<Pathogenic Th cell regulation of chronic airway inflammation in mouse and human system>
- Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.: CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells. *These authors contributed equally to this work. Nat. Immunol. in press.
- Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.: Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology. Front. Immunol. 10:570 (2019).
- Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.: CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 115(42):E9849-E9858 (2018).
- Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat. Commun. 9(1):4231 (2018).
- Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T.: The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells. J. Leukoc. Biol. 104(5):895-901 (2018).
- Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T.: Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. Immunity 49(1):134-150 (2018).
- Mato, N., Hirahara, K., Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T.: Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Sci. Rep. 7(1):6805 (2017).
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- Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation 401-415 (2016).
- Hirahara, K., and Nakayama, T.: CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int. Immunol. 28(4):163-171 (2016).
- Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.: Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA 113(20):E2842-51 (2016).
- Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114(4):289-298 (2015).
- Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, K. H., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42(2):294-308 (2015).
- Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35(2): 69-78 (2014).
- Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745 (2011).
- Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A., and Nakayama, T.: Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergology International 59:67-73 (2010).
- Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R. M., Shirai, M., and Nakayama, T.: Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in mouse asthma model. J Allergy Clin. Immunol. 125:461-468.e6 (2010).
- Iwamura, C., and Nakayama, T.: Role of NKT cells in allergic asthma. Curr. Opin. Immunol. 22:807-813 (2010).