DEPARTMENT OF IMMUNOLOGY, GRADUATE SCHOOL OF MEDICINE, CHIBA UNIVERSITY

<Th2 cell differentiation and chromatin remodeling of the Th2 cytokine gene loci>

  1. Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y. M., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24:611-622 (2006).
  2. Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., and Shinnakasu, R.: Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
  3. Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., and Nakayama, T.: Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through Ubiquitin-Proteasome Pathway. J. Biol. Chem. 280:29409-29419 (2005).
  4. Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., and Nakayama, T.: Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279:39454-39464 (2004).
  5. Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., and Nakayama, T.: Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279:26983-26990 (2004).
  6. Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., and Nakayama, T.: CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing Th2 cells. J. Biol. Chem. 279:23123-23133 (2004).
  7. Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hosokawa, H., Hasegawa, A., Taniguchi, M., and Nakayama, T.: CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity 19:281-294 (2003).
  8. Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M., and Nakayama, T.: Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J. Biol. Chem. 277:42399-42408 (2002).