Pharmacotherapy occupies a very important part of medicine. In order to find
innovative and appropriate pharmacological strategies it is important to
analyze and understand the pathophysiology of various diseases. In the
department of pharmacology, we are conducting a variety of research to
clarify the pathophysiology of cardiovascular diseases such as arrhythmia,
ischemic heart disease, and heart failure using the patch-clamp method and
other functional experiments in various kinds of genetically-engineered
animals and disease models. We also conduct a research to clarify the
regulatory mechanism of intercellular signaling through nitric oxide (NO) in
relation to functional alteration in physiology and pathophysiology with use
of biochemical and molecular biological techniques. Research & Education1.Functional role of ion channels clarified by use of genetically engineered mice. 2.Development of novel antiarrhythmic agents for the treatment of atrial fibrillation. 3.Molecular mechanism of cardioprotection by preconditioning and postconditioning during myocardial ischemia and reperfusion. 4.Regulatory role of nitric oxide (NO) in cellular signaling through S-nitrosylation. 5.Mechanisms of inter-cellular signaling by NO. |
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Department of Pharmacology, |
| Chiba University Graduate School of Medicine | |