業績

 
 
 

[2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001] [2000] [1999] [1998] [1997]

 

2018年

  • Mita, Y., Kimura, M.Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y., and Nakayama, T. : Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-in ltrating T cells. Int Immunol. In Press.(2018).
  • Ihara, F., Sakurai, D., Yonekura, S., Iinuma, T., Yagi, R., Sakurai, T., Ito, T., Matsuura, A., Morimoto, Y., Arai, T., Suzuki, S., Katayama, K., Nakayama, T., and Okamoto, Y. : Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Allergy. 73(9):1823-1832 (2018).
  • Sakurai, D., Uchida, R., Ihara, F., Kunii, N., Nakagawa, T., Chazono, H., Hanazawa, T., Motohashi, S., and Okamoto, Y. : Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells. BMC Res Notes. 16;11(1):479 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H. and Motohashi, S. : Invariant natural killer T infiltration in neuroblastoma with favorable outcome. Pediatr Surg Int. 34(2):195-201 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H. and Motohashi, S. : Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors. Pediatr Surg Int. 34(2):169-176 (2018).
  • Kawashima, T., Ikari, N., Watanabe, Y., Kubota, Y., Yoshio, S., Kanto, T., Motohashi, S., Shimojo, N. and Tsuji, N.M. : Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-β from Human Dendritic Cells. Front Immunol. 9:27 (2018).

 

2017年

      • Ihara, F., Sakurai, D., Horinaka, A., Fujisawa, A., Makita, Y., Sakurai, T., Yamasaki, K., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma. Cancer Immunol Immunother. 66(10):1275-85 (2017).
      • Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S. and Nakayama, T. : Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol Rev. 278(1):87-100 (2017).

 

2016年

        • Kamata, T., Suzuki, A., Mise, N., Ihara, F., Takami, M., Makita, Y., Horinaka, A., Harada, K., Kunii, N., Yoshida, S., Yoshino, I., Nakayama, T. and Motohashi, S. : Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells. Cancer Immunol Immunother. 65(12):1477-89 (2016).
        • Kimura, M. Y., Thomas, J., Tai, X., Guinter, T. I., Shinzawa, M., Etzenperger, R., Li, Z., Love, P., Nakayama, T. and Singer, A. : Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors. Nat Immunol. 17:1415-1423 (2016).
        • Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y. and Nakayama, T. : Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci Immunol. 1(3):eaaf9154 (2016).
        • Aoki, T., Hino, M., Koh, K., Kyushiki, M., Kishimoto, H., Arakawa, Y., Hanada, R., Kawashima, H., Kurihara, J., Shimojo, N. and Motohashi, S. : Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers. Pediatr Blood Cancer. 63(8):1461-4 (2016).
        • Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. and Nakayama, T. : Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 7:11289 (2016).
        • Mise, N., Takami, M., Suzuki, A., Kamata, T., Harada, K., Hishiki, T., Saito, T., Terui, K., Mitsunaga, T., Nakata, M., Ikeuchi, T., Nakayama, T., Yoshida, H. and Motohashi, S. : Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant NKT cells. Cancer Sci. 107(3):233-241 (2016).
        • Horinaka, A., Sakurai, D., Ihara, F., Makita, Y., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer. Cancer Sci. 107(3):207-16 (2016).

 

2015年

      • Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J, Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. and Nakayama, T. : Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells. J Biol Chem. 290(21):13095-103 (2015).
      • Pobezinsky, L. A., Etzensperger, R., Jeurling, S., Alag, A., Kadakia, T., McCaughtry, T. M., Kimura, M. Y., Sharrow, S. O., Guinter, T. I., Feigenbaum, L. and Singer, A. : Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nat Immunol. 16:517-24 (2015).
      • Frigault, M. J., Lee, J., Basil, M., Carpenito, C., Motohashi, S., Scholler, J., Kawalekar, O. U., Guedan, S., McGettigan, S., Posey, A Jr., Ang, S., Cooper, L. J., Platt, J. M., Johnson, F. B., Paulos, C. M., Zhao, Y., Kalos, M., Milone, M. C. and June, C. H. : Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Cancer Immunol Res. 3(4):356-67 (2015).
      • Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y. and Nakayama, T. : The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway. Immunity 42(2):294-308 (2015).

 

2014年

        • Sun, Y., Furihata, T., Ishii, S., Nagai, M., Harada, M., Shimozato, O., Kamijo, T., Motohashi, S., Yoshino, I., Kamiichi, A., Kobayashi, K. and Chiba, K. : Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers: potential biomarker implications. Clin Transl Med. 3:37 (2014).
        • Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T. : Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc Natl Acad Sci U S A. 111(35):12829-34 (2014).
        • Luckey, M. A., Kimura, M. Y., Waickman, A. T., Feigenbaum, L., Singer, A. and Park, J. H. : The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat Immunol.15(7):638-45 (2014).

 

2013年

        • Fujii, S., Shimizu, K., Okamoto, Y., Kunii, N., Nakayama, T., Motohashi, S. and Taniguchi, M. : NKT cells as an ideal anti-tumor immunotherapeutic. Front Immunol. 4:409 (2013).
        • Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S. and Nakayama, T. : The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells. Immunity 39(5):819-32 (2013).
        • Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S. and Nakayama, T. : Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci U S A. 110(46):18626-31 (2013).
        • Van Laethem, F., Tikhonova, A., Pobezinsky, L. A., Tai, X., Kimura, M. Y., Le Saout, C., Guinter, T. I., Adams, A., Sharrow, S. O., Bernhardt, G., Feigenbaum, L. and Singer, A. : Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell. 154(6):1326-1341 (2013).
        • Tai, X., Erman, B., Alag, A., Mu, J., Kimura, M., Katz, G., Guinter, T., McCaughtry, T., Etzensperger, R., Feigenbaum, L., Singer, D. S. and Singer, A. : Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity. 38(6):1116-28 (2013).
        • Kimura, M. Y., Pobezinsky, L. A., Guinter, T. I., Thomas, J., Adams, A., Park, J. H., Tai, X. and Singer, A. : IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death. Nat Immunol. 14(2):143-151 (2013).

 

2012年

            • Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y. and Nakayama, T. : Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc Natl Acad Sci U S A. 109(42):16992-7 (2012).
            • Nagato, K., Motohashi, S., Ishibashi, F., Okita, K., Yamasaki, K., Moriya, Y., Hoshino, H., Yoshida, S., Hanaoka, H., Fujii, S., Taniguchi, M., Yoshino, I. and Nakayama, T. : Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells. J Clin Immunol. 32(5):1071-81 (2012).
            • Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V. and Nakayama, T. : The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat Immunol. 13(8):778-86 (2012).
            • Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S. and Nakayama, T. : Murine Schnurri-2 controls Natural Killer cell function and lymphoma development. Leuk Lymphoma. 53(3):479-86 (2012).
            • Nagai, M., Furihata, T., Matsumoto, S., Ishii, S., Motohashi, S., Yoshino, I., Ugajin, M., Miyajima, A., Matsumoto, S. and Chiba, K. : Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem Biophys Res Commun. 418(4):818-23 (2012).
            • Adoro, S., McCaughtry, T., Erman, B., Alag, A., Van Laethem, F., Park, J. H., Tai, X., Kimura, M., Wang, L., Grinberg, A., Kubo, M., Bosselut, R., Love, P. and Singer, A. : Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 31(2):366-377 (2012).

 

2011年

            • Taniguchi, M., Fujii, S., Nakayama, T., Motohashi, S., Dashtsoodal, N., Watarai, H., and Harada, M. : Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Deprived NKT Cells. Natural killer T cells: Balancing the Regulation of Tumor Immunity 1-14 (2011).
            • Motohashi, S., Okamoto, Y., Yoshino, I. and Nakayama, T. : Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer. Clin Immunol. 140(2):167-76 (2011).
            • Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, S. F. and Nakayama, T. : Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71(14):4790-8 (2011).
            • Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T. and Okamoto, Y. : Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. Clin Immunol. 138(3):255-65 (2011).
            • Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A. and Okamoto, Y. : Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer. Cancer Immunol Immunother. 60(2):207-15 (2011).

 

2010年

            • Okita, K., Motohashi, S., Shinnakasu, R., Nagato, K., Yamasaki, K., Sato, Y., Kitamura, H., Hijikata, A., Yamashita, M., Shimizu, K., Fujii, S., Ohara, O., Taniguchi, M., Sakaida, I. and Nakayama, T. : A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci. 101(11):2333-40 (2010).
            • Ishii, Y., Motohashi, S., Shimizu, K., Nakayama, T., Taniguchi, M. and Fujii, S. : Application of NKT cells in immunotherapy. Curr Immunol Rev. 6(2):109-15 (2010).
            • Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y. and Taniguchi, M. : Adjuvant activity mediated by iNKT cells. Semin Immunol. 22(2):97-102 (2010).
            • Suzuki, M., Wada, H., Yoshino, M., Tian, L., Shigematsu, H., Suzuki, H., Alaa, M., Tamura, H., Fujiwara, T., Nagato, K., Motohashi, S., Moriya, Y., Hoshino, H., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y. and Yoshino, I. : Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling. Ann Surg Oncol. 17(3):878-88 (2010).
            • Park, J. H., Adoro, S., Guinter, T., Erman, B., Alag, A. S., Catalfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., Kubo, M., Hennighausen, L., Feigenbaum, L. and Singer, A. l. : Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol. 11:257-264 (2010).
            • Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, M. Y., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M. and Nakayama, T. : Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J Immunol. 184(8):4510-4520 (2010).

 

2009年

            • Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M. and Nakayama, T. : CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 183(12):8203-15 (2009).
            • Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M. and Nakayama, T. : Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J Immunol. 183(8):5388-96 (2009).
            • Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T. and Okamoto, Y. : Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. Cancer Sci. 100(6):1092-8 (2009).
            • Motohashi, S. and Nakayama, T. : Natural killer T cell-mediated immunotherapy for malignant diseases. Front Biosci (Schol Ed). 1:108-16 (2009).
            • Alaa, M., Suzuki, M., Yoshino, M., Tian, L., Suzuki, H., Nagato, K., Fujiwara, T., Wada, H., Moriya, Y., Hoshino, H., Motohashi, S., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y., Abdrabou, A., Elkholy, M., Mahfouz, T. and Yoshino, I. : Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. Int J Oncol. 34(3):805-12 (2009).
            • Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T. and Nakayama, T. : A phase I-II study of α-Galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer. J Immunol. 182(4):2492-501 (2009).
            • Motohashi, S. and Nakayama, T. : Invariant natural killer T cell-based immunotherapy for cancer. Immunotherapy. 1(1):73-82 (2009).
            • Nakayama, T., and Kimura, M. Y.: Memory Th1/Th2 cell generation controlled Schnurri-2. Memory T-cells, edited by Maurizio Zanetti, (2009).

 

2008年

            • Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S. and Nakayama, T. : Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J Biol Chem. 283(42):28216-25 (2008).
            • Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I. and Nakayama, T. : Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int Immunol. 20(7):849-60 (2008).
            • Suzuki, M., Mohamed, S., Nakajima, T., Kubo, R., Tian, L., Fujiwara, T., Suzuki, H., Nagato, K., Chiyo, M., Motohashi, S., Yasufuku, K., Iyoda, A., Yoshida, S., Sekine, Y., Shibuya, K., Hiroshima, K., Nakatani, Y., Yoshino, I. and Fujisawa, T. : Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Int J Oncol. 33(1):113-9 (2008).
            • Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A. and Nakayama, T. : Bmi1 regulates memory CD4 T cell sirvival via repression of the Noxa gene. J Exp Med. 205(5):1109-20 (2008).
            • Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T. and Okamoto, Y. : Phase I study of α-Galactosylceramide-pulsed anitgen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. Cancer Immunol Immunother. 57(3):337-45 (2008).
            • Motohashi, S. and Nakayama, T. : Clinical applications of natural killer T cell-based immunotherapy for cancer. Cancer Sci. 99(4):638-45 (2008).

 

2007年

            • Suzuki, M., Shigematsu, H., Nakajima, T., Kubo, R., Motohashi, S., Sekine, Y., Shibuya, K., Iizasa, T., Hiroshima, K., Nakatani, Y., Gazdar, A. F. and Fujisawa, T. : Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer. Clin Cancer Res. 13(20):6087-92 (2007).
            • Iwamura, C., Kimura, M. Y., Shinoda, K., Endo, Y., Hasegawa, A., Yamashita, M. and Nakayama, T. : Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int Immunol. 19(6):755-762 (2007).
            • Kimura, M. Y., Iwamura, C., Suzuki, A., Miki, T., Hasegawa, A., Sugaya, K., Yamashita, M., Ishii, S. and Nakayama, T.: Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J Immunol. 178(8):4926-4936 (2007).
            • Kimura, M. Y., Iwamura, C., Suzuki, A., Kitajima, M., Hosokawa, H., Hasegawa, A., Yamashita, M. and Nakayama, T. : Schnurri-2 controls the generation of memory Th1 and Th2 cells. 13th International congress of Immunology pp.475-479 (2007).
            • Kaneko, T., Hosokawa, H., Yamashita, M., Wang, C. R., Hasegawa, A., Kimura, M. Y., Kitajima, M., Kimura, F., Miyazaki, M. and Nakayama, T. : Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol Immunol. 44(9):2249-2256 (2007).

 

2006年

            • Hosokawa, H., Kimura, M. Y., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M. and Nakayama, T. : Regulation of Th2 development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol. 177(11):7656-7664 (2006).
            • Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T. and Nakayama, T. : A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. Clin Cancer Res. 12(20):6079-86 (2006).
            • Seino, K., Motohashi, S., Fujisawa, T., Nakayama, T. and Taniguchi, M. : Natural killer T cell-mediated antitumor immune responses and their clinical applications. Cancer Sci. 97(9):807-12 (2006).
            • Tenda, Y., Yamashita, M., Kimura, M. Y., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki N. and Nakayama, T. : Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J Allergy Clin Immunol. 118(3):725-733 (2006).
            • Sekine, Y., Yasufuku, K., Motohashi, S. and Fujisawa, T. : Triple reconstruction of pulmonary artery, superior vena cava and bronchus for lung cancer. Interact Cardiovasc Thorac Surg. 5(4):509-510 (2006).
            • Iizasa, T., Suzuki, M., Yoshida, S., Motohashi, S., Yasufuku, K., Iyoda, A., Shibuya, K., Hiroshima, K., Nakatani, Y. and Fujisawa, T. : Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann Thorac Surg. 82(1):254-60 (2006).
            • Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, M. Y., Hasegawa, A. and Nakayama, T. : Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24(5):611-622 (2006).
            • Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M. B., Shimizu, C., Hashimoto, K., Kimura, M. Y., Yamashita, M. and Nakayama, T. : Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J Immunol. 176(4):2546-2554 (2006).
            • Nigo, I. Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y. and Nakayama, T. : Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci U S A. 103(7):2286-2291 (2006).

 

2005年

            • Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H. and Shinnakasu, R. : Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
            • Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A. and Nakayama, T. : Dendritic cell maturation by CD11c- T cells and Vα24+ NKT cell activation by α-Galactosylceramide. Int J Cancer. 117(2):265-73 (2005).
            • Yoshino, M., Hiroshima, K., Motohashi, S., Shibuya, K., Iyoda, A., Sekine, Y. and Fujisawa, T. : Papillary carcinoma of the thymus gland. Ann Thorac Surg. 80(2):741-2 (2005).
            • Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M. and Nakayama, T. : Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J Biol Chem. 280(33):29409-29419 (2005).
            • Seino, K., Fuji, S., Harada, M., Motohashi, S., Nakayama, T., Fujisawa, T. and Taniguchi, M. : Vα14 NKT cell-mediated anti-tumor responses and their clinical application. Springer Semin Immunopathol. 27(1):65-74 (2005).
            • Miyamoto, T., Kaneko, T., Yamashita, M., Tenda, Y., Inami, M., Suzuki, A., Ishii, S., Kimura, M., Hashimoto, K., Shimada, H., Yahata, H., Ochiai, T., Saito, I., DeGregori, J. and Nakayama, T. : Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int Immunol. 17:759-768 (2005).
            • Suzuki, H., Sekine, Y., Motohashi, S., Chiyo, M., Suzuki, M., Haga, Y., Hiroshima, K., Ohwada, H., Iizasa, T., Saitoh, Y., Baba, M. and Fujisawa, T. : Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases. Surg Today. 35(3):243-6 (2005).
            • Ishikawa, A., Motohashi, S., Ishikawa, E., Fuchida, H., Higashino, K., Otsuji, M., Iizasa, T., Nakayama, T., Taniguchi, M. and Fujisawa, T. : A phase I study of α-Galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer. Clin Cancer Res. 11(5):1910-7 (2005).
            • Kimura, M. Y., Hosokawa, H., Yamashita, M., Hasegawa, A., Iwamura, C., Watarai, H., Taniguchi, M., Takagi, T., Ishii, S. and Nakayama, T. : Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J Exp Med. 201:397-408 (2005).
            • Kimura, M. Y. and Nakayama, T. : Differentiation of NK1 and NK2 cells. Crit Rev Immunol.25(5):361-374 (2005).
            • Motohashi, S., Sekine, Y., Iizasa, T., Nakano, K., Numata, T. and Fujisawa, T. : Thyroid cancer with massive invasion into the neck and mediastinal great veins. 53(1):55-7 (2005).

 

2004年

            • Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M. and Nakayama, T. : STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. J Immunol. 173:4967-4975 (2004).
            • Yamaji, H., Iizasa, T., Koh, E., Suzuki, M., Otsuji, M., Chang, H., Motohashi, S., Yokoi, S., Hiroshima, K., Tagawa, M., Nakayama, T. and Fujisawa, T. : Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer. Cancer Immunol Immunother. 53(9):786-92 (2004).
            • Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M. and Nakayama, T. : Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J Biol Chem. 279:39454-39464 (2004).
            • Iizasa, T., Chang, H., Suzuki, M., Otsuji, M., Yokoi, S., Chiyo, M., Motohashi, S., Yasufuku, K., Sekine, Y., Iyoda, A., Shibuya, K., Hiroshima, K. and Fujisawa, T. : Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in non-small cell lung cancer. Clin Cancer Res. 10(16):5361-6 (2004).
            • Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J. and Nakayama, T. : Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem. 279:26983-26990 (2004).
            • Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M. and Nakayama, T. : CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing Th2 cells. J Biol Chem. 279:23123-23133 (2004).
            • Kobayashi, S., Kaneko, Y., Seino, K., Yamada, Y., Motohashi, S., Koike, J., Sugaya, K., Kuriyama, T., Asano, S., Tsuda, T., Wakao, H., Harada, M., Kojo, S., Nakayama, T. and Taniguchi, M. : Impaired IFN-γ production of Vα24 NKT cells in non-remitting sarcoidosis. Int Immunol. 16(2):215-22 (2004).

 

2003年

            • Ishikawa, A., Motohashi, S., Shibuya, K., Baba, M., Toyosaki, T., Ohwada, H., Saito, N., Suzuki, K. and Fujisawa, T. : Small solitary pulmonary metastasis detected before primary sigmoid colon cancer: report of a case. Surg Today. 33(9):709-11 (2003).
            • Sekine, Y., Iwata, T., Chiyo, M., Yasufuku, K., Motohashi, S., Yoshida, S., Suzuki, M., Iizasa, T., Saitoh, Y. and Fujisawa, T. : Minimal alteration of pulmonary function after lobectomy in lung cancer patients with chronic obstructive pulmonary disease. Ann Thorac Surg. 76(2):356-61 (2003).
            • Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hosokawa, H., Hasegawa, A., Taniguchi, M. and Nakayama, T. : CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity. 19:281-294 (2003).
            • Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., Shinkai, H., Koseki, H., Taniguchi, M., Ziegler, S. F. and Nakayama, T. : CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int Immunol. 8:987-992 (2003).
            • Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M. and Nakayama, T. : TH1-biased immunity induced by exposure to Antarctic winter. J Allergy Clin Immunol. 111(6):1353-1360 (2003).
            • Fukuda, K., Yoshida, H., Sato, T., Furumoto, T., Mizutani-Koseki, Y., Suzuki, Y., Saito, Y., Takemori, T., Kimura, M., Sato, H., Taniguchi, M., Nishikawa, S., Nakayama, T. and Koseki, H. : Mesenchymal expression of Fokl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Developmental Biol. 255:278-289 (2003).
            • Sakamoto, M., Hasegawa, A., Sugaya, K., Hashimoto, K., Kimura, M., Yamashita, M., Suzuki, K. and Nakayama, T. : Destinct calcium response induced by T-cell antigen receptor stimulation in thymocytes and mature T cells. Bioimages. 11:1-8 (2003).

 

2002年

            • Motohashi, S., Kobayashi, S., Ito, T., Magara, K. K., Mikuni, O., Kamada, N., Iizasa, T., Nakayama, T., Fujisawa, T. and Taniguchi M. : Preserved IFN-γ production of circulating Vα24 NKT cells in primary lung cancer patients. Int J Cancer. 102(2):159-65 (2002).
            • Asai, K., Hachimura, S., Kimura, M., Toraya, T., Yamashita, M., Nakayama, T. and Kaminogawa, S. : T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. J Immunol. 169:4723-4731 (2002).
            • Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M. and Nakayama, T. : Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem. 277:42399-42408 (2002).
            • Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C. -R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N. and Nakayama, T. : Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J Immunol. 169:2134-2140 (2002).
            • Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M. and Nakayama, T. : Th1/Th2 cell differentiation of developing CD4 single-positive thymocytes. Int Immunol. 14:943-951 (2002).
            • Akutsu, Y., Nakayama, T., Harada, M., Kawano, T., Motohashi, S., Shimizu, E., Ito, T., Kamada, N., Saito, T., Matsubara, H., Miyazawa, Y., Ochiai, T. and Taniguchi, M. : Expansion of lung Vα14 NKT cells by administration of α-galactosylceramide-pulsed dendritic cells. Jpn J Cancer Res. 93(4):397-403 (2002).
            • Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H. and Ziegler, S. F. : The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol. 168:87-94 (2002).

 

2001年

            • Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi M., Koseki, H. and Nakayama, T. : Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity. 15:275-287 (2001).
            • Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S., Kawano, T., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M. and Taniguchi, M. : Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int Immunol. 13(7):853-61 (2001).
            • Shin, T., Nakayama, T., Akutsu, Y., Motohashi, S., Shibata, Y., Harada, M., Kamada, N., Shimizu, C., Shimizu, E., Saito, T., Ochiai, T. and Taniguchi, M. : Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells. Int J Cancer. 91(4):523-8 (2001).
            • Nakayama, T., Yamashita, M., Kawano, T., Shimizu, C., Shibata, Y., Kamata, T., Kaneko, Y., Kobayashi, S., Takeda, U., Motohashi, S., Cui, J. and Taniguchi, M. : The role of α-GalCer-activated Vα14 NKT cells in the regulation of Th2 cell differentiation. Int Arch Allergy Immunol. 124(1-3):38-42 (2001).
            • Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondo, E., Kaneko, Y., Okada, S., Tokuhisa T., Yokoyama, M., Taniguchi, M., Katsura, Y. and Nakayama, T. : Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lack proximal promoter activity. Int Immunol. 13:105-117 (2001).

 

2000年

            • Yamashita, M., Katsumata, M., Iwashima, M., Kimura, M., Shimizu, C., Kamata, T., Shin, T., Seki, N., Suzuki, S., Taniguchi, M. and Nakayama, T. : T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med. 191:1869-1879 (2000).
            • Kimura, M., Yamashita, M., Kubo, M., Iwashima, M., Shimizu, C., Tokoyoda, K., Chiba, J., Taniguchi, M., Katsumata, M. and Nakayama, T. : Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int Immunol. 12:817-824 (2000).

 

1999年

            • Kawano, T., Nakayama, T., Kamada, N., Kaneko, Y., Harada, M., Ogura, N., Akutsu, Y., Motohashi, S., Iizasa, T., Endo, H., Fujisawa, T., Shinkai, H. and Taniguchi, M. : Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells. Cancer Res. 59(20):5102-5 (1999).
            • Cui, J., Watanabe, N., Kawano, T., Yamashita, Y., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M. and Nakayama, T.: Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J Exp Med. 190:783-792 (1999).
            • Fujisawa, T., Iizasa, T., Saitoh, Y., Sekine, Y., Motohashi, S., Yasukawa, T., Shibuya, K., Hiroshima, K. and Ohwada, H. : Smoking before surgery predicts poor long-term survival in patients with stage I non-small-cell lung carcinomas. J Clin Oncol. 17(7):2086-91 (1999).
            • Yamashita, M., Kimura, M., Kubo, M., Shimizu, C., Tada, T., Perlmutter, R. M. and Nakayama, T. : T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A. 96:1024-1029 (1999).
            • Iizasa, T., Fujisawa, T., Suzuki, M., Motohashi, S., Yasufuku, K., Yasukawa, T., Baba, M. and Shiba, M. : Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin Cancer Res. 5(1):149-53 (1999).

 

1998年

            • Shimizu, C., Li, X., Kimura, M., Hashimoto, K., Sugaya, K., Kubo, M., Suzuki, S. and Nakayama, T. : A novel immunosuppressant, FTY720, increases the efficiency of a superantigen-induced peripheral T-cell deletion whilst inhibiting negative selection in the thymus. Immunology. 94:503-512 (1998).
            • Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T. and Nakayama, T. : Requirement for p56lck tyrosine kinase activation in Th subset differentiation. Int Immunol. 10:577-591 (1998).
            • Nakayama, T., Yamashita, M., Kubo, M., Kimura, M., Shimizu, C. and Tada, T. : TCR-mediated signal transduction pathways that control helper T cell differentiation: Requirement for activation of Lck tyrosine kinase and Ras/MAPK pathway in Th2 cell differentiation. 10th International congress of Immunology pp.589-593 (1998).

 

1997年

            • Ran, S., Kimura, H., Iwai, N., Yamamoto, N. and Motohashi, S. : A case of synovial sarcoma treated by adoptive immunotherapy after resection of metastatic lung tumors. Jpn J Lung Cancer. 37(7):1023-1028 (1997).
            • Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T. and Nakayama, T. : TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.350-351 (1997).

 

PageTop