研究業績

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肝胆膵外科

当教室における研究

肝胆膵外科臨床においては切除が困難といわれている肝門部胆管癌をはじめとする胆道癌、膵癌、原発性および転移性肝癌などの外科治療を研究対象に、治療成績向上のための新しい手技、治療法の開発、確立のための臨床・基礎研究を行っており、国内外に多数発表しています。

また、当教室では生体肝移植術も積極的に施行しており、その外科手術の研究および基礎的研究も行っています。

臨床研究

  1. 肝門部胆管癌に対する術式の工夫と、拡大手術・縮小手術
  2. 高度進行転移性肝癌に対する術前化学療法に関する研究
  3. 黄疸肝における肝切除時の生体反応と術後合併症に関する研究
  4. 膵・胆道癌に対する術前および術後化学療法の有用性に関する研究
  5. 肝膵切除時における免疫栄養療法の有用性に関する研究
  6. 進行肝胆膵癌に対する術前化学療法の有用性に関する研究
  7. 門脈・下大静脈腫瘍栓を有する進行肝細胞癌に対する積極的外科切除の治療成績
  8. 進行膵癌に対する動・門脈合併切除再建の手術成績
  9. 生体肝移植における自家静脈グラフトを用いた肝静脈再建の工夫
  10. 良性胆道狭窄や難治性胆汁瘻に対する胆道IVRによる治療の確立

基礎的研究

  1. 肝胆膵悪性腫瘍の病理学的および分子生物学的検討
  2. 粘液産生胆道腫瘍の病態の解析
  3. 癌細胞と周囲間質細胞の相互作用
  4. 癌幹細胞の意義、役割の研究
  5. 癌進展と炎症反応の関連に関する研究
  6. 生体肝移植における過小グラフト克服に関する研究
  7. 肝阻血再灌流障害の機序に関する検討
  8. 肝胆膵悪性腫瘍における浸潤・転移の分子生物学的機構の解明
  9. プロテオミクスを用いた肝胆膵悪性腫瘍に対する早期診断・個別化治療の開発
  10. 肝切除後の肝再生の分子生物学的機序の解明

Publication(過去5年間でFirst authorが当教室からの英文論文)

2023

Hosokawa I, Takayashiki T, Kuboki S, Takano S, Togasaki K, Miyazaki M, Ohtsuka M. Prognostic impact of proximal ductal margin status in perihilar cholangiocarcinoma according to the presence or absence of lymph node metastasis. Surgery. 2023; 174: 11-20.

Hosokawa I, Kuboki S, Miyazaki M, Ohtsuka M. Portal vein reconstruction using an autologous left renal vein-graft in living related right-lobe liver transplantation. Asian J Surg. 2023; 46: 2537-2539. 

Hosokawa I, Takayashiki T, Togasaki K, Ohtsuka M. Resection and reconstruction of a combined-type right posterior hepatic artery in left trisectionectomy for perihilar cholangiocarcinoma. Asian J Surg. 2023; 46: 5743-5744. 

Hosokawa I, Ohtsuka M. Reply to comment on “surgical implications of the confluence patterns of the left intrahepatic bile ducts in right hepatectomy for perihilar cholangiocarcinoma.”.  J Hepatobiliary Pancreat Sci. 2023; 30: e7-e8.

Mishima T, Takano S, Takayashiki T, Kuboki S, SuzukiS, Sakai N, Hosokawa I,  Konishi T, Nishino H, Nakada S, Kouchi Y, Kishimoto T, Ohtsuka M. Serum elastase-1 predicts malignancy in intraductal papillary mucinous neoplasm of the pancreas. Pancreatology (In press)

Konishi T, Takano S, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Hosokawa I, Mishima T, Nishino H, Nakada S, Ohtsuka M. Clinical benefits of pulmonary resection for lung metastases from pancreatic cancer. Langenbeck’s Archives of Surgery. 2023. In press.      

Sugiura K, Masuike Y, Suzuki K, Shin AE, Sakai N, Matsubara H, Ohtsuka M, Sims PA, Lengner CJ, Rustgi AK. LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3. JCI Insight. 2023 Jul 24;8(14):e167310. doi: 10.1172/jci.insight.167310.

Shinichiro Nakada, Yuichiro Otsuka, Jun Ishii, Tetsuya Maeda, Kazutaka Kimura , Yu Matsumoto, Yuko Ito, Hideaki Shimada, Kimihiko Funahashi, Masayuki Ohtsuka and Hironori Kaneko. The Outcome of Conversion to Hand-Assisted Laparoscopic Surgery in Laparoscopic Liver Resection J. Clin. Med. 2023; 12: 4808

Togasaki K, Hosokawa I, Takayashiki T, Takano S, Ohtsuka M. Impact of the course of the segment 4 hepatic artery on proximal ductal margin status in right hepatectomy for perihilar cholangiocarcinoma. Surgery. 2023 in press.

2022 

・Aoki Y, Furukawa K, Suzuki D, Takayashiki T, Kuboki S, Takano S, Kawasaki Y, Shiko Y, Ohtsuka M. Influence of sarcopenia as defined by EWGSOP2 on complications after pancreaticoduodenectomy and on the prognosis of pancreatic head cancer: A prospective cohort study. Nutrition. 2022;99-100:8

・Sato N, Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohira G, Matsubara H, Ohtsuka M. Yin Yang 1 regulates ITGAV and ITGB1, contributing to improved prognosis of colorectal cancer. Oncol Rep. 2022;47(5):87.

・Kawahara K, Takano S, Furukawa K, Takayashiki T, Kuboki S, Ohtsuka M. The effect of the low stromal ratio induced by neoadjuvant chemotherapy on recurrence patterns in borderline resectable pancreatic ductal adenocarcinoma. Clin Exp Metastasis. 2022 ;39(2):311-322. 

・Hosokawa I, Furukawa K, Takayashiki T, Kuboki S, Takano S, Miyazaki M, Ohtsuka M. Surgical implications of the confluence patterns of the left intrahepatic bile ducts in right hepatectomy for perihilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 2022;29(4):460-468. 

2021 

・Sasaki K, Takano S, Tomizawa S, Miyahara Y, Furukawa K, Takayashiki T, Kuboki S, Takada M, Ohtsuka M. C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer. J Exp Clin Cancer Res. 2021;40(1):212. 

・Tabe S, Tonooka T, Hoshino I, Takiguchi N, Soda H, Gunji H, Nabeya Y, Ohtsuka M. Laparoscopic ileo-transverse bypass may contribute to achieving curative resection for locally advanced right colon cancer: a case report. Surg Case Rep. 2021;7(1):135.

・Shimazaki R, Takano S, Satoh M, Takada M, Miyahara Y, Sasaki K, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Sogawa K, Motohashi S, Nomura F, Miyazaki M, Ohtsuka M. Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. Cell Oncol (Dordr). 2021;44(4):937-950.

・Konishi T, Yoshidome H, Shida T, Furukawa K, Takayashiki T, Kuboki S, Takano S, Miyazaki M, Ohtsuka M. Phosphorylated mTOR expression as a predictor of survival after liver resection for colorectal liver metastases. J Surg Oncol. 2021;124(4):598-606. 

・Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohtsuka M. Recurrence patterns and their effects on clinical outcomes after R1 resection of colorectal liver metastases: a propensity score-matched analysis. Langenbecks Arch Surg. 2021;406(8):2739-2747. 

・Suda R, Sakai N, Matsushita K, Ishige T, Kawasaki Y, Shiko Y, Furukawa K, Mishima T, Nakadai E, Ohtsuka M. Prediction of mismatch repair deficient biliary tract cancer: Role of morphological features and host immune response detected by routine hematoxylin-eosin staining. J Hepatobiliary Pancreat Sci. 2021;28(8):680-691.

・Kuboki S, Furukawa K, Takayashiki T, Takano S, Miyazaki M, Ohtsuka M. Clinical implication of ICG test in major hepatectomy for biliary tract cancer. Minerva Surg. 2021;76(3):202-210. 

・Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohtsuka M. Differential effects of KRAS mutational status on long-term survival according to the timing of colorectal liver metastases. BMC Cancer. 2021;21(1):412. 

・Oka Y, Takano S, Kouchi Y, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Hosokawa I, Mishima T, Konishi T, Kishimoto T, Ohtsuka M. Simultaneous brain and lung metastases of pancreatic ductal adenocarcinoma after curative pancreatectomy: a case report and literature review. BMC Gastroenterol. 2021;21(1):9. 

・Yokota T, Nojima H, Kuboki S, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Ohtsuka M. Sphingosine-1-phosphate Receptor-1 Promotes Vascular Invasion and EMT in Hepatocellular Carcinoma. J Surg Res. 2021;259:200-210. 

・Kawasaki K, Kuboki S, Furukawa K, Takayashiki T, Takano S, Ohtsuka M. LGR5 induces β-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma. Liver Int. 2021;41(4):865-881. 

2020

・Sakai N, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Kagawa S, Mishima T, Nakadai E, Ohtsuka M. Outcome of interventional radiology for delayed postoperative hemorrhage in hepatobiliary and pancreatic surgery. J Gastroenterol Hepatol. 2020;35(12):2264-2272. 

・Konishi T, Yoshidome H, Shimizu H, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Miyazaki M, Ohtsuka M. Splenic enlargement induced by preoperative chemotherapy is a useful indicator for predicting liver regeneration after resection for colorectal liver metastases. World J Surg Oncol. 2020;18(1):139.

・Furukawa A, Furukawa K, Suzuki D, Yoshitomi H, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M. Effect of immunonutrition on infectious complications in low skeletal muscle mass patients after pancreaticoduodenectomy. Clin Nutr. 2021;40(1):103-109.

・Takagi Y, Sakai N, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Kagawa S, Mishima T, Nakadai E, Miyauchi H, Matsubara H, Ohtsuka M. High expression of Krüppel-like factor 5 is associated with poor prognosis in patients with colorectal cancer. Cancer Sci. 2020;111(6):2078-2092.  

・Hosokawa I, Shimizu H, Ohtsuka M, Miyazaki M. Liver Transection-First Approach in Left Trisectionectomy for Perihilar Cholangiocarcinoma. Ann Surg Oncol. 2020;27(7):2381-2386. 

・Takano S, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Mishima T, Nakadai E, Miyazaki M, Ohtsuka M. Long-term outcomes and significance of preoperative lymphocyte-to-monocyte ratio as a prognostic indicator in patients with invasive pancreatic neoplasms after repeat pancreatectomy. BMC Cancer. 2020;20(1):111. 

・Sato N, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Mishima T, Nakadai E, Mikata R, Kato N, Ohtsuka M. Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review. BMC Gastroenterol. 2020;20(1):13. 

・Takayashiki T, Yoshitomi H, Furukawa K, Kuboki S, Miyazaki M, Ohtsuka M. Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction. Hepatobiliary Pancreat Dis Int. 2020;19(1):97-100.

2019

・Ueda A, Sakai N, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Kagawa S, Mishima T, Nakadai E, Miyazaki M, Ohtsuka M. Is hepatic artery coil embolization useful in distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer? World J Surg Oncol. 2019;17(1):124. 

・Ashizawa Y, Kuboki S, Nojima H, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Miyazaki M, Ohtsuka M. OLFM4 Enhances STAT3 Activation and Promotes Tumor Progression by Inhibiting GRIM19 Expression in Human Hepatocellular Carcinoma. Hepatol Commun. 2019;3(7):954-970. 

・Sugiura K, Mishima T, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takada M, Miyazaki M, Ohtsuka M. The Expression of Yes-Associated Protein (YAP) Maintains Putative Cancer Stemness and Is Associated with Poor Prognosis in Intrahepatic Cholangiocarcinoma. Am J Pathol. 2019;189(9):1863-1877. 

・Nishino H, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Nojima H, Sasaki K, Miyazaki M, Ohtsuka M. Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection versus distal pancreatectomy for pancreatic body/tail cancer. Surg Open Sci. 2019;1(1):14-19. 

・Nakada S, Kuboki S, Nojima H, Yoshitomi H, Furukawa K, Takano T, Miyazaki M, Ohtsuka M. Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer. Ann Surg Oncol. 2019;26:907-17.

・Yokota T, Takano S, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Nakadai E, Ohtsuka M. Successful treatment of a locally advanced unresectable pancreatic cancer patient with interstitial pneumonitis by conversion surgery following gemcitabine plus nab-paclitaxel chemotherapy: A case report. Mol Clin Oncol. 2019;10(4):419-424.

・Takahashi M, Yoshitomi H, Kato A, Furukawa K, Takayashiki T, Kuboki S, Takano S, Sugiura K, Kawasaki K, Miyazaki M, Ohtsuka M. A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer. Surg Case Rep. 2019;5(1):21. 

・Hosokawa I, Ohtsuka M, Yoshitomi H, Furukawa K, Miyazaki M, Shimizu H. Right intersectional transection plane based on portal inflow in left trisectionectomy. Surg Radiol Anat. 2019;41(5):589-593. 

・Hosokawa I, Shimizu H, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S,Koda K, Miyazaki M, Ohtsuka M. Outcomes of left trisectionectomy and right hepatectomy for perihilar cholangiocarcinoma. HPB (Oxford). 2019;21(4):489-498. 

2018

・Okura R, Takano S, Yokota T, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Miyazaki M, Ohtsuka M. Conversion surgery with gemcitabine plus nab-paclitaxel for locally advanced unresectable pancreatic cancer: A case report. Mol Clin Oncol. 2018;9(4):389-393. 

・Hosokawa I, Shimizu H, Yoshitomi H, Furukawa K, Takayashiki T, Miyazaki M, Ohtsuka M. Impact of Biliary Drainage on Multidetector-Row Computed Tomography on R0 Resection of Perihilar Cholangiocarcinoma. World J Surg. 2018;42(11):3676-3684. 

・Yoneura N, Takano S, Yoshitomi H, Nakata Y, Shimazaki R, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M. Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer. Int J Mol Med. 2018;42(2):821-830. 

 

2017

・Takayanagi R, Takano S, Sugiura K, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Kato A, Miyazaki M, Ohtsuka M. Successful radical surgical resection of initially unresectable intrahepatic cholangiocarcinoma by downsizing chemotherapy with gemcitabine plus cisplatin: a case report. Surg Case Rep. 2017;3(1):116. 

・Suzuki K, Takano S, Yoshitomi H, Nishino H, Kagawa S, Shimizu H, Furukawa K, Miyazaki M, Ohtsuka M. Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer. Oncotarget. 2017;8(39):66098-66111. 

・Higashihara T, Yoshitomi H, Nakata Y, Kagawa S, Takano S, Shimizu H, Kato A, Furukawa K, Ohtsuka M, Miyazaki M. Sex Determining Region Y Box 9 Induces Chemoresistance in Pancreatic Cancer Cells by Induction of Putative Cancer Stem Cell Characteristics and Its High Expression Predicts Poor Prognosis. Pancreas. 2017;46(10):1296-1304. 

・Nishino H, Takano S, Yoshitomi H, Suzuki K, Kagawa S, Shimazaki R, Shimizu H, Furukawa K, Miyazaki M, Ohtsuka M. Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression. Cancer Med. 2017;6(11):2686-2696.