業績

2018年 

  1. Kasuya Y, Umezawa H, Hatano M., Stress-Activated Protein Kinases in Spinal Cord Injury: Focus on Roles of p38. Int. J. Mol. Sci. 2018.19: 867
  2. Ogasawara T, Kohashi Y, Hatano M, Ikari J, Taniguchi T, Tsuruoka N, Watanabe-Takano H, Fujimura L, Sakamoto A, Hirata H, Fukushima Y, Fukuda T, Kurasawa K, Tatsumi K, Tokuhisa T, Arima M, TH2 response governed by Bcl6 function in naturally occurring memory phenotype CD4+ T cells. Front. Immunol., 2018.10 April 
  3. Chikada H, Ida K, Ando E, Inagaki Y, Sakamoto A, Kamiya A.Establishment and analyses of a mouse model that regulates sex-related differences in drug metabolism in the liver.  Laboratory Investigation. 2018.

        

2017

  1. Umezawa H, Naito Y, Tanaka K, Yoshioka K, Suzuki K, Sudo T, Hagihara M, Hatano M, Tatsumi K, Kasuya Y. Genetic and pharmacological inhibition of p38α improves locomotor recovery after spinal cord injury. Front. Pharmacol. (Neuropharmacol.) 2017  Feb 17, 8:72.
  2. Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K, Murayama T. Antifibrotic effects of cyclosporine A on TGF-β1–treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α. FASEB J 2017 in press (Published online before print April 26, 2017, doi: 10.1096/fj.201601357R).
  3.  Ogasawara T, Hatano M, Satake H, Ikari J, Taniguchi T, Tsuruoka T, Takano H, Fujimura L, Sakamoto A, Hirata H, Sugiyama K, Fukushima Y, Fukuda T, Kurasawa K, Tatsumi K, Tokuhisa T, Arima M. Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory Th2 cell. Proc Natl Acad Sci USA., 2017 Jan 31;114(5):E741-E750. 
  4. Shimazui T, Nakada TA, Fujimura L, Sakamoto A, Hatano M, Oda S. Development of Noninvasive In Vivo Approach to Assess Vascular Permeability in Inflammation Using Fluorescence Imaging. Shock. 2017 Dec 4. 
  5. Oami T, Watanabe E, Hatano M, Teratake Y, Fujimura L, Sakamoto A, Ito C, Toshimori K, Swanson PE, Oda S. Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model. Shock. 2017 Oct 25. 

 

2016

  1. Teratake Y, Kuga C,  Hasagewa Y, Sato Y, Kitahashi M, Fujimura L, Watanabe-Takano H, Sakamoto A, Arima M, Tokuhisa T, Hatano M. Transcriptional repression of p27 is essential for murine embryonic development.  Scientific Reports. 2016. online at www.nature.com/articles/srep26244.
  2. Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, Fukamizu A. Severe hypomyelination and developmental defects are caused in mice lacking protein arginine methyltransferase 1 (PRMT1) in the central nervous system. J. Biol. Chem. 2016. 291:2237-2245.
  3. Fujita T, Yoshioka K, Umezawa H, Tanaka K, Naito Y, Nakayama T, Hatano M,Tatsumi K, Kasuya Y. Role of CD69 in the pathogenesis of elastase-induced pulmonary inflammationand emphysema. Biochem Biophys Rep. 2016. 7:400-407.
  4. Oami T, Watanabe E, Hatano M, Sunahara S, Fujimura L, Sakamoto A, Ito C, Toshimori K, Oda S. Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model. Crit Care Med. 2016 Sep 9. [Epub ahead of print]
  5. Saito T, Sakamoto A, Hatano M, Iwai J, Higashimoto Y, Yoshida H. Systemic and local cytokine profile in biliary atresia. Eur J Pediatr Surg 2016 Sep 16. [Epub ahead of print]
  6. Hosokawa J, Suzuki K, Meguro K, Tanaka S, Maezawa Y, Suto A, Fujimura L, Sakamoto A, Clevaers H, Ohara O, Nakajima H. IkBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2. J Allergy Clin Immunol. 2016. Dec 21;7:2050.

 

2015

  1. Hashimoto M, Sato T, Muroyama Y, Fujimura L, Hatano M, Saito T. Nepro is localized in the nucleolus and essential for preimplantation development in mice.  Dev Growth Differ. 2015. 57(7):529-38.
  2. Watanabe-Takano H, Takano K, Hatano M, Tokuhisa T, Endo T. DA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 Cells. PLoS One. 2015. 10: e0127888.
  3. Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F. Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 2015. 6:5102-5117.
  4. Kim JD, Park KE, Ishida J, Kako K, Hamada J, Kani S, Takeuchi M, Namiki K, Fukui H, Fukuhara S, Hibi M, Kobayashi M, Kanaho Y, Kasuya Y, Mochizuki N, Fukamizu A. PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Sci. Adv. 2015. 1:e1500615.
  5. Kobayashi T, Tanaka K, Fujita T, Umezawa H, Amano H, Yoshioka K, Naito Y, Hatano M, Kimura S, Tatsumi K, Kasuya Y. Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis. 2015. Respir. Res. 16:99.
  6. Yoshioka K, Namiki K, Sudo T, Kasuya Y. p38α controls self–renewal and fate decision of neurosphere–forming cells in adult hippocampus. FEBS Open Bio. 2015. 5:437-444.
  7. Meguro, K, Suzuki, K, Hosokawa, J, Sanayama, Y, Tanaka, S, Furuta, S, Ikeda, K, Takatori, H, Suto, A, Sakamoto, A, Ohara, O, Nakajima, H. Roles of B Cell Leukemia/Lymphoma 3 in the development of T follicular helper cells and the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatology 2015. 2. doi: 10.1002/art.39266.

 

2014

  1. Watanabe-Takano H, Takano K, Sakamoto A, Matsumoto K, Tokuhisa T, Endo T, Hatano M. DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation. Proc Natl Acad Sci USA., 2014. 111, E2291-E2300.
  2. Ikari J, Inamine A, Yamamoto T, Watanabe-Takano H, Yoshida N, Fujimura L, Taniguchi T, Sakamoto A, Hatano M, Tatsumi K, Tokuhisa T, Arima M. Plant homeodomain finger protein 11 promotes class switch recombination to IgE in murine activated B cells. Allergy 2014. 69, 223-230.
  3. Naito Y, Yoshioka K, Tanaka K, Tatsumi K, Kimura S, Kasuya Y. Endothelin B receptor-mediated encephalopathic events in mouse sepsis model. Life Sci. 2014. 118:340-346.
  4. Tanaka K, Yoshioka K, Tatsumi K, Kimura S, Kasuya Y. Endothelin regulates function of IL-17-producing T cell subset.Life Sci. 2014. 118:244-247.
  5. Tanaka K, Fujita T, Umezawa H, Namiki K, Yoshioka K, Hagihara M, Sudo T, Kimura S, Tatsumi K, Kasuya Y. Therapeutic effect of lung mixed culture-derived epithelial cells on lung fibrosis. Lab. Invest.2014. 94:1247-1259.
  6. Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y. p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease. J. Recept. Signal Transduct. 2014. 34:299-306.

 

2013

  1. Takahashi W, Watanabe E, Fujimura L, Watanabe-Takano H, Yoshidome H, Swanson PE, Tokuhisa T, Oda S, Hatano M. Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis. Crit Care 2013. 17, R160.
  2. Kamoda H, Ohtori S, Ishikawa T, Miyagi M, Arai G, Suzuki M, Sakuma Y, Oikawa Y, Kubota G, Orita S, Eguchi Y, Yamashita M, Yamauchi K, Inoue G, Hatano M, Takahashi K. The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model. J Bone Joint Surg Am.,2013. 95, 1109-1116.
  3. Ito C, Yamatoya K, Yoshida K, Fujimura L, Hatano M, Miyado K, Toshimori K. Integration of the mouse sperm fertilization-related protein equatorin into the acrosome during spermatogenesis as revealed by super-resolution and immunoelectron microscopy. Cell Tissue Res.,2013. 352, 739-750.
  4. Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, Matsuo O. Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production. Life Sci.,2013. 93, 89-95.
  5. Tsuruoka N, Arima M, Yoshida N, Okada S, Sakamoto A, Hatano M, Satake H, Arguni E, Wang JY, Yang JH, Nishikura K, Sekiya S, Shozu M, Tokuhisa T. ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells. J Biol Chem.,2013. 288, 826-836.
  6. Huang J, Li X, Kohno K, Hatano M, Tokuhisa T, Murray PJ, Brocker T, Tsuji M. Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J Immunol Methods 2013. 387, 254-61.
  7. Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma. Yamamoto N, Kinoshita T, Nohata N, Yoshino H, Itesako T, Fujimura L, Mitsuhashi A, Usui H, Enokida H, Nakagawa M, Shozu M, Seki N. Int J Oncol. 2013. 43(6):1855-63.

 

2012

  1. Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, Higashiyama S. BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis. Blood 2012. 119, 2688-2698.
  2. Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, Kasuya Y. Mechanism for p38α-mediated experimental autoimmune encephalomyelitis. J. Biol. Chem. 2012. 287:24228-24238.
  3. Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Matsunaga H, Iwamura C, Nakayama T, Tatsumi K. Role of CD69 in acute lung injury. Life Sci. 2012. 90:657-665.
  4. Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N. Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.  Int J Oncol. 2012. 40(6):1770-8.
  5. Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Watanabe-Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N. Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma. Biochem Biophys Res Commun. 2012. 418(2):378-83.
  6. Fujimura L, Hatano M. Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells. Methods Mol Biol. 2012. 839:173-85.
  7. Kinoshita T, Nohata N, Yoshino H, Hanazawa T, Kikkawa N, Fujimura L, Chiyomaru T, Kawakami K, Enokida H, Nakagawa M, Okamoto Y, Seki N. Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. Int J Oncol. 2012. 40(1):185-93.
  8. Shigeta A, Tada Y, Wang JY, Ishizaki S, Tsuyusaki J, Yamauchi K, Kasahara Y, Iesato K, Tanabe N, Takiguchi Y, Sakamoto A, Tokuhisa T, Shibuya K, Kirishima K, West J, Tatsumi K. CD40 amplifies Fas-mediated apoptosis: A mechanism contributing to emphysema. American J. Physiology-Lung Cellular and Molecular Physiology 2012. 303:L141-L151.

 

2011

  1. Ohtsuka H, Sakamoto A, Horigome S, Ichii H, Arima M, Hatano M, Okada S, Tokuhisa T. Bcl6 is required for the development of mouse CD4+ and CD8a+ dendritic cells. J Immunol. 2011. 186, 255-263.
  2. Seto T, Yoshitake M, Ogasawara T, Ikari J, Sakamoto A, Hatano M, Hirata H, Fukuda T, Kuriyama T, Tatsumi K, Tokuhisa T, Arima M. Bcl6 in pulmonary epithelium coordinately controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation. Clin Exp Allergy 2011. 41, 1568-1578.
  3. Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Takano H, Hatano M, Koike T, Tokuhisa T. CXCR4 expression on activated B cells is downregulated by CD63 and IL21. J Immunol. 2011. 186, 2800-2808.
  4. Yamauchi K, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Ishizaki S, Matsunaga H, Iwamura C, Nakayama T, Tatsumi K. Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir. Res. 2011. 12:131.
  5. Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet. 2011. 56(8):595-601.

 

2010

  1. Otaki JM, Hatano M, Matayoshi R, Tokuhisa T, Yamamoto H. The proto-oncogene BCL6 promotes survival of olfactory sensory neurons. Develop Neurobiol., 2010. 70, 434-435.
  2. Ohta, Y., Fujimura, L., Nishio, S., Arima, M., Sakamoto, A., Shimada, H., Ochiai, T., Tokuhisa, T. and Hatano, M. A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism. Int. J. Oncol., 2010. 36, 427-434.
  3. Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N, Kasuya Y. N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis. J. Biol. Chem. 2010. 285:33294-33306.
  4. MiyauchiY, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J.Exp.Med. 2010. 207:751-762.

 

2009

  1. Kato Y, Miyahara K, Hatano M, Hasegawa Y, Seki T, Frykman PK, Kusafuka J, Lane GJ, Yamataka A. Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice. Pediatr Surg Int., 2009. 25, 961-965.
  2. Fujimura L., Takano-Watanabe, H., Sato, Y., Tokuhisa, T. and Hatano, M. Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. Neuroscience Lett., 2009. 467, 6-10.

 

2008

  1. Wakashin H, Hirose K, Maezawa Y, Kagami SI, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I. Nakajima H. IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice.  Am. J. Resp. Crit. Care Med., 2008. 178, 1023-1032.
  2. Ouchida R, Yamasaki S, Hikida M, Masuda K, Kawamura K, Wada A, Mochizuki S, Tagawa M, Sakamoto A, Hatano M, Tokuhisa T, Koseki H, Saito T, Kurosaki T, Wang Ji-Y. A lysozomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta degradation. Immunity, 2008. 29, 33-43.
  3. Saito T, Kitayama D, Sakamoto A, Tsuruoka N, Arima M, Hatano M, Miyazaki M, Tokuhisa, T. A distinct role for IL-4 and IL-21 in their collaboration on proliferation and differentiation of activated B cells. Immunobiol.,2008. 213, 545-555.
  4. Kitayama D, Sakamoto A, Tsuruoka N, Arima M, Hatano M, Miyazaki M, Tokuhisa, T. A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21. Mol. Immunol.,2008. 45, 1337-1345.
  5. Abe R, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Watanabe E, Nakada T, Hatano M, Tokuhisa T. Up-regulation of interleukin-10 messenger RNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients. J. Surg. Res.,2008. 147, 1-8.
  6. Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol. Cell 2008. 32:221-231.
  7. Asada S, Ikeda A, Nagao R, HamaH., SudoT, FukamizuA, Kasuya Y, Kishi T. Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFb-TrCP ubiquitin ligase. Int. J. Mol. Med. 2008. 22:95-104.
  8. Furuya, M, Ishida J, Inaba S, Kasuya Y, Kimura S, Nemori R, Fukamizu A.  Impaired placental neovascularization in mice with pregnancy-associated hypertension. Lab. Invest. 2008. 88:416-429.
  9. Ouchida,R, Ukai,A, Mori,H, Kawamura,K, Dolle,MET, Tagawa,M, Sakamoto,A, Tokuhisa,T, Yokosuka,T, Saito,T, Yokoi,M, Hanaoka,F, Vijg,J, Wang,J. Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations. DNA Repair  2008. 7:1392-1398.

 

2007

  1. Tsuruoka N, Arima M, Arguni E, Saito T, Kitayama D, Sakamoto A, Hatano M, Tokuhisa T. Bcl6 protects apoptosis of naive B cells stimulated with IL-21.  Immunol. Lett., 2007. 110, 145-151.
  2. Kobayashi H, Kusafuka J, Lane GJ, Yamataka A, Satoh K, Hayakawa T, Kase Y, Hatano M. The mechanism of intestinal motility in homozygous mutant Ncx/Hox11L.1-deficient mice--a model for intestinal neuronal dysplasia. J. Pediatr. Surg., 2007. 42, 2062-2066.
  3. Ichii H, Sakamoto A, Arima M, Hatano M, Kuroda Y, Tokuhisa T. Bcl6 is essential for the generation of long-term memory CD4+ T cells. Int. Immunol.,2007. 19, 427-433.
  4. Kitahashi M, Sato Y, Fujimura L, Ozeki C, Arima M, Sakamoto A, Yamamoto S, Tokuhisa T, Hatano M. Identification of the consensus DNA sequence for Nczf-binding. DNA Cell Biol.,2007. 26, 395-401.
  5. Aoki T, Jusuf AA, Iitsuka Y, Isono K, Tokuhisa T, Hatano M. Ncx (Enx, Hox11L.1) is required for the neuronal cell death in enteric ganglia of mice. J. Pediatr. Surg.,2007. 42, 1081-1088.
  6. Furuya M, Suyama T, Usui H, Kasuya Y, Nishiyama M, Tanaka N, Ishiwata I, Nagai Y, Shozu M, Kimura S. Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis. Human Pathol. 2007. 38:1676-1687.
  7. Namiki K, Nakamura A, Furuya M, Mizuhashi S, Matsuo Y, Tokuhara N, Sudo T, Hama H, Kuwaki T, Yano S, Kimura S, Kasuya Y. Involvement of p38α in kainate-induced seizure and neuronal cell damage. J Recept. Signal Transduct. 2007. 27:99-111.
  8. Hasegawa M, Furuya M, Kasuya Y, Nishiyama M, Sugiura T, Nikaido T, Momota Y, Ichinose M, Kimura S. CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity. Lab. Invest.2007. 87:882-892.
  9. Asada S, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Daitoku H, Kako K, Kishi T, Kasuya Y, Fukamizu A. Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell. Signal. 2007. 19:519-527.
  10. Khiong K, Murakami M, Kitabayashi C, Ueda N, Sawa S, Sakamoto A, Kotzin BL, Rozzo SJ, Ishihara K, Verella-Garcia M, Kappler J, Marrack P, Hirano T. Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model. J.Clinic.Invest. 2007. 117:1270-1281.

 

2006

  1. Yoshida K, Sakamoto A, Yamashita K, Arguni E, Horigome S, Arima M, Hatano M, Seki N, Ichikawa T. Tokuhisa T. Bcl6 controls granzyme B expression in effector CD8+ T cells. Eur. J. Immunol., 2006. 36, 3146-3156.
  2. Tamachi T, Maezawa Y, Ikeda K, Kagami S, Hatano M, Seto Y, Suto A, Suzuki K, Watanabe N, Saito Y, Tokuhisa T, Iwamoto I. Nakajima H. IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J. Allergy Clin. Immunol.,2006. 118, 606-614.
  3. Takamori Y, Matsudo Y, Fujimura L, Kang M, Harada Y, Moriya H, Tokuhisa T, Hatano M. Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level. Int. J. Mol. Med., 2006. 18, 963-967.
  4. Maeda Y, Fujimura L, 0-Wang J, Hatano M, Sakamoto A, Arima M, Ebara M, Ino H, Yamashita T, Saisho H, Tokuhisa T. Role of Clast1 in differentiation of cerebellar granule cells. Mol. Brain Res.,2006. 1104, 18-26.
  5. Matsudo Y, Takamori Y, Fujimura L, Nishio S, Sasagawa K, Komuro I, Tokuhisa T, Hatano M. Overexpression of Nd1, a novel Ketch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy. Transgenic Res., 2006.15, 573-581.
  6. Arguni E, Arima M, Tsuruoka N, Sakamoto A, Hatano M, Tokuhisa T. JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells. Int, Immunol., 2006. 18,1079-1089.
  7. Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y. Involvement of p38α mitgen-activated protein kinase in lung metastasis of tumor cells. J. Biol. Chem. 2006. 281:36767-36775.
  8. Ukai A, Maruyama T, Mochizuki S, Ouchida R, Masuda K, Kawamura K, Tagawa M, Kinoshita K, Sakamoto A, Tokuhisa T, O-Wang J.Role of DNA polymerase q in tolerance of endogenous and exogenous DNA damage in mouse B cells. Genes to Cells 2006. 11: 111-121.

 

2005

  1. Nakada T, Hirasawa H, Oda S, Shiga H, Matsuda K, Watanabe E, Abe R, Hatano M, Tokuhisa T. Not toll-like receptor 4 nor CD14 polymorphysms but tumore necrosis factor and interleukin-10polymorphysms attenuate survival from sepsis in Japanese critically ill patients.  J. Surg. Res., 2005.129: 322-328.
  2. Chandrasekar B, Mummidi S, Valente AJ, Patel DN, Bailey SR, Freeman GL, Hatano M, Tokuhisa T, Jensen LE. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, IRAK,TRAF6, c-Src, PI3K, Akt, JNK, and AP-1 signaling.  J. Biol. Chem.,2005. 280: 26263-26277.
  3. Ohkubo Y, Arima M, Arguni E, Okada S, Yamashita K, Asari S, Obata S, Sakamoto A, Hatano M, O-Wang J, Ebara M, Saisho H, Tokuhisa T. A role for c-Fos/AP-1 in B lymphocyte terminal differentiation.  J. Immunol., 2005. 174: 7703-7710.
  4. Kawakami H, Tomita M, Matsuda T, Ohta T, Tanaka Y, Fujii M, Hatano M, Tokuhisa T, Mori N. Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax.  Int. J. Cancer,2005. 115: 967-974.
  5. Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T. Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through induction of P53 and activation of JNK.  J. Clin. Invest.,2005. 115: 910-918.
  6. Watanabe E, Hirasawa H, Oda S, Matsuda K, Hatano M, Tokuhisa T. The Extremely High Interleukin-6 Blood Levels and Outcome in the Critically Ill Are Associated with Tumor Necrosis Factor- and Interleukin-1-Related Gene Polymorphisms. Crit. Care Med., 2005. 33: 89-97.
  7. Asari S, Sakamoto A, Okada S, Ohkubo Y, Arima M, Hatano M, Kuroda K, Tokuhisa T. Abnormal erythroid differentiation in neonatal Bcl6-deficient mice.  Exp. Hematol.,2005. 33: 26-34.
  8. Inoue A, Kang M, Fujimura L, Takamori Y, Sasagawa K, Itoh H, Tokuhisa T, Hatano M. Overexpression of Nd1-S, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts. DNA Cell Biol., 2005. 24: 30-34.
  9. Yamashita K, Sakamoto A, Ohkubo Y, Arima M, Hatano M, Kuroda K, Tokuhisa T. C-fos overexpression in splenic B cells augments development of marginal zone B cells.  Mol. Immunol., 2005. 42: 617-625.
  10. Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A. Neurochondrin negatively regulates CaMKII phosphorylation and nervous system specific gene disruption results in epileptic seizure. J. Biol. Chem. 2005. 280: 20503-20508.
  11. Suyama T, Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ichikawa T, Ueda T, Nikaido T, Ito H, Ishikura H. Up-regulation of the interferon γ (IFN-γ)-inducible chemokines IFN-inducible T-cell α chemoattractant and monokine induced by IFN-γ and of their receptor CXC receptor 3 in human renal cell carcinoma. Cancer-Am. Cancer Soc. 2005. 103:258-267.
  12. Kusunoki T, Sugai M, Gonda H, Nambu Y, Nagata-Nakajima N, Katakai T, Kusunoki M, Sakamoto A, Tokuhisa T, Nakahata T, Yokota Y, Shimizu A.CpG inhibits IgE class switch recombination through suppression of NFkB activity, but not through Id2 or Bcl6. Biochem. Biophys. Res. Commun.2005. 328:499-506.
  13. Kobayashi K, Yokote K, Fujimoto M, Yamashita K, Sakamoto A, Kitahara M, Kawamura H, Maezawa Y, Asaumi S, Tokuhisa T, Mori S, Saito Y.Targeted disruption of TGF-b-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury. Circ.Res. 2005. 96:904-912.

 

2004

  1. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. Role of autophagy during the early neonatal starvation period. Nature,2004. 432: 1032-1036.
  2. Mori S, Sakamoto A, Yamashita K, Fujimura L, Arima M, Hatano M, Miyazaki M, Tokuhisa T. Effect of c-fos overexpression on development and proliferation of peritoneal B cells. Int. Immunol.,2004. 16: 1477-1486.
  3. Fujimura L, Matsudo Y, Kang M, Takamori Y, Tokuhisa T, Hatano M. Protective role of Nd1 in doxorubicin-induced cardiotoxicity. Cardiovasc. Res., 2004. 64: 315-321.
  4. Takamor, M, Hatano M, Arima M, Sakamoto A, Fujimura L, Hartatik T, Kuriyama T, Tokuhisa T. BAZF is required for activation of naive CD4 T cells by TCR-triggering. Int. Immunol., 2004. 16 :1439-1449.
  5. Yanai T, Kobayashi H, Yamataka A, Lane GJ, Miyano T, Hayakawa T, Satoh K, Kase Y, Hatano M. Acetylcholine-related bowel dysmotility in homozygous mutant NCX/HOX11L.1-deficient (NCX-/-) mice-evidence that acetylcholine is implicated in causing intestinal neuronal dysplasia. J Pediatr Surg. 2004. 39: 927-930.
  6. Asari S, Okada S, Ohkubo Y, Sakamoto A, Arima M, Hatano M, Kuroda Y, Tokuhisa T. Early erythropoiesis in the bone marrow and spleen after stem cell transplantation. Transplantation, 2004. 78: 516-523.
  7. Kawamura K, O-Wang J, Ogawa R, Bahar R, Seimiya M, Chiyo M, Wada A, Okada S, Hatano M, Tokuhisa T, Kimura H, Watanab, S, Honda I , Sakiyama S, Tagawa M. DNA polymerase ? is preferentially expressed in lymphoid tissues and upregulated in human cancers. Eur. J. Immunol., 2004. 34: 1322-1332.
  8. Seimiya M, Wada A, Kawamura K, Sakamoto A, Ohkubo Y, Okada S, Hatano M, Tokuhisa T, Watanabe T, Saisho H, Tagawa M, O-Wang J. Impaired lymphocyte development and function in Clast5/Stra13/DEC1 transgenic mice . Int. J. Cancer, 2004. 109: 9-16.
  9. Irukayama-Tomobe Y, Miyauchi T, Kasuya Y, Sakai S, Goto K, Yamaguchi I.  Activation of peroxisome proliferator-activated receptor-α decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes. J. Cardiovasc. Pharmacol. 2004. 44:S358-361.
  10. Sakurai K, Matsuo Y, Sudo T, Takuwa Y, Kimura S, Kasuya Y. Role of p38 mitogen-activated protein kinase in thrombus formation. J. Recept. Signal Transduct 2004. 24:283-296.
  11. Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, Sugaya T, Matsuzaki H, Yamamoto R, Shiota N, Okunishi H, Kihara M, Umemura S, Sugiyama F, Yagami K, Kasuya Y, Mochizuki N, Fukamizu A. Regulatory roles for APJ, a seven-transmembrane receptor related to AT1, in blood pressure in vivo. J. Biol. Chem. 2004. 279:26274-26279.
  12. Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I. Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway. Circulation 2004. 109:904-910.
  13. Ichii H, Sakamoto A, Kuroda Y, Tokuhisa T.Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells.. J.Immunol. 2004. 173: 883-891.

 

2003

  1. Okada S, Obata S, Hatano M, Tokuhisa T. Dominant negative effect of the c-fos family gene products on inducible nitric oxide synthase expression in macrophages. Int. Immunol., 2003. 15: 1275-1285.
  2. Honda K, Arima M, Cheng G, Taki S, Hirata H, Eda F, Fukushima F, Yamaguchi B, Hatano M, Tokuhisa T, Fukuda T. Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine. J. Exp. Med., 2003. 198: 533-543.
  3. Takeda N, Arima M, Tsuruoka N, Okada S, Hatano H, Sakamoto A, Kohno K, Tokuhisa T. Bcl6 Is a Transcriptional Repressor for the IL-18 Gene.  J. Immunol., 2003. 171:426-431.
  4. Takenaga M, Hatano M, Yamashita Y, Okada S, Kuroda Y, Tokuhisa T. Bcl6-dependent transcriptional repression by BAZF. Biochem. Biophys. Res. Commun., 2003. 303: 600-608.
  5. Obata S, Okada S, Ohkubo Y, Murasawa M, Hatano M, Sekiya S, Tokuhisa T. Overexpression of the c-fos gene perturbs functional maturation of M1 cells into macrophages.  Mol. Immunol., 2003. 39: 585-594.
  6. Utani A, Momota Y, Endo H, Kasuya Y, Beck K, Suzuki Y, Nomizu M, Shinkai H.  Laminin α3 LG4 module induces matrix metalloproteinase-1 through mitogen-activated protein kinase signaling.J. Biol. Chem. 2003. 278:34483-34490.
  7. Kayaba Y, Nakamura A, Kasuya Y, Ohuchi T, Yanagisawa M, Komuro I, Fukuda Y, Kuwaki T. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am. J. Physiol.-Regul. Integr. Comp. Physiol.2003. 285:R581-R593.

 

2002

  1. Sasagawa K, Matsudo Y, Kang M, Fujimura L, Iitsuka Y, Okada S, Ochiai T, Tokuhisa T, Hatano M. Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments.  J. Biol. Chem., 2002. 277: 44140-44146.
  2. Bahar R, O-Wang J, Kawamura K, Seimiya M, Wang Y, Hatano M, Okada S, Tokuhisa T, Watanabe T, Tagawa M. Growth retardation, polyploidy and multinucleation induced by Clast3, a novel cell cycle-regulated protein.  J. Biol. Chem., 2002. 277: 40012-40019.
  3. Nakagawa Y, Okada O, Hatano M, Ebara M, Saisho H, Tokuhisa T. Downregulation of bcl-xL is relevant to UV-induced apoptosis in fibroblasts.  J. Biochem. Mol. Biol. 2002. 35: 452-458.
  4. Toyama H, Okada S, Hatano M, Takahashi Y, Takeda N, Ichii H, Takemori T, Kuroda Y, Tokuhisa T. Memory B cells without somatic hypermutation are generateded from Bcl6-deficient B cells.  Immunity, 2002. 17: 329-339.
  5. Arima M, Toyama H, Ichii H, Kojima S, Okada S, Hatano M, Cheng G, Kubo M, Fukuda T, Tokuhisa T. A Putative Silencer Element in the IL-5 Gene Recognized by Bcl6.  J. Immunol., 2002. 169: 829-836.
  6. Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, Arima M, Kuroda Y, Tokuhisa T. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nature Immunol., 2002. 3: 558-563.
  7. Hikita S, Hatano M, Inoue A, Sekita N, Kobayashi K, Ohtaki M, Ogasawara T, Okada S, Hirasawa H, Tokuhisa T. Overexpression of TIAP/m-survivin in thymocytes enhances cell proliferation.  Mol. Immunol., 2002. 39: 289-298.
  8. Seimiya M, Bahar R, Wang Y, Kawamura K, Tada Y, Okada S, Hatano M, Tokuhisa T, Saisho H, Watanabe T, Tagawa M, O-Wang J. Clast5/Stra13 is a negative regulator of B lymphocyte activation.  Biochem. Biophys. Res. Commun., 2002. 292: 121-127.
  9. Murasawa M, Okada S, Obata S, Hatano M, Moriya H, Tokuhisa T. GL7 defines the cycling stage of pre-B cells in murine bone marrow. Eur. J. Immunol., 2002. 32: 291-298.
  10. 10. Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. Essential role of p38 mitogen-activated protein kinase  in contact hypersensitivity. J. Biol. Chem. 2002. 277:37896-37903.
  11. Murakami M, Sakamoto A, Bender J, Kappler J, Marrack P. CD25+CD4+ T cells contribute to the control of  memory CD8+ T cells. Proc.Natl.Acad.Sci.USA 2002. 99:8832-8837.

 

2001

  1. Narita M, Bahar R, Hatano M, Kang M, Tokuhisa T, Goto S, Saisho H, Sakiyama S, Tagawa M. Tissue-specific expression of a suicide gene for selective killing of neurob lastoma cells using a promoter region of the NCX gene.  Cancer Gene Ther., 2001. 8: 997-1002.
  2. Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, Mano H, Hirasawa H, Tokuhisa T. Isoform-dependent interaction of BRDG1 with Tec kinase. Biochem. Biophys. Res. Commun., 2001. 289: 414-420.
  3. Zhang H, Okada S, Hatano M, Okabe S, Tokuhisa T. A novel functional domain of Bcl6 family that recruits histone deacethylases. Biochim. Biophys. Acta, 2001. 1540: 188-200.
  4. Kang M, Matsudo Y, Sasagawa K, Tokuhisa T, Hatano H. Nd1, a novel murine Kelch family protein, may play a role as a housekeeping gene.  Biochim. Biophys. Acta, 2001. 1519: 167-174.
  5. Takanami-Ohnishi Y, Asada S, Tsunoda H, Fukamizu A, Goto K, Yoshikawa H, Kubo T, Sudo T, Kimura S, Kasuya Y. Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition. Biochem. Biophys. Res. Commun. 2001.288:1155-1161.
  6. Oishi Y, Sumida T, Sakamoto A, Kita Y, Kurasawa K, Nawata Y, Takabayashi K, Takahashi H, Yashida S, Taniguchi M, Saito Y, Iwamoto I. Selective reduction and recovery of invariant Va24 JaQ T cell receptor T cells in correlation with disease activity in patients with systemic lupus erythematosus. J.Rheumatol. 2001. 28:275-283.

 

  

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