1999年以降の主な業績です。

論文

1999年
  1. Yanai, K., Hirota, K., Taniguchi-Yanai, K., Shigematsu, Y., Shimamoto, Y., Saito, T., Chowdhury, S., Takiguchi, M., Arakawa, M., Nibu, Y., Sugiyama, F., Yagami, K. and Fukamizu, A., Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. J. Biol. Chem. 274(49), 34605-34612, 1999.
  2. Sugahara, K., Sadohara, T., Sugita, M., Iyama, K. and Takiguchi, M., Differential expression of CCAAT enhancer binding protein family in rat alveolar epithelial cell proliferation and in acute lung injury. Cell & Tissue Res. 297(2), 261-270, 1999.
  3. Braissant, O., Honegger, P., Loup, M., Iwase, K., Takiguchi, M. and Bachmann, C. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neuroscience Letters. 266(2), 89-92, 1999 May 7.
  4. Zhang, W. Y., Takiguchi, M., Koshiyama, Y., Gotoh, T., Nagasaki, A., Iwase, K., Yamamoto, K., Takeshima, H., Negi, A. and Mori, M. Expression of citrulline-nitric oxide cycle in lipopolysaccharide and cytokine-stimulated rat astroglioma C6 cells. Brain Res. 849(1-2), 78-84, 1999.
  5. Fujimura, S., Sakuramoto, K., Du, M., Kuroiwa, K. and Ohmura, Y. Aspect of nitric oxide, released from gastro-carcinogenic N-alkyl-N-nitroso compounds, in gastro-carcinogenesis. In 3rd International Gastric Cancer Congress. J. -P. Kim, J. -S. Min, Y. -J. Mok (eds.) Monduzzi Editore, Bologna, Italy, pp.947-950, 1999.
  6. Hiwasa, T., Chen, Z., Nomura, J., Yamamori, H., Tashiro, T., Nakajima, N. and Suzuki N. Differential sensitivity to mitomycin C between human RSa cell line and its derivative UVr-1. Anticancer Res. 19(5B), 3915-3920, 1999.
  7. Lin, L., Islam, M. M., Du, M., Ohmura, Y., Hiwasa, T. and Fujimura, S. Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to phosphorylation. Int. J. Oncol. 15(2), 293-299, 1999.
  8. Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umezawa, K., Ito, H. and Suzuki, N. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Lett. 444(2-3):173-6, 1999.
  9. Chi, X. J., Hiwasa, T., Maki, M., Sugaya, S., Nomura, J., Kita, K. and Suzuki, N. Suppression of okadaic acid-induced apoptosis by overexpression of calpastatin in human UVr-1 cells. FEBS Lett. 459(3), 391-394, 1999 Oct 15.
  10. Hiwasa, T., Takeda, A. and Umezawa, K. Inhibition of Thrombin and Calpain by a Ras Inhibitor, Damnacanthal. J. Biochem. Mol. Biol. & Biophys. 2, 311-316, 1999.
  11. 2000年
  12. Arase, Y., Hiwasa, T., Hasegawa, R., Nomura, J., Ito, H. and Suzuki, N. Prevention of v-Ha-ras-dependent apoptosis by PDGF coordinates in phosphorylation of ERK and Akt. Biochem. Biophys. Res. Commun. 267, 33-39, 2000.
  13. Hiwasa, T., Arase, Y., Kikuno, K., Hasegawa, R., Sugaya, S., Kita, K., Saido, T., Yamamori, H., Maki, M. and Suzuki, N. Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ. 7, 531-537, 2000.
  14. Kuroiwa, N., Yusa, T., Nakamura, Y., Sakiyama, S., Hiwasa, T., Lin, L., Moriyama, Y. and Fujimura, S. Regulation of the activity and polymerization status of recombinant human cytosolic thymidine kinase by thiols and ATP. Int. J. Oncol. 16, 305-313, 2000.
  15. Iwase, K., Miyanaka, K., Shimizu, A., Nagasaki, A., Gotoh, T., Mori, M. and Takiguchi, M. Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. J. Biol. Chem. 275, 11929-11933, 2000.
  16. Oyadomari, S., Matsuno, F., Chowdhury, S., Kimura, T., Iwase, K., Araki, E., Shichiri, M., Mori, M. and Takiguchi, M. The gene for hepatocyte nuclear factor (HNF)-4a is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver. FEBS Lett. 478, 141-146, 2000.
  17. 2001年
  18. Kimura, T., Chowdhury, S., Tanaka, T., Shimizu, A., Iwase, K., Oyadomari, S., Gotoh, T., Matsuzaki, H., Mori, M., Akira, S. and Takiguchi, M. CCAAT/enhancer-binding protein b is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes. FEBS Lett. 494, 105-111, 2001.
  19. Kuroiwa, N., Nakayama, M., Fukuda, T., Fukui, H., Ohwada, H., Hiwasa, T. and Fujimura, S. Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase. J. Immunol. Meth. 253, 1-11, 2001.
  20. Shimada, H., Shimizu, T., Ochiai, T., Liu, T. -L., Sashiyama, H., Nakamura, A., Matsubara, H., Gunji, Y., Kobayashi, S., Tagawa, M., Sakiyama, S. and Hiwasa, T. Preclinical study of adenoviral p53 gene therapy for esophageal cancer. Surg. Today 31, 597-604, 2001.
  21. Sugita, K., Chi, X. -J., Hiwasa, T. and Suzuki, N. Stidies on p53 and Bax protein expression in Cockayne syndrome cells after UV irradiation and interferon-α treatment. Cell Biochem. Func. 19, 221-225, 2001.
  22. Oyadomari, S., Takeda, K., Takiguchi, M., Gotoh, T., Matsumoto, M., Wada, I., Akira, S., Araki, E. and Mori, M. Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway. Proc. Natl. Acad. Sci. USA 98, 10845-10850, 2001.
  23. Sugahara, K., Iyama, K., Kimura, T., Sano, K., Darlington, G. J., Akiba, T. and Takiguchi, M. Mice lacking CCAAT/enhancer-binding protein-α show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs. Cell Tissue Res. 306, 57-63, 2001.
  24. Sugita, T., Hiwasa, T., Nomura, J., Kita, K., Hiroshima, K., Suzuki, H., Sekiya, S. and Suzuki, N. Hypermutable change of human UVr-1 cells by p53 overexpression. Biochem. Biophys. Res. Commun. 289, 756-762, 2001.
  25. 2002年
  26. Shimada, H., Liu, T. -L., Ochiai, T., Shimizu, T., Haupt, Y., Hamada, H., Abe, T., Oka, M., Takiguchi, M. and Hiwasa, T. Facilitation of adenoviral wild-typr p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells. Oncogene 21, 1208-1216, 2002.
  27. Hiwasa, T., Nakata, M., Nakata, M., Ohno,S., Maki, M., Suzuki, K. and Takiguchi M. Regulation of transformed state by calpastatin via PKCε in NIH3T3 mouse fibroblasts. Biochem. Biophys. Res. Commun. 250, 510-517, 2002.
  28. Hiwasa, T., Shimada, H., Ochiai, T., Liu, T. -L., Yuasa, Y., Takiguchi, M. and Ohkoshi, M. Decrease in growth factor receptors after treatment with serine protease inhibitor ONO-3403. Int. J. Oncol. 20, 797-802, 2002.
  29. Suzuki, K., Nakajima, H., Kagami, S., Suto, A., Ikeda, K., Hirose, K., Hiwasa, T., Takeda, K., Saito, Y., Akira, S. and Iwamoto, I. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J. Exp. Med. 196, 27-38, 2002.
  30. Fujita, Y., Kitagawa, M., Nakamura, S., Azuma, K., Ishii, G., Higashi, M., Kishi, H., Hiwasa, T., Koda, K., Nakajima, N. and Harigaya, K. CD44 signaling through focal adhesion kinase and its anti-apotototic effect. FEBS Lett. 528, 101-108, 2002.
  31. Akiba, T., Kuroiwa, N., Shimizu-Yabe, A., Iwase, K., Hiwasa, T., Yokoe, H., Kubosawa, H., Kageyama, R., Dahrington, G. J., Mori, M., Tanzawa, H. and Takiguchi, M. Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein α for the expression in the parotid gland. J. Biochem. 132, 621-627, 2002.
  32. 2003年
  33. Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A. and Hiwasa, T. Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. Int. J. Oncol. 23, 1071-1077, 2003.
  34. Hiwasa, T., Shimada, H., Sakaida, T., Kitagawa, M., Kuroiwa, N., Ochiai, T. and Takiguchi, M. Drug-sensitivity pattern analysis for study of functional relationship between gene products. FEBS Lett. 552, 177-183, 2003.
  35. Hiwasa, T. Substrates for calpain, proteasome and caspase. Recent Res. Devel. Biochem. 4, 629-642, 2003.
  36. Arai, M., Yokosuka, O., Chiba, T., Imazeki, F., Kato, M., Hashida, J., Ueda, Y., Sugano, S., Hashimoto, K., Saisho, H., Takiguchi, M. and Seki, N. Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration. J. Biol. Chem. 278, 29813-29818, 2003.
  37. Sakao, E., Ishihara, A., Horikawa, K., Akiyama, M., Arai, M., Kato, M., Seki, N., Fukunaga, K., Shimizu-Yabe, A., Iwase, K., Ohtsuka, S., Sato, T., Kohno, Y., Shibata, S. and Takiguchi, M. Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver. J. Biol. Chem. 278, 30450-30457, 2003.
  38. Suzuki, K., Nakajima, H., Ikeda, K., Tamachi, T., Hiwasa, T., Saito, Y. and Iwamoto, I. Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046. Biochem. Biophys. Res. Commun. 309, 768-773, 2003.
  39. 2004年
  40. Mori, M., Shimada, H., Gunji, Y., Matsubara, H., Hayashi, H., Nimura, Y., Kato, M., Takiguchi, M., Ochiai, T. and Seki, N. S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastasis of gastric cancer. Oncol. Rep. 11, 1287-1295, 2004.
  41. Arai, M., Yokosuka, O., Fukai, K., Imazaki, F., Chiba, T., Sumi, H., Kato, M., Takiguchi, M., Saisho, H., Muramatsu, M. and Seki, N. Gene expression profiles in liver regeneration with oval cell induction. Biochem. Biophys. Res. Commun. 317, 370-376, 2004.
  42. Ohtsuka, S., Iwase, K., Kato, M., Seki, N., Shimizu-Yabe, A., Miyauchi, O., Sakao, E., Kanazawa, M., Yamamoto, S., Kohno, Y. and Takiguchi, M. An mRNA amplification procedure with directional cDNA cloning and strand-specific cRNA synthesis for comprehensive gene expression analysis. Genomics 84, 715-729, 2004.
  43. Machida, T., Kubota, M., Saeki, N., Takiguchi, M., Yamaura, A. and Hiwasa, T. Increase in metalloproteinase activity in the plasma of smoke-extract-injected rats. Int. J. Mol. Med. 14, 659-662, 2004.
  44. Nakashima, K., Shimada, H., Ochiai, T., Kuboshima, M., Kuroiwa, N., Okazumi, S., Matsubara, H., Nomura, F., Takiguchi, M. and Hiwasa, T. Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int. J. Cancer 112, 1029-1035, 2004.
  45. Chang, H., Iizasa, T., Shibuya, K., Iyoda, A., Suzuki, M., Moriya, Y., Liu, T. -L., Hiwasa, T., Hiroshima, K. and Fujisawa, T. Increased expression of collagen XVIII and its prognostic value in nonsmall cell lung carcinoma. Cancer 100, 1665-1672, 2004.
  46. Iwadate, Y., Sakaida, T., Hiwasa, T., Nagai, Y., Ishikura, H., Takiguchi, M. and Yamaura, A. Molecular classification and survival prediction in human gliomas based on proteome analysis. Cancer Res. 64, 2496-2501, 2004.
  47. Oohira, G., Yamada, S., Ochiai, T., Matsubara, H., Okazumi, S., Ando, K., Tsujii, H., Hiwasa, T. and Shimada, H. Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transfer. Int. J. Oncol. 25, 563-569, 2004.
  48. 2005年
  49. Shimada, H., Nakashima, K., Ochiai, T., Nabeya, Y., Takiguchi, M., Nomura, F. and Hiwasa, T. Serological identification of tumor antigens of esophageal squamous cell carcinoma. Int. J. Oncol., 26, 77-86, 2005.
  50. Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S. and Yamaura, A. Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. Int. J. Oncol., 26, 993-998, 2005.
  51. Fukuda, M. E., Iwadate, Y., Machida, T., Hiwasa, T., Nimura, Y., Nagai, Y., Takiguchi, M., Tanzawa, H., Yamaura, A. and Seki, N. Cathepsin D is a potential serum marker for poor prognosis in glioma patients. Cancer Res., 65, 5190-5194, 2005.
  52. 2006年
  53. Kuboshima, M., Shimada, H., Liu, T.-L., Nakashima, K., Nomura, F., Takiguchi, M., Hiwasa, T. and Ochiai, T. Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. Int. J. Oncol. 28, 463-468, 2006.
  54. Kuboshima, M., Shimada, H., Liu, T.-L., Nomura, F., Takiguchi, M., Hiwasa, T. and Ochiai, T. Presence of serum TRIM21 antibodies in patients with esophageal squamous cell carcinoma. Cancer Sci., 97, 380-386, 2006.
  55. Hiwasa, T., Shimada, H., Ochiai, T. and Takiguchi, M. Serological identification of antigens by recombinant cDNA expression cloning (SEREX) using antibodies from patients with esophageal squamous cell carcinoma. In Moleculomics and Thereafter (ISBN: 81-308-0019-5), Hiwasa T. (ed.), Research Signpost, Kerala, India, pp 99-117, 2006.
  56. Hiwasa, T. DSPA, a new method for comprehensive analysis of gene function. In Moleculomics and Thereafter (ISBN: 81-308-0019-5), Hiwasa T. (ed.), Research Signpost, Kerala, India, pp 143-157, 2006.
  57. Osawa, A., Kato, M., Matsumoto, E., Iwase, K., Sugimoto, T., Matsui, T., Ishikura, H., Sugano, S., Kurosawa, H., Takiguchi, M. and Seki, N. Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells. Genomics, 88, 52-64, 2006.
  58. Liu, T.-L., Shimada, H., Ochiai, T., Shiratori, T., Lin, S.-E., Kitagawa, M., Harigaya, K., Maki, M., Oka, M., Abe, T., Takiguchi, M. and Hiwasa, T. Enhancement of chemosensitivity toward peplomycin by calpastatin-stabilized NF-κB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism. Apoptosis, 11, 1025-1037, 2006.
  59. Tonouchi, A., Ohtsuka, M., Ito, H., Kimura, F., Shimizu, H., Kato, M., Nimura, Y., Iwase, K., Hiwasa, T., Seki, N., Takiguchi, M. and Miyazaki, M. (2006) Relationship between pancreatic secretory trypsin inhibitor and early recurrence of intrahepatic cholangiocarcinoma following surgical resection. Am. J. Gastroenterol. 101, 1601-1610.
  60. Adachi-Uehara, N., Kato, M., Nimura, Y., Seki, N., Ishihara, A., Matsumoto, E., Iwase, K., Ohtsuka, S., Kodama, H., Mizota, A., Yamamoto, S., Adachi-Usami, E. and Takiguchi, M. (2006) Up-regulation of genes for oxidative phosphorylation and protein turnover in diabetic mouse retina. Exptl. Eye Res. 83, 849-857.
  61. Kai, N., Iwase, K., Imai, K., Nakahira, E., Soma, M., Ohtsuka, S., Yagi, T., Kobayashi, K., Koga, H., Takiguchi, M. and Yuasa, S. (2006) Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as reverled by laser capture microdissection and mKIAA cDNA array analysis. Brain Res. 1073-1074, 60-70.
  62. Kawakami, K., Enokida, H., Tachiwada, T., Gotanda, T., Tsuneyoshi, K., Kubo, H., Nishiyama, K., Takiguchi, M., Nakagawa, M. and Seki, N. (2006) Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling. Oncol. Rep. 16, 521-531.
  63. 2007年
  64. Shimada, H., Kuboshima, M., Shiratori, T., Nabeya, Y., Takeuchi, A., Takagi, H., Nomura, F., Takiguchi, M., Ochiai, T. and Hiwasa, T. (2007) Serum anti-myogegalin antibodies in patients with esophageal squamous cell carcinoma. Int. J. Oncol. 30, 97-103.
  65. Kumazawa, T., Hiwasa, T., Takiguchi, M., Suzuki, O. and Sato, K. (2007) Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts. Int. J. Mol. Med. 19, 765-770.
  66. Ishihara, A., Matsumoto, E., Horikawa, K., Kudo, T., Sakao, E., Nemoto, A, Iwase, K., Sugiyama, H., Tamura, Y., Shibata, S. and Takiguchi, M. (2007) Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene Spot-14 in the mouse liver. J. Biol. Rhythms 22, 324-334.
  67. Shiratori, T., Shimada, H., Kagaya, A., Kuboshima, M., Nabeya, Y., Machida, T., Goto, K., Takiguchi, M., Ochiai, T. and Hiwasa, T. (2007) Sensitization against anticancer drugs by tranfection with UBE2I variant gene into ras-NIH3T3 mouse fibroblasts. Anticancer Res. 27, 3227-3234.
  68. 2008年
  69. Moriya, S., Takiguchi, M. and Seki, N. (2008) Expression of the WT1 gene-KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells. Int. J. Oncol. 32, 349-356.
  70. Iwadate, Y., Hayama, M., Adachi, A., Mausutani, T., Nagai, Y., Hiwasa, T. and Saeki, N. (2008) High serum level of plasminogen activator inhibitor-1 predicts histological grade of intracerebral gliomas. Anticancer Res. 28, 415-418.
  71. Fukasawa, S., Kino, M., Kobayashi, M., Suzuki, H., Komiya, A., Imamoto, T., Hirokawa, Y., Shiraishi, T., Takiguchi, M., Ishida, H., Shindo, T., Seki, N., and Ichikawa, T. (2008) Genetic changes in pT2 and pT3 prostate cancer detected by comparative genomic hybridization. Prostate Cancer Prostatic Dis. 11, 303-310.
  72. Tomizawa, M., Toyama, Y., Ito, C., Toshimori, K., Iwase, K., Takiguchi, M., Saisho, H., and Yokosuka, O. (2008) Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 333, 17-27.
  73. 2009年
  74. Dong, M., Chen, S., Kita, K., Ichimura, Y., Guo, W., Lv, S., Sugaya, S., Hiwasa, T., Takiguchi, M., Mori, N., Kashima, A., Morimura, K., Hirota, J. and Suzuki, N. (2009) Anti-proliferative and apoptosis-inducible activity of Sarcodonin G from Sarcodon scabrosus in Hela cells. Int. J. Oncol. 34, 201-207.
  75. Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H. and Takiguchi, M. (2009) Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. Int. J. Oncol. 34, 641-648.
  76. Sugiyama, H., Kumamoto, T., Suganami, A., Nakanishi, W., Sowa, Y., Takiguchi, M., Ishikawa, T. and Tamura, Y. (2009) Insight into estrogenicity of phytoestrogens using in silico simulation. Biochem. Biophys. Res. Commun. 379, 139-144.
  77. Matsushita, K., Tomonaga, T., Kajiwara, T., Shimada, H., Itoga, S., Hiwasa, T., Kubo, S., Ochiai, T., Matsubara, H. and Nomura, F. (2009) c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy. Front. Biosci. 14, 3401-3408.
  78. Zahed, M., Suzuki, T., Suganami, A., Sugiyama, H., Harada, K., Takiguchi, M., Tamura, Y. and Suzuki, N. (2009) Screening of SMB7-binding peptides by combination of phage display and docking simulation analysis. Protein & Peptide Lett. 16, 301-305.
  79. Shimada, H., Kagaya, A., Shiratori, T., Nomura, F., Takiguchi, M., Matsubara, H. and Hiwasa, T. (2009) Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma-possible new serum marker for esophageal cancer-. J. Gastroenterology 44, 691-696.
  80. Guo, W., Sugaya, S., Satoh, M., Tomonaga, T., Nomura, F., Hiwasa, T., Takiguchi, M., Kita, K. and Suzuki, N. (2009) Nm23-H1 is responsible for SUMO-2-involved DNA synthesis induction after X-ray irradiation in human cells. Arch. Biochemi. Biophys. 486, 81-87.
  81. Shinmen, N., Koshida, T., Kumazawa, T., Sato, K., Shimada, H., Matsutani, T., Iwadate, Y., Takiguchi, M. and Hiwasa, T. (2009) Activation of NFAT signal by p53-K120R mutant. FEBS Lett. 583, 1916-1922.
  82. Shimada, H., Shiratori, T., Yasuraoka, M., Kagaya, A., Kuboshima, M., Nomura, F., Takiguchi, M., Ochiai, T., Matsubara, H. and Hiwasa, T. (2009) Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma. BMC Cancer 9, MSNo.232.
  83. Moriya, Y., Iyoda, A., Kasai, Y., Sugimoto, T., Hashida, J., Nimura, Y., Kato, M., Takiguchi, M., Fujisawa, T., Seki, N. and Yoshino, I. (2009) Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer. Lung Cancer 64, 86-91.
  84. 2010年
  85. Koshida, T., Kitagawa, M., Iwase, K., Takiguchi, M. and Hiwasa, T. (2010) Stimulation of p53 transactivation ability by nicastrin in mouse fibroblasts. SRX Biology 2010, ID 606391.
  86. Matsumoto, E., Ishihara, A., Tamai, S., Nemoto, A., Iwase, K., Hiwasa, T., Shibata, S. and Takiguchi, M. (2010) Time-of-day and Nutrients in Feeding Govern Daily Expression Rhythms of the Gene for Sterol Regulatory Element-binding Protein (SREBP)-1 in the Mouse Liver. J. Biol. Chem. 285 (43), 33028-33036.
  87. 2011年
  88. Tumurkhuu, G., Koide, N., Hiwasa, T., Ookoshi, M., Dagvadorj, J., Noman, A.S., Iftakhar-E-Khuda, I., Naiki, Y., Komatsu, T., Yoshida, T. and Yokochi, T. (2011) ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 17(1), 97-105.
  89. Mori, M., Hosoya, M., Hiwasa, T., Hayakawa, S., Uzawa, A. and Kuwabara, S. (2011) Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica. Neurol. Sci. 32, 795-799.
  90. Nabeya, Y., Suzuki, T., Furuya, A., Koide, N., Ohkoshi, M., Takiguchi, M., Ochiai, T., Matsubara, H. and Hiwasa, T. (2011) Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells. Cancer Sci. 102(8), 1509-1515.
  91. Kagaya, A., Shimada, H., Shiratori, T., Kuboshima, M., Nakashima-Fujita, K., Yasuraoka, M., Nishimori, T., Kurei, S., Hachiya, T., Murakami, A., Tamura, Y., Nomura, F., Ochiai, T., Matsubara, H., Takiguchi, M. and Hiwasa, T. (2011) Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. Proteome Sci. 9, Article ID:31.
  92. Hiwasa, T., Utsumi, T., Yasuraoka, M., Hanamura, N., Shimada, H., Nakajima, H., Kitagawa, M., Iwadate, Y., Goto, K., Takeda, A., Ohtsuka, K., Ariga, H. and Takiguchi, M. (2011) Functional similarity of anticancer drugs by MTT bioassay. J Cancer Sci Ther, 3: 250-255.
  93. 2012年
  94. Shimada, H., Yajima, S., Oshima, Y., Hiwasa, T., Tagawa, M., Matsushita, K. and Nomura, F. Impact of serum biomarkers on esophageal squamous cell carcinoma. Esophagus 2012, 9, 131-140.
  95. Matsutani, T., Hiwasa, T., Takiguchi, M., Oide, T., Kunimatsu, M., Saeki, N. and Iwadate, Y. (2012) Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. J. Experiment. Clin. Cancer Res., 31, 85.
  96. 2013年
  97. Miyauchi, O., Iwase, K., Ito, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H. and Takiguchi, M. (2013) Efficient subtractive cloning of genes activated by lipopolysaccharide and interferonγ in the primary-cultured cortical cells of newborn mice. PLoS ONE, 8, e79236.
  98. 2014年
  99. Iwase, K., Ishihara, A., Yoshimura, S., Andoh, Y., Kato, M., Seki, N., Matsumoto, E., Hiwasa, T., Muller, D., Fukunaga, K. and Takiguchi, M. (2014) The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. J. Neurochem., 128, 233-245.
  100. Adachi-Hayama, M., Adachi, A., Shinozaki, N., Matsutani, T., Hiwasa, T., Takiguchi, M., Saeki, N. and Iwadate, Y. (2014) Circulating anti-filamin C antibody as a potential serum biomarker for low-grade gliomas. BMC Cancer 14, 452.
  101. Morii, S., Kato, M., Seki, N., Shinmen, N., Iwase, K., Takiguchi, M. and Hiwasa, T. (2014) Inhibition of Cell Growth by Nuclear Receptor COUP-TFI: possible involvement of decorin in growth inhibition. Biochem. Physiol., S4-001.
  102. 日和佐隆樹(2014)疾患抗体マーカーの開発.医学のあゆみー臨床プロテオミクス.251巻.953-957頁.
  103. 2015年
  104. Machida T, Kubota M, Kobayashi E, Iwadate Y, Saeki N, Yamaura A, Nomura F, Takiguchi M, Hiwasa T (2015) Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). J Translat Med 13: 71.
  105. Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E, Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chin H, Nishi E, Machida T, Iwata Y, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Katayama K, Kikkawa Y, Sunami K, Takizawa H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H, Hiwasa T(2015) Identification of cerebral infarction-specific antibody markers from autoantibodies detected in patients with systemic lupus erythematosus. J Mol Biomark Diagnos 6: 2.
  106. Shimada H, Ito M, Kagaya A, Shiratori T, Kuboshima M, Suzuki M, Liu TL, Nabeya Y, Matsubara H, Matsushita K, Nomura F, Takiguchi M, Hiwasa T(2015) Elevated serum antibody levels against cyclin L2 in patients with esophageal squamous cell carcinoma. J Cancer Sci Ther 7(2): 60-66.
  107. Kuroiwa N, Iwase K, Morii S, Takiguchi M, Hiwasa T(2015) Up-regulation of growth-inhibitory or tumor suppressive genes by overexpression of C/EBPα or C/EBPβ in ras-transformed NIH3T3 cells. Integr Mol Med 2(2): 150-157.
  108. Muto M, Mori M, Hiwasa T, Takiguchi M, Iwadate Y, Uzawa A, Uchida T, Masuda H, Sugimoto K, Kuwabara S (2015) Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies. J Neuroimmunol 284: 30-36.
  109. Hiwasa T, Iwase K, Suichi T, Hino Y, Kimura R, Shinmen N, Takiguchi M (2015) Identification of the p53-responsive element in the promoter region of the human decorin gene. Mol Biol 4: 1.
  110. Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa I, Wada T, Aotsuka A, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Goto K, Matsumura R, Sugiyama T, Takizawa H, Shimada H, Ito M, Wang H, Taira A, Arita E, Iwase K, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2015) Association of serum antibody levels against TUBB2C with diabetes and cerebral infarction. Gratis J Biomed Sci 1(2): 49-63.
  111. Hiwasa T, Machida T, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Mine S, Ohno M, Chen PM, Nishi E, Kitamura K, Yamazoe R, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Matsutani T, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Goto K, Matsumura R, Sugiyama T, Hayashi H, Hasegawa R, Shimada H, Ito M, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2015) Elevated levels of autoantibodies against ATP2B4 and BMP-1 in sera of patients with atherosclerosis-related diseases. Immunome Res 11: 097.
  112. Hirono S, Iwadate Y, Kambe M, Hiwasa T, Takiguchi M, Nakatani Y, Saeki N (2015) Role of Evaluating MGMT Status and 1p36 Deletion in Radiosurgery-Induced Anaplastic Ependymoma That Rapidly and Completely Resolved by Temozolomide Alone: Case Report and Review of the Literature. J Neurol Surg Rep 76(1): e43-7.
  113. Dong M, Hiwasa T, Cong B, Shi QW, Wang SM, Kita K, Sugaya S, Suzuki N (2015) Protein kinase Cα-mediated cyto-toxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells. Int J Oncol 47: 1939-1944.
  114. 2016年
  115. Kano M, Matsushita K, Rahmutulla B, Yamada S, Shimada H, Kubo S, Hiwasa T, Matsubara H, Nomura F (2015) Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams. Gene Ther 23(1): 50-56 .
  116. Hiwasa T, Zhang XM, Kimura R, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kamitsukasa I, Wada T, Aotsuka S, Mine S, Takizawa H, Kashiwado K, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2016) Elevated adiponectin antibody levels in sera of patients with atherosclerosis-related coronary artery disease, cerebral infarction, and diabetes mellitus. J Circ Biomark 5: 8.
  117. Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K (2016) Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients. Oncotarget 7(50): 82493-82503. doi: 10.18632/oncotarget.12696.
  118. 2017年
  119. Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Ema R, Amata A, Sakao S, Nagashima K, Tatsumi K, Hiwasa T (2017) Circulating anti-coatomer protein complex subunit epsilon (COPE) autoantibodies as a potential biomarker for cardio- and cerebro-vascular events in patients with obstructive sleep apnea. J Clin Sleep Med 13(3): 393-400. doi: 10.5664/jcsm.6488.
  120. Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N (2017) The pluripotent stem-cell marker alkaline phosphatase is highly expressed in refractory glioblastoma with DNA hypomethylation. Neurosurgery 80(2): 248-256. doi: 10.1093/neuros/nyw026.
  121. Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H, Kudo T, Doi H, Mine S, Machida T, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Iwata Y, Harada J, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kitamura K, Takizawa H, Kashiwado K, Shimada H, Ito M, Goto K, Zhang XM, Kimura R, Wang H, Taira A, Arita E, Ashino H, Iwase K, Hiwasa T (2017) An anti-deoxyhypusine synthase antibody as a marker of atherosclerosis-related cerebral infarction, myocardial infarction, diabetes mellitus, and chronic kidney disease. SM Atheroscler J 1(1): 1001. doi: http://smjournals.com/atherosclerosis/in-press.php#x
  122. Hiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine S, Machida T, Sato E, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Kitamura K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Sunami K, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ito M, Shimada H, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Goto K, Kudo T, Doi H (2017) Serum SH3BP5-specific antibody level is a biomarker of atherosclerosis. Immunome Res 13(2), 132. doi: 10.4172/17457580.1000132
  123. Chen PM, Ohno M, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka M, Kita T, Kimura T, Nishi E (2017) Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome. Int J Cardiol 243: 1-8.  doi.org/10.1016/j.ijcard.2017.04.047. PMID: 28747015
  124. 芦野洋美、向井克之、中島宏、横浜康継 (2017) 緑藻ヒトエグサ及びミル由来脂溶性成分による鶏胚漿尿膜上血管新生の抑制. 調査研究ジャーナル, 6(1), 21-28.
  125. 日和佐隆樹(2017)動脈硬化関連疾患の血清抗体マーカー.動脈・静脈の疾患(上).日本臨床,75巻,増刊号4,281-284頁.
  126. Sugimoto K, Tomiyoshi G, Mori M, Kuwabara S, Hirano S, Sawai S, Beppu M, Muto M, Uzawa A, Kitamura K, Takemoto M, Hattori A, Yamamoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Mine S, Machida T, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Kobayashi Y, Nakamura R, Shinmen N, Kuroda H, Wang H, Zhang XM, Hiwasa T (2017) Identification of serum anti-GADD34 antibody as a common marker of diabetes mellitus and Parkinson disease. J Alzheim Dis Parkins 7: 358. doi: 10.4172/2161-0460.1000358.
  127. Zhang XM, Wang H, Mine S, Takemoto M, Yokote K, Kitamura K, Kobayashi Y, Machida T, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Hiwasa T (2017) Association of serum anti-prolylcarboxypeptidase antibody marker with atherosclerotic diseases accompanied by hypertension. J Mol Biomark Diagn 8: 361. doi: 10.4172/2155-9929.1000361
  128. Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S (2017) Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors. Oncotarget 8(63): 106206-106221. PMID: 29290942. doi: 10.18632/oncotarget.22175.
  129. 2018年
  130. 日和佐隆樹(2018)動脈硬化症の血清抗体マーカーの開発.in silico創薬におけるスクリーニングの高速化・高精度化技術.(株)技術情報協会.483-491頁.
  131. Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Kamitsukasa I, Shin H, Wada T, Aotsuka A, Nishi E, Ohno M, Takemoto M, Yokote K, Takahashi S, Zhang XM, Takiguchi M, Iwadate Y (2018) Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack. Oncotarget 9(10): 8836-8848. doi.org/10.18632/oncotarget.23653.
  132. Wang H, Zhang XM, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kimura R, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Yoshida Y, Kobayashi E, Matsutani M, Iwadate Y, Sugimoto K, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Machida T, Takizawa H, Kashiwado K, Shimada H, Ito M, Goto K, Iwase K, Ashino H, Taira A, Arita E, Takiguchi M, Hiwasa T (2018) Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. Oncotarget 9: 5600-5613. doi.org/10.18632/oncotarget.23789.
  133. Kobayashi S, Hiwasa T, Arasawa T, Kagaya A, Ishii S, Shimada H, Ito M, Suzuki M, Kano M, Rahmutulla B, Kitamura K, Sawabe Y, Shin H, Takiguchi M, Nomura F, Matsubara H, Matsushita K (2018) Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library. Oncotarge 9(26): 18559-18569. doi: 10.18632/oncotarget.24963. PMID: 29719626.
  134. Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Tsushima K, Sakao S, Nagashima K, Iwata Y, Ozaki T, Nagase H, Tatsumi K, Hiwasa T, Kobayashi Y (2018) Autoantibody against NBL1 in obstructive sleep apnea patients with cardiovascular disease. PLoS ONE 13(3): e0195015. doi: 10.1371/journal.pone.0195015. PMID: 29596467.
  135. Yoshioka M, Matsutani T, Hara A, Hirono S, Hiwasa T, Takiguchi M, Iwadate Y (2018) Real-time methylation-specific PCR for the evaluation of methylation status of MGMT gene in glioblastoma. Oncotarget 9(45): 27728-27735. doi: 10.18632/oncotarget.25543. PMID: 29963232.
  136. Hamanaka S, Nakagawa T, Hiwasa T, Ohta Y, Kasamatsu S, Ishigami H, Taida T, Okimoto K, Saito K, Maruoka D, Matsumura T, Takizawa H, Kashiwado K, Kobayashi S, Matsushita K, Matsubara H, Katsuno T, Arai M, Kato N (2018) Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis. J Gastroenterol Hepatol, in press.
  137. Yoshida Y, Hiwasa T, Machida T, Kobayashi E, Mine S, Matsushima J, Takiguchi M, Iwadate Y (2018) Elevation of autoantibody in patients with ischemic stroke. Neurol Med Chir (Tokyo) 58(7): 303-310. doi: 10.2176/nmc.ra.2018-0022. PMID: 29848906.

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