柴崎　忠雄のページ(Tadao Shibasaki)

2013

Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S: Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. Science Signaling 6: ra94, 2013.

Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe T, Oiso Y, Takenawa T, Seino S: Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion. J Biol Chem 288: 25851-25864, 2013. (UE and ST contributed equally to this work.)

Kim M, Platt M, Shibasaki T, Quaggin S, Backx P, Seino S, Simpson J, Drucker D: GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med 19: 567-575, 2013.

2012

Shibasaki T: Elucidation of function and role of cAMP sensor Epac2A in insulin secretion. Diabetol Int 3: 187-196, 2012 (Online).

Seino S, Takahashi H, Takahashi T, Shibasaki T: Treating diabetes today: a matter of selectivity of sulphonylureas. Diabetes Obes Metab 14 (Suppl. 1): 9-13, 2012.

2011　

Seino S, Shibasaki T, Minami K: Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J Clin Invest. 121(6):2118-2125, 2011.

2010　

Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J, Miki T, Seino S. Rim2alpha determines docking and priming states in insulin granule exocytosis. Cell Metab. 12(2):117-129, 2010.

Seino S, Shibasaki T, Minami K. Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment. Proc Jpn Acad Ser B Phys Biol Sci. 86(6):563-577, 2010.

De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, Shibasaki T, Gribble F, Renstrﾃｶm E, Seino S, Eliasson L, Rorsman P. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metab. 11(6):543-553, 2010.

2009

Seino S, Takahashi H, Fujimoto W, Shibasaki T：Roles of cAMP signalling in insulin granule exocytosis. Diabetes Obes Metab. Suppl 4:180-188, 2009.

Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S.: The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 325(5940):607-610, 2009.

Sugawara K, Shibasaki T, Mizoguchi A, Saito T, Seino S.: Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Genes Cells. 14(4):445-56, 2009.

Niimura M, Miki T, Shibasaki T, Fujimoto W, Iwanaga T, Seino S.: Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. J Cell Physiol. 219(3):652-658, 2009.

2008

Saito T, Shibasaki T, Seino S.: Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Biomed Res. 29(2): 85-91, 2008.

2007

Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S.: Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci USA. 104(49):19333-19338, 2007.

2006

Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, Seino S.: Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol Genomics. 2006;24(3):290-297.

2005

Seino S, Shibasaki T.: PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev. 85(4):1303-1342, 2005.

Shibasaki T, Seino S.: Physical and functional interaction of noc2/rab3 in exocytosis. Methods Enzymol. 2005;403:408-419.

Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, Okuno M, Iwanaga T, Seino S.: Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 2005; 579(13):2926-2932.

Sasaki T, Shibasaki T, Beguin P, Nagashima K, Miyazaki M, Seino S.: Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem. J Biol Chem. 2005; 280(10):9308-9312.

2004

Shibasaki T, Sunaga Y, Seino S.: Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis. Diabetes. 2004 Dec;53 Suppl 3:S59-62.

Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S: Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci USA. 2004;101(22):8313-8318.

Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S.: Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem. 2004; 279(9):7956-7961.

2003

Minami K, Shibasaki T, Miki T, Seino S.: Seikagaku. 2003; 75(10):1312-23. Review.

2002

Kashima Y, Shibasaki T, Seino S.: [Regulation of insulin secretion by incretins] Nippon Rinsho. 2002; 60 Suppl 10:646-50. Review. Japanese.

Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, Tajima N, Iwanaga T, Seino S.: Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002; 277(52):50497-502.

Miki T, Suzuki M, Shibasaki T, Uemura H, Sato T, Yamaguchi K, Koseki H, Iwanaga T, Nakaya H, Seino S.: Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med. 2002; 8(5):466-472.

2001

Sunaga Y, Gonoi T, Shibasaki T, Ichikawa K, Kusama H, Yano H, Seino S.: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001; 431(1):119-125.

Ueno H, Shibasaki T, Iwanaga T, Takahashi K, Yokoyama Y, Liu LM, Yokoi N, Ozaki N, Matsukura S, Yano H, Seino S.: Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. Genomics. 2001; 78(1-2):91-98.

Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H, Seino S.: Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem. 2001; 276(49):46046-4653.

Beguin P, Nagashima K, Gonoi T, Shibasaki T, Takahashi K, Kashima Y, Ozaki N, Geering K, Iwanaga T, Seino S.: Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature. 2001; 411(6838):701-706.

2000

Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S.: cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000; 2(11):805-811.

Usui H, Nishiyama M, Moroi K, Shibasaki T, Zhou J, Ishida J, Fukamizu A, Haga T, Sekiya S, Kimura S.: RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling. Int J Mol Med. 2000; 5(4):335-340.

1999

Shibasaki T, Moroi K, Nishiyama M, Zhou J, Sakamoto A, Masaki T, Ito K, Haga T, Kimura S.: Characterization of the carboxyl terminal-truncated endothelin B receptor coexpressed with G protein-coupled receptor kinase 2. Biochem Mol Biol Int. 1999; 47(4):569-577. Erratum in: Biochem Mol Biol Int 1999 Jun;47(6):1098.

1996

Shan LH, Nishiyama M, Shibasaki T, Moroi K, Goto K, Masaki T, Kimura S.: Endothelin ETA and ETB receptors mediate endothelin-1-induced apamin-sensitive relaxation in the guinea pig ileum. Jpn J Pharmacol. 1996; 70(3):259-267.

1995

Sato H, Yamaguchi M, Shibasaki T, Ishii T, Bannai S: Induction of stress proteins in mouse peritoneal macrophages by the anti-rheumatic agents gold sodium thiomalate and auranofin. Biochem Pharmacol. 49(10):1453-1457, 1995.