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136.    Ueda K, Takano H, Niitsuma Y, Hasegawa H, Uchiyama R, Oka T, Miyazaki M, Nakaya H, Komuro I. Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice. J Clin Invest;120:2016-2029,2010.
135.    Toko H, Takahashi H, Kayama Y, Okada S, Minamino T, Terasaki F, Kitaura Y, Komuro I. ATF6 is important under both pathological and physiological states in the heart. J Mol Cell Cardiol;49:113-120,2010.
134.    Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima N, Otsu K. Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy;6:2010.
133.    Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest;120:1506-1514,2010.
132.    Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I. X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes. J Mol Cell Cardiol;48:1280-1289,2010.
131.    Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res;106:1692-1702,2010.
130.    Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I. Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis. Circ Res;106:391-398,2010.
129.    Liao CH, Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I. Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J Clin Invest;120:242-253,2010.
128.    Yoshida M, Shiojima I, Ikeda H, Komuro I. Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. J Mol Cell Cardiol;47:698-705,2009.
127.    Tamura A, Ogura T, Uemura H, Reien Y, Kishimoto T, Nagai T, Komuro I, Miyazaki M, Nakaya H. Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current. J Pharmacol Sci;110:150-159,2009.
126.    Saito R, Kaneko E, Tanaka Y, Honda K, Matsuda T, Baba A, Komuro I, Kita S, Iwamoto T, Takano Y. Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+ exchanger knockout mice. Biol Pharm Bull;32:1928-1930,2009.
125.    Qin Y, Yasuda N, Akazawa H, Ito K, Kudo Y, Liao CH, Yamamoto R, Miura S, Saku K, Komuro I. Multivalent ligand-receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation. Hypertens Res;32:875-883,2009.
124.    Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I. Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol;29:889-894,2009.
123.    Moriya J, Minamino T, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y, Komuro I. Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia. Circ Cardiovasc Interv;2:245-254,2009.
122.    Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med;15:1082-1087,2009.
121.    Matsuura K, Honda A, Nagai T, Fukushima N, Iwanaga K, Tokunaga M, Shimizu T, Okano T, Kasanuki H, Hagiwara N, Komuro I. Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest;119:2204-2217,2009.
120.    Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J,   Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H, Komuro I. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med;206:1565-1574,2009.
119.    Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I. PDK1 coordinates survival pathways and b-adrenergic response in the heart. Proc Natl Acad Sci U S A;106:8689-8694,2009.
118.    Inokuchi Y, Shimazawa M, Nakajima Y, Komuro I, Matsuda T, Baba A, Araie M, Kita S, Iwamoto T, Hara H. A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion. J Neurosci Res;87:906-917,2009.
117.    Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol;47:664-675,2009.
116.    Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature;454:345-349,2008.
115.    Yasuda N, Miura S, Akazawa H, Tanaka T, Qin Y, Kiya Y, Imaizumi S, Fujino M, Ito K, Zou Y, Fukuhara S, Kunimoto S, Fukuzaki K, Sato T, Ge J, Mochizuki N, Nakaya H, Saku K, Komuro I. Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep;9:179-186,208
114.    Yasuda N, Akazawa H, Qin Y, Zou Y, Komuro I. A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II. Naunyn Schmiedebergs Arch Pharmacol;377:393-399,2008.
113.    Toko H, Minamino T, Komuro I. Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy. Trends Cardiovasc Med;18:88-93,2008.
112.    Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I. Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res;103:261-268,2008.
111.    Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. HIF-1a signaling upstream of NKX2.5 is required for cardiac development in Xenopus. J Biol Chem;283:11841-11849,2008.
110.    Monzen K, Ito Y, Naito AT, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima M, Nagai R, Komuro I. A crucial role of a high mobility group protein HMGA2 in cardiogenesis. Nat Cell Biol;10:567-574,2008.
109.    Lai ZF, Chen YZ, Feng LP, Meng XM, Ding JF, Wang LY, Ye J, Li P, Cheng XS, Kitamoto Y, Monzen K, Komuro I, Sakaguchi N, Kim-Mitsuyama S. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. Am J Physiol Heart Circ Physiol;295:H708-716,2008.
108.    Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res;102:607-614,2008.
107.    Kami D, Shiojima I, Makino H, Matsumoto K, Takahashi Y, Ishii R, Naito AT, Toyoda M, Saito H, Watanabe M, Komuro I, Umezawa A. Gremlin enhances the determined path to cardiomyogenesis. PLoS One;3:e2407,2008.
106.    Ajima R, Akazawa H, Kodama M, Takeshita F, Otsuka A, Kohno T, Komuro I, Ochiya T, Yokota J. Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Genes Cells;13:987-999,2008.
105.    Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J;71:1958-1964,2007.
104.    Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro I, Ono K. Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart. J Mol Cell Cardiol;42:1045-1053,2007.
103.    Van den Boom V, Kooistra SM, Boesjes M, Geverts B, Houtsmuller AB, Monzen K, Komuro I, Essers J, Drenth-Diephuis LJ, Eggen BJ. UTF1 is a chromatin-associated protein involved in ES cell differentiation. J Cell Biol;178:913-924,2007.
102.    Takano H, Hasegawa H, Kuwabara Y, Nakayama T, Matsuno K, Miyazaki Y, Yamamoto M, Fujimoto Y, Okada H, Okubo S, Fujita M, Shindo S, Kobayashi Y, Komiyama N, Takekoshi N, Imai K, Himi T, Ishibashi I, Komuro I. Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction. Int J Cardiol;122:41-47,2007.
101.    Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature;446:444-448,2007.
100.    Sakai M, Tamura K, Tsurumi Y, Tanaka Y, Koide Y, Matsuda M, Ishigami T, Yabana M, Tokita Y, Hiroi Y, Komuro I, Umemura S. Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression. Am J Physiol Renal Physiol;292:F1526-1536,2007.
99.     Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol;176:329-341,2007.
98.     Matsui Y, Kita S, Katsuragi T, Komuro I, Iwamoto T, Ohjimi H. Involvement of Na+/Ca2+ exchanger type-1 in ischemia-induced neovascularization in the mouse hindlimb. Ann N Y Acad Sci;1099:478-480,2007.
97.     Ifuku M, Farber K, Okuno Y, Yamakawa Y, Miyamoto T, Nolte C, Merrino VF, Kita S, Iwamoto T, Komuro I, Wang B, Cheung G, Ishikawa E, Ooboshi H, Bader M, Wada K, Kettenmann H, Noda M. Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. J Neurosci;27:13065-13073,2007.
96.     Ueda K, Takano H, Hasegawa H, Niitsuma Y, Qin Y, Ohtsuka M, Komuro I. Granulocyte colony stimulating factor directly inhibits myocardial ischemia-reperfusion injury through Akt-endothelial NO synthase pathway. Arterioscler Thromb Vasc Biol;26:e108-113,2006.
95.     Tateno K, Minamino T, Toko H, Akazawa H, Shimizu N, Takeda S, Kunieda T, Miyauchi H, Oyama T, Matsuura K, Nishi J, Kobayashi Y, Nagai T, Kuwabara Y, Iwakura Y, Nomura F, Saito Y, Komuro I. Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res;98:1194-1202,206
94.     Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circ Res;99:1411-1418,2006.
93.     Naito AT, Shiojima I, Akazawa H, Hidaka K, Morisaki T, Kikuchi A, Komuro I. Developmental stage-specific biphasic roles of Wnt/b-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A;103:19812-19817,2006.
92.     Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, Tomita S, Uehara Y, Karnik SS, Yanagisawa H, Koike H, Komuro I, Saku K. Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor. J Biol Chem;281:19288-19295,2006.
91.     Matsudo Y, Takamori Y, Fujimura L, Nishio S, Sasagawa K, Komuro I, Tokuhisa T, Hatano M. Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy. Transgenic Res;15:573-581,2006.
90.     Nieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, Miyauchi H, Orimo M, Okada S, Takamura M, Nagai T, Kaneko S, Komuro I. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation;114:953-960,2006.
89.     Kunieda T, Minamino T, Katsuno T, Tateno K, Nishi J, Miyauchi H, Orimo M, Okada S, Komuro I. Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res;98:532-539,2006.
88.     Hasegawa H, Takano H, Shiraishi H, Ueda K, Niitsuma Y, Tadokoro H, Komuro I. Intracoronary injection of granulocyte colony-stimulating factor ameliorates the progression of left ventricular remodeling after myocardial ischemia/reperfusion in rabbits. Circ J;70:942-944,2006.
87.     Hasegawa H, Takano H, Ohtsuka M, Ueda K, Niitsuma Y, Qin Y, Tadokoro H, Shiomi M, Komuro I. G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits. Biochem Biophys Res Commun;344:370-376,2006.
86.     Hasegawa H, Takano H, Kohro T, Ueda K, Niitsuma Y, Aburatani H, Komuro I. Amelioration of hypertensive heart failure by amlodipine may occur via antioxidative effects. Hypertens Res;29:719-729,2006.
85.     Hasegawa H, Takano H, Iwanaga K, Ohtsuka M, Qin Y, Niitsuma Y, Ueda K, Toyoda T, Tadokoro H, Komuro I. Cardioprotective effects of granulocyte colony-stimulating factor in swine with chronic myocardial ischemia. J Am Coll Cardiol;47:842-849,2006.
84.     Urano A, Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, Taki T, Akazawa H, Nakajima H, Komuro I, Yoshida N, Hayashi Y, Handa H, Kitamura T, Nosaka T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol;25:6834-6845,2005.
83.     Saegusa N, Sato T, Saito T, Tamagawa M, Komuro I, Nakaya H. Kir6.2-deficient mice are susceptible to stimulated ANP secretion: KATP channel acts as a negative feedback mechanism? Cardiovasc Res;67:60-68,2005.
82.     Ohtsu Y, Johkura K, Ito K, Akashima T, Asanuma K, Ogiwara N, Oka T, Komuro I, Sasaki K, Amano J. Stimulation of P19CL6 with multiple reagents induces pulsating particles in vivo. Curr Med Res Opin;21:795-803,2005.
81.     Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I. Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res;97:144-151,2005.
80.     Hasegawa H, Takano H, Zou Y, Qin Y, Hizukuri K, Odaka K, Toyozaki T, Komuro I. Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. J Mol Cell Cardiol;38:257-265,2005.
79.     Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med;11:305-311,2005.
78.     Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol;6:499-506,2004.
77.     Toko H, Zou Y, Minamino T, Masaya M, Harada M, Nagai T, Sugaya T, Terasaki F, Kitaura Y, Komuro I. Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium. Arterioscler Thromb Vasc Biol;24:664-670,2004.
76.     Tatsuguchi M, Hiratsuka E, Machida S, Nishikawa T, Imamura S, Shimizu S, Nishimura M, Komuro I, Furutani Y, Furutani M, Nagao H, Komatsu K, Kasanuki H, Matsuoka R. Swimming exercise in infancy has beneficial effect on the hearts in cardiomyopathic Syrian hamsters. J Muscle Res Cell Motil;25:69-76,2004
75.     Saegusa N, Sato T, Ogura T, Komuro I, Nakaya H. Inhibitory effects of AMP 579, a novel cardioprotective adenosine A1/A2A receptor agonist, on native IKr and cloned HERG current. Naunyn Schmiedebergs Arch Pharmacol;370:492-499,2004.
74.     Ohtsuka M, Takano H, Zou Y, Toko H, Akazawa H, Qin Y, Suzuki M, Hasegawa H, Nakaya H, Komuro I. Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J;18:851-853,2004.
73.     Ohtsuka M, Takano H, Suzuki M, Zou Y, Akazawa H, Tamagawa M, Wakimoto K, Nakaya H, Komuro I. Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model. Biochem Biophys Res Commun;314:849-853,2004.
72.     Ohsawa Y, Toko H, Katsura M, Morimoto K, Yamada H, Ichikawa Y, Murakami T, Ohkuma S, Komuro I, Sunada Y. Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity. Hum MolGenet;13:151-157,2004.
71.     Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T. Oxidative stress induces insulin resistance by activating the nuclear factor-kB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Diabetologia;47:794-805,2004.
70.     Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J;23:212-220,2004.
69.     Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J Cell Biol;167:351-363,2004.
68.     Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, Sano M, Toko H, Akazawa H, Sato T, Nakaya H, Kasanuki H, Komuro I. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem;279:11384-11391,2004.
67.     Kasai H, Yao A, Oyama T, Hasegawa H, Akazawa H, Toko H, Nagai T, Kinugawa K, Kohmoto O, Maruyama K, Takahashi T, Nagai R, Miyawaki A, Komuro I. Direct measurement of Ca2+ concentration in the SR of living cardiac myocytes. Biochem Biophys Res Commun;314:1014-1020,2004.
66.     Iwanaga K, Takano H, Ohtsuka M, Hasegawa H, Zou Y, Qin Y, Odaka K, Hiroshima K, Tadokoro H, Komuro I. Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine. Biochem Biophys Res Commun;325:1353-1359,2004.
65.     Iwamoto T, Kita S, Zhang J, Blaustein MP, Arai Y, Yoshida S, Wakimoto K, Komuro I, Katsuragi T. Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med;10:1193-1199,2004.
64.     Ikeda Y, Imai Y, Kumagai H, Nosaka T, Morikawa Y, Hisaoka T, Manabe I, Maemura K, Nakaoka T, Imamura T, Miyazono K, Komuro I, Nagai R, Kitamura T. Vasorin, a transforming growth factor b-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. ProcNatl Acad Sci U S A;101:10732-10737,2004.
63.     Hayashi D, Kudoh S, Shiojima I, Zou Y, Harada K, Shimoyama M, Imai Y, Monzen K, Yamazaki T, Yazaki Y, Nagai R, Komuro I. Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1. Biochem Biophys Res Commun;322:310-319,2004.
62.     Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, Komuro I. A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J Cell Biol;164:395-405,2004.
61.     Akazawa H, Komazaki S, Shimomura H, Terasaki F, Zou Y, Takano H, Nagai T, Komuro I. Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure. J Biol Chem;279:41095-41103,2004.
60.     Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation;108:3024-3030,2003.
59.     Zou Y, Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I. Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation;108:748-753,2003.
58.     Yao A, Kohmoto O, Oyama T, Sugishita Y, Shimizu T, Harada K, Matsui H, Komuro I, Nagai R, Matsuo H, Serizawa T, Maruyama T, Takahashi T. Characteristic effects of α1-β1,2-adrenergic blocking agent, carvedilol, on [Ca2+]i in ventricular myocytes compared with those of timolol and atenolol. Circ J;67:83-90,2003.
57.     Yamashita J, Kita S, Iwamoto T, Ogata M, Takaoka M, Tazawa N, Nishikawa M, Wakimoto K, Shigekawa M, Komuro I, Matsumura Y. Attenuation of ischemia/reperfusion-induced renal injury in mice deficient in Na+/Ca2+ exchanger. J Pharmacol Exp Ther;304:284-293,2003.
56.     Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Y, Shigekawa M, Imai Y, Komuro I. Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp Biochem Physiol B Biochem Mol Biol;135:9-15,2003.
55.     Sato M, Moroi K, Nishiyama M, Zhou J, Usui H, Kasuya Y, Fukuda M, Kohara Y, Komuro I, Kimura S. Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit. Life Sci;73:917-932,2003.
54.     Naito AT, Tominaga A, Oyamada M, Oyamada Y, Shiraishi I, Monzen K, Komuro I, Takamatsu T. Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002. Exp Cell Res;291:56-69,2003.
53.     Nagai T, Tanaka-Ishikawa M, Aikawa R, Ishihara H, Zhu W, Yazaki Y, Nagai R, Komuro I. Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes. Biochem Biophys Res Commun;305:806-810,2003.
52.     Mizukami M, Hasegawa H, Kohro T, Toko H, Kudoh S, Zou Y, Aburatani H, Komuro I. Gene expression profile revealed different effects of angiotensin II receptor blockade and angiotensin-converting enzyme inhibitor on heart failure. J Cardiovasc Pharmacol;42 Suppl 1:S1-6,2003.
51.     Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, Toko H, Komuro I. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation;108:2264-2269,2003.
50.     Kudoh S, Akazawa H, Takano H, Zou Y, Toko H, Nagai T, Komuro I. Stretch-modulation of second messengers: effects on cardiomyocyte ion transport. Prog Biophys Mol Biol;82:57-66,2003.
49.     Kayaba Y, Nakamura A, Kasuya Y, Ohuchi T, Yanagisawa M, Komuro I, Fukuda Y, Kuwaki T. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol;285:R581-593,2003.
48.     Iijima Y, Nagai T, Mizukami M, Matsuura K, Ogura T, Wada H, Toko H, Akazawa H, Takano H, Nakaya H, Komuro I. Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J;17:1361-1363,2003.
47.     Hasegawa H, Yamamoto R, Takano H, Mizukami M, Asakawa M, Nagai T, Komuro I. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats. J Mol Cell Cardiol;35:953-960,2003.
46.     Fan C, Duhagon MA, Oberti C, Chen S, Hiroi Y, Komuro I, Duhagon PI, Canessa R, Wang Q. Novel TBX5 mutations and molecular mechanism for Holt-Oram syndrome. J Med Genet;40:e29,2003.
45.     Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH. Sox6 regulation of cardiac myocyte development. Nucleic Acids Res;31:5941-5948,2003.
44.     Zou Y, Yamazaki T, Nakagawa K, Yamada H, Iriguchi N, Toko H, Takano H, Akazawa H, Nagai R, Komuro I. Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats. Hypertens Res;25:117-124,2002.
43.     Toko H, Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I. Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart. J Biol Chem;277:24735-24743,2002.
42.     Toko H, Oka T, Zou Y, Sakamoto M, Mizukami M, Sano M, Yamamoto R, Sugaya T, Komuro I. Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy. Hypertens Res;25:597-603,2002.
41.     Takimoto E, Yao A, Toko H, Takano H, Shimoyama M, Sonoda M, Wakimoto K, Takahashi T, Akazawa H, Mizukami M, Nagai T, Nagai R, Komuro I. Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload. FASEB J;16:373-378,2002.
40.     Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest;110:177-184,2002.
39.     Sato M, Toyozaki T, Odaka K, Uehara T, Arano Y, Hasegawa H, Yoshida K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Tadokoro H, Irie T, Tanada S, Komuro I. Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. Circulation;106:1397-1402,2002.
38.     Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M, Shojima N, Ono H, Onishi Y, Fujishiro M, Katagiri H, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Komuro I, Fujita T. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension;40:872-879,2002.
37.     Monzen K, Zhu W, Kasai H, Hiroi Y, Hosoda T, Akazawa H, Zou Y, Hayashi D, Yamazaki T, Nagai R, Komuro I. Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes. Biochem Biophys Res Commun;298:493-500,2002.
36.     Minamino T, Toko H, Tateno K, Nagai T, Komuro I. Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis? Lancet;360:2083-2084; author reply 2084,2002.
35.     Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation;105:1541-1544,2002.
34.     Matsumura Y, Yamashita J, Kita S, Iwamoto T, Ogata M, Takaoka M, Wakimoto K, Shigekawa M, Komuro I. Pathophysiological roles of Ca2+ overload via the Na+/Ca2+ exchanger and endothelin-1 overproduction in ischaemia/reperfusion-induced acute renal failure. Clin Sci (Lond);103 Suppl 48:389S-392S,2002.
33.     Matsumoto Y, Aihara H, Yamauchi-Kohno R, Reien Y, Ogura T, Yabana H, Masuda Y, Sato T, Komuro I, Nakaya H. Long-term endothelin a receptor blockade inhibits electrical remodeling in cardiomyopathic hamsters. Circulation;106:613-619,2002.
32.     Kushida S, Ogura T, Komuro I, Nakaya H. Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action. Eur J Pharmacol;457:19-27,2002.
31.     Kuriyama N, Kobayashi Y, Kuroda N, Desai K, Yamamoto Y, Komiyama N, Komuro I, Fitzgerald PJ. Effect of coronary stent overexpansion on lumen size and intimal hyperplasia at follow-up. Am J Cardiol;89:1297-1299,2002.
30.     Ikeda Y, Hiroi Y, Hosoda T, Utsunomiya T, Matsuo S, Ito T, Inoue J, Sumiyoshi T, Takano H, Nagai R, Komuro I. Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease. Circ J;66:561-563,2002.
29.     Asakawa M, Takano H, Nagai T, Uozumi H, Hasegawa H, Kubota N, Saito T, Masuda Y, Kadowaki T, Komuro I. Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation;105:1240-1246,2002.
28.     Aikawa R, Nitta-Komatsubara Y, Kudoh S, Takano H, Nagai T, Yazaki Y, Nagai R, Komuro I. Reactive oxygen species induce cardiomyocyte apoptosis partly through TNF-a. Cytokine;18:179-183,2002.
27.     Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension;39:233-238,2002.
26.     Zou Y, Yao A, Zhu W, Kudoh S, Hiroi Y, Shimoyama M, Uozumi H, Kohmoto O, Takahashi T, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation;104:102-108,2001.
25.     Zou Y, Hiroi Y, Uozumi H, Takimoto E, Toko H, Zhu W, Kudoh S, Mizukami M, Shimoyama M, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation;104:97-101,2001.
24.     Wakimoto K, Kuro-o M, Yanaka N, Komuro I, Nabeshima YI, Imai Y. Expression of Na+/Ca2+ exchanger (NCX1) gene in the developmental mouse embryo and adult mouse brain. Comp Biochem Physiol B Biochem Mol Biol;130:191-198,2001.
23.     Uozumi H, Hiroi Y, Zou Y, Takimoto E, Toko H, Niu P, Shimoyama M, Yazaki Y, Nagai R, Komuro I. gp130 plays a critical role in pressure overload-induced cardiac hypertrophy. J Biol Chem;276:23115-23119,2001.
22.     Sawada Y, Nakamura K, Doi K, Takeda K, Tobiume K, Saitoh M, Morita K, Komuro I, De Vos K, Sheetz M, Ichijo H. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci;114:1221-1227,2001.
21.     Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, Ishii S, Yazaki Y, Nagai R, Komuro I. Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J Cell Biol;153:687-698,2001.
20.     Meacci E, Donati C, Cencetti F, Oka T, Komuro I, Farnararo M, Bruni P. Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-a in C2C12 myoblasts. Cell Signal;13:593-598,2001.
19.     Hosoda T, Monzen K, Hiroi Y, Oka T, Takimoto E, Yazaki Y, Nagai R, Komuro I. A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes. J Biol Chem;276:35978-35989,2001.
18.     Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet;28:276-280,2001.
17.     Hiroi Y, Hiroi J, Kudoh S, Yazaki Y, Nagai R, Komuro I. Two distinct mechanisms of angiotensin II-induced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes. Hypertens Res;24:385-394,2001.
16.     Hirata Y, Matsumoto A, Aoyagi T, Yamaoki K, Komuro I, Suzuki T, Ashida T, Sugiyama T, Hada Y, Kuwajima I, Nishinaga M, Akioka H, Nakajima O, Nagai R, Yazaki Y. Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload. Cardiovasc Res;51:585-591,2001.
15.     Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M. COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development. J Biol Chem;276:2797-2801,2001.
14.     Gu Y, Zou Y, Aikawa R, Hayashi D, Kudoh S, Yamauchi T, Uozumi H, Zhu W, Kadowaki T, Yazaki Y, Komuro I. Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Mol Cell Biochem;223:35-46,2001.
13.     Aikawa R, Nagai T, Tanaka M, Zou Y, Ishihara T, Takano H, Hasegawa H, Akazawa H, Mizukami M, Nagai R, Komuro I. Reactive oxygen species in mechanical stress-induced cardiac hypertrophy. Biochem Biophys Res Commun;289:901-907,2001.
12.     Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem;275:15239-15245,2000.
11.     Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I. Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. J Biol Chem;275:35291-35296,2000.
10.     Wakimoto K, Kuro OM, Yanaka N, Omori K, Komuro I, Imai Y, Nabeshima Y. Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice. DNA Seq;11:75-81,2000.
9.     Wakimoto K, Kobayashi K, Kuro-O M, Yao A, Iwamoto T, Yanaka N, Kita S, Nishida A, Azuma S, Toyoda Y, Omori K, Imahie H, Oka T, Kudoh S, Kohmoto O, Yazaki Y, Shigekawa M, Imai Y, Nabeshima Y, Komuro I. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects inheartbeat. J Biol Chem;275:36991-36998,2000.
8.     Tsuruda T, Kato J, Kitamura K, Imamura T, Koiwaya Y, Kangawa K, Komuro I, Yazaki Y, Eto T. Enhanced adrenomedullin production by mechanical stretching in cultured rat cardiomyocytes. Hypertension;35:1210-1214,2000.
7.     Tanaka M, Komuro I, Inagaki H, Jenkins NA, Copeland NG, Izumo S. Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev Dyn;219:248-260,2000.
6.     Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, Hiroi Y, Oka T, Hayashi D, Hirai H, Kudoh S, Toko H, Kawamura K, Nagai R, Yazaki Y, Komuro I. Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice. Biochem Biophys Res Commun;270:1074-1079,2000.
5.     Takano H, Nagai T, Asakawa M, Toyozaki T, Oka T, Komuro I, Saito T, Masuda Y. Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-a expression in neonatal rat cardiac myocytes. Circ Res;87:596-602,2000.
4.     Shiojima I, Oka T, Hiroi Y, Nagai R, Yazaki Y, Komuro I. Transcriptional regulation of human cardiac homeobox gene CSX1. Biochem Biophys Res Commun;272:749-757,2000.
3.     Shimoyama M, Hayashi D, Zou Y, Takimoto E, Mizukami M, Monzen K, Kudoh S, Hiroi Y, Yazaki Y, Nagai R, Komuro I. Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. Circulation;102:1996-2004,2000.
2.     Saito S, Hiroi Y, Zou Y, Aikawa R, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. b-adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J Biol Chem;275:34528-34533,2000.
1.     Oka T, Shiojima I, Monzen K, Kudoh S, Hiroi Y, Shiokawa K, Asashima M, Nagai R, Yazaki Y, Komuro I. Fibroblast growth factor plays a critical role in SM22a expression during Xenopus embryogenesis. Arterioscler Thromb Vasc Biol;20:907-914,2000.

Clinical Reports

152.    Takaoka H, Takano H, Nakagawa K, Kobayashi Y, Hiroshima K, Komuro I. Buerger's disease-like vasculitis associated with Kimura's disease. Int J Cardiol;140:e23-26,2010.
151.    Uehara M, Funabashi N, Ueda M, Murayama T, Takaoka H, Sawada K, Kasahara T, Yanagawa N, Komuro I. Quality of coronary arterial 320-slice computed tomography images in subjects with chronic atrial fibrillation compared with normal sinus rhythm. Int J Cardiol;2010.
150.    Nomura S, Funabashi N, Tsubura M, Uehara M, Shiina Y, Daimon M, Tateno K, Nagai T, Komuro I. Cardiac sarcoidosis evaluated by multimodality imaging. Int J Cardiol;2010.
149.    Nakayama T, Komiyama N, Yokoyama M, Namikawa S, Kuroda N, Kobayashi Y, Komuro I. Pioglitazone induces regression of coronary atherosclerotic plaques in patients with type 2 diabetes mellitus or impaired glucose tolerance: a randomized prospective study using intravascular ultrasound. Int J Cardiol;138:157-1652010
148.    Murayama T, Funabashi N, Uehara M, Takaoka H, Komuro I. New classification of aortic dissection during the cardiac cycle as pulsating type and static type evaluated by electrocardiogram-gated multislice CT. Int J Cardiol;142:177-186,2010.
147.    Kawakubo M, Funabashi N, Takahashi M, Sueishi M, Motoyoshi Y, Mikata T, Uchida I, Asakawa T, Takahashi R, Takamatsu M, Matsuoka Y, Minegishi M, Naga H, Yajima R, Kataoka A, Lee K, Komuro I. Relationship of natriuretic peptide and transthoracic echocardiographic findings in 135 subjects with muscular dystrophy. Int J Cardiol;2010.
146.    Ishio N, Kobayashi Y, Iwata Y, Kitahara H, Fukushima K, Asano T, Nakayama T, Kuroda N, Komuro I. Ubiquitous atherosclerosis in coronary arteries without angiographically significant stenosis. Heart Vessels;25:35-40,2010.
145.    Ichimoto E, Kobayashi Y, Iijima Y, Kuroda N, Kohno Y, Komuro I. Long-term clinical outcomes after sirolimus-eluting stent implantation in dialysis patients. Int Heart J;51:92-97,2010.
144.    Hori Y, Funabashi N, Uehara M, Ueda M, Takaoka H, Nakamura K, Murayama T, Komuro I. Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis. Int J Cardiol;142:152-158,2010.
143.    Fukushima K, Kobayashi Y, Kitahara H, Iwata Y, Kuroda N, Ooyama M, Nomura F, Komuro I. Effect of 450-mg loading dose of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement. Heart Vessels;25:182-186,2010.
142.    Fukushima K, Kobayashi Y, Kitahara H, Iwata Y, Kuroda N, Ooyama M, Kuwabara Y, Nomura F, Komuro I. Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study. Heart Vessels;25:41-44,2010.
141.    Sugimoto K, Kobayashi Y, Miyahara H, Kuroda N, Funabashi N, Komuro I. Early stent thrombosis because of stent dislodgement in a coronary artery aneurysm. Circ J;73:1759-1761,2009.
140.    Nakayama T, Kobayashi Y, Takano H, Kuroda N, Hiroshima K, Komuro I. Silent very late thrombotic occlusion of sirolimus-eluting stent confirmed by directional coronary atherectomy. Circ J;73:1762-1764,2009.
139.    Kadohira T, Kobayashi Y, Niitsuma Y, Imamaki M, Komuro I. Global ST-segment elevation associated with impending cardiac rupture during diagnostic cardiac catheterization. Int Heart J;50:539-542,2009.
138.    Yoshida N, Funabashi N, Uehara M, Yajima R, Kataoka A, Ueda M, Takaoka H, Komuro I. Differentiation of diagnosis and prognoses of non-coronary arterial primary myocardial diseases with left ventricular focal myocardial thinning evaluated by multislice computed tomography. Int J Cardiol;2009.
137.    Wakatsuki Y, Funabashi N, Mikami Y, Shiina Y, Kawakubo M, Takahashi M, Yajima R, Uehara M, Takaoka H, Komuro I. Left atrial compensatory function in subjects with early stage primary hypertension assessed by using left atrial volumetric emptying fraction acquired by transthoracic echocardiography. Int J Cardiol;136:363-367,2009.
136.    Uehara M, Tanabe N, Funabashi N, Takaoka H, Ikari J, Toyama S, Shimizu H, Hoshino S, Sugiura T, Saito M, Kawata N, Matsuura Y, Kuriyama T, Tatsumi K, Komuro I. Detailed distribution of acute pulmonary thromboemboli: Direct evidence for reduction of acquisition length and radiation dose for triple rule-out CT angiography. Int J Cardiol;2009.
135.    Uehara M, Funabashi N, Miyagi J, Suzuki M, Sekine T, Takaoka H, Takahashi K, Komuro I. Comparison of three techniques for evaluation of de novo asymptomatic pulmonary arterial thrombosis following deep vein thrombosis in total knee arthroplasty. Int J Cardiol;2009.
134.    Sugimoto K, Kobayashi Y, Kuroda N, Komuro I. Cost analysis of sirolimus-eluting stents in the Japanese health insurance system. Int Heart J;50:723-730,2009.
133.    Shimizu I, Iguchi N, Watanabe H, Umemura J, Tobaru T, Asano R, Misu K, Nagayama M, Aikawa M, Funabashi N, Komuro I, Sumiyoshi T. Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients. Int J Cardiol;2009.
132.    Shiina Y, Funabashi N, Teramoto K, Uehara M, Takaoka H, Mikami Y, Takahashi A, Saito M, Daimon M, Lee K, Kawakubo M, Sekine Y, Takahashi M, Yajima R, Tani A, Komuro I. Suitable solutions for reconstituting the ultrasound contrast agent "Levovist" used in contrast echocardiogram: in vitro and in vivo evaluation of the influence of osmotic pressure. Int J Cardiol;136:335-340,2009.
131.    Shiina Y, Funabashi N, Lee K, Murayama T, Nakamura K, Wakatsuki Y, Daimon M, Komuro I. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol;131:424-429,2009
130.    Shiina Y, Funabashi N, Lee K, Daimon M, Sekine T, Kawakubo M, Takahashi M, Yajima R, Tanabe N, Kuriyama T, Komuro I. Right atrium contractility and right ventricular diastolic function assessed by pulsed tissue Doppler imaging can predict brain natriuretic peptide in adults with acquired pulmonary hypertension. Int J Cardiol;135:53-59,2009.
129.    Shiina Y, Funabashi N, Lee K, Daimon M, Sekine T, Kawakubo M, Sekine Y, Takahashi M, Yajima R, Wakatsuki Y, Tanabe N, Kuriyama T, Komuro I. Doppler imaging predicts cardiac events in chronic pulmonary thromboembolism. Int J Cardiol;133:167-172,2009.
128.    Sekine T, Daimon M, Hasegawa R, Toyoda T, Kawata T, Funabashi N, Komuro I. The impact of sleep deprivation on the coronary circulation. Int J Cardiol;2009.
127.    Ono H, Funabashi N, Uehara M, Yajima R, Kataoka A, Ueda M, Miyauchi H, Daimon M, Takaoka H, Komuro I. Comprehensive evaluation of characteristics of left ventricular myocardium in a subject with non-coronary arterial cardiac dysfunction through segment by segment analysis using various diagnostic modalities. Int J Cardiol;2009.
126.    Narumi H, Yoshida K, Hashimoto N, Umehara I, Funabashi N, Yoshida S, Komuro I. Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening. Int J Cardiol;135:150-155,2009.
125.    Nakamura K, Funabashi N, Uehara M, Ueda M, Murayama T, Takaoka H, Komuro I. Left atrial wall thickness in paroxysmal atrial fibrillation by multislice-CT is initial marker of structural remodeling and predictor of transition from paroxysmal to chronic form. Int J Cardiol;2009.
124.    Miyazaki S, Funabashi N, Nagai T, Uehara M, Kataoka A, Takaoka H, Ueda M, Komuro I. Cardiac sarcoidosis complicated with atrioventricular block and wall thinning, edema and fibrosis in left ventricle: Confirmed recovery to normal sinus rhythm and visualization of edema improvement by administration of predonisolone. Int J Cardiol;2009.
123.    Mikami Y, Sakuma H, Nagata M, Ishida M, Kurita T, Komuro I, Ito M. Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction. AJR Am J Roentgenol;193:W321-326,2009.
122.    Kudo K, Funabashi N, Uehara M, Murayama T, Yajima R, Hayakawa N, Ueda M, Takaoka H, Komuro I. Reversible left ventricular wall thickening during recovery procedure in takotsubo cardiomyopathy demonstrated by multislice computed tomography. Int J Cardiol;2009.
121.    Kitahara H, Kobayashi Y, Takebayashi H, Nakamura Y, Kuroda N, Miyazaki A, Haruta S, Komuro I. Angiographic patterns of restenosis after sirolimus-eluting stent implantation. Circ J;73:508-511,2009.
120.    Kitahara H, Kobayashi Y, Takebayashi H, Fujimoto Y, Nakamura Y, Kuroda N, Himi T, Miyazaki A, Haruta S, Komuro I. Re-restenosis and target lesion revascularization after treatment of sirolimus-eluting stent restenosis: retrospective analysis of 4 Japanese hospitals. Circ J;73:867-871,2009.
119.    Kawata T, Daimon M, Hasegawa R, Teramoto K, Toyoda T, Sekine T, Yamamoto K, Uchida D, Himi T, Yoshida K, Komuro I. Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus. Int J Cardiol;132:286-288,2009.
118.    Ichimoto E, Jo K, Kobayashi Y, Inoue T, Nakamura Y, Kuroda N, Miyazaki A, Komuro I. Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction. Circ J;73:1669-1673,2009.
117.    Hama Y, Funabashi N, Ueda M, Kanaeda T, Uehara M, Nakamura K, Murayama T, Mikami Y, Takaoka H, Kawakubo M, Lee K, Takano H, Komuro I. Images in cardiovascular medicine. Right-sided heart wall thickening and delayed enhancement caused by chronic active myocarditis complicated by sustained monomorphic ventricular tachycardia. Circulation;119:e200-203,2009.
116.    Asano T, Kobayashi Y, Fukushima K, Iwata Y, Kitahara H, Ishio N, Nakayama T, Kuroda N, Komuro I. Effect of balloon inflation time on expansion of sirolimus-eluting stent. Heart Vessels;24:335-339,2009.
115.    Utsumi T, Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Takano H, Nakaya H, Komuro I. Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis. Int J Cardiol;128:294-295,2008.
114.    Nakamura K, Funabashi N, Miyauchi H, Aminaka M, Uehara M, Ueda M, Murayama T, Hori Y, Nakayama T, Daimon M, Kuroda N, Kobayashi Y, Komuro I. Hemangioma located just above the left main coronary artery, in a subject who had cardiac arrest due to ventricular fibrillation, led to a diagnosis of Brugada syndrome. Int J Cardiol;127:437-441,2008.
113.    Kitahara H, Kobayashi Y, Yamaguchi M, Ohkubo K, Nakayama T, Kuroda N, Komuro I. Damage to polymer of paclitaxel-eluting stent. Circ J;72:1907-1908,2008.
112.    Kitahara H, Kobayashi Y, Yamaguchi M, Fujimoto Y, Nameki M, Nakayama T, Kuroda N, Komuro I. Damage to polymer of undelivered sirolimus-eluting stents. J Invasive Cardiol;20:130-133,2008.
111.    Kadohira T, Kobayashi Y, Asano T, Uehara M, Funabashi N, Nakayama T, Kuroda N, Komuro I. Fatal very late stent thrombosis in a young diabetic patient with severely diffuse coronary atherosclerosis. Int Heart J;49:507-513,2008.
110.    Fujita T, Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Takano H, Nakaya H, Komuro I. Takayasu arteritis evaluated by multi-slice computed tomography in an old man. Int J Cardiol;125:286-287,2008.
109.    Uehara M, Funabashi N, Mikami Y, Shiina Y, Nakamura K, Komuro I. Quantitative effect of atorvastatin on size and content of non-calcified plaques of coronary arteries 1 year after atorvastatin treatment by multislice computed tomography. Int J Cardiol;130:269-275,2008.
108.    Takano H, Nakagawa K, Ishio N, Daimon M, Kobayashi Y, Hiroshima K, Komuro I. Active myocarditis in a patient with chronic active Epstein-Barr virus infection. Int J Cardiol;130:e11-13,2008.
107.    Shiina Y, Funabashi N, Lee K, Toyoda T, Sekine T, Honjo S, Hasegawa R, Kawata T, Wakatsuki Y, Hayashi S, Murakami S, Koike K, Daimon M, Komuro I. Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography. Int J Cardiol;129:193-197,2008.
106.    Shiina Y, Funabashi N, Fujikawa A, Lee K, Sekine T, Uehara M, Mikami Y, Tanabe N, Kuriyama T, Komuro I. Quantitative evaluation of chronic pulmonary thromboemboli by multislice CT compared with pulsed Tissue Doppler Imaging and its relationship with brain natriuretic peptide. Int J Cardiol;130:505-512,2008.
105.    Ohkubo K, Kobayashi Y, Komuro I. Do not forget vasospastic angina in patients with chest pain at rest and no significant coronary stenosis with multidetector computed tomography. Am J Cardiol;101:1519,2008.
104.    Odaka K, Uehara T, Arano Y, Adachi S, Tadokoro H, Yoshida K, Hasegawa H, Imanaka-Yoshida K, Yoshida T, Hiroe M, Irie T, Tanada S, Komuro I. Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111In Fab fragment of monoclonal antibody specific for tenascin-C. Int Heart J;49:481-492,2008.
103.    Nakayama K, Kuwabara Y, Daimon M, Shindo S, Fujita M, Narumi H, Mizuma H, Komuro I. Valsartan Amlodipine Randomized Trial (VART): design, methods, and preliminary results. Hypertens Res;31:21-28,2008.
102.    Nakamura K, Funabashi N, Uehara M, Suzuki K, Terao M, Okubo K, Mita Y, Maeda F, Komuro I. Quantitative 4-dimensional volumetric analysis of left ventricle in ischemic heart disease by 64-slice computed tomography: a comparative study with invasive left ventriculogram. Int J Cardiol;129:42-52,2008.
101.    Nakamura K, Funabashi N, Uehara M, Suzuki K, Terao M, Okubo K, Mita Y, Maeda F, Komuro I. Impairment factors for evaluating the patency of drug-eluting stents and bare metal stents in coronary arteries by 64-slice computed tomography versus conventional coronary angiography. Int J Cardiol;130:349-356,2008.
100.    Mizuno N, Funabashi N, Nakamura K, Uehara M, Suzuki K, Terao M, Okubo K, Mita Y, Maeda F, Komuro I. Utility of multislice computed tomography with a 64-data acquisition system for four-dimensional volumetric analysis using a pulsating phantom and considering pulsation rate and reconstruction methods. Int JCardiol;130:477-480,2008.
99.     Kitahara H, Kobayashi Y, Fujimoto Y, Nakamura Y, Nakayama T, Kuroda N, Himi T, Miyazaki A, Komuro I. Late stent thrombosis in patients receiving ticlopidine and aspirin after sirolimus-eluting stent implantation. Circ J;72:168-169,2008.
98.     Iwata Y, Kobayashi Y, Fukushima K, Kitahara H, Asano T, Ishio N, Nakayama T, Kuroda N, Komuro I. Incidence of premature discontinuation of antiplatelet therapy after sirolimus-eluting stent implantation. Circ J;72:340-341,2008.
97.     Fukushima K, Kobayashi Y, Kitahara H, Iwata Y, Nakayama T, Kuroda N, Ooyama M, Nomura F, Komuro I. Effect of 150-mg vs 300-mg loading doses of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement. Circ J;72:1282-1284,2008.
96.     Asano T, Kobayashi Y, Fukushima K, Iwata Y, Kitahara H, Ishio N, Kuroda N, Komuro I. Safety and efficacy of low-dose clopidogrel in Japanese patients undergoing coronary stenting: preliminary 30-day clinical outcome. Circ J;72:1707-1708,2008.
95.     Uehara M, Funabashi N, Yasukawa K, Terai M, Komuro I. Coarctation of the descending aorta, patent ductus arteriosus, deficiency of right superior vena cava, and persistent left superior vena cava in a five-month infant demonstrated by multislice computed tomography. Int J Cardiol;122:61-63,2007.
94.     Uehara M, Funabashi N, Ogawa Y, Minamino T, Komuro I. Double outlet right ventricle demonstrated by multislice computed tomography. Int J Cardiol;121:218-220,2007.
93.     Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Funabashi N, Kobayashi Y, Shiojima I, Komuro I. Coronary aneurysm reduced after coronary stenting. Int J Cardiol;121:76-77,2007.
92.     Narumi H, Funabashi N, Takano H, Sekine T, Ueda M, Hori Y, Fukawa T, Minamino T, Kobayashi Y, Komuro I. Remarkable thickening of right atrial wall in subjects with cardiac amyloidosis complicated with sick sinus syndrome. Int J Cardiol;119:222-224,2007.
91.     Nakamura K, Funabashi N, Miyauchi H, Aminaka M, Uehara M, Ueda M, Nakayama T, Kuroda N, Kobayashi Y, Takano H, Komuro I. Images in cardiovascular medicine. Occurrence of multiple fibrofatty replacements exclusively in the left ventricle of a patient with monomorphic sustained ventricular tachycardia.Circulation;115:e640-642,2007.
90.     Mikami Y, Funabashi N, Kijima T, Uehara M, Shiina Y, Lee K, Nakayama T, Daimon M, Kuroda N, Kobayashi Y, Takano H, Komuro I. Focal fibrosis in the left ventricle of subjects with cardiac amyloidosis evaluated by multislice computed tomography. Int J Cardiol;122:72-75,2007.
89.     Kawakubo M, Funabashi N, Uehara M, Ueda M, Hasegawa H, Sekine T, Ichimoto E, Yasukawa K, Takahashi O, Yamamoto Y, Komuro I. Appearance of noncompaction-like remodeling of the anatomical right ventricle in a middle-aged subject with modified transposition of the great arteries who did not undergo surgery. Int J Cardiol;122:161-163,2007.
88.     Kameda Y, Funabashi N, Kawakubo M, Uehara M, Hasegawa H, Kobayashi Y, Komuro I. Heart in an eggshell-eggshell appearance calcified constrictive pericarditis demonstrated by three-dimensional images of multislice computed tomography. Int J Cardiol;120:269-272,2007.
87.     Hori Y, Funabashi N, Miyauchi H, Nakagawa K, Shimura H, Miyazaki M, Kozono H, Nagai Y, Ishikura H, Nagai T, Kobayashi Y, Komuro I. Angiosarcoma in the right atria demonstrated by fusion images of multislice computed tomography and positron emission tomography using F-18 Fluoro-Deoxyglucose. Int J Cardiol;123:e15-17,2007.
86.     Hori Y, Ueda M, Nakayama T, Saegusa N, Uehara M, Lee K, Sekine T, Daimon M, Kobayashi Y, Funabashi N, Komuro I. Occurrence of de novo sustained monomorphic ventricular tachycardia induced after percutaneous transluminal alcohol septal myocardial ablation for hypertrophic obstructive cardiomyopathy. Int J Cardiol;119:403-407,2007.
85.     Funabashi N, Maeda F, Nakamura K, Suzuki K, Mita Y, Matsuo K, Niwa K, Komuro I. Channel-like appearance of a patent foramen ovale with left to right shunt demonstrated by 64-slice computed tomography. Int J Cardiol;119:119-121,2007.
84.     Asano T, Kobayashi Y, Ohno M, Nakayama T, Kuroda N, Komuro I. Multivessel coronary artery spasm refractory to intensive medical treatment. Angiology;58:636-639,2007.
83.     Ando H, Funabashi N, Uehara M, Suzuki M, Sato H, Hashimoto M, Ishida A, Yanagawa N, Fukuchi Y, Kikawa T, Imada M, Komuro I. Abnormal collateral arterial systems in Takayasu's arteritis and Leriche's syndrome evaluated by whole body acquisition using multislice computed tomography. Int J Cardiol;121:306-308,2007.
82.     Ohtsuka M, Uchida E, Nakajima T, Yamaguchi H, Takano H, Komuro I. Transferring images via the wireless messaging network using camera phones shortens the time required to diagnose acute coronary syndrome. Circ J;71:1499-1500,2007.
81.     Mizuno N, Funabashi N, Imada M, Tsunoo T, Endo M, Komuro I. Utility of 256-slice cone beam tomography for real four-dimensional volumetric analysis without electrocardiogram gated acquisition. Int J Cardiol;120:262-267,2007.
80.     Miyagi J, Funabashi N, Suzuki M, Asano M, Kuriyama T, Komuro I, Moriya H. Predictive indicators of deep venous thrombosis and pulmonary arterial thromboembolism in 54 subjects after total knee arthroplasty using multislice computed tomography in logistic regression models. Int J Cardiol;119:90-94,2007
79.     Ishio N, Kobayashi Y, Takebayashi H, Iijima Y, Kanda J, Nakayama T, Kuroda N, De Gregorio J, Kouno Y, Suzuki M, Haruta S, Komuro I. Impact of drug-eluting stents on clinical and angiographic outcomes in dialysis patients. Circ J;71:1525-1529,2007.
78.     Imada M, Funabashi N, Asano M, Uehara M, Ueda M, Komuro I. Anatomical remodeling of left atria in subjects with chronic and paroxysmal atrial fibrillation evaluated by multislice computed tomography. Int J Cardiol;119:384-388,2007.
77.     Imada M, Funabashi N, Asano M, Uehara M, Hori Y, Ueda M, Komuro I. Epidemiology of fat replacement of the right ventricular myocardium determined by multislice computed tomography using a logistic regression model. Int J Cardiol;119:410-413,2007.
76.     Funabashi N, Yoshida K, Tadokoro H, Odaka K, Tsunoo T, Mori S, Endo M, Tanada S, Komuro I. Tricolored "tricolore" myocardium by selective intracoronary injection of contrast using 256-slice cone-beam computed tomography. Int J Cardiol;117:273-275,2007.
75.     Funabashi N, Suzuki K, Terao M, Maeda F, Nakamura K, Mita Y, Asano M, Kudo M, Kurokawa M, Komuro I. New acquisition method to exclusively enhance the left side of the heart by a small amount of contrast material achieved by multislice computed tomography with 64 data acquisition system. Int J Cardiol;114:265-269,2007.
74.     Funabashi N, Mizuno N, Yoshida K, Tsunoo T, Mori S, Tanada S, Endo M, Komuro I. Superiority of synchrony of 256-slice cone beam computed tomography for acquiring pulsating objects. Comparison with conventional multislice computed tomography. Int J Cardiol;118:400-405,2007.
73.     Funabashi N, Misumi K, Ohnishi H, Asano M, Komuro I. Characterization and morphology of atherosclerotic plaque of coronary arteries: utility of electron-beam tomography to detect non-calcified plaque: a comparison with conventional coronary angiography and intravascular ultrasound. Int J Cardiol;115:108-113,2007.
72.     Funabashi N, Asano M, Komuro I. Predictors of non-calcified plaques in the coronary arteries of 242 subjects using multislice computed tomography and logistic regression models. Int J Cardiol;117:191-197,2007.
71.     Fukushima K, Kobayashi Y, Okuno T, Nakamura Y, Sakakibara M, Nakayama T, Kuroda N, Miyazaki A, Shimizu Y, Komuro I. Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation. Circ J;71:617-619,2007.
70.     Yoshida T, Kobayashi Y, Nakayama T, Kuroda N, Komiyama N, Komuro I. Stent deformity caused by coronary artery spasm. Circ J;70:800-801,2006.
69.     Niitsuma Y, Funabashi N, Imamaki M, Komuro I, Miyazaki M. Atherosclerotic right internal thoracic arterial aneurysm demonstrated by multislice computed tomography. Int J Cardiol;106:270-272,2006.
68.     Kuriyama N, Kobayashi Y, Nakayama T, Kuroda N, Komuro I. Images in cardiovascular medicine. Damage to polymer of a sirolimus-eluting stent. Circulation;114:e586-587,2006.
67.     Komajda M, Erdmann E, Komuro I, Schernthaner G, Itoh H, Matsuzaki M. Case studies: reducing risk in patients with diabetes. Drugs Today (Barc);42 Suppl C:37-41,2006.
66.     Kawakubo M, Funabashi N, Nakagawa K, Komuro I. Images in cardiovascular medicine. Demonstration of multislice computed tomography of graft destruction and rupture to the pericardium after replacement of ascending aorta for stanford type-a dissection. Circulation;114:e366-367,2006.
65.     Hasegawa H, Takano H, Shindo S, Takeda S, Funabashi N, Nakagawa K, Toyozaki T, Kuwabara Y, Komuro I. Images in cardiovascular medicine. Transition from left ventricular hypertrophy to massive fibrosis in the cardiac variant of Fabry disease. Circulation;113:e720-721,2006.
64.     Funabashi N, Komuro I. Patency of gastroepiploic arterial graft to left circumflex branch with distal portion of the anastomotic site demonstrated by multislice computed tomography. Int J Cardiol;107:130-131,2006.
63.     Funabashi N, Asano M, Komuro I. Giant coronary sinus diverticulum with persistent left superior vena cava demonstrated by multislice computed tomography. Int J Cardiol;111:468-469,2006.
62.     Funabashi N, Asano M, Sekine T, Nakayama T, Komuro I. Direction, location, and size of shunt flow in congenital heart disease evaluated by ECG-gated multislice computed tomography. Int J Cardiol;112:399-404,2006.
61.     Funabashi N, Komiyama N, Kato H, Umekita H, Asano M, Komuro I. Retrospective ECG-gated left ventriculography using multislice CT following left ventricular bolus injection and evaluation of its utility and motion artifact at every cardiac phase. Int J Cardiol;113:132-138,2006.
60.     Funabashi N, Komuro I. Aberrant fistula arteries from the left main branch and right coronary artery to the left pulmonary arterial sinus demonstrated by multislice computed tomography. Int J Cardiol;106:428-430,2006.
59.     Funabashi N, Sekine T, Komuro I. Idiopathic diverticulum-type enlargement of the right atrium demonstrated by multislice computed tomography. Heart;92:1144,2006.
58.     Funabashi N, Asano M, Komuro I. Thrombosed cystic aortic arch pseudoaneurysm demonstrated by multislice computed tomography. Int J Cardiol;108:399-400,2006.
57.     Funabashi N, Maeda F, Nakamura K, Suzuki K, Mita Y, Asano M, Narumi H, Kurokawa M, Komuro I. Patency of the left coronary artery by 64-slice multislice computed tomography following implantation of sirolimus-eluting stent. Int J Cardiol;111:333-335,2006.
56.     Funabashi N, Asano M, Komuro I. Right coronary artery aneurysm with fistula to left ventricle: multislice CT appearance. J Thorac Imaging;21:63-65,2006.
55.     Funabashi N, Asano M, Komuro I. Non-calcified plaques of coronary arteries with obvious outward remodeling demonstrated by multislice computed tomography. Int J Cardiol;109:264,2006.
54.     Funabashi N, Komiyama N, Asano M, Komuro I. Endocardial fibrosis in subacute non-Q wave myocardial infarction demonstrated by multislice computed tomography. Int J Cardiol;109:430-431,2006.
53.     Funabashi N, Nakagawa K, Komuro I. Partial myocardial fibrosis in hypertrophic cardiomyopathy demonstrated by 18F-fluoro-deoxyglucose positron emission tomography and multislice computed tomography. Int J Cardiol;107:284-286,2006.
52.     Funabashi N, Asano M, Komuro I. Malformation of abdominal arteries in Takayasu's arteritis demonstrated by multislice computed tomography. Int J Cardiol;109:114-115,2006.
51.     Funabashi N, Asano M, Komuro I. Feeding artery of a recurrent pheochromocytoma from the left internal thoracic artery demonstrated by multislice computed tomography. Int J Cardiol;109:392-393,2006.
50.     Funabashi N, Asano M, Komuro I. Occurrence of lung tumor between internal thoracic arterial and saphenous vein grafts to coronary arteries demonstrated by multislice computed tomography. Int J Cardiol;110:94-95,2006.
49.     Sekine T, Daimon M, Hasegawa R, Teramoto K, Kawata T, Tanaka N, Takei Y, Takazawa K, Yoshida K, Komuro I. Cibenzoline improves coronary flow velocity reserve in patients with hypertrophic obstructive cardiomyopathy. Heart Vessels;21:350-355,2006.
48.     Kishida S, Funabashi N, Harada Y, Komuro I, Moriya H. Utility of four-dimensional analysis of the acetabular labrum applying motion-gated multislice computed tomography: comparison with arthroscopy and harris hip score. J Comput Assist Tomogr;30:991-1000,2006.
47.     Kawata T, Daimon M, Hasegawa R, Teramoto K, Toyoda T, Sekine T, Yamamoto K, Uchida D, Himi T, Yoshida K, Komuro I. Effect on coronary flow velocity reserve in patients with type 2 diabetes mellitus: comparison between angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor antagonist. Am Heart J;151:798 e799-715,2006.
46.     Funabashi N, Yoshida K, Tadokoro H, Odaka K, Tsunoo T, Mori S, Endo M, Tanada S, Komuro I. Time series of volumetric measurement of porcine three dimensional segmented myocardial perfusion by selective contrast injection using 256-slice cone beam computed tomography. Int J Cardiol;111:455-456,2006.
45.     Funabashi N, Sato H, Asano M, Nakayama T, Komuro I. Utility of triple channel injection of contrast material with mixture of saline, with acquisition in the cephalic direction for arterial trees in the thorax using multislice computed tomography. Int J Cardiol;113:97-103,2006.
44.     Funabashi N, Koide K, Mizuno N, Nagamura K, Ochi S, Yanagawa N, Okamoto Y, Uno K, Komuro I. Influence of heart rate on the detectability and reproducibility of multislice computed tomography for measuring coronary calcium score using a pulsating calcified mock-vessel in comparison with electron beamtomography. Int J Cardiol;113:113-117,2006.
43.     Asano T, Kobayashi Y, Mintz GS, Ishio N, Fujimaki S, Ogawa Y, Nakayama T, Kuroda N, Komuro I. Effect of plaque volume on subsequent vessel remodeling at edges of sirolimus-eluting stents. Am J Cardiol;98:1041-1044,2006.
42.     Funabashi N, Asano M, Komuro I. Multislice CT of the abdominal aorta in a patient with Takayasu's arteritis reveals malformation of collateral arteries and occlusion of abdominal aorta. Heart;91:392,2005.
41.     Funabashi N, Komuro I. Images in clinical medicine. Heart-shaped tumor in pulmonary trunk. N Engl J Med;352:608,2005.
40.     Funabashi N, Komuro I. Focal myocardial fibrosis and edema in acute myocarditis demonstrated by multislice computed tomography. Int J Cardiol;105:346-348,2005.
39.     Funabashi N, Asano M, Komuro I. Constrictive pericarditis with persistent left superior vena cava flow into right atria through coronary sinus demonstrated by multislice computed tomography. Int J Cardiol;105:229-230,2005.
38.     Funabashi N, Asano M, Komuro I. Large collateral conus branch to the left anterior descending branch of the coronary artery in a subject with angina pectoris demonstrated by multislice computed tomography. Int J Cardiol;103:105-106,2005.
37.     Funabashi N, Komiyama N, Komuro I. Patency of the right coronary artery following implantation of metallic stent demonstrated by multislice computed tomography. Heart;91:436,2005.
36.     Yokoyama M, Komiyama N, Courtney BK, Nakayama T, Namikawa S, Kuriyama N, Koizumi T, Nameki M, Fitzgerald PJ, Komuro I. Plasma low-density lipoprotein reduction and structural effects on coronary atherosclerotic plaques by atorvastatin as clinically assessed with intravascular ultrasound radio-frequency signal analysis: a randomized prospective study. Am Heart J;150:287,2005.
35.     Ueda M, Tada H, Kurosaki K, Itoi K, Koyama K, Naito S, Ito S, Komuro I, Oshima S, Taniguchi K. Pulmonary vein morphology before and after segmental isolation in patients with atrial fibrillation. Pacing Clin Electrophysiol;28:944-953,2005.
34.     Kawata T, Daimon M, Hasegawa R, Teramoto K, Toyoda T, Sekine T, Yamamoto K, Uchida D, Himi T, Yoshida K, Komuro I. Serum asymmetric dimethylarginine as a marker of coronary microcirculation in patients with non-insulin dependent diabetes mellitus: correlation with coronary flow reserve. Heart;91:1607-1608,2005.
33.     Hasegawa R, Daimon M, Toyoda T, Teramoto K, Sekine T, Kawata T, Watanabe H, Kuwabara Y, Yoshida K, Komuro I. Effect of mental stress on coronary flow velocity reserve in healthy men. Am J Cardiol;96:137-140,2005.
32.     Funabashi N, Yoshida K, Tadokoro H, Nakagawa K, Komiyama N, Odaka K, Tsunoo T, Mori S, Tanada S, Endo M, Komuro I. Cardiovascular circulation and hepatic perfusion of pigs in 4-dimensional films evaluated by 256-slice cone-beam computed tomography. Circ J;69:585-589,2005.
31.     Funabashi N, Yoshida K, Tadokoro H, Nakagawa K, Komiyama N, Odaka K, Tsunoo T, Mori S, Endo M, Tanada S, Komuro I. Three dimensional segmented myocardial perfusion images by selective intracoronary injection of contrast using 256 slice cone beam computed tomography. Heart;91:1349-1351,2005.
30.     Daimon M, Watanabe H, Yamagishi H, Kuwabara Y, Hasegawa R, Toyoda T, Yoshida K, Yoshikawa J, Komuro I. Physiologic assessment of coronary artery stenosis without stress tests: noninvasive analysis of phasic flow characteristics by transthoracic Doppler echocardiography. J Am Soc Echocardiogr;18:949-955,2005.
29.     Naito AT, Minamino T, Tateno K, Nagai T, Komuro I. Steroid-responsive thromboangiitis obliterans. Lancet;364:1098,2004.
28.     Funabashi N, Ishida A, Yoshida K, Komuro I. Images in cardiovascular medicine. Double aortic arch with a compressed trachea demonstrated by multislice computed tomography. Circulation;110:e68-69,2004.
27.     Funabashi N, Sekine T, Komuro I. Patency of the left subclavian artery following implantation of stent graft to rectify a stenosis, as demonstrated by multislice computed tomography. Heart;90:362,2004.
26.     Yamamoto M, Komiyama N, Koizumi T, Nameki M, Yamamoto Y, Toyoda T, Okuno T, Tateno K, Sano K, Himi T, Kuriyama N, Namikawa S, Yokoyama M, Komuro I. Usefulness of rapid quantitative measurement of myoglobin and troponin T in early diagnosis of acute myocardial infarction. Circ J;68:639-644,2004.
25.     Toyoda T, Baba H, Akasaka T, Akiyama M, Neishi Y, Tomita J, Sukmawan R, Koyama Y, Watanabe N, Tamano S, Shinomura R, Komuro I, Yoshida K. Assessment of regional myocardial strain by a novel automated tracking system from digital image files. J Am Soc Echocardiogr;17:1234-1238,2004.
24.     Toyoda T, Akasaka T, Watanabe N, Akiyama M, Neishi Y, Kume T, Komuro I, Yoshida K. Evaluation of abnormal motion of interventricular septum after coronary artery bypass grafting operation: assessment by ultrasonic strain rate imaging. J Am Soc Echocardiogr;17:711-716,2004.
23.     Teramoto K, Daimon M, Hasegawa R, Toyoda T, Sekine T, Kawata T, Yoshida K, Komuro I. Acute effect of oral vitamin C on coronary circulation in young healthy smokers. Am Heart J;148:300-305,2004.
22.     Nameki M, Ishibashi I, Miyazaki Y, Sakai Y, Namikawa S, Kuriyama N, Komiyama N, Tsunoda K, Masuda Y, Komuro I. Comparison between nicorandil and magnesium as an adjunct cardioprotective agent to percutaneous coronary intervention in acute anterior myocardial infarction. Circ J;68:192-197,2004.
21.     Funabashi N, Kobayashi Y, Kudo M, Asano M, Teramoto K, Komuro I, Rubin GD. New method of measuring coronary diameter by electron-beam computed tomographic angiography using adjusted thresholds determined by calibration with aortic opacity. Circ J;68:769-777,2004.
20.     Tsuji T, Nakamura S, Komuro I, Mikami M, Baba M, Tanaka M. A living case of pulmonary ossification associated with osteoclast formation from alveolar macrophage in the presence of T-cell cytokines. Intern Med;42:834-838,2003.
19.     Kuroda N, Kobayashi Y, Mintz GS, Komuro I. Images in cardiovascular medicine. Multiple ruptured plaques: serial intravascular ultrasound examinations. Circulation;108:e131-132,2003.
18.     Funabashi N, Misumi K, Ohnishi H, Watanabe M, Suzuki Y, Imai N, Yoshida K, Komuro I. Endoluminal perspective volume rendering of coronary arteries using electron-beam computed tomography. Circ J;67:1064-1067,2003.
17.     Funabashi N, Yonezawa M, Iesaka Y, Umekita H, Yanagawa N, Matsumoto Y, Yoshida K, Komuro I. Complications of pulmonary vein isolation by catheter ablation evaluated by ECG-gated multislice computed tomography. Heart Vessels;18:220-223,2003.
16.     Funabashi N, Ito K, Komuro I. Multi-vessel dissections in Marfan syndrome demonstrated by multislice computed tomography. Heart;89:1146,2003.
15.     Funabashi N, Yoshida K, Komuro I. Thinned myocardial fibrosis with thrombus in the dilated form of hypertrophic cardiomyopathy demonstrated by multislice computed tomography. Heart;89:858,2003.
14.     Funabashi N, Teramoto K, Komuro I. Patency of multiple coronary artery bypass grafts demonstrated by multislice CT. Heart;89:818,2003.
13.     Funabashi N, Komiyama N, Komuro I. Fibromuscular dysplasia in renovascular hypertension demonstrated by multislice CT: comparison with conventional angiogram and intravascular ultrasound. Heart;89:639,2003.
12.     Funabashi N, Komiyama N, Komuro I. Patency of coronary artery lumen surrounded by metallic stent evaluated by three dimensional volume rendering images using ECG gated multislice computed tomography. Heart;89:388,2003.
11.     Funabashi N, Komiyama N, Komuro I. Multiple cystic aneurysms in aortitis demonstrated by three dimensional volume rendering images of multislice computed tomography. Heart;89:257,2003.
10.     Funabashi N, Komiyama N, Yanagawa N, Mayama T, Yoshida K, Komuro I. Images in cardiovascular medicine. Coronary artery patency after metallic stent implantation evaluated by multislice computed tomography. Circulation;107:147-148,2003.
9.     Funabashi N, Toyozaki T, Matsumoto Y, Yonezawa M, Yanagawa N, Yoshida K, Komuro I. Images in cardiovascular medicine. Myocardial fibrosis in fabry disease demonstrated by multislice computed tomography: comparison with biopsy findings. Circulation;107:2519-2520,2003.
8.     Kuroda N, Kobayashi Y, Desai K, Costantini C, Kobayashi M, Komuro I. Impact of change in the price of percutaneous coronary intervention devices on medical expenses. Circ J;67:576-578,2003.
7.     Koizumi T, Miyazaki A, Komiyama N, Sun K, Nakasato T, Masuda Y, Komuro I. Improvement of left ventricular dysfunction during exercise by walking in patients with successful percutaneous coronary intervention for acute myocardial infarction. Circ J;67:233-237,2003.
6.     Yamazaki M, Takano H, Miyauchi H, Daimon M, Funabashi N, Nagai T, Komiyama N, Yoshida K, Komuro I. Detection of Takayasu arteritis in early stage by computed tomography. Int J Cardiol;85:305-307,2002.
5.     Ishizaka N, Kage N, Iida H, Mutoh S, Hirata Y, Komuro I, Miyairi T, Kitamura T, Morota T, Takamoto S, Nagai R. Massive pulmonary artery thrombosis, pulmonary hypertension and untreated atrial septal defect. Cardiology;97:53-54,2002.
4.     Funabashi N, Komiyama N, Hasegawa H, Kato H, Yamamoto Y, Yoshida K, Komuro I. Images in cardiovascular medicine. Feeding artery of a left atrial myxoma demonstrated by three-dimensional volume-rendering images with multislice computed tomography. Circulation;106:e63-64,2002.
3.     Daimon Y, Watanabe S, Takeda S, Hijikata Y, Komuro I. Two-layered appearance of noncompaction of the ventricular myocardium on magnetic resonance imaging. Circ J;66:619-621,2002.
2.     Shimoyama M, Murata Y, Sumi KI, Hamazoe R, Komuro I. Docetaxel induced cardiotoxicity. Heart;86:219,2001.
1.     Koizumi T, Komiyama N, Komuro I, Tanigawa T, Iwase T, Ishiwata S, Nishiyama S, Nakanishi S, Momomura S. Efficacy of nifekalant hydrochloride on the treatment of life-threatening ventricular tachyarrhythmias during reperfusion for acute myocardial infarction. Cardiovasc Drugs Ther;15:363-365,2001.

ページの先頭へ

英文総説・著書

Review Article

42.     Hasegawa H, Takano H, Komuro I. Therapeutic Implications of PPARγ in Cardiovascular Diseases. PPAR Res;2010:876049,2010.
41.     Takano H, Komuro I. Peroxisome proliferator-activated receptor γ and cardiovascular diseases. Circ J;73:214-220,2009.
40.     Akazawa H, Yasuda N, Komuro I. Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor. Mol Cell Endocrinol;302:140-147,2009.
39.     Akazawa H, Komuro I. "Change can happen" by PKA: proteasomes in in vivo hearts. J Mol Cell Cardiol;46:445-447,2009.
38.     Minamino T, Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Clin Pract Cardiovasc Med;5:637-648,2008.
37.     Minamino T, Komuro I. Role of telomeres in vascular senescence. Front Biosci;13:2971-2979,2008.
36.     Oka T, Komuro I. Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure. Circ J;72 Suppl A:A13-16,2008.
35.     Toko H, Shiojima I, Komuro I. Promotion of cardiac hypertrophy by TRPC-mediated calcium entry. J Mol Cell Cardiol;42:481-483,2007.
34.     Takano H, Ueda K, Hasegawa H, Komuro I. G-CSF therapy for acute myocardial infarction. Trends Pharmacol Sci;28:512-517,2007.
33.     Minamino T, Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res;100:15-26,2007.
32.     Toko H, Shiojima I, Komuro I. The gene expression profiling of concentric and eccentric cardiac hypertrophy. Hypertens Res;29:941-942,2006.
31.     Tateno K, Minamino T, Miyauchi H, Kunieda T, Komuro I. Application of hematopoietic cells to therapeutic angiogenesis. Curr Pharm Des;12:557-563,2006.
30.     Takano H, Qin Y, Hasegawa H, Ueda K, Niitsuma Y, Ohtsuka M, Komuro I. Effects of G-CSF on left ventricular remodeling and heart failure after acute myocardial infarction. J Mol Med;84:185-193,2006.
29.     Minamino T, Komuro I. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J Clin Invest;116:2316-2319,2006.
28.     Komuro I. New mechanism of heart protection by angiotensin receptor blockers. Drugs Today (Barc);42 Suppl C:25-28,2006.
27.     Komajda M, Erdmann E, Komuro I, Schernthaner G, Itoh H, Matsuzaki M. Case studies: reducing risk in patients with diabetes. Drugs Today (Barc);42 Suppl C:37-41,2006.
26.     Akazawa H, Zou Y, Komuro I. A novel mechanism of mechanical stress-induced hypertrophy. Novartis Found Symp;274:20-31; discussion 31-40, 152-155, 272-156,2006.
25.     Minamino T, Komuro I. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J Clin Invest;116:2316-2319,2006.
24.     Takano H, Hasegawa H, Nagai T, Komuro I. The role of PPARγ-dependent pathway in the development of cardiac hypertrophy. Timely Top Med Cardiovasc Dis;9:E10,2005.
23.     Nagai T, Shiojima I, Matsuura K, Komuro I. Promotion of cardiac regeneration by cardiac stem cells. Circ Res;97:615-617,2005.
22.     Akazawa H, Komuro I. Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases. Pharmacol Ther;107:252-268,2005.
21.     Shiojima I, Komuro I. Cardiac developmental biology: from flies to humans. Jpn J Physiol;55:245-254,2005.
20.     Minamino T, Miyauchi H, Yoshida T, Tateno K, Kunieda T, Komuro I. Vascular cell senescence and vascular aging. J Mol Cell Cardiol;36:175-183,2004.
19.     Minamino T, Miyauchi H, Yoshida T, Tateno K, Komuro I. The role of vascular cell senescence in atherosclerosis: antisenescence as a novel therapeutic strategy for vascular aging. Curr Vasc Pharmacol;2:141-148,2004.
18.     Minamino T, Miyauchi H, Tateno K, Kunieda T, Komuro I. Akt-induced cellular senescence: implication for human disease. Cell Cycle;3:449-451,2004.
17.     Komuro I, Ohtsuka M. Forefront of Na+/Ca2+ exchanger studies: role of Na+/Ca2+ exchanger--lessons from knockout mice. J Pharmacol Sci;96:23-26,2004.
16.     Takano H, Zou Y, Hasegawa H, Akazawa H, Nagai T, Komuro I. Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases. Antioxid Redox Signal;5:789-794,2003.
15.     Takano H, Ohtsuka M, Akazawa H, Toko H, Harada M, Hasegawa H, Nagai T, Komuro I. Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. Curr Pharm Des;9:1121-1127,2003.
14.     Takano H, Hasegawa H, Nagai T, Komuro I. Implication of cardiac remodeling in heart failure: mechanisms and therapeutic strategies. Intern Med;42:465-469,2003.
13.     Takano H, Hasegawa H, Nagai T, Komuro I. The role of PPARg-dependent pathway in the development of cardiac hypertrophy. Drugs Today (Barc);39:347-357,2003.
12.     Minamino T, Komuro I. The role of telomerase activation in the regulation of vascular smooth muscle cell proliferation. Drug News Perspect;16:211-216,2003.
11.     Akazawa H, Komuro I. Too much Csx/Nkx2-5 is as bad as too little? J Mol Cell Cardiol;35:227-229,2003.
10.     Akazawa H, Komuro I. Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res;92:1079-1088,2003.
9.     Zou Y, Takano H, Akazawa H, Nagai T, Mizukami M, Komuro I. Molecular and cellular mechanisms of mechanical stress-induced cardiac hypertrophy. Endocr J;49:1-13,2002.
8.     Takano H, Zou Y, Akazawa H, Toko H, Mizukami M, Hasegawa H, Asakawa M, Nagai T, Komuro I. Inhibitory molecules in signal transduction pathways of cardiac hypertrophy. Hypertens Res;25:491-498,2002.
7.     Takano H, Komuro I. Roles of peroxisome proliferator-activated receptor γ in cardiovascular disease. J Diabetes Complications;16:108-114,2002.
6.     Takano H, Komuro I. b-blockers have beneficial effects even on unclassified cardiomyopathy such as isolated ventricular noncompaction. Intern Med;41:601-602,2002.
5.     Monzen K, Nagai R, Komuro I. A role for bone morphogenetic protein signaling in cardiomyocyte differentiation. Trends Cardiovasc Med;12:263-269,2002.
4.     Minamino T, Komuro I. Role of telomere in endothelial dysfunction in atherosclerosis. Curr Opin Lipidol;13:537-543,2002.
3.     Nagai T, Takano H, Komuro I. The cell cycle can be a new target for the treatment of cardiac hypertrophy? J Mol Cell Cardiol;33:1769-1771,2001.
2.     KomuroI. Molecular mechanism of cardiac hypertrophy and development. Jpn Circ J;65:353-358,2001.
1.     Komuro I. Molecular mechanism of mechanical stress-induced cardiac hypertrophy. Jpn Heart J;41:117-129, 2000.

Books

10.     Tateno K, Minamino T, Toko H, Komuro I. Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. “Future Aspects of Medical Sciences and Education ”Challenge of Integrated Medical Sciences” edited by Nadal-Ginard B and Takakura K. pp52-55, International Research andEducational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women’s Medical University, Japan, 2007.
9.     Takano H, Komuro I. Cardiovascular Regeneration and Stem Cell Therapy. “Cytokines and heart remodeling” edited by Leri A, Anversa P and Frishman WH. pp139-147, Blackwell Futura, USA, 2007.
8.     Hasegawa H, Takano H, Zou Y, Akazawa H, and Komuro I. Second Messenger Systems Involved in Heart Mechanotransduction. “MEDICAL INTELLIGENCE UNIT, Cardiac Mechanotransduction” edited by Weckstrom M and Tavi P. pp93-105, Springer, USA, 2006.
7.     Akazawa H, Komuro I. A novel mechanism of mechanical stress-induced hypertrophy. "HEART FAILURE: MOLECULES, MECHANISMS AND THERAPEUTIC TARGETS” edited by Bock G and Goode J. pp20-40, John Wiley & Sons Ltd, UK, 2006.
6.     Akawaza H, Komuro I. Transcription Factors and Hypertrophy. “Molecular Mechanisms of Cardiac Hypertrophy and Failure” edited by Walsh RA. pp59-70, Taylor & Francis, UK, 2005.
5.     Akazawa H, Komuro I. Cariac homeobox protein Csx/Nkx2.5 and its associated proteins. "Cardiovascular Development and Congenital Malformations, Molecular and Genetic Mechanisms" edited by Artman M, Benson DW, Srivastava D, and Nakazawa M. pp31-36, Blackwell Publishing, Oxford, 2005.
4.     Takano H, Zou Y, Akazawa H, Nagai T, Mizukami M, Toko H, Komuro I. Ca2+-Dependent Signaling Pathways Through Calcineurin and Ca2+/Calmodulin-Dependent Protein Kinase in Development of Cardiac Hypertrophy. "SIGNAL TRANSDUCTIONAND CARDIAC HYPERTROPHY" edited by Dhalla NS, Hryshko LV, Kardami E. &PK. pp85-94, Kluwer Academic Publishers, Boston, 2003.
3.     Mizuno T, Shiojima I, and Komuro I. Developmental Stage-Specific Transcriptional Regulation of Human Cardiac Homeobox Gene CSX1. "Etiology and Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and DevelopmentalBiology" edited by Clark EB, Nakazawa M, and Takao A. pp71-75, Futura Publishing Co., Inc, NY, 2000.
2.     Shiojima I, Komuro I, Yazaki Y. From Scar Tissues to Viable Myocytes: A Novel Therapeutic Strategy for the   Treatment of Heart Failure. "Heart Failure Frontiers in Cardiology" edited by Kitabatake A, Sasayama S, and Francis GS. pp227-233, Springer-Verlag, Tokyo, 2000.
1.     Komuro I. Molecular mechanism of mechanical stress-induced cardiac hypertrophy. "The Hypertrophied Heart" edited by Takeda N, Nagano M, and Dhalla NS. pp109-121, Kluwer Academic Publishers, Boston, 2000.

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