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1) Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition. Takanami-Ohnishi Y., et al., Biochem Biophys Res Commun 288: 1155-1161 2002.

2) Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. Takanami-Ohnishi Y., et al., J Biol Chem 277: 37896-37903, 2002.

3) uÚG”畆‰Š‚Ö‚Ìp38 mitogen-activated protein kinase ‚ÌŠÖ—^‹@\‚̉𖾁v ””’J‘Pr, http://www.cosmetology.or.jp/2003/11-15.pdf

4) Role of p38 mitogen-activated protein kinase in thrombus formation. Sakurai K., et al., J Recept Signal Transduct 24: 283-296 2004.

5) uŠO•”ŠÂ‹«ˆöŽq‚É‚æ‚è”­Ç‚·‚閝«•ÂÇ«”xŽ¾Š³‚Ì•ªŽq‰ðÍv ””’J‘Pr, http://www.nissan-zaidan.or.jp/membership/2004/05_seika/0014.pdf

6) Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells. Matsuo Y., et al., J Biol Chem 281: 36767-36775, 2006.

7) gnvolvement of p38alpha in kainate-induced seizure and neuronal cell damage. Namiki K., et al., J Recept Signal Transduct 27: 99-111, 2007.

8) up38‘jŠQÜv ””’J‘Pr, ‘¼, “ú–{–ò—Šw‰ïŽ 133: 357-359, 2009.

9) Mechanism of p38alpha-mediated experimental autoimmune encephalomymyelitis. Namiki K, et al., J Biol Chem. 287: 24228-24238, 2012.

10) Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y: p38 Mitogen-Activated Protein Kinase Accelerates Emphysema in Mouse Model of Chronic Obstructive Pulmonary Disease. J Recept Signal Transduct. 34(4):299-306, 2014.

11) p38MAPK‘jŠQÜC””’J‘PrFÅVŠÖßƒŠƒEƒ}ƒ`Šw -Š°‰ðEŽ¡—Âð–ÚŽw‚µ‚½Œ¤‹†‚ƍŐVŽ¡—Ã-@“ú–{—Տ°@72F525-529, 2014.

12jp38‚Ì‹@”\‚Æ‘jŠQ–ò‚Ì“®Œü@””’J‘Pr@“ú–{–ò—Šw‰ïŽ 145: 21-26, 2015.@

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1) The utilization of gene targeting models during in preclinical study of drug discovery process--example of phenotypic and functional analysis of Cacna1beta gene product. Miyamoto N., et al., Curr Pharm Biotechnol 10 261-267 2009.

2) N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis. Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y:J. Biol. Chem. 285(43):33294-33306, 2010.

3) Cacna1beta-deficient mice resistant to brain injury, Kasuya Y., et al., 2012 in preparation.

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1) Laminin alpha 3 LG4 module induces matrix metalloproteinase-1 through mitogen-activated protein kinase signaling. Utani A., et al., J Biol Chem 278: 34483-3449, 2003.

2) Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway. Irukayama-Tomobe Y., et al., Circulation 109: 904-910, 2004.

3) Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. Ishida J., et al., J Biol Chem 279: 26274-26279, 2004.

4) Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. Dateki M., et al., J Biol Chem 280: 20503-20508, 2005.

5) Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. Iemitsu M., et al., J Appl Physiol 101: 151-163, 2006.

6) Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Asada S., et al., Cell Signal 19: 519-527 2007.

7) Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase. Asada S., et al., Int J Mol Med 22: 95-104, 2008.

8) Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Yamagata K., et al., Mol Cell 32: 221-231, 2008.

9) Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension. Furuya M, et al., Laboratory Investigation, 88(4): 416-429, 2008.

10) The utilization of gene targeting models during in preclinical study of drug discovery process -Example of phenotypic and functional analysis of Cacna1b gene product- Miyamoto N, et al., Curr. Pharmaceut. Biotech. 10(2):261-267, 2009.

11) Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice. Tsuyusaki J, et al., J . Receptor Signal Transduct. 31(6):434-439, 2011.

12) Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Yamauchi K, et al.,Respir. Res. Oct 5;12:131., 2011.

13) Functional analysis of guinea pig beta1-adrenoceptor. Tanaka Y, et al., J Receptor Signal Transduct. 31(6):395-401, 2011.

14) Mechanism for p38alpha-mediated experimental autoimmune encephalomyelitis. Namiki K, et al., J. Biol. Chem. 287(29): 24228-24238, 2012.

15) Role of CD69 in acute lung injury. Ishizaki S,et al., Life Sci. 90(17-18): 657-665, 2012.

16) Endothelin B receptor-mediated encephalopathic events in mouse sepsis model. Naito Y, et al., Life Sci, 24;118(2):340-346, 2014.

17) Endothelin regulates function of IL-17-producing T cell subset. Tanaka K, et al., Life Sci. 118(2):244-247, 2014.

18) Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis. Tanaka K, et al., Laboratory Investigation, 94(11):1247-1259, 2014.

19) p38 Mitogen-Activated Protein Kinase Accelerates Emphysema in Mouse Model of Chronic Obstructive Pulmonary Disease. Amano H, et al., J Recept Signal Transduct. 34(4):299-306, 2014.

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