木村定雄のページ(Sadao Kimura) (s-kimura(a)faculty.chiba-u.jp)
Arata Y, Kimura S, Matsuo H, Narita K: Proton magnetic resonance studies of ribonuclease T1. Assignment of histidine-40 peak and analysis of the active site. Biochem Biophys Res Commun, 73:133-40, 1976.
Arata Y, Kimura S, Matsuo H, Narita K: Proton and phosphorus nuclear magnetic resonance studies of ribonuclease T1. Biochemistry 18:18-24, 1979.
Kimura S, Matsuo H, Narita K: Hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome c and analysis of their microenvironment. Int J Peptides Protein Res, 14: 472-478, 1979.
Kimura S, Matsuo H, Narita K: Hydrogen-tritium exchange titration of the histidine residues in ribonuclease T1 and analysis of their microenvironments. J Biochem, 86: 301-310, 1979.
Kimura S, Lewis RV, Gerber LD, Brink L, Rubinstein M, Stein S, Udenfriend S: Purification to homogeneity of camel pituitary pro-opiocortin, the common precursor of opioid peptides and corticotropin. Proc Natl Acad Sci USA, 76: 1756-1759, 1979.
Stern AS, Lewis RV, Kimura S, Rossier J, Gerber LD, Brink L, Stein S, Udenfriend S: Isolation of the opioid heptapeptide Met-enkephalin[Arg6,Phe7] from bovine adrenal medullary granules and striatum. Proc Natl Acad Sci USA, 76: 6680-6683, 1979.
Kimura S, Lewis RV, Stern AS, Rossier J, Stein S, Udenfriend S: Probable precursors of [Leu]enkephalin and [Met]enkephalin in adrenal medulla: Peptides of 3-5 kilodaltons. Proc Natl Acad Sci USA, 77: 1681-1685, 1980.
Rossier J, Trifaro JM, Lewis RV, Lee RW, Stern A, Kimura S, Stein S, Udenfriend S: Studies with [35S]methionine indicate that the 22,000-dalton [Met]enkephalin-containing protein in chromaffin cells is a precursor of [Met]enkephalin. Proc Natl Acad Sci USA, 77: 6889-91, 1980.
Lewis RV, Stern AS, Kimura S, Stein S, Udenfriend S: Enkephalin biosynthetic pathway: Proteins of 8,000-14,000 daltons in bovine adrenal medulla. Proc Natl Acad Sci USA, 77: 5018-5020, 1980.
Lewis RV, Stern AS, Kimura S, Rossier J, Stein S, Udenfriend S: An about 50,000-dalton protein in adrenal medulla: A common precursor of [Met]- and [Leu]enkephalin. Science, 208: 1459-1461, 1980.
Stern AS, Lewis RV, Kimura S, Jones BN, Kilpatrick DL, Stein S, Udenfriend U: Opioid hexapeptides and heptapeptides in adrenal medulla and brain. Possible implifications of the biosynthesis of enkephalins. Arch Biochem Biophys, 205: 606-613, 1980.
Jones BN, Stern AS, Lewis RV, Kimura S, Stein S, Udenfriend S: Structure of two adrenal polypeptides containing multiple enkephalin sequences. Arch Biochem Biophys, 204: 392-395, 1980.
Lewis RV, Stern AS, Kimura S, Rossier J, Brink L, Gerber LD, Stein S, Udenfriend S: Opioid peptides and precursors in the adrenal medulla. Adv Biochem Psychopharmacol 22: 167-79, 1980.
Stern AS, Lewis RV, Kimura S, Jones BN, Kilpatrick DL, Stein S, Udenfriend S: Biosynthesis of the enkephalins: Precursors and intermediates. Biosynthesis, modifications and processing of cellular and viral polyproteins. Eur J Cell Biol, 22: p791, 1980.
Jones BN, Lewis RV, Paabo S, Kojima K, Kimura S, Stein S: Effects of flow rate and eluent composition on the high performance liquid chromatography of proteins. J Liquid chromatogr, 3: 1373-1383, 1980.
Stern AS, Lewis RV, Kimura S, Kilpatrick DL, Jones BN, Kojima K, Stein S, Udenfriend, Shively JE: Biosynthesis of the enkephalins: precursors and intermediates. "Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins", edited by Koch G and Richter D. Academic Press, p99-110, 1980.
Kilpatrick DL, Taniguchi T, Jones BN, Stern AS, Shively JE, Hullihan J, Kimura S, Stein S, Udenfriend U: A highly potent adrenal opioid peptide of molecular weight 3200 that contains both a Met- and Leu-enkephalin sequence. Proc Natl Acad Sci USA, 78: 3265-3268, 1981.
Ichikawa H, Kurasawa S, Arai Y, Ito T, Kimura S, Sugita Y: Purification, crystalization and characterization of fructose-bisphosphate aldose from rice bran. Biochem Int, 4: 153-160, 1982.
Kimura S, Okada M, Sugita Y, Kanazawa I, Munekata E: Novel neuropeptides, neurokinin a and b, isolated from porcine spinal cord. Proc Jpn Acad, 59 (Ser.B): 101-104, 1983.
Imagawa S, Abe T, Kimura S, Sugita Y, Yamashita K: Studies on subfractions of hemoglobin A1b and hemoglobin A1c in diabetic subjects. Endocrinol Jpn. 31: 725-731, 1984.
Kimura S, Goto K, Ogawa T, Sugita Y, Kanazawa I: Pharmacological characterization of novel mammalian tachykinins, neurokinin a and b. Neurosci Res, 2: 97-104, 1984.
Kanazawa I, Ogawa T, Kimura S, Munekata E: Regional distribution of substance P, neurokinin a and neurokinin b in rat central nervous system. Neurosci Res, 2: 111-120, 1984.
Munekata E, Okada M, Kimura S, Sugita Y, Kanazawa I, Matsuto T, Otsuka M: Neurokinin a and b, synthesis and pharmacological properties. Chemistry Lett, 1013-1016, 1984.
Kimura S, Abe K, Sugita Y: Differences in C-terminal amino acid sequences between erythrocyte and liver cytochrome b5 isolated pig and human. Evidences for two tissue-specific forms of cytochrome b5. FEBS lett, 169: 143-146, 1984.
Abe K, Kimura S, Kizawa R, Anan FK, Sugita Y: Amino acid sequences of cytochrome b5 from human, porcine, and bovine erythrocytes and comparison with liver microsomal cytochrome b5. J Biochem, 97: 1657-1668, 1985.
Ogawa T, Kanazawa I, Kimura S: Regional distributin of substance P, neurokinin a and neurokinin b in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection. Brain Res, 359: 152-157, 1985.
Saito A, Ishikawa T, Kimura S, Goto K: Pharmacological analysis of autonomic innervation of the right atria of rats and guinea pigs: Demonstration of nonadrenergic noncholinergic nerves. J Pharmacol Exp Ther, 238: 713-719, 1986.
Saito A, Kimura S, Goto K: Calcitonin gene-related peptide as potential neurotransmitter in guinea pig right atrium. Am J Physiol, 250: H693-H698, 1986.
Kimura S, Goto K, Shigematsu Y, Sugita Y, Kanazawa I: The mammarian tachykinins and their receptors: Structure-activity relationship of the mammarian tachykinins. "Neuroendocrine Molecular Biology", edited by Fink J, Harmar AJ. and McKerns KW. Plenum Publishing Co. p135-145, 1986.
Kimura S, Ogawa T, Goto K, Shigematsu Y, Yamashita H, Sugita Y, Munekata E, Kanazawa I: The mammalian tachykinin peptide family and their receptors. "Natural products and biological activities", edited by Imura H, Goto T, Murachi T, Nakajima T. University of Tokyo Press, p281-291, 1986.
Kimura S, Sugita Y, Kanazawa I, Saito A, Goto K: Isolation and amino acid sequence of calcitonin gene-related peptide from porcine spinal cord. Neuropeptides, 9: 75-82, 1987.
Goto K, Kimura S, Saito A: Inhibitory effects of calcitonin gene-related peptides on exitation and contraction of smooth muscles of rat vas deferens. J Pharmacol Exp Ther, 241: 635-641, 1987.
Goto K, Ishikawa T, Kimura S, Saito A: Intra nerve-mediated inotropic responses of left atria of rats and guinea pigs: Demonstration of a-adrenergic and noncholinergic responses in guinea pigs. J Pharmacol Exp Ther, 243: 723-730, 1987.
Saito A, Ishikawa T, Kimura S, Goto K: Role of caicitonin gene-related peptides as cardiac neurotransmitter in guinea pig left atria. J Pharmacol Exp Ther, 243: 731-736, 1987.
Iwabuchi H, Komori S, Ohashi H, Kimura S: The amino acid sequence of a smooth muscle contracting peptides from chicken rectum. Identity to chicken neurotensis. Jpn J Pharamcol, 44: 455-459, 1987.
Uchida Y, Nomura A, Ohtsuka M, Hasegawa S, Goto K, Kimura S, Sugita Y, Uchiyama Y: Neurokinin A is a potent bronchoconstrictor. Am Rev Respir Dis, 136: 718-721, 1987.
Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 322: 411-415, 1988.
Yanagisawa M, Inoue A, Ishikawa T, Kasuya Y, Kimura S, Kumagaye S, Nakajima K, Watanabe TX, Sakakibara S, Goto K, Masaki T: Primary structure, synthesis and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci USA, 85: 6944-6967, 1988.
Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: Positive chronotropic effects of endothelin, anovel endothelium-derived vasoconstrictor peptide. Pflugers Arch, 413: 108-110, 1988.
Kimura S, Kasuya Y, Sawamura T, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Structure-activity relationship of endothelin: Importance of the C-terminal moiety. Biochem Biophys Res Commun, 156: 1182-1186, 1988.
Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: The positive inotropic action of a novel endothelium-derived vasoconstrictor peptide, endothelin, on guinea-pig atria. Am J Physiol, 255: H970-H973, 1988.
Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T: A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J Hypertension, 6(Suppl.4): S188-S191, 1988.
Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T: Effects of endothelin on the renal artery from spontaneously hypertensive and wister Kyoto rats. Eur J Pharmacol, 152: 373-374, 1988.
Watanabe M, Watanabe T, Ishii T, Matsuba H, Kimura S, Fujita T, Kominami E, Katsunuma N, Uchiyama Y: Immunocytochemical localization of cathepsin B, H and their endogenous inhibitor, cystatin beta in islet endocrine cells of the rat pancreas. J Histochem Cytochem, 36: 783-791, 1988.
Makino N, Kimura S: Subunits of Panulirus japonicus hemocyanin. 1. Isolation and properties. Eur J Biochem, 173: 423-430, 1988.
Hiroshima O, Sano Y, Yuzuriha T, Yamato C, Saito A, Okamura N, Uchiyama Y, Kimura S, Goto K: Solubilization and characterization of calcitonin gene-related peptide binding site from porcine spinal cord. J Neurochem, 50: 480-485, 1988.
1989
Goto K, Kasuya Y, Matsuki K, Takuwa Y, Kurihara H, Ishikawa T, Kimura S, Yanagisawa M, Masaki T: Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. Proc. Natl. Acad. Sci. USA 86: 3915-3918, 1989.
Shinmi O, Kimura S, Sawamura T, Sugita Y, Yoshizawa T, Yanagisawa M, Masaki T, Kanazawa I: Endothelin-3 is a novel neuropeptide: Isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. Biochem. Biophys. Res. Commun. 164: 587-593, 1989.
Sawamura T, Kimura S, Shinmi O, Sugita Y, Yanagisawa M, Masaki T: Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1. Biochem. Biophys. Res. Commun. 162: 1287-1294, 1989.
Shinmi O, Kimura S, Yoshizawa T, Sawamura T, Uchiyama Y, Sugita Y, Kanazawa I, Yanagisawa M, Goto K, Masaki T: Presence of endothelin-1 in porcine spinal cord: Isolation and sequence determination. Biochem. Biophys. Res. Commun. 162: 340-346, 1989.
Kasuya Y, Takuwa Y, Yanagisawa M, Kimura S, Goto K, Masaki T: Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover. Biochem. Biophys. Res. Commun. 161: 1049-1055, 1989.
Kasuya Y, Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T: Mechanism of contraction to endothelin in the isolated porcine coronary artery. Am. J. Physiol. 257: H1828-H1835, 1989.
Watanabe H, Miyazaki H, Kondoh M, Masuda Y, Kimura S, Yanagisawa M, Masaki T, Murakami K: Two distinct types of endothelin receptors are present on chick cardiac membranes. Biochem. Biophys. Res. Commun. 161: 1252-1259, 1989.
Suzuki N, Matsumoto H, Kitada C, Kimura S, Fujino M: Production of endothelin-1 by tumor cells with epithelial-like morphology. J. Biochem. 106: 736-741, 1989.
Miyauchi T, Ishikawa T, Tomobe Y, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T: Characteristics of pressor response to endothelin in spontaneously hypertensive and wister Kyoto rats. Hypertensions 14: 427-434, 1989.
Yoshizawa T, Kimura S, Kanazawa I, Uchiyama Y, Yanagisawa M, Masaki T: Endothelin evoke a ventral root depolarization in the isolated spinal cord of the newborn rat: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release. Neurosci. Lett. 102:179-184, 1989.
Yoshizawa T, Kimura S, Kanazawa I, Yanagisawa M, Masaki T: Endothelin-1 depolarizes a ventral root potential in the newborn rat spinal cord. J. Cardiovasc. Pharmacol. 13(Suppl.5):S216-S217, 1989.
Miyazaki H, Kondoh M, Watanabe H, Murakami K, Takahashi M, Yanagisawa M, Kimura S, Goto K, Masaki T: Biochemical characterization of endothelin receptor. J. Cardiovasc. Pharmacol. 13(Suppl.5):S155-S156, 1989.
Shiba R, Yanagisawa M, Miyauchi T, Kimura S, Goto K, Masaki T: Elimination of intravenously injected endothelin from circulation blood in the rat. J. Cardiovasc. Pharmacol. 13(Suppl.5):S98-S101, 1989.
Kimura S, Kasuya Y, Sawamura T, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Conversion from big endothelin to 21-residue endothelin is required for expression of full vasoconstrictor activity: Structure-activity relationships of big endothelin. J. Cardiovasc. Pharmacol. 13(Suppl.5):S5-S7, 1989.
Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T: The endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA 86:2863-2867, 1989.
Li L, Ishikawa T, Miyauchi T, Yanagisawa M, Kimura S, Goto K, Masaki T: Pressor response to endothelin in guinea pigs. Jpn. J. Pharmacol. 49:549-552, 1989.
Saito A, Shiba R, Kimura S, Yanagisawa M, Goto K, Masaki T: Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoconstrictor peptide. Eur. J. Pharmacol. 162:353-358, 1989.
Tamatani T, Kimura S, Hashimoto T, Onozaki K: Purification of guinea pig tumor necrosis factor (TNF): Comparison of its antiproliferative and differentiative activities for myeloid leukemic cell lines with those of recombinant human TNF. J. Biochem. 105:55-60, 1989.
Watanabe T, Watanabe M, Ishii M, Matsuba H, Kimura S, Fujita T, Kominami E, Katsunuma N, Uchiyama Y,: An immunocytochemical study on colocalization of cathepsins B and atrial natriuretic peptides in secretory granules of atrial myoendocrine cells of the rat heart. J. Histochem. Cytochem. 37:347-351, 1989.
Fujimori A, Saito A, Kimura S, Watanabe T, Uchiyama Y, Kawasaki H, Goto K: Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery. Biochem. Biophys. Res. Commun. 165:1391-1398, 1989.
Sano Y, Hiroshima O, Yuzuriha T, Yamato C, Saito A, Kimura S, Hirabayashi T, Goto K: Calcitonin gene-related peptide-binding sites of porcine cardia muscles and coronary arteries: solubilization and characterization. J. Neurochem. 52:1919-1924, 1989.
Goto K, Ishikawa T, Fujimori A, Saito A, Kimura S: Control of the cardiovascular function by novel peptide (CGRP)-containing nerves. in "Regulatory Roles of Neuropeptides" edited by Takagi H. Excepta Medica, International Congress Series 912, p55-70, 1989.
1990
Giaid A, Hamid QA, Springall NR, Yanagisawa M, Shinmi O, Sawamura T, Masaki T, Kimura S, Corrin R, Polak JM: Detection of endothelin immunoreactivity and mRNA in pulmonary tumors. J. Pathology 162:15-22, 1990.
Sawamura T, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Analysis of big endothelin-1 digestion by cathepsin D. Biochem. Biophys. Res. Commun. 172:883-889, 1990.
Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T:Cloning of a cDNA encoding a non-isopeptide-selective subtype receptor. Nature 348:732-735, 1990.
Hamaoki M, Kato H, Sugi M, Fujimoto M, Kurihara H, Toshizumi M, Yanagisawa M, Kimura S, Masaki T, YazakiY: Hybridoma 9:63-69, 1990.
Suzuki N, Matsumoto H, Kitada C, Kimura S, Miyauchi T, Fujino M: A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma. J. Immunol. Methods 27:165-170, 1990.
Miyazaki H, Kondoh M, Watanabe H, Masuda Y, Murakami K, Takahashi M, Yanagisawa M, Kimura S, Goto K, Masaki T: Affinity labelling of endothelin receptor and characterization of solubilized endothelin-endothelin receptor complex. Eur. J. Biochem. 187, 125-129, 1990.
Yoshizawa T, Shinmi O, Gibson S, Yanagisawa M, Kimura S, Uchiyama Y, Polak JM, Masaki T, Kanazawa I: Endothelin is a novel hypothlamo-neurophysial peptide. Science 247:462-464, 1990.
Miyauchi T, Tomobe Y, Shiba R, Ishikawa T, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T: Involvement of endothelin in the regulation of human vascular tonus. Circulation 81:1874-1880, 1990.
Sawamura T, Kimura S, Shinmi O, Sugita Y, Kobayashi M, Mitsui Y, Yanagisawa M, Goto K, Masaki T: Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. Biochem. Biophys. Res. Commun. 169:1138-1144, 1990.
Sawamura T, Kimura S, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T: Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme. Biochem. Biophys. Res. Commun. 168, 1230-1236, 1990.
Fujimori A, Saito A, Kimura S, Goto K: Release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive vasodilator nerves in the rat mesentery artery. Neurosci. Lett. 112:173-178, 1990.
Masaki T, Yanagisawa M, Goto K, Kimura S: Role of endothelin in mechanisms of local blood pressure control. J. Hypertens. Suppl. 8:S107-S112, 1990.
Masaki T, Yanagisawa M, Inoue A, Kimura S, Goto K: Study on the endothelin gene and its expression. Jpn. Circ. J. 54:1221-1225, 1990.
Masaki T, Yanagisawa M, Takuwa Y, Kasuya Y, Kimura S, Goto K: Cellular mechanism of vasoconstriction induced by endothelin. Adv. Second Messenger Phosphoprotein Res. 24:425-428, 1990.
Yamashita Y, Uchida Y, Nomura A, Hasegawa S, Kimura S: Determination of biological peptide leukotrienes C4 and D4 by fluorometric detection combined with high-performance liquid chromatography. Prostaglandins Leukot Essent Fatty Acids, 39, 119-123, 1990.
1991
Ishikawa T, Li L, Shinmi O, Kimura S, Yanagisawa M, Goto K, Masaki T:Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Circ. Res. 69:918-926, 1991.
Masaki T, Kimura S,Yanagisawa M, Goto K: Molecular and cellular mechanism of endothelin regulation. Circulation 84:1457-1467, 1991.
Shigeno T, Mima T, Yanagisawa M, Saito A, Fujimori M, Shiba R, Goto K, Kimura S, Yamashita K, Yamasaki Y, Masaki T, Takakura K: Possible role of endothelin in the pathogenesis of cerebral vasospasm. J. Cardiovasc. Pharmacol. 17(Suppl. 7):S480-S483, 1991.
Giaid A, Masaki T, Ouimet T, Yanagisawa M, Gaspar L, Cantin M, Kimura S, Castellucci VF: Expression of endothelin-like peptide in the nervous system of the marine mollusk Aplysia. J. Cardiovasc. Pharmacol. 17(Suppl. 7):S449-S451, 1991.
Saito A, Shiba R, Yanagisawa M, Masaki T, Kimura S, Yamada K, Mima T, Shigeno T, Goto K: Characterization of the effect of endothelins in canine cerebral arteries. J. Cardiovasc. Pharmacol. 17(Suppl. 7):S219-S221, 1991.
Tomobe Y, Ishikawa T, Yanagisawa M, Kimura S, Masaki T, Goto K: Mechanism of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and wister-kyoto rats. J. Pharmacol. Exp. Ther. 257:555-561, 1991.
Saito A, Shiba R, Yanagisawa M, Masaki T, Kimura S, Yamada K, Mima T, Shigeno T, Goto K: Endothelins: vasoconstrictor effects and localization in canine cerebral arteries. Br. J. Pharmacol. 103:1129-1135, 1991.
Sakurai T, Yanagisawa M, Inoue A, Ryan U, Kimura S, Mitsui Y, Goto K, Masaki T: cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Biochem. Biophys. Res. Commun. 175:44-47, 1991.
Sawamura T, Kasuya Y, Matsushita Y, Suzuki N, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells. Biochem. Biophys. Res. Commun. 174:779-784, 1991.
Miyagawa K, Kimura S, Yoshida T, Sakamoto H, Takaku F, Sugimura Y, Terada M: Structural analysis of a mature hst-1 protein with transforming growth factor activity. Biochem. Biophys. Res. Commun. 174:404-410, 1991.
Masaki T, Yanagisawa M, Goto K, Kimura S, Takuwa Y: Cardiovascular Significance of Endothelin, in "Cardiovascular Significance of Endothelium-Derived Vasoactive Factors", edited by Rubanyi GM, Futura Publishing Co., p65-81, 1991.
1992
Yorimitsu K, Shinmi O, Nishiyama M, Moroi K, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S: Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal adenocarcinoma (ACHN) cells. Analysis of endothelin-2 biosynthetic pathway. FEBS Lett. 314:395-398, 1992.
Goto K, Yanagisawa M, Kimura S, Masaki T: Cardiovascular effects of endothelin. Jpn. Circ. J. 56:162-169, 1992.
1993
Sawamura T, Shinmi O, Kishi N, Sugita Y, Yanagisawa M, Goto K, Masaki T, Kimura S: Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. Biochim. Biophys. Acta 1161:295-302, 1993.
Giaid A, Yanagisawa M, Langleben D, Michel R, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Path FRC, Stewart DJ: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Eng. J. Med. 328:1732-1739, 1993.
Shinmi O, Yorimitsu K, Moroi K, Nishiyama M, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S: Endothelin converting enzyme from human renal adenocarcinoma (ACHN) cells is a phosphoramidon-sensitive, membrane-bound metalloprotease. J. Cardiovasc. Pharmacol. 22(Suppl.8):S61-S64, 1993.
1994
Opgenorth TJ, Kimura S, Wu-Wong JR: Characterization of endothelin converting enzyme. Methods in Neurosci. 23:251-265, 1994.
1995
Yorimitsu K, Moroi K, Inagaki N, Saito T, Masuda Y, Masaki T, Seino S, Kimura S: Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. Biochem Biophys Res Commun 208:721-727, 1995.
Nishiyama M, Takahara Y, Masaki T, Nakajima N, Kimura S: Pharmacological heterogeneity of both endothelin ETA- and ETB-receptors in the human saphenous vein. Jpn. J. Pharmacol. 69:391-398, 1995.
Nishiyama M, Shan LH, Moroi K, Masaki T, Kimura S: Heterogeneity of endothelin ETA receptor-mediated contractions in the rabbit saphenous vein. Eur J Pharmacol 286:209-212, 1995.
Nishiyama M, Moroi K, Shan LH, Yamamoto M, Takasaki C, Masaki T, Kimura S: Two different endothelin B receptor subtypes mediate contraction of the rabbit saphenous vein. Jpn J Pharmacol 68:235-243, 1995.
Kobayashi S, Nakaya H, Takizawa T, Hara Y, Kimura S, Saito T, Masuda Y: Effects of endothelin-1 on ATP-sensitive K+ current in cardiac cells. Heart Vessels Suppl.9:106-108, 1995.
1996
Watabe Y, Kuramochi H, Furuya Y, Inagaki N, Seino S, Kimura S, Shimazaki J: Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells. J. Biol. Chem. 271:25126-25130, 1996.
Okamoto O, Suzuki Y, Kimura S, Shinkai H: Extracellular matrix 22-kDa protein interacts with decorin core protein and is expressed in cutaneous fibrosis. J. Biochem. 119:106-114, 1996.
Shan L-H, Nishiyama M, Shibasaki T, Moroi K, Goto K, Masaki T, Kimura S: Endothelin ETA and ETB receptors mediate endothelin-1-induced apamin-sensitive relaxation in the guinea-pig ileum. Jpn. J. Pharmacol. 70:259-267, 1996.
Kobayashi S, Nakaya H, Takizawa T, Hara Y, Kimura S, Saito T, Masuda Y: Endothelin-1 inhibits ATP-sensitive K+ current in guinea-pig ventricular cells. J. Cardiovasc. Pharmacol. 27:12-19, 1996.
Nakaya H, Kobayashi S, Takizawa T, Hara Y, Uemura H, Saito T, Kimura S, Masuda Y: Modulation of cardiac ATP-sensitive K+ channels: Potential electrophysiological outcome during myocardial ischemia and reperfusin. in: Recent Progresdsd in Elecyropharmacology of the Heart, edited by Toyama J, Hiraoka M, Kodama I. CRC Press, p107-117, 1996.
1997
Yamamoto T, Nozaki-Taguchi N, Kimura S:Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test. Neuroscience, 81:249-254, 1997.
Yamamoto T, Nozaki-Taguchi N, Kimura S: Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw. Brain Res, 754:329-332, 1997.
Yamamoto T, Nozaki-Taguchi N, Kimura S: Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci Lett, 224:107-110, 1997.
Mizuguchi T, Nishiyama M, Moroi K, Tanaka H, Saito T, Masuda Y, Masaki T, de Wit D, Yanagisawa M, Kimura S: Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse. Br J Pharmacol, 120:1427-1430, 1997.
Wei S, Kasuya Y, Yanagisawa M, Kimura S, Masaki T, Goto K: Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery. Eur J Pharmacol 321:307-314, 1997.
Hohki G, Terada N, Hamano N, Kitaura M, Nakajima T, Yoshie O, Ikeda T, Kimura S, Konno A: The effects of eotaxin on the surface adhesion molecules of endothelial cells and on eosinophil adhesion to microvascular endothelial cells. Biochem Biophys Res Commun, 241:136-141, 1997.
1998
Tanaka H, Moroi K, Iwai J, Takahashi H, Ohnuma N, Hori S, Takimoto M, Nishiyama M, Masaki T, Yanagisawa M, Sekiya S, Kimura S: Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization. J Biol Chem, 273:11378-11383, 1998.
1999
Gonda K, Okamoto H, Takuwa N, Yatomi Y, Okazaki H, Sakurai T, Kimura S, Sillard R, Harii K, Takuwa Y: The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. Biochem J 337: 67-75, 1999.
Yamamoto T, Nozaki-Taguchi N, Sakashita Y, Kimura S: Nociceptin/Orphanin FQ: Role in nociceptive information processing. Prog Neurobiol, 57: 527-535, 1999.
Shibasaki T, Moroi K, Nishiyama M, Zhou J, Sakamoto A, Masaki T, Ito K, Haga T, Kimura S: Characterization of the carboxyl-terminal truncated endothelin B receptor coexpressed with G protein-coupled receptor kinase 2. Biochem Mol Biol Int, 47: 569-577, 1999.
2000
Homma S, OppenheimRW, Yaginuma H, Kimura S: Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Dev. Biol. 217: 121-137, 2000.
Usui H, Nishiyama M, Moroi K, Shibasaki T, Zhou J, Ishida J, Fukamizu A, Haga T, Sekiya S, Kimura S: RGS domain in the amino-terminus of G protein-coupled receptor kinase-2 inhibits Gq-mediated signaling. Int J Mol Med, 5: 335-340, 2000.
Kurihara Y, Kurihara H, Morita H, Cao WH, Ling GY, Kumada M, Kimura S, Nagai R, Yazaki Y, Kuwaki T: Role of endothelin-1 in stress response in the central nervous system. Am J Physiol, 279: R515-R521, 2000.
2001
Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S: Characterization of RGS5 in regulation of G protein-coupled receptor signaling. Life Sciences, 68: 1457-1469, 2001.
Takanami-Ohnishi Y, Asada S, Tsunoda H, Fukamizu A, Goto K, Yoshikawa H, Kubo T, Sudo T, Kimura S, Kasuya Y: Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition. Biochem Biophys Res Commun, 288: 1155-1161, 2001.
2002
Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, and Kasuya Y. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem, 277: 37896-37903, 2002.
2003
Sato M, Moroi K, Nishiyama M, Zhou J, Usui H, Kasuya Y, Fukuda M, Kohara Y, Komuro I, Kimura S: Characterization of a novel C. elegans RGS protein with a C2 domain - Evidence for interaction between C2 domain and Galfaq subunit - Life Sciences, 73: 917-932, 2003.
2004
Furuya M, Nishiyama M, Kimura S, Suyama T, Naya Y, Ito H, Nikaido T, Ishikura H: Expression of a Regulator of G Protein Signaling, RGS5 in Angiogenic Vessels of Human Renal Cell Carcinoma. J Pathology, 203, 551-558, 2004.
Asada S, Takanami-Ohnishi Y, Zhou J, Hama H, Fukamizu A, Kimura S, Goto K, Kasuya Y: Cytodifferentiation enhances Erk activation induced by endothelin-1 in promary cultured astrocytes. J Cardiovasc Pharmacol, 44 (Suppl.1), S307-S312, 2004.
Amano S, Tatsumi K, Tanabe N, Kasahara Y, Kurosu K, Takiguchi Y, Kasuya Y, Kimura S, Kuriyama T: Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension. Respirology. 9, 184-189, 2004.
Sakurai K, Matsuo Y, Sudoh T, Takuwa Y, Kimura S, Kasuya Y: Role of p38 mitogen-activated protein kinase in thrombus formation. J. Receptors Signal Transduction, 24, 283-296, 2004.
2005
Suyama T, Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ichikawa T, Ueda T, Nikaido T, Ito H, Ishikura H: Up-Regulation of IFN-?-Inducible Chemokine I-TAC and Mig, and Their Receptor CXCR3 in Human Renal Cell Carcinoma. Cancer, 103, 258-67, 2005.
Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT: RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci USA, 102:15030-15035, 2005.
Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H: Pathophysiology of Tumor Neovascularization. Vasc Health Risk Management, I(4),277-290, 2005.
2006
Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y: Involvement of p38alpha mitgen-activayed protein kinase in lung metastasis of tumor cells. J Biol Chem, 281, 36767-36775, 2006.
2007
Namiki K, Nakamura A, Furuya M, Mizuhashi S, Matsuo Y, Tokuhara N, Sudo T, Hama H, Kuwaki T, Yano S, Kimura S, Kasuya Y: Involvement of p38a mitgen-activated protein kinase in kainate-induced seizure and neuronal cell damage. J Receptor Signal Transduct Res, 27: 99-111, 2007.
Moroi K, Nishiyama M, Kawabata S, Ichiba H, Yajima T, Kimura S: Phosphorylation of Ser166 in RGS5 by protein kinase C causes loss of RGS function. Life Sciences, 81: 40-50, 2007.
2008
Furuya M, Ishida J, Inaba S, Kasuya Y, Kimura S, Nemori R, Fukamizu A: Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension. Laboratory Investigation, 88(4): 416-429, 2008.
2010
Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y: N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis J Biol Chem, 285(43):33294-33306, 2010.
2011
Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S: Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2: Roles of its N-terminal domain. Cellular Signalling, 23(6):1041-1049, 2011.
Tanaka Y, Takahashi H, Shibata S, Namiki K, Kimura S, Koike K, Kasuya Y: Functional analysis of guinea pig beta1-adrenoceptor. J Receptor Signal Transduct. 31(6):395-401, 2011.
2012
Sakurai K, Lee EY, Morita A, Kimura S, Kawamura K, Kasamatsu A, Shiiba M, Yabe Y, Yokote K, Miki T: Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive sweetener. J Diabetes Invest, 3(2):156-163, 2012.
Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, Kasuya Y: Mechanism for p38alpha-mediated experimental autoimmune encephalomyelitis. J Biol Chem, 287(29): 24228-24238, 2012.
2013
Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R: Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agricultural and Food Chemistry, 61:128-136, 2013.
Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S: Chapter 239, In silico search for biologically active peptides. in "Handbook of the Biologically Active Peptides", 2nd edition, edited by Kastin AJ, Academic Press, pp1743-1748, 2013.
2014
Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y: p38 Mitogen-Activated Protein Kinase Accelerates Emphysema in Mouse Model of Chronic Obstructive Pulmonary Disease. J Recept Signal Transduct. 34(4):299-306, 2014.
Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y: Endothelin regulates function of IL-17-producing T cell subset. Life Sci. 118(2):244-247, 2014.
Naito Y, Yoshioka K, Tanaka K, Tatsumi K, Kimura S, Kasuya Y: Endothelin B receptor-mediated encephalopathic events in mouse sepsis model. Life Sci, 24;118(2):340-346, 2014.
Tanaka K, Fujita T, Umezawa H, Namiki K, Yoshioka K, Hagihara M, Sudo T, Kimura S, Tatsumi K, Kasuya Y: Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis. Laboratory Investigation, 94(11):1247-1259, 2014.
2015
Kobayashi T, Tanaka K, Fujita T, Umezawa H, Amano H, Yoshioka K, Naito Y, Hatano M, Kimura S, Tatsumi K, Kasuya Y: Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis. Respiratory Research, Aug 20;16:99 (14 pages), 2015.
2016
Song D, Nishiyama M, Kimura S: Potent inhibition of angiotensin AT1 receptor signaling by RGS8: Importance of the C terminal third exon part of its RGS domain. J Recept Signal Transduct. 36(5):478-487, 2016.
著書・総説
西山真理子、木村定雄：キーワード解説 RGS（Gタンパク質シグナル調節因子） 日本薬理学雑誌 139(1): 41-42, 2012.
木村定雄、西山真理子、石井祟洋、廣瀬修一、山崎寛之：『ペプチドと創薬』 創薬候補ペプチドの探索 遺伝子情報からの予測 遺伝子医学MOOK 8: 57-62, 2007.
諸井佳代子、西山真理子、木村定雄：最近の話題 新しい酸素センサー兼ＮＯセンサー、RGSタンパク質. 日本薬理学雑誌 127: 50, 2006.
木村定雄：日本で発見された血管作動物質 エンドセリン 循環器専門医 8(2): 345-347, 2000.
木村定雄：エンドセリン研究の最前線 Progress in Medicine 18(8): 345-347, 1998.
木村定雄：心血管における2種のエンドセリン受容体発現のスイッチ機構の解析 長寿科学総合研究 1997(1)：194-197, 1998.
広瀬茂久、木村定雄：エンドセリンとその受容体 p97-110 「ホメオスタシス」日本内分泌学会編（ホルモンの分子生物学７）、学会出版センター 1997.
西山真理子、木村定雄：II 視床下部ー下垂体系の分子機構 NO（一酸化窒素）「現代の神経内分泌学」 （吉田尚 編） p85-90, メディカルサイエンスインターナショナル、1996.
花沢豊行、今野昭義、西山真理子、木村定雄：鼻アレルギーとＮＯ、「気道アレルギー’95」～気管支喘息とアレルギー性鼻炎～、メディカルレビュー社、p41-50,1995.
新海宏、岡本修、木村定雄：22kD細胞外マトリックス(ECM)成分の構造と機能 第１報 強皮症調査研究班 平成6年度研究報告書 p36-40, 1995.
沢村達也、木村定雄、真崎知生：10.4 エンドセリンの生合成 新生化学実験講座10 血管 内皮と平滑筋 10章 血管作動物質を用いた実験 p359-366, 東京化学同人 1993.
後藤勝年、木村定雄：10.5 新しい血管作動性神経ペプチドの調整と実験 新生化学実験講座10 血管 内皮と平滑筋 10章 血管作動物質を用いた実験 p367-376, 東京化学同人 1993.
新見修、依光一之、木村定雄：エンドセリン変換酵素研究の動向 最新医学 48(4): 615-618, 1993.
木村定雄、西山真理子、依光一之：血管平滑筋収縮・弛緩因子 循環器専門医 1(1): 93-102, 1993.
木村定雄：血圧調節にかかわるペプチド因子の構造と活性化機構 Cell Science 8(4): 317-325, 1992.
木村定雄：エンドセリンの検査法について 医学検査 41(4): 813-817, 1992.
木村定雄：血管内皮細胞から見た循環器疾患の新しい転開 血管内皮細胞由来の血管収縮・弛緩因子 呼吸と循環 11：1043-1049, 1992.
木村定雄、後藤勝年、栗崎純一、辻典子、水町功子、吉武充：食品蛋白質に由来する生理活性ペプチドの探索に関する研究 牛乳蛋白質由来の腸管作動性ペプチドの解析 農林水産業特別試験研究成果報告会講演要旨 p12-13, 1992.
木村定雄：エンドセリンの構造活性相関とプロセシング 蛋白質・核酸・酵素 36(14)：2362-2371, 1991.
木村定雄、柳沢正史、後藤勝年、真崎知生：３章 精製と構造決定 エンドセリン 新生化学実験講座９ ホルモンＩ ペプチドホルモン p116-126, 東京化学同人 1991.
諸井佳代子、木村定雄、門田健：ウシ脳コート小泡で見られるGTP結合site：カゼインキナーゼIIとの関連 神経化学 30(1)：178-179, 1991.
沢村達也、木村定雄、真崎知生：エンドセリン Neurological Surgery 18(9)：797-806, 1990.
木村定雄：神経ペプチド各論 タヒキニン・ファミリー サブスタンスP、ニューロキニンＡ、ニューロキニンB 日本臨床 47(5)：962-968, 1990.
後藤勝年、木村定雄、真崎知生：新しい心血管作動性ペプチド 蛋白質・核酸・酵素 35(10)：1925-1939, 1990.
新見修、木村定雄、真崎知生：血管作動物質 エンドセリン 治療学 24(4)：457-461, 1990.
柴玲子、柳沢正史、木村定雄、後藤勝年、真崎知生：新しい生理活性物質 エンドセリン Clinical Neuroscience 8(3): 342-343, 1990.
真崎知生、柳沢正史、木村定雄、他：エンドセリン研究の最近の動向 内分泌の進歩 7：112-121, 1990.
木村定雄、真崎知生：「血管研究の進歩」江橋節郎編 III章 血管作動ペプチドの研究方法 ８ エンドセリンの単離と構造決定 p263-273、学会出版センター 1990.
木村定雄：エンドセリンの生化学 実験医学 8(18)：2399-2404, 1990.
藤森明、斉藤亜紀良、木村定雄、後藤勝年：ラット腸管膜動脈における神経性血管拡張反応とその伝達物質の同定 血管 13(1)：35, 1990.
沢村達也、新見修、木村定雄：「循環器系疾患への新しいアプローチ」内皮細胞由来の新しい血管収縮ペプチド エンドセリン BIO medica 4(7): 674-678, 1989.
真崎知生、柳沢正史、木村定雄、他：エンドセリンの薬理作用 脳卒中 11(6)：641-645, 1989.
木村定雄：Receptor 作用物質別レセプター論 ペプチドー蛋白系 脳・消化管ペプチド サブスタンスP、ニューロキニンと類似ペプチド 日本臨床 47：282-286, 1989.
野村明広、内田義之、大塚真人、濱田雅史、石井幸雄、山下裕子、長谷川鎮雄、木村定雄：モルモット肺内のニューロキニンＡ・ニューロキニンB・サブスタンスPの高速液体クロマトグラフィー及びラジオイムノアッセイによる定量 アレルギー 37：147-156, 1988.
斉藤亜紀良、木村定雄、後藤勝年：ラット輸精管におけるカルシトニン遺伝子関連ペプチド(CGRP)の作用 日本平滑筋学会雑誌 22(4)：322-324,1986.
木村定雄：Neurotransmitter 新しい展望 ペプチド性神経伝達物質とレセプター タヒキニンFamilyとそのレセプターを例として 神経研究の進歩 30(4)：620-633, 1986.
重松由香、木村定雄：新しい神経ペプチド ニューロキニン Medical Companion 5(10): 1572, 1985.
木村定雄：逆相系HPLCによるペプチドの分離 p127-139 「タンパク質・ペプチドの高速液体クロマトグラフィー」宇井信生、岩永貞昭、崎山文夫編（化学増刊102）化学同人、1984.
木村定雄：エンドルフィンとエンケファリンの生合成 神経研究の進歩 27(3): 498-508, 1983.
木村定雄：オピオイドペプチド研究の動向 日本臨床 41(3): 635-646, 1983.
木村定雄：副腎髄質中のエンケファリン前駆体 医学の歩み 120(10)：988-998, 1982.
木村定雄、杉田良樹：生体微量ペプチドの取り扱い方 生物物理 22：223-228, 1982.
木村定雄、杉田良樹：逆相系HPLCによるペプチドの分離 LC family 17：1-6, 1982.
木村定雄：副腎髄質中のエンケファリン前駆体 蛋白質核酸酵素 26：125-137, 1981.
松尾壽之、寒川賢治、木村定雄、成田耕造：トリチウム交換法によるタンパク質中のヒスチジン残基のpKaの測定と環境解析の試み 蛋白質核酸酵素 20：479-492, 1975.