Y: Molecular pharmacology and pathological significance of endothelin. Jpn. J. Pharmacol. 72: 261-290, 1997.

 

1996

Watabe Y, Kuramochi H, Furuya Y, Inagaki N, Seino S, Kimura S, Shimazaki J: Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells. J. Biol. Chem. 271: 25126-25130, 1996.

Kadota T, Yamaai T, Saito Y, Akita Y, Kawashima S, Moroi K, Inagaki N, Kadota K: Expression of dopamine transporter at the tips of growing neurites of PC12 cells. J. Histochem. Cytochem. 44: 989-996, 1996.

Okamoto O, Suzuki Y, Kimura S, Shinkai H: Extracellular matrix 22-kDa protein interacts with decorin core protein and is expressed in cutaneous fibrosis. J. Biochem. 119: 106-114, 1996.

Shan L-H, Nishiyama M, Shibasaki T, Moroi K, Goto K, Masaki T, Kimura S: Endothelin ETA and ETB receptors mediate endothelin-1-induced apamin-sensitive relaxation in the guinea-pig ileum. Jpn. J. Pharmacol. 70: 259-267, 1996.

Kobayashi S, Nakaya H, Takizawa T, Hara Y, Kimura S, Saito T, Masuda Y: Endothelin-1 inhibits ATP-sensitive K+ current in guinea-pig ventricular cells. J. Cardiovasc. Pharmacol. 27: 12-19, 1996.

Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y: Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. -Marked increase in endothelin-1 production in the failing heart-. Circulation 93: 1214-1222, 1996.

Uesugi M, Kasuya Y, Hama H, Yamamoto M, Hayashi K, Masaki T, Goto K: Endogenous endothelin-1 initiates astrocytic growth after spinal cord injury. Brain Res. 728: 255-259, 1996.

Nakaya H, Kobayashi S, Takizawa T, Hara Y, Uemura H, Saito T, Kimura S, Masuda Y: Modulation of cardiac ATP-sensitive K+ channels: Potential electrophysiological outcome during myocardial ischemia and reperfusin. in: Recent Progresdsd in Elecyropharmacology of the Heart, edited by Toyama J, Hiraoka M, Kodama I. CRC Press, p107-117, 1996.

 

1995

Yorimitsu K, Moroi K, Inagaki N, Saito T, Masuda Y, Masaki T, Seino S, Kimura S: Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. Biochem. Biophys. Res. Commun. 208: 721-727, 1995.

Nishiyama M, Takahara Y, Masaki T, Nakajima N, Kimura S: Pharmacological heterogeneity of both endothelin ETA- and ETB-receptors in the human saphenous vein. Jpn. J. Pharmacol. 69: 391-398, 1995.

Nishiyama M, Shan L-H, Moroi K, Masaki T, Kimura S: Heterogeneity of endothelin ETA receptor-mediated contractions in the rabbit saphenous vein. Eur. J. Pharmacol. 286: 209-212, 1995.

Nishiyama M, Moroi K, Shan L-H, Yamamoto M, Takasaki C, Masaki T, Kimura S: Two different endothelin B receptor subtypes mediate contraction of the rabbit saphenous vein. Jpn. J. Pharmacol. 68: 235-243, 1995.

Kobayashi S, Nakaya H, Takizawa T, Hara Y, Kimura S, Saito T,. Masuda Y: Effects of endothelin-1 on ATP-sensitive K+ current in cardiac cells. Heart Vessels Suppl.9: 106-108, 1995.

Kadota T, Yamaai T, Saito Y, Kawashima S, Moroi K, Kadota K: Expression of a dopamine transporter in PC12h cells: An immunohistchemical study with an antipeptide antibody. Acta Anat. Nipponia 70: 248-251, 1995.

Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K: Molecular characterization of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors. Eur. J. Biochem. 228: 102-108, 1995.

Yamada G, Hama H, Kasuya Y, Masak T, Goto K: Possible sources of endothelin-1 in damaged rat brain. J. Cardiovasc. Pharmacol. 26 (Suppl.): 486-490, 1995.

Asada S, Kasuya Y, Sakurai T, Masaki T, Goto K: ET-1-induced down-regulation of ETB receptor mRNA: participation of cAMP. J. Cardiovasc. Pharmacol. 26 (Suppl.): 272-275, 1995.

Sakai S, Yorikane R, Miyauchi T, Sakurai T, Kasuya Y, Yamaguchi I, Sugishita Y, Goto K: Altered production of endothelin-1 in the hypertrophied rat heart. J. Cardiovasc. Pharmacol. 26 (Suppl.): 452-455,1995.

Miyauchi T, Sakai S, Ihara M, Kasuya Y, Yamaguchi I, Goto K, Sugishita Y: Increased endothelin-1 binding sites in the cardiac membranes in rats with chronic heart failure. J. Cardiovasc. Pharmacol. 26 (Suppl.): S448-451,1995.

 

1994

Ozaki N, Moroi K, Kadota T, Suzuki S, Kadota K: Dopamine D1 and D2 receptors and their signal system present in coated vesicles prepared from bovine striatal tissue. J. Neurochem. 62: 582-591, 1994.

Opgenorth TJ, Kimura S, Wu-Wong JR: Characterization of endothelin converting enzyme. Methods in Neurosci. 23: 251-265, 1994.

Sakurai T, Abe Y, Kasuya Y, Takuwa N, Shiba R, Yamashita T, Endo T, Goto K: Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without the activation of mitogen-activated protein kinases. J. Biol. Chem. 269: 14118-14122, 1994.

Yasuda N, Kasuya Y, Yamada G, Hama H, Masaki T, Goto K: Loss of contractile activity of endothelin-1 induced by electrical field stimulation-generated free radicals. Br. J. Pharmacol. 113: 21-28, 1994.

Kasuya Y, Abe Y, Hama H, Sakurai T, Asada S, Masaki T, Goto K: Endothelin-1 activates mitogen-activated protein kinases through two independent signaling pathways in rat astrocytes. Biochem. Biophys. Res. Commun. 204: 1325-1333, 1994. 

 

1993

Sawamura T, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. Biochim. Biophys. Acta 1161: 295-302, 1993.

Giaid A, Yanagisawa M, Langleben D, Michel R, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Path FRC, Stewart DJ: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Eng. J. Med. 328: 1732-1739, 1993.

Shinmi O, Yorimitsu K, Moroi K, Nishiyama M, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S: Endothelin converting enzyme from human renal adenocarcinoma (ACHN) cells is a phosphoramidon-sensitive, membrane-bound metalloprotease. J. Cardiovasc. Pharmacol. 22(Suppl.8): S61-S64, 1993.

Kadota T, Mizote M, Moroi K, Ozaki N, Kadota K: Rapid recovery of structure and function of the cholinergic synapses in the cat superior cervical ganglion in vivo following stimulation-induced exhaustion. J. Neurocytol. 22: 743-752,1993.

Masaki T, Kasuya Y, Goto K: Endothelin in regulation of vascular tone. Atherosclerosis Reviews 25: 111-118, 1993.

 

1992

Yorimitsu K, Shinmi O, Nishiyama M, Moroi K, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S: Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal adenocarcinoma (ACHN) cells. Analysis of endothelin-2 biosynthetic pathway. FEBS Lett. 314: 395-398, 1992.

Kadota T, Fujita M, Moroi K, Kadota K: Localization of a 82 kDa protein in postsynaptic density and its association with cytoskeletons. Neurosci. Res. 15: 124-129, 1992.

Goto K, Yanagisawa M, Kimura S, Masaki T: Cardiovascular effects of endothelin. Jpn. Circ. J. 56: 162-169, 1992.

Sakurai T, Morimoto H, Kasuya Y, Takuwa Y, Nakauchi H, Masaki T, Goto K: Level of ETB receptor mRNA is down-regulated by endothelins through decreasing the intracellular stability of mRNA molecules. Biochem. Biophys. Res. Commun. 186: 342-347, 1992.

Hama H, Sakurai T, Kasuya Y, Fujiki M, Masaki T, Goto K.: Action of endothelin-1 on rat astrocyte through ETB receptor. Biochem. Biophys. Res. Commun. 186: 355-362, 1992.

Kasuya Y, Takuwa Y, Yanagisawa M, Masaki T, Goto K: A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle. Br. J. Pharmacol. 107: 456-462, 1992.

Noguchi J, Yanagisawa M, Imamura M, Kasuya Y, Sakurai T, Tanaka T, Masaki T: Complete primary structure and tissue expression of chicken pectralis M-protein. J. Biol. Chem. 267: 20302-20310, 1992.

 

1991

Ishikawa T, Li L, Shinmi O, Kimura S, Yanagisawa M, Goto K, Masaki T:Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Circ. Res. 69: 918-926, 1991.

Masaki T, Kimura S, Yanagisawa M, Goto K: Molecular and cellular mechanism of endothelin regulation. Circulation 84: 1457-1467, 1991.

Shigeno T, Mima T, Yanagisawa M, Saito A, Fujimori M, Shiba R, Goto K, Kimura S, Yamashita K, Yamasaki Y, Masaki T, Takakura K: Possible role of endothelin in the pathogenesis of cerebral vasospasm. J. Cardiovasc. Pharmacol. 17(Suppl. 7): S480-S483, 1991.

Giaid A, Masaki T, Ouimet T, Yanagisawa M, Gaspar L, Cantin M, Kimura S, Castellucci VF: Expression of endothelin-like peptide in the nervous system of the marine mollusk Aplysia. J. Cardiovasc. Pharmacol. 17(Suppl. 7): S449-S451, 1991.

Saito A, Shiba R, Yanagisawa M, Masaki T, Kimura S, Yamada K, Mima T, Shigeno T, Goto K: Characterization of the effect of endothelins in canine cerebral arteries. J. Cardiovasc. Pharmacol. 17(Suppl. 7): S219-S221, 1991.

Tomobe Y, Ishikawa T, Yanagisawa M, Kimura S, Masaki T, Goto K: Mechanism of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and wister-kyoto rats. J. Pharmacol. Exp. Ther. 257: 555-561, 1991.

Saito A, Shiba R, Yanagisawa M, Masaki T, Kimura S, Yamada K, Mima T, Shigeno T, Goto K: Endothelins: vasoconstrictor effects and localization in canine cerebral arteries. Br. J. Pharmacol. 103: 1129-1135, 1991.

Sakurai T, Yanagisawa M, Inoue A, Ryan U, Kimura S, Mitsui Y, Goto K, Masaki T: cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Biochem. Biophys. Res. Commun. 175: 44-47, 1991.

Sawamura T, Kasuya Y, Matsushita Y, Suzuki N, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells. Biochem. Biophys. Res. Commun. 174: 779-784, 1991.

Miyagawa K, Kimura S, Yoshida T, Sakamoto H, Takaku F, Sugimura Y, Terada M: Structural analysis of a mature hst-1 protein with transforming growth factor activity. Biochem. Biophys. Res. Commun. 174: 404-410, 1991.

Watanabe Y: Practical nonlinear analysis using pseudo-random impulse train inputs--A case study of the crayfish brain responses. Zool. Sci. 8: 847-853, 1991.

Moroi K, Kuga T, Kadota K: Bovine brain coated vesicles contain guanine nucleotide regulatory proteins. Jpn. J. Pharmacol. 55: 399-402, 1991.

Abe Y, Kasuya Y, Kudo M, Yamashita K, Goto K, Masaki T, Takuwa Y: Endothelin-1-induced phosphorylation of the 20 KDa myosin light chain and caldesmon in porcine coronary artery smooth muscle. Jpn. J. Pharmacol. 57: 431-435, 1991.

Masaki T, Kasuya Y, Yanagisawa M, Goto K: A hypothesis for mechanism of endothelin-induced vasoconstriction. in "Ion channels of vascular smooth muscle cells and endothlial cells", edited by H. Kuriyama: pp209-215, 1991.

Masaki T, Yanagisawa M, Goto K, Kimura S, Takuwa Y: Cardiovascular Significance of Endothelin, in "Cardiovascular Significance of Endothelium-Derived Vasoactive Factors", edited by Rubanyi GM, Futura Publishing Co., p65-81, 1991.

 

1990

Giaid A, Hamid QA, Springall NR, Yanagisawa M, Shinmi O, Sawamura T, Masaki T, Kimura S, Corrin R, Polak JM: Detection of endothelin immunoreactivity and mRNA in pulmonary tumors. J. Pathology 162: 15-22, 1990.

Sawamura T, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Analysis of big endothelin-1 digestion by cathepsin D. Biochem. Biophys. Res. Commun. 172: 883-889, 1990.

Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T: Cloning of a cDNA encoding a non-isopeptide-selective subtype receptor. Nature 348: 732-735, 1990.

Hamaoki M, Kato H, Sugi M, Fujimoto M, Kurihara H, Toshizumi M, Yanagisawa M, Kimura S, Masaki T, Yazaki Y: Hybridoma 9: 63-69, 1990.

Suzuki N, Matsumoto H, Kitada C, Kimura S, Miyauchi T, Fujino M: A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma. J. Immunol. Methods 27: 165-170, 1990.

Miyazaki H, Kondoh M, Watanabe H, Masuda Y, Murakami K, Takahashi M, Yanagisawa M, Kimura S, Goto K, Masaki T: Affinity labelling of endothelin receptor and characterization of solubilized endothelin-endothelin receptor complex. Eur. J. Biochem. 187: 125-129, 1990.

Yoshizawa T, Shinmi O, Gibson S, Yanagisawa M, Kimura S, Uchiyama Y, Polak JM, Masaki T, Kanazawa I: Endothelin is a novel hypothlamo-neurophysial peptide. Science 247: 462-464, 1990.

Miyauchi T, Tomobe Y, Shiba R, Ishikawa T, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T: Involvement of endothelin in the regulation of human vascular tonus. Circulation 81: 1874-1880, 1990.

Sawamura T, Kimura S, Shinmi O, Sugita Y, Kobayashi M, Mitsui Y, Yanagisawa M, Goto K, Masaki T: Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. Biochem. Biophys. Res. Commun. 169: 1138-1144, 1990.

Sawamura T, Kimura S, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme. Biochem. Biophys. Res. Commun. 168: 1230-1236, 1990.

Fujimori A, Saito A, Kimura S, Goto K: Release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive vasodilator nerves in the rat mesentery artery. Neurosci. Lett. 112: 173-178, 1990.

Kanisawa M, Suzuki S, Moroi K: The mode of action of ochratoxin A in acute enteritis in rats. J. Environ. Pathol. Toxicol. Oncol. 10: 56-63, 1990.

Nishiyama M, Kuga T: Central effects of the neurotropic mycotoxin fumitremorgin A in the rabbit (II) Effects on the brain stem. Jpn. J. Pharmacol. 52: 201-208, 1990.

Masaki T, Yanagisawa M, Goto K, Kimura S: Role of endothelin in mechanisms of local blood pressure control. J. Hypertens. Suppl. 8: S107-S112, 1990.

Masaki T, Yanagisawa M, Inoue A, Kimura S, Goto K: Study on the endothelin gene and its expression. Jpn. Circ. J. 54: 1221-1225, 1990.

Masaki T, Yanagisawa M, Takuwa Y, Kasuya Y, Kimura S, Goto K: Cellular mechanism of vasoconstriction induced by endothelin. Adv. Second Messenger Phosphoprotein Res. 24: 425-428, 1990.

Takuwa Y, Kasuya Y, Takuwa N, Kudo M, Yanagisawa M, Goto K, Masaki T: Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells. J. Clin. Invest. 85: 653-658, 1990.

 

1989

Goto K, Kasuya Y, Matsuki K, Takuwa Y, Kurihara H, Ishikawa T, Kimura S, Yanagisawa M, Masaki T: Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. Proc. Natl. Acad. Sci. USA 86: 3915-3918, 1989.

Shinmi O, Kimura S, Sawamura T, Sugita Y, Yoshizawa T, Yanagisawa M, Masaki T, Kanazawa I: Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. Biochem. Biophys. Res. Commun. 164: 587-593, 1989.

Sawamura T, Kimura S, Shinmi O, Sugita Y, Yanagisawa M, Masaki T: Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1. Biochem. Biophys. Res. Commun. 162: 1287-1294, 1989.

Shinmi O, Kimura S, Yoshizawa T, Sawamura T, Uchiyama Y, Sugita Y, Kanazawa I, Yanagisawa M, Goto K, Masaki, T.: Presence of endothelin-1 in porcine spinal cord: Isolation and sequence determination. Biochem. Biophys. Res. Commun. 162: 340-346, 1989.

Kasuya Y, Takuwa Y, Yanagisawa M, Kimura S, Goto K, Masaki T: Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover. Biochem. Biophys. Res. Commun. 161: 1049-1055, 1989.

Kasuya Y, Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: Mechanism of contraction to endothelin in the isolated porcine coronary artery. Am. J. Physiol. 257: H1828-H1835, 1989.

Watanabe H, Miyazaki H, Kondoh M, Masuda Y, Kimura S, Yanagisawa M, Masaki T, Murakami K: Two distinct types of endothelin receptors are present on chick cardiac membranes. Biochem. Biophys. Res. Commun. 161: 1252-1259, 1989.

Suzuki N, Matsumoto H, Kitada C, Kimura S, Fujino M: Production of endothelin-1 by tumor cells with epithelial-like morphology. J. Biochem. 106: 736-741, 1989.

Miyauchi T, Ishikawa T, Tomobe Y, Yanagisawa, M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki, T.: Characteristics of pressor response to endothelin in spontaneously hypertensive and wister Kyoto rats. Hypertensions 14: 427-434, 1989.

Yoshizawa T, Kimura S, Kanazawa I, Uchiyama Y, Yanagisawa M, Masaki T: Endothelin evoke a ventral root depolarization in the isolated spinal cord of the newborn rat: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release. Neurosci. Lett. 102: 179-184, 1989.

Yoshizawa T, Kimura S, Kanazawa I, Yanagisawa M, Masaki, T.: Endothelin-1 depolarizes a ventral root potential in the newborn rat spinal cord. J. Cardiovasc. Pharmacol. 13(Suppl.5): S216-S217, 1989.

Miyazaki H, Kondoh M, Watanabe H, Murakami K, Takahashi M, Yanagisawa M, Kimura S, Goto K, Masaki T: Biochemical characterization of endothelin receptor. J. Cardiovasc. Pharmacol. 13(Suppl.5): S155-S156, 1989.

Shiba R, Yanagisawa M, Miyauchi T, Kimura S, Goto K, Masaki T: Elimination of intravenously injected endothelin from circulation blood in the rat. J. Cardiovasc. Pharmacol. 13(Suppl.5): S98-S101, 1989.

Kimura S, Kasuya Y, Sawamura T, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Conversion from big endothelin to 21-residue endothelin is required for expression of full vasoconstrictor activity: Structure-activity relationships of big endothelin. J. Cardiovasc. Pharmacol. 13(Suppl.5): S5-S7, 1989.

Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T: The endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA 86: 2863-2867, 1989.

Li L, Ishikawa T, Miyauchi T, Yanagisawa M, Kimura S, Goto K, Masaki T: Pressor response to endothelin in guinea pigs. Jpn. J. Pharmacol. 49: 549-552, 1989.

Saito A, Shiba R, Kimura S, Yanagisawa M, Goto K, Masaki T: Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoconstrictor peptide. Eur. J. Pharmacol. 162: 353-358, 1989.

Tamatani T, Kimura S, Hashimoto T, Onozaki K: Purification of guinea pig tumor necrosis factor (TNF): Comparison of its antiproliferative and differentiative activities for myeloid leukemic cell lines with those of recombinant human TNF. J. Biochem. 105: 55-60, 1989.

Watanabe T, Watanabe M, Ishii M, Matsuba H, Kimura S, Fujita T, Kominami E, Katsunuma N, Uchiyama Y: An immunocytochemical study on colocalization of cathepsins B and atrial natriuretic peptides in secretory granules of atrial myoendocrine cells of the rat heart. J. Histochem. Cytochem. 37: 347-351, 1989.

Fujimori A, Saito A, Kimura S, Watanabe T, Uchiyama Y, Kawasaki H, Goto K: Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery. Biochem. Biophys. Res. Commun. 165: 1391-1398, 1989.

Moroi K, Kuga T, Kadota K: Detection and characterization of 3H-clonidine binding sites in coated vesicles isolated from bovine brain. Jpn. J. Pharmacol. 51: 128-131, 1989.

Nishiyama M, Kuga T: Central effects of the neurotropic mycotoxin fumitremorgin A in the rabbit (I) Effects on the spinal cord. Jpn. J. Pharmacol. 50: 167-173, 1989.

Sano Y, Hiroshima O, Yuzuriha T, Yamato C, Saito A, Kimura S, Hirabayashi, T., Goto, K.: Calcitonin gene-related peptide-binding sites of porcine cardia muscles and coronary arteries: solubilization and characterization. J. Neurochem. 52: 1919-1924, 1989.

Goto K, Ishikawa T, Fujimori A, Saito A, Kimura S: Control of the cardiovascular function by novel peptide (CGRP)-containing nerves. in "Regulatory Roles of Neuropeptides" edited by Takagi H. Excepta Medica, International Congress Series 912, p55-70, 1989.

 

1988

Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 322: 411-415, 1988.

Yanagisawa M, Inoue A, Ishikawa T, Kasuya Y, Kimura S, Kumagaye S, Nakajima K, Watanabe TX, Sakakibara S, Goto K, Masaki T: Primary structure, synthesis and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc. Natl. Acad. Sci. 85: 6944-6967, 1988.

Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: Positive chronotropic effects of endothelin, anovel endothelium-derived vasoconstrictor peptide. Pflugers Arch. 413: 108-110, 1988.

Kimura S, Kasuya Y, Sawamura T, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Structure-activity relationship of endothelin: Importance of the C-terminal moiety. Biochem. Biophys. Res. Commun. 156: 1182-1186, 1988.

Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: The positive inotropic action of a novel endothelium-derived vasoconstrictor peptide, endothelin, on guinea-pig atria. Am. J. Physiol. 255: H970-H973, 1988.

Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T: A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J. Hypertension 6(Suppl.4): S188-S191, 1988.

Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T: Effects of endothelin on the renal artery from spontaneously hypertensive and wister Kyoto rats. Eur. J. Pharmacol. 152: 373-374, 1988.

Watanabe M, Watanabe T, Ishii T, Matsuba H, Kimura S, Fujita T, Kominami E, Katsunuma N, Uchiyama Y: Immunocytochemical localization of cathepsin B, H and their endogenous inhibitor, cystatin beta in islet endocrine cells of the rat pancreas. J. Histochem. Cytochem. 36: 783-791, 1988.

Makino N, Kimura S: Subunits of Panulirus japonicus hemocyanin. 1. Isolation and properties. Eur. J. Biochem. 173: 423-430, 1988.

Hiroshima O, Sano Y, Yuzuriha T, Yamato C, Saito A, Okamura N, Uchiyama Y, Kimura S, Goto K: Solubilization and characterization of calcitonin gene-related peptide binding site from porcine spinal cord. J. Neurochem. 50: 480-485, 1988.

Moroi K, Takashi K , Kuga T: Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats. Jpn. J. Pharmacol. 47: 367-378, 1988.