研究成果

業績

2017

  1. Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K,Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A. Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia In press.
  2. Kohno H, Ueda H, Matsuura K, Tamura Y, Watanabe M, Matsumiya G. Long-term consequences of atrial fibrillation after aortic valve replacement. Asian Cardiovasc Thorac Ann. 2017 Jan 1;218492317689902. doi: 10.1177/0218492317689902. [Epub ahead of print]
  3. Muto T, Ohwada C, Takaishi K, Isshiki Y, Nagao Y, Hasegawa N, Kawajiri-Manako C, Togasaki E, Shimizu R, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Takeuchi M, Sakaida E, Misawa S, Shimizu N, Iseki T, Kuwabara S, Nakaseko C. Safety and efficacy of granulocyte-colony stimulating factor monotherapy for peripheral blood stem cell collection in POEMS Syndrome. Biol Blood Marrow Transplant 2017; 23(2):361-3.

2016

  1. Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A. The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med 2016;213:1459-1477.
  2. Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, and Iwama A. (2016) Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes. Blood 2016;128(5):638-649.
  3. Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt G, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A. Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells. Exp Hematol 2016;44:282-296.
  4. Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW. Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2. Cancer Cell. 2016 Aug 8;30(2):337-48.
  5. Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE. miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell. 2016 Feb 8;29(2):214-28.
  6. Notta F, Zandi S, Takayama N, Dobson S, Gan OI, Wilson G, Kaufmann KB, McLeod J, Laurenti E, Dunant CF, McPherson JD, Stein LD, Dror Y, Dick JE. Distinct routes of lineage development reshape the human blood hierarchy across ontogeny. Science. 2016 Jan 8;351(6269):aab2116.
  7. Abe S, Ishida K, Masuda M, Ueda H, Kohno H, Matsuura K, Tamura Y, Watanabe M, Matsumiya G. A prospective, randomized study of inhaled prostacyclin versus nitric oxide in patients with residual pulmonary hypertension after pulmonary endarterectomy. Gen Thorac Cardiovasc Surg. 2016 Oct 25. [Epub ahead of print]
  8. Ono M, Sawa Y, Nakatani T, Tominaga R, Matsui Y, Yamazaki K, Saiki Y, Niinami H, Matsumiya G, Arai H; Japanese HeartMate II Investigators.. Japanese Multicenter Outcomes With the HeartMate II Left Ventricular Assist Device in Patients With Small Body Surface Area. Circ J. 2016; 25;80(9):1931-6.
  9. Maruyama T, Kohno H, Ishida K, Ishizaka T, Funabashi N, Kobayashi Y, Matsumiya G. Change of luminal diameter of skeletonized and non-skeletonized radial artery graft at early and late postoperative period. Heart Vessels. 2016 ;31(4):474-81.
  10. Kato M, Yamashita T, Suzuki R, Matsumoto K, Nishimori H, Takahashi S, Iwato K, Nakaseko C, Kondo T, Imada K, Kimura F, Ichinohe I, Hashii Y, Kato K, Atsuta A, Taniguchi S, Fukuda T. Donor cell-derived hematologic malignancy: a survey by the Japan Society for Hematopoietic Cell Transplantation. Leukemia 2016;30(8):1742-5.
  11. Shimizu R, Muto T, Aoyama K, Choi K, Takeuchi M, Koide S, Hasegawa N, Isshiki Y, Togasaki E, Kawajiri C, Nagao Y, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Ohwada C, Sakaida E, Iseki T, Starczynowski DT, Iwama A, Yokote K, Nakaseko C. Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leuk Res 2016; 50: 85-94.
  12. Hirono, S., Lee, EY., Kuribayashi, S., Fukuda, T., Saeki, N., Minokoshi, Y., Iwanaga, T., Miki, T. (2016) Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide. Endocrinology 2016 Jan;157(1):245-57. doi: 10.1210/en.2015-1560. Epub 2015 Oct 27.
  13. Morita, A., Mukai, E., Hiratsuka, A., Takatani, T., Iwanaga, T., Lee, EY., Miki T. (2016) Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function. Endocrine 2016 Mar; 51(3):429-39. doi: 10.1007/s12020-015-0733-4.
  14. Morimoto, M., Lee, E.Y., Zhang, X., Inaba, Y., Inoue, H., Ogawa, M., Shirasawa, T., Yokosuka, O., Miki, T. (2016) Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. Nutrition & Diabetes 2016 Jun 27;6:e213. doi: 10.1038/nutd.2016.21.
  15. Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K. Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. Stem Cells Transl Med. 2016 Oct 5; pii: sctm.2016-0104. [Epub ahead of print]
  16. Eto K, Kunishima S. Linkage between the mechanisms of thrombocytopenia and thrombosis. Blood. 2016 Mar 10;127(10)1234-41.
  17. Yokote K, Chanprasert S, Lee L, Eirich K, Takemoto M, Watanabe A, Koizumi N, Lessel D, Mori T, Hisama FM, Ladd PD, Angle B, Baris H, Cefle K, Palanduz S, Ozturk S, Chateau A, Deguchi K, Easwar TK, Federico A, Fox A, Grebe TA, Hay B, Nampoothiri S, Seiter K, Streeten E, Piña-Aguilar RE, Poke G, Poot M, Posmyk R, Martin GM, Kubisch C, Schindler D, Oshima J. WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. Hum Mutat. 2017 Jan;38(1):7-15.
  18. Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Sci Rep. 2016 May 16;6:25955.
  19. Angela M, Endo Y, Asou HK, Yamamoto T, Tumes DJ, Tokuyama H, Yokote K, Nakayama T. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. Nat Commun. 2016 Nov 30;7:13683.
  20. Hashimoto N, Tanaka T*. Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus. J. Hum. Genet. 62:141-150, (2017).
  21. Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T*. Cushing syndrome due to ACTH-secreting pheochromocytoma aggravated by a glucocorticoid-driven positive-feedback loop. J Clin Endocrinol Metab. 2016 Mar; 101:841-846 (2016).
  22. Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, Nakayama T. Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 2016 Apr 7; 7: 11289.
  23. Furihata T, Morio H, Zhu M, Suzuki Y, Ide H, Tsubota A, Fu Z, Anzai N, Chiba K. Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet. 2016 Sep 23; pii: S1347-4367(16)30092-1. doi: 10.1016/j.dmpk.2016.09.004. [Epub ahead of print]
  24. Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T. Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2. Sci Rep. 2016 Sep 21;6:33549.
  25. Furihata T, Ito R, Kamiichi A, Saito K, Chiba K. Establishment and characterization of a new conditionally immortalized human astrocyte cell line. J Neurochem. 2016 Jan;136(1):92-105.
  26. Muroyama Y, Baba A, Kitagawa M, Saito T. Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling. PLoS Genet. 2016 Dec 27;12(12):e1006514.

2015

  1. Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and Iwama A. Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner. Blood 2015 Sep 3; 126:1172-1183.
  2. Wang C, Oshima M, Gashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, and Iwama A. Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice. Plos One 2015 Jul 10; 10(7):e0132041.
  3. Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K. Loss-of-TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator. Blood 2015 Jan 8; 125:304-315.
  4. Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R. IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015 May 11;209(3):453-66.
  5. Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, Sturm D, Kushida MM, Head R, Cusimano MD, Bernstein M, Clarke ID, Dick JE, Pfister SM, Rich JN, Arrowsmith CH, Taylor MD, Jabado N, Bazett-Jones DP, Lupien M, Dirks PB. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer Cell. 2015 Dec 14;28(6):715-29.
  6. Toriumi T, Takayama N, Murakami M, Sato M, Yuguchi M, Yamazaki Y, Eto K, Otsu M, Nakauchi H, Shirakawa T, Isokawa K, Honda MJ. Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth. Biomed Res. 2015;36(1):31-45.
  7. Fujii T, Sakata A, Nishimura S, Eto K, and Nagata S. TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. PNAS. 2015 Oct 13;112(41):12800-5.
  8. Karagiannis P, Eto K. Manipulating megakaryocytes to manufacture platelets ex vivo. J Thromb Haemost. 2015 Jun;13 Suppl 1:S47-53.
  9. Arai Y, Takeda J, Aoki K, Kondo T, Takahashi S, Onishi Y, Ozawa Y, Aotsuka N, Kouzai Y, Nakamae H, Ota S, Nakaseko C, Yamaguchi H, Kato K, Atsuta Y, Takami A. Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy. Blood 2015; 126(3): 415-22.
  10. Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C. Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2015; 56(10): 2982-5.
  11. Misawa S, Sato Y, Katayama K, Hanaoka H, Sawai S, Beppu M, Nomura F, Shibuya K, Sekiguchi Y, Mitsuma S, Iwai Y, Watanabe K, Ohwada C, Takeuchi M, Sakaida E, Nakaseko C, Kuwabara S. Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: Retrospective cohort study. BMJ Open 2015 Nov 11;5(11):e009157.
  12. Shimamoto A, Yokote K, Tahara H. Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. Front Genet. 2015 Jan 29;6:10.
  13. Endo Y, Asou HK, Matsugae N, Hirahara K, Shinoda K, Tumes DJ, Tokuyama H, Yokote K, Nakayama T. Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1. Cell Rep. 2015 Aug 11;12(6):1042-55.
  14. Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K. Pioglitazone improves fat tissue distribution and hyperglycemia in a case of cockayne syndrome with diabetes. Diabetes Care. 2015 May;38(5):e76.
  15. Furihata T, Sun Y, Chiba K. Cancer-type Organic Anion Transporting Polypeptide 1B3: Current knowledge of the gene structure, expression profile, functional implications and future perspectives. Curr Drug Metab. 2015;16(6):474-85.
  16. Furihata T, Fu Z, Suzuki Y, Matsumoto S, Morio H, Tsubota A, Matsumoto S, Chiba K. Differential inhibition features of direct-acting anti-hepatitis C virus agents against human organic anion transporting polypeptide 2B1. Int J Antimicrob Agents. 2015 Oct;46(4):381-8.
  17. Furihata T, Kawamatsu S, Ito R, Saito K, Suzuki S, Kishida S, Saito Y, Kamiichi A, Chiba K. Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5; 12:7.
  18. Hashimoto M, Sato T, Muroyama Y, Fujimura L, Hatano M, Saito T. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Dev Growth Differ. 2015 Sep;57(7):529-38