DEPARTMENT OF IMMUNOLOGY, GRADUATE SCHOOL OF MEDICINE, CHIBA UNIVERSITY

<GATA3, its regulation and effector function>

  1. Hossain, M. B., Hosokawa, H., Hasegawa, A., Watarai, H., Taniguchi, M., Yamashita, M., and Nakayama, T.: Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells. Immunology 125:377-386 (2008).
  2. Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11 (2008).
  3. Yamashita, M., Onodera, A., and Nakayama, T.: Immune mechanisms of allergic airway diseases: Regulation by transcription factors. Crit. Rev. Immunol. 27:539-546 (2007).
  4. Hosokawa, H., Kimura, Y. M., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., and Nakayama, T.: Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177:7656-7664 (2006).
  5. Shinnakasu, R., Yamashita, M., Shinoda, K., Endo, Y., Hosokawa, H., Hasegawa, A., Ikemizu, S., and Nakayama, T.: Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. J. Immunol. 177:5801-5810 (2006).
  6. Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y. M., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24:611-622 (2006).
  7. Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M. B., Shimizu, C., Hashimoto, K., Kimura, Y. M., Yamashita, M., and Nakayama, T.: Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J. Immunol. 176:2546-2554 (2006).
  8. Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., and Shinnakasu, R.: Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
  9. Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., and Nakayama, T.: Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J. Biol. Chem. 280:29409-29419 (2005).
  10. Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., and Nakayama, T.: Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279:26983-26990 (2004).