千葉大学大学院 医学研究院  

       Department of Medical Physiology
       Graduate School of Medicine Chiba University


2018 2017 2016 2015  2014 2013 2012 2011 2010 
   2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
   1999 1998 1997 1996 1995 1994


Kitamoto, T., Sakurai, K., Lee E.Y., Yokote, K., Accili, D., Miki, T. (2018) Distinct roles of systemic and local actions of insulin on pancreatic β-cells. Metabolism (in press)



Watanabe, Y., Matsumoto, A., Miki, T., Seino, S., Anzai, N., Nakaya, H.(2017) Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes. J Pharmacol Sci 135(1):37-43. doi: 10.1016/j.jphs.2017.08.009.

Miki, T., Lee, E.Y., Eguchi, A., Sakurai, K., Sawabe, Y., Yoshida, T., Saito, K., Yokoh, H., Ishikawa, K., Yokote, K., Kuzuya, T., Miki, E., Mori, C., Nomura, F. (2017) Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance. J Diabetes Investig (in press)



Morimoto, M., Lee, E.Y., Zhang, X., Inaba, Y., Inoue, H., Ogawa, M., Shirasawa, T., Yokosuka, O., Miki, T. (2016) Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. Nutrition & Diabetes (in press)

Yoshida, M., Lee, EY., Kohno, T., Tanaka, T., Miyazaki, M., Miki T. (2016) Importance of hepatocyte nuclear factor 4α in glycerol-induced glucose-6-phosphatase expression in liver. Biomed Res 37(2):85-93, 2016. doi: 10.2220/biomedres.37.85.

Morita, A., Mukai, E., Hiratsuka, A., Takatani, T., Iwanaga, T., Lee, EY., Miki T. (2016) Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function. Endocrine 51(3):429-39. doi: 10.1007/s12020-015-0733-4.



Hirono, S., Lee, EY., Kuribayashi, S., Fukuda, T., Saeki, N., Minokoshi, Y., Iwanaga, T., Miki, T. (2016) Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide. Endocrinology 157(1):245-57. doi: 10.1210/en.2015-1560. Epub 2015 Oct 27.

Lee, EY., Sakurai, K., Zhang, X., Toda, C., Tanaka, T., Jiang, M., Shirasawa, T., Tachibana, K., Yokote, K., Vidal-Puig, A., Minokoshi, Y., Miki, T. (2015) Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in InsrP1195L/+ mice fed high-fat-diet. Scientific Reports 5:17565.  doi:10.1038/srep17565

Nakagomi, A., Okada, S., Yokoyama, M., Yoshida, Y., Shimizu, I., Miki, T., Kobayashi, Y., Minamino, T. (2015) Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. npj Aging and Mechanisms of Disease 1, 15009, 2015. doi:10.1038/npjamd.2015.9

Seino, Y., Ogata, H., Maekawa, R., Iida, A., Harada, N., Miki, T., Inagaki, N., Tsunekawa, S., Seino, S., Oiso, Y., Hamada, Y. (2015) Fructose induces KATP channel-independent GIP and GLP-1 secretion and KATP channel-dependent insulin secretion J Diabetes Investig 6:522-526.

Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T. (2015) Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion. J Endocrinol 224(3):205-14.

Matsushita, K., Kitamura, K., Rahmutulla, B., Tanaka, N., Ishige, T., Satoh, M., Hoshino, T., Miyagi, S., Mori, T., Itoga, S., Shimada, H., Tomonaga, T., Kito, M., Nakajima-Takagi, Y., Kubo, S., Nakaseko, C., Hatano, M., Miki, T., Matsuo,  M., Fukuyo, M., Kaneda, A., Iwama, A., Nomura, F. (2015) Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 6, 5102-5117.

Oarada, M., Takahashi-Nakaguchi, A., Abe, T., Nikawa, T., Miki, T. Gonoi, T. (2015) Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.  Nutrition. 31, 757-765.



Ogata, H., Seino, Y., Harada, N., Iida, A., Suzuki, K., Izumoto, T., Ishikawa, K., Uenishi, E., Ozaki, N., Hayashi, Y., Miki, T., Inagaki, N., Tsunekawa, S., Hamada, Y., Seino, S., Oiso, Y. (2014)KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol. 222(2):191-200.

Kawamoto, K., Yabe, S., Konno, M., Ishii, H., Nishida. N., Jun Koseki, J., Fukuda, S., Tomimaru, Y., Hama, N., Wada H., Kobayashi, S., Eguchi, H., Tanemura, M., Ito, T., Lee, E-Y., Mukai, E., Miki, T., Doki, Y., Mori, M., Hamazaki, T., Nagano, H., Okochi, H. (2014) Murine insulinoma cell-conditioned medium with ΒETA2/Neurod1 transduction  efficiently induces the differentiation of adipose-derived mesenchymal stem cells into β-like cells both in vitro  and in vivo.  Stem Cell Research & Therapy 4:8

Mukai E, Ohta T, Kawamura H, Lee EY, Morita A, Sasase T, Miyajima K, Inagaki N, Iwanaga T, Miki T.(2014)   Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in Spontaneously Diabetic Torii rats. Diabetes Res Clin Pract. 106:303-11.



Oarada, M., Miki, T., Kohno, S., Sakai, K., Nikawa, T., Yoneyama, M., Gonoi, T.(2013) Refeeding with a
standard diet after a 48-h fast elicits an inflammatory response in the mouse liver. J Nutr Biochem 24(7):1314-23.

Seino, Y., Miki, M., Fujimoto, W., Lee, EY., Takahashi, Y., Minami, K., Oiso, Y., Seino, S. (2013) Cephalic phase insulin secretion is KATP channel-independent. J Endocrinol  218(1):25-33..



Sakurai, K., Lee, EY., Morita, A., Kimura, S., Kawamura, H., Kasamatsu, A.,Shiiba, M., Yabe, D., Yokote,K., Miki, T. (2012) Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus  non-nutritive sweetener. J Diabetes Invest 3:156-63

Ogata, S., Miki, T., Seino, S., Tamai, S., Kasai, H., Nemoto, T. (2012) A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. PLoS ONE 12;7(5):e37048.


Iwanaga, T., Miki, T., Takahashi-Iwanaga, H. (2011) Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenophysis of mice. Biomed Res 32:73-81.

Nishida, A., Takizawa, T., Matsumoto, A., Miki, T., Seino, S., and Nakaya, H. (2011) Inhibition of  ATP-Sensitive  K(+) Channels and L-Type Ca(2+) Channels by Amiodarone Elicits Contradictory  Effect on Insulin Secretion in MIN6 Cells. J Pharmacol Sci 116(1):73-80.

Nakamura, K., Minami, K., Tamura, K., Iemoto, K., Miki, T., and Seino, S. (2011) Pancreatic β-cells are generated  by neogenesis from non-β-cells after birth. Biomed Res 3:167-74.
Sakurai, K., Lee, EY., Morita, A., Kimura, S., Kawamura, H., Kasamatsu, A.,Shiiba, M., Yabe, D., Yokote,K., Miki, T. (2011) Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive  sweetener. J Diabetes Invest (in press)

 Lee, EY., Inoue, S., Senoo, A., Shimizu, H., Suzuki Y., Ishizuka, N., Imazeki, N., Sasaki, K., Kako, M., Osaka, T., Miki,  T. (2011) Beneficial effects of ventromedial hypothalamus (VMH) lesioning on function and morphology of the  liver after hepatectomy in rats. Brain Res (in press)         


 Yasuda, T., Shibasaki, T., Minami, K., Takahashi, H., Mizoguchi, A., Uriu, Y., Mori, Y., Miyazaki, J-I, Miki,T., and    Seino, S.(2010) Rim2α determines docking and priming states in insulin granule exocytosis. Cell Metab      12(2):117-129.

 Iwasaki, M., Minami K., Shibasaki, T., Miki, T., Jun-ichi Miyazaki, J-I., and Seino, S. (2010) Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cAMP signaling. J Diabetes Invest 4, 137-142 



 Ravier, M.A., Nenquin, M., Miki, T., Seino, S., and Henquin, JC. (2009) Glucose controls cytosolic Ca2+ and insulin  secretion in mouse islets lacking ATP-sensitive K+ channels owing to a knockout of the pore-forming subunit   Kir6.2. Endocrinology 150:33-45.

 Niimura,M., Miki,T., Shibasaki,T., Fujimoto, W., Iwanaga,T., and Seino S. (2009) Critical role of the N-termial     cyclic AMP-binding domain of Epac2A in its subcellular localization and function J Cell Physiol 219(3):652-658.

 Zlatkovic J, Arrell DK, Kane GC, Miki T, Seino S, Terzic A. (2009) Proteomic profiling of KATP channel-deficient   hypertensive heart maps risk for maladaptive cardiomyopathic outcome. Proteomics 9(5):1314-1325.

 Fujimoto, W., T. Miki1, T., Ogura, T., Zhang, M., Seino, Y., Satin, L.S., Nakaya, H., Seino, S. (2009) Niflumic       acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by    cyclic AMP in mice. Diabetologia 52(5):863-872.

 Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S.(2009)   The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 325(5940):607-610.

 Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ Jr,  Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y.(2009)  LKB1 regulates pancreatic    beta cell size, polarity, and  function. Cell Metab 10:296-308.



 Seino, Y., Miki, T., Kiyonari, H., Abe, T., Fujimoto, W., Kimura, K., Takeuchi, A., Takahashi, Y., Oiso, Y., Iwanaga, T.   and Seino, S. (2008) Intestine specific homeobox (ISX) participates in the maintenance of vitamin A metabolism  by regulation of beta-carotene 15, 15'-monooxygenase (bcmo1) expression. J. Biol. Chem. 283(8):4905-4911.

 Fukuzaki, K., Sato, T., Miki, T., Seino, S., Nakaya, H. (2008) Role of sarcolemmal ATP-sensitive K+ channels in the   regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice. J. Physio:             5811)2767-2778.

 Kentner, A.C., Takeuchi, A., James, J.S., Miki, T., Seino, S., Hayley, S., Bielajew, C. (2008) The effects of rewarding   ventral tegmental area stimulation and environmental enrichment on lipopolysaccharide-induced sickness     behavior and cytokine expression in female rats. Brain Res. 1217:50-61.

 Yamada, S., Nelson, T.J., Crespo, R., Terzic, C., Liu, X.K., Miki, T., Seino, S., Behfar, A., Terzic, A. (2008) Embryonic   stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells 26:2644-2653.



 Miyake, A., Yamada, K., Kosaka, T., Miki, T., Seino, S. and Inagaki, N. (2007) Disruption of Kir6.2-containing      ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice. Eur. J. Neurosci. 25,      2349-2363.

 Fujimoto, W.*, Shiuchi, T.*, Miki, T.* (*; contributed equally), Minokoshi, Y., Takahashi, Y., Takeuchi, A., Kimura,   K., Saito, M., Iwanaga, T., and Seino, S. (2007) Dmbx1 is essential in agouti-related protein action. Proc. Natl.    Acad. Sci. U S A. 104, 15514-15519.

 Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh,   T., Miyazaki, J-I., and Seino, S. (2007) Essential role of Epac2/Rap1 signaling in regulation of insulin granule    dynamics by cAMP. Proc. Natl. Acad. Sci. U S A. 104(49):19333-193338.

 Xu, J., Zhang, L., Allaby, T., Chou, A., Belanger, G., Radziuk, J., Jasmin, B.J., Miki, T., Seino, S., and Renaud, J-M.    (2007) KATP channel deficient pancreatic s-cells are streptozotocin resistant due to lower GLUT2 activity.      Am. J. Physiol. Endocrinol. Metab 292(4):H1706-713.

 Reyes, S., Kane, G.C., Miki, T., Seino, S., and Terzic, A. (2007) KATP channels confer survival advantage in cocaine  overdose. Mol. Psychiatry. 12(12):1060-1061.



 Zhang, C., Miki, T., Shibasaki, T., Yokokura, M., Saraya, A. and Seino, S. (2006) Identification and characterization  of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol. Genomics 24,   290-297

 Sun, H.S., Feng, Z.P., Miki, T., Seino, S. and French, R.J. (2006) Enhanced neuronal damage after ischemic insults in  mice lacking Kir6.2-containing ATP-sensitive K+ channels. J. Neurophysiol. 95, 2590-2601

 Deacon, R.M., Brook, R.C., Meyer, D., Haeckel, O., Ashcroft, F.M., Miki, T., Seino, S. and Liss, B. (2006) Behavioral   phenotyping of mice lacking the K(ATP) channel subunit Kir6.2. Physiol. Behav. 87, 723-733

 Oyama, K., Minami, K., Ishizaki, K., Fuse, M., Miki, T., and Seino, S. (2006) Spontaneous recovery from         hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice. Diabetes 55, 1930-1938.

 Choeiri, C., Staines, W.A., Miki, T., Seino, S., Renaud, J.M., Teutenberg, K. and Messier, C. (2006) Cerebral glucose   transporters expression and spatial learning in the K-ATP Kir6.2(-/-) knockout mice. Behav. Brain Res. 172,     233-239.

 Kane, G.C., Behfar, A., Dyer, R.B., O'Cochlain, D.F., Liu, X.K., Hodgson, D.M., Reyes, S., Miki, T., Seino, S. and Terzic,  A. (2006) KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure  in hypertension. Hum. Mol. Genet. 15, 2285-2297.

 Yamada, S., Kane, G.C., Behfar, A., Liu, X.K., Dyer, R.B., Faustino, R.S., Miki, T., Seino, S. and Terzic, A. (2006)      Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart    failure revealed in KCNJ11 Kir6.2-null mutant. J. Physiol. 577, 1053-1065.

 Kane, G.C., Lam, C.F., O'Cochlain, F., Hodgson, D.M., Reyes, S., Liu, X.K., Miki, T., Seino, S., Katusic, Z.S. and Terzic,   A. (2006) Gene knockout of the KCNJ8-encoded Kir6.1 KATP channel imparts fatal susceptibility to endotoxemia.  FASEB J. 20, 2271-2280.

 Gumina, R., O'cochlain, D.F., Kurtz, C., Bast, P., Pucar, D., Mishra, P., Miki, T., Seino, S., Macura, S. and Terzic, A.    (2006) KATP channel knockout worsens myocardial calcium stress-load in vivo and impairs recovery in stunned  heart. Am. J. Physiol. Heart Circ. Physiol. 292, H1706-1713.

 Olson, T.M., Alekseev, A.E., Moreau, C., Liu, X.K., Zingman, L.V., Miki, T., Seino, S., Asirvatham, S.J., Jahangir, A. and  Terzic, A. (2006) KATP channel mutation confers risk for adrenergic atrial fibrillation originating from vein of   Marshall. Nat. Clin. Pract. Cardiovasc. Med. 4, 110-116.


 Saito, T., Sato, T., Miki, T., Seino, S. and Nakaya, H. (2005) Role of ATP-sensitive K+ channels in            electrophysiological alterations during myocardial ischemia: a study using Kir6.2-null mice. Am. J. Physiol.     Heart Circ. Physiol. 288, H352-357

 Miki, T., Minami, K., Shinozaki, H., Matsumura, K., Saraya, A., Ikeda, H., Yamada, Y., Holst, J.J. and Seino, S. (2005)  Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin      secretion and gut motility. Diabetes 54, 1056-1063

 Choeiri, C., Staines, W., Miki, T., Seino, S. and Messier, C. (2005) Glucose transporter plasticity during memory   processing. Neuroscience 130, 591-600.

 Kimura, K., Miki, T., Shibasaki, T., Zhang, Y., Ogawa, M., Saisho, H., Okuno, M., Iwanaga, T. and Seino, S. (2005)   Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579, 2926-2932.

 Thabet, M., Miki, T., Seino, S. and Renaud, J.M. (2005) Treadmill running causes significant fiber damage in     skeletal muscle of KATP channel deficient mice. Physiol. Genomics 22, 204-212.

 Matsumura, K., Miki, T., Jhomori, T., Gonoi, T. and Seino, S. (2005) Possible role of PEPT1 in gastrointestinal     hormone secretion. Biochem. Biophys. Res. Commun. 336, 1028-1032.

 Liss, B., Haeckel, O., Wildmann, J., Miki, T., Seino, S. and Roeper J. (2005) KATP channel promote the differential   degeneration of dopaminergic midbrain neurons. Nat. Neurosci. 8, 1742-1751.

 Miki, T. and Seino, S. (2005) Roles of KATP channels as metabolic sensors in acute metabolic changes. J. Mol. Cell.  Cardiol. 38:917-925.


 Matsumoto, M., Miki, T., Shibasaki, T., Kawaguchi, M., Shinozaki, H., Nio, J., Saraya, A., Koseki, H., Miyazaki, M.,   Iwanaga, T. and Seino, S. (2004) Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine   cells. Proc. Natl. Acad. Sci. U S A 101, 8313-8318.

 Nishimura, M., Yokoi, N., Miki, T., Horikawa, Y., Yoshioka, H., Takeda, J., Ohara, O. and Seino, S. (2004)        Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to      microarray. DNA Res. 11, 315-323.

 Liu, X.K., Yamada, S., Kane, G.C., Alekseev, A.E., Hodgson, D.M., O'Cochlain, F., Jahangir, A., Miki, T., Seino, S. and   Terzic, A. (2004) Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes  to catecholamine-induced ventricular dysrhythmia. Diabetes 53 Suppl 3, S165-168.

 Kane, G.C., Behfar, A., Yamada, S., Perez-Terzic, C., O'Cochlain, F., Reyes, S., Dzeja, P.P., Miki, T., Seino, S. and Terzic,  A. (2004) ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting   in cardiac deficits. Diabetes 53 Suppl 3, S169-175.

 Minami, K., Miki, T., Kadowaki, T. and Seino, S. (2004) Roles of ATP-sensitive K+ channels as metabolic sensors:   studies of Kir6.x null mice. Diabetes 53 Suppl 3, S176-180.

 Remedi, M.S., Koster, J.C., Markova, K., Seino, S., Miki, T., Patton, B.L., McDaniel, M.L. and Nichols, C.G. (2004)    Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes 53,     3159-3167.

 Seino, S. and Miki, T. (2004) Gene targeting approach to clarification of ion channel function: studies of Kir6.x   null mice. J. Physiol. 554:295-300.


 Suzuki, M., Saito, T., Sato, T., Tamagawa, M., Miki, T., Seino, S. and Nakaya, H. (2003) Cardioprotective effect of   diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in  mice. Circulation 107, 682-685

 Gumina, R.J., Pucar, D., Bast, P., Hodgson, D.M., Kurtz, C.E., Dzeja, P.P., Miki, T., Seino, S. and Terzic A. (2003)     Knockout of the KATP channel subunit Kir6.2 negates ischemic preconditioning-induced protection of        myocardial energetics. Am. J. Physiol. Heart Circ. Physiol. 284, H2106-2113.

 Niki, I., Niwa, T., Yu, W., Budzko, D., Miki, T. and Senda T. (2003) Ca2+ influx does not trigger glucose-induced   traffic of the insulin granules and alteration of their distribution. Exp. Biol. Med. (Maywood) 228, 1218-1226.

 Gong, B., Legault, D., Miki, T., Seino, S. and Renaud, J.M. (2003) KATP channels depress force by reducing action   potential amplitude in mouse EDL and soleus muscle. Am. J. Physiol. Cell Physiol. 285, C1464-1474.

 Minami, K., Morita, M., Saraya, A., Yano, H., Terauchi, Y., Miki, T., Kuriyama, T., Kadowaki, T. and Seino, S. (2003)  ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase     signaling. Am. J. Physiol. Endocrinol. Metab. 285, E1289-1296.

 Seino. S. and Miki, T. (2003) Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog.     Biophys. Mol. Biol. 81, 133-176.


 Suzuki, M., Sasaki, N., Miki, T., Sakamoto, N., Ohmoto-Sekine, Y., Tamagawa, M., Seino, S., Marban, E., and      Nakaya, H. (2002) Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury
 in mice. J. Clin. Invest. 109, 509-516.

 Miki, T., Suzuki, M., Shibasaki, T., Uemura, H., Sato, T., Yamaguchi, K., Koseki, H., Iwanaga, T., Nakaya, H. and     Seino, S. (2002) Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat. Med. 8,     466-472

 Zhang, Y., Miki, T., Iwanaga, T., Koseki, Y., Okuno, M., Sunaga, Y., Ozaki, N., Yano, H., Koseki, H. and Seino, S. (2002) Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx     family. J. Biol. Chem. 277, 28065-28069.

 Miki, T., Minami, K., Zhang, L., Morita, M., Gonoi, T., Shiuchi, T., Minokoshi, Y., Renaud, J.M. and Seino, S. (2002)   ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. Am. J.    Physiol. Endocrinol. Metab. 283, E1178-84.

 Zingman, L.V., Hodgson, D.M., Bast, P.H., Kane, G.C., Perez-Terzic, C., Gumina, R.J., Pucar, D., Bienengraeber, M.,   Dzeja, P.P., Miki, T., Seino, S., Alekseev, A.E, and Terzic. A. (2002) Kir6.2 is required for adaptation to stress. Proc.   Natl. Acad. Sci. USA 99, 13278-13283.


 Nishigori, H., Tomura, H., Tonooka, N., Kanamori, M., Yamada, S., Sho, K., Inoue, I., Kikuchi, N., Onigara, K., Kojima,  I., Kohama, T., Yamagata, K., Yang, Q., Matsuzawa, Y., Miki, T., Seino,S., Kim, M-Y., Choi, H-S., Lee, Y-K., Moore,   D.D. and Takeda, J. (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in   Japanese subjects. Proc. Natl. Acad. Sci. USA 98, 575-580.

 Miki, T., Iwanaga, T., Nagashima, K. and Seino, S. (2001) Roles of the KATP channels in cell survival and       differentiation of endocrine pancreas. Diabetes 50 Suppl 1, S48-51. Winarto, A., Miki, T., Seino, S., Iwanaga, T.   (2001) Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP    channels in the survival of insulin cells and the maintenance of islet architecture. Arch. Histol. Cytol. 64, 59-67.

 Suzuki, M., Li, R.A., Miki, T., Uemura, H., Sakamoto, N., Ohmoto-Sekine, Y., Ogura, T., Tamagawa, M., Seino, S.    and Nakaya, H. (2001) Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by   Kir6.2-knockout nice. Circ. Res. 88, 570-577.

 Yamada, K., Ji, J.J., Yuan, H., Miki, T., Sato, S., Horimoto, N., Shimizu, T., Seino, S. and Inagaki, N. (2001) Protective  role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292, 1543-1546.

 Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J.  and Seino, S. (2001) ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of      glucose  homeostasis. Nat. Neurosci. 5, 507-512.

 Sano, R., Miki, T., Suzuki, Y., Shimada, F., Taira, M., Kanatsuka, A., Makino, H., Hashimoto, N. and Saito, Y. (2001)  Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes. Diabetes Res. Clin. Pract. 54,    79-88.

 Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H. and Seino, S. (2001) Critical role of        cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 276, 46046-46053.


 Mitsuhashi, N., Miki, T., Senbongi, H., Yokoi, N., Yano, H., Miyazaki, M., Nakajima, N., Iwanaga,T., Yokoyama, Y.,   Shibata, T. and Seino, S. (2000) MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron   homeostasis. J. Biol. Chem. 275, 17536-17540.

 Minami, K., Yano, H., Miki, T., Nagashima, K., Tanaka, H., Wang, C-Z., Miyazaki, J. and Seino, S. (2000) Insulin    secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines. Am. J.      Physiol. Endocrinol. Metab. 279: E773-E781.

 Gong, B., Miki, T., Seino, S. and Renaud, J.M. (2000) A K+ATP channel deficiency affects resting tension, not     contractile force, during fatigue in skeletal muscle. Am. J. Physiol. Cell Physiol. 279, C1351-C1358.

 Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Iwanaga, T., Matuura,  Y., Takai, Y. and Seino, S. (2000) cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat. Cell Biol. 2,  805-811.

 Li, R.A., Leppo, M., Miki, T., Seino, S. and Marban, E. (2000) Molecular basis of electrocardiographic ST segment   elevation. Circ. Res. 87, 837-839

 Someya, T., Miki, T., Sugihara, S., Minagawa, M., Yasuda, T., Kohno, Y. and Seino, S. (2000) Characterization of    genes encoding the pancreatic s-cell ATP-sensitive K+ channel in persistent hyperinsulinemic hypoglycemia of   infancy in Japanese patients. Endocrine. J. 47, 715-722.

 Seino, S., Iwanaga, T., Nagashima, K. and Miki, T. (2000) Diverse roles of KATP channels learned    from Kir6.2  genetically engineered mice. Diabetes 49, 311-318.


 Nishimura, M., Miki, T., Yokoi, N., Yano, H., Sato, Y. and Seino, S. (1999) Angiopoietin-3, a novel member of the   anigiopoietin family. FEBS Lett. 448, 254-256.2000年

 Kawaki, J., Nagashima, K., Tanaka, J., Miki, T., Miyazaki, T., Gonoi, T., Nakajima, N., Iwanaga, T., Yano, H. and     Seino, S. (1999) Unresponsiveness to glibenclamide during chronic treatment induced by reduction of        ATP-sensitive K+ channel activity. Diabetes 48, 2001-2006.

 Miki, T., Inagaki, N., Nagashima, K., Gonoi, T., and Seino, S. (1999) Structure and Function of ATP-sensitive K+    channels. Current Topics in Membranes 46, 373-385.

 Miki, T., Nagashima, K., and Seino, S. (1999) The structure and function of the ATP-sensitive K+ channel in     insulin secreting pancreatic s-cells. J. Mol. Endocrinol. 22, 113-123.


 Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, JI.   and Seino, S. (1998) Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.    Proc. Natl. Acad. Sci. USA 95, 10402-10406.


 Mizuta, M., Kurose, T., Miki, T., Shoji-Kasai, Y., Takahashi, M., Seino, S. and Matsukura, S. (1997) Localization and  functional role of synaptotagmin III in insulin secretory vesicles in pancreatic s-cells. Diabetes 46, 2002-2006.

 Miki, T., Tashiro, F., Iwanaga, T., Nagashima, K., Yoshitomi, H., Aihara, H., Nitta, Y., Gonoi, T., Inagaki, N., Miyazaki,  JI. and Seino, S. (1997) Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP   channel. Proc. Natl. Acad. Sci. USA 94, 11969-11973.

 Seino, S., Inagaki, N., Namba, N., Wang, C-H., Nagashima, K., Miki, T., Agulilar-Bryan, L., Bryan, J. and Gonoi, T.   (1997) Molecular basis of functional diversity of ATP-sensitive K+ channels. Jpn. J. Physiol. 47, 3-4.


 Miki, T., Taira, M., Hockman, S., Shimada, F., Lieman, J., Napolitano, M., Ward, D., Taira, M., Makino, H. and      Manganiello, VC. (1996) Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of  the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family. Genomics 36, 476-485.

 Nishikawa, T., Iizuka, T., Omura, M., Kuramoto, N., Miki, T., Ito, H., Chiba, S. (1996) Effect of mazindol on body   weight and insulin sensitivity in severely obese patients after a very-low-calorie diet therapy. Endocr. J. 43,     671-677.




 Shimada, F., Kanatsuka, A., Sakurada, M., Hashimoto, N., Sano, H., Hatanaka, Y., Miki, T., Makino, H. and Yoshida,  S. (1994) Insulin response to intravenous glucose in a family with a glucokinase mutation. Horm. Metab. Res.   26, 392-394.



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