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Obstetrics and Gynecology, Reproductive Medicine

Overview

Our research activity is multidisciplinary and innovative with aims of improving women’s health. Current projects include: basic and clinical study on hormonal therapy of the endometrial cancer, surgical and medical management of advanced ovarian cancer, establishment of a novel animal model and the discovery of new therapeutic strategy for uterine leiomyoma, pathogenesis and clinical management of trophoblastic diseases, development of preventive measure of endometrial cancer, molecular diagnosis of hereditary endocrine diseases.

Professor:
Kaori Koga

TEL: +81-43-226-2121
FAX: +81-43-226-2122
e-mail: kaorikoga●chiba-u.jp
URL: http://www.m.chiba-u.ac.jp/class/gyne/

※　Please change "●" mark to at-mark if you send emails.

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Research & Education

  1. Biomarkers for decision making of intermittent debulking surgery.
  2. Molecular carcinogenesis of ovarian cancer and its therapeutic application.
  3. Establishment of a novel explant model of uterine leiomyoma and its application for discovery of new therapeutic agents.
  4. Metabolome analysis of uterine leiomyoma.
  5. Cytogenesis and molecular diagnosis of hydatidiform mole.
  6. Epigenetic control of trophoblastic invasion to myometrium.
  7. Cohort study of trophoblastic disease at Chiba prefecture.
  8. Genetic diagnosis of endocrine diseases.
  9. Establishment of a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer.
  10. Prevention of neonatal brain damage.

Recent Publications

  • Spermatogonium-Derived Complete Hydatidiform Mole, Usui H, Shozu M, N Engl J Med 384: 936-943, 2021
  • Introduction of rectosigmoid colectomy improves survival outcomes in early-stage ovarian cancer patients, Tate S, Nishikimi K, Matsuoka A, Otsuka S, Shozu M, Int J Clin Oncol 26: 986-994, 2021
  • Variant Prolactin Receptor in Agalactia and Hyperprolactinemia, Kobayashi T, Usui H, Tanaka H, Shozu M, N Engl J Med 379: 2230-2236, 2018