Environment alters epigenome and causes cancer 当講座は千葉大学医学部で昭和42年に開設された生化学第二講座に端を発します。
平成25年に分子腫瘍学と改称し、癌エピゲノム研究を遂行しています。
論文リスト

  1. Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A. Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. Cancer Lett, 407: 21-31, 2017.
  2. Okabe A, Funata S, Matsusaka K, Namba H, Fukuyo M, Rahmutulla B, Oshima M, Iwama A, Fukayama M, Kaneda A. Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus. Sci Rep, 7: 7924, 2017.
  3. Funata S, Matsusaka K, Yamanaka R, Yamamoto S, Okabe A, Fukuyo M, Aburatani H, Fukayama M, Kaneda A. Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection. Oncotarget, 2017 July 21 published on line. doi.org/10.18632/oncotarget.19423
  4. Matsusaka K*, Funata S*, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A. Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. J Pathol, 242:391-399, 2017. (*equal first authors)
  5. Shiga N, Takayanagi S, Muramoto R, Murakami T, Qin R, Suzuki Y, Shinohara K, Kaneda A, Nemoto T. Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy. Bioorg Med Chem Lett, 27:2197-2200, 2017.
  6. Takane K. Akagi K. Fukuyo M. Yagi K. Takayama T. Kaneda A. DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. Cancer Med, 6:1023-1035, 2017.
  7. Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A. Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia, 31:861-871, 2017. doi: 10.1038/leu.2016.268.
  8. Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A. Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide. ACS Omega, 1:1164-72, 2016.
  9. Namba-Fukuyo H, Funata S, Matsusaka K, Fukuyo M, Rahmutulla B, Mano Y, Fukayama M, Aburatani H, Kaneda A. TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection. Oncotarget, 7:81512-26, 2016.
  10. Matsusaka K, Ushiku T, Urabe M, Fukuyo M, Abe H, Ishikawa S, Seto Y, Aburatani H, Hamakubo T, Kaneda A, Fukayama M. Coupling CDH17 and CLDN18 Markers for Comprehensive Membrane-targeted Detection of Human Gastric Cancer. Oncotarget, 7:64168-81, 2016.
  11. Takane K, Matsusaka K, Ota S, Fukuyo M, Yue Y, Nishimura M, Abe H, Sakai E, Matsushita K, Miyauchi H, Fukayama M, Aburatani H, Nakatani Y, Takayama T, Matsubara H, Akagi K, Kaneda A. Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis. Oncotarget, 7:84003-16, 2016.
  12. Funata S, Fukayama M, Kaneda A. De novo methylation in cancer. In: Encyclopedia of Life Sciences (eLS). John Wiley & Sons, Ltd: Chichester. doi: 10.1002/9780470015902.a0026465
  13. Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M. Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens. PLoS One, 11:e0154430, 2016.
  14. Kita K, Sugita K, Sato C, Sugaya S, Kaneda, A. Extracellular Release of Annexin A2 is Enhanced upon Oxidative Stress Response via the p38 MAPK Pathway after Low-Dose X-Ray Radiation. Radiat Res, 186: 79-91, 2016.
  15. Sakai E, Fukuyo M, Matsusaka K, Ohata K, Doi N, Takane K, Matsuhashi N, Fukushima J, Nakajima A, Kaneda A. TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors. Cancer Sci, 107:820-7, 2016.
  16. Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M. Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV. Nat Microbiol, 1:16026, 2016.
  17. Fujimoto M, Mano Y, Anai M, Yamamoto S, Fukuyo M, Aburatani H, Kaneda A. Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence. World J Biol Chem, 7:188-205, 2016.
  18. Suzuki Y, Tanaka Y, Nakano S, Dodo K, Yoda N, Shinohara K, Kita K, Kaneda A, Sodeoka M, Hamada Y, Nemoto T. Platinum-Catalyzed Friedel-Crafts-Type C-H Coupling-Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles. Chemistry, 22:4418-21, 2016.
  19. Ishige T, Nishimura M, Satoh M, Fujimoto M, Fukuyo M,Semba T, Kado S, Tsuchida S, Sawai S, Matsushita K, Togawa A, Matsubara H, Kaneda A, Nomura F. Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation. Sci Rep, 6:21681, 2016.
  20. Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, Fukushima J, Fukayama M, Akagi K, Aburatani H, Nakajima A, Kaneda A. Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. Int J Cancer 138: 1634-44, 2016.
  21. Kaneda A, Nonaka A, Fujita T, Yamanaka R, Fujimoto M, Miyazono K, Aburatani H. Epigenomic regulation of Smad1 signaling during cellular senescence induced by Ras activation. Methods Mol Biol. 1344:341-53, 2016.
  22. Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T. Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes. Mol Cell Biol 35:3841-53, 2015.
  23. Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F. Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 6:5102-17, 2015.
  24. Kaneda A, Yagi K. Quantitative DNA methylation analysis for epigenotyping of colorectal cancer. Methods Mol Biol, 1238:289-99, 2015.
  25. Abe H, Kaneda A, Fukayama M. Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations. Pathobiology. 82:212-23, 2015.
  26. Sato T, Kita K, Sato C, Kaneda A. Hochu-ekki-to (Bu-zhong-yi-qi-tang), a herbal medicine, enhances cisplatin-induced apoptosis in HeLa cells. Mol Med Rep. 2:6215-20, 2015.
  27. Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A. Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients. Cancer Med, 3:1235-45, 2014.
  28. Kaneda A, Matsusaka K, Sakai E, Funata S. DNA methylation accumulation and its predetermination of future cancer phenotypes. J Biochem, 20:978-87, 2014.
  29. Matsusaka K, Funata S, Fukayama S, Kaneda A. DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus. World J Gastroenterol, 20:3916-26, 2014.
  30. Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A. Methylation epigenotypes and genetic features in colorectal laterally spreading tumors. Int J Cancer, 135:1586-95, 2014
  31. Tanaka T, Arai M, Jiang X, Sugaya S, Kanda T, Fujii K, Kita K, Sugita K, Imazeki F, Miyashita T, Kaneda A, Yokosuka O. Downregulation of microRNA-431 by human interferon-β inhibits viability of medulloblastoma and glioblastoma cells via upregulation of SOCS6. Int J Oncol 44:1685-90, 2014.
  32. Sakai E, Nakajima A, Kaneda A. Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol. 20:978-87, 2014.
  33. Tanaka T, Arai M, Minemura S, Oyamada A, Saito K, Jiang X, Tsuboi M, Sazuka S, Maruoka D, Matsumura T, Nakagawa T, Sugaya S, Kanda T, Katsuno T, Kita K, Kishimoto T, Imazeki F, Kaneda A, Yokosuka O. Expression level of sonic hedgehog correlates with the speed of gastric mucosa regeneration in artificial gastric ulcers. J Gastroenterol Hepatol. 29:736-41, 2014.
  34. Kikuchi Y, Tsuji E, Yagi K, Matsusaka K, Tsuji S, Kurebayashi J, Ogawa T, Aburatani H, Kaneda A. Aberrantly methylated genes in human papillary thyroid cancer and correlation of their methylation to BRAF/RAS mutation. Front Genet. 4:271, 2013.
  35. Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep. 3:1911, 2013.
  36. Kaneda A, Matsusaka K, Aburatani H, Fukayama M. Epstein-Barr virus infection as an epigenetic driver of tumorigenesis. Cancer Res. 72:3445-3450, 2012.
  37. Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 22: 208-219, 2012.
  38. Yagi K, Takahashi H, Akagi K, Matsusaka K, Seto Y, Aburatani H, Nakajima A, Kaneda A. Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma. Am J Pathol. 180: 616-625, 2012.
  39. Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M. Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res. 71:7187-7197, 2011.
  40. Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M, Tsuji S, Oshima M, Miyazono K, Aburatani H. Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genet. 7:e1002359, 2011.
  41. Kaneda A, Yagi K. Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes. Cancer Sci. 102:18-24, 2011.
  42. Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A†. Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci, 101:1501-10, 2010.
  43. Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A. Three DNA methylation epigenotypes in human colorectal cancer. Clin Cancer Res, 16:21-33, 2010.
  44. Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci USA, 104:20926-31, 2007.
  45. Hayashi H, Nagae G, Tsutsumi S, Kaneshiro K, Kozaki T, Kaneda A, Sugisaki H, Aburatani H. High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling array. Hum Genet, 120: 701-11, 2007.
  46. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M, Ushijima T. High levels of aberrant DNA methylation in Helicobacterpylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res, 12: 989-95, 2006.
  47. Kaneda A, Feinberg AP. Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer Res, 65: 11236-40, 2005.
  48. Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor β-activated SMAD. Mol Cell Biol, 25: 8097-107, 2005.
  49. Sakatani T*, Kaneda A*, Iacobuzio-Donahue CA*, Carter MG, Witzel SD, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science, 307: 1976-8, 2005. (*equal first authors)
  50. Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, and Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res, 15:15-20, 2005.
  51. Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res, 65: 828-34, 2005.
  52. Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T, Kaneda, A. Decreased fidelity in replicating CpG methylation patterns in cancer cells. Cancer Res, 65: 11-17, 2005.
  53. Okochi-Takada E, Ichimura S, Kaneda A, Sugimura T, Ushijima, T. Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. Mutat Res, 568: 187-94, 2004.
  54. Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, Kaminishi M, Sugimura T, Ushijima, T. Lysyl Oxidase is a tumor-suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res, 64: 6410-15, 2004.
  55. Kaneda A, Kaminishi M, Sugimura T, Ushijima T. Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer Lett, 212: 203-10, 2004.
  56. Kaneda A, Tsukamoto T, Takamura-Enya T, Watanabe N, Kaminishi M, Sugimura T, Tatematsu M, Ushijima T. Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci, 95: 58-64, 2004.
  57. Ushijima T, Watanabe N, Okochi E, Kaneda A, Sugimura T, Miyamoto K. Fidelity of the methylation pattern and its variation in the genome. Genome Res, 13: 868-74, 2003.
  58. Kaneda A, Takai D, Kaminishi M, Okochi E, Ushijima T. Methylation-sensitive- representational difference analysis and its application to cancer research. Ann N Y Acad Sci, 983: 131-41, 2003.
  59. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima, T. Identification of silencing of nine genes in human gastric cancers. Cancer Res, 62: 6645-50, 2002.
  60. Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T, Ushijima T. Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing. Jpn J Cancer Res, 93: 1100-6, 2002.
  61. Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T, Ushijima T. Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. Int J Cancer, 100: 57-62, 2002.
  62. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell, 109: 113-24, 2002.
  63. McKenzie AN, Li X, Largaespada DA, Sato A, Kaneda A, Zurawski SM, Doyle EL, Milatovich A, Francke U, Copeland NG, Jenkins NA, Zurawski G. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol, 150: 5436-44, 1993.