DEPARTMENT OF IMMUNOLOGY, GRADUATE SCHOOL OF MEDICINE, CHIBA UNIVERSITY

<Regulation of memory CD4 T cell (Th1/Th2/Th17) generation and maintenance>

  1. Endo, Y., Onodera, A., Obata-Ninomiya, K., Koyama-Nasu, R., Asou, H. K., Ito, T., Yamamoto, T., Kanno, T., Nakajima, T., Ishiwata, K., Kanuka, H., Tumes, D. J., and Nakayama, T.: Acc1 determines memory potential of indivisual CD4+ T cells by regulating de novo fatty acid biosynthesis. Nat. Metab. 1(2):261-275 (2019).
  2. Endo, Y., Yokote, K., and Nakayama, T.: The obesity-related pathology and Th17 cells. Cell. Mol. Life Sci. 74(7):1231-1245 (2017).
  3. Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 cells in health and disease. Annu. Rev. Immunol. 35:53-84 (2017).
  4. Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. (*these authors contributed equally to this work) Nat. Commun. 7:13683 (2016).
  5. Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I., and Nakayama, T.: Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat. Commun. 7:11289 (2016).
  6. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, Y. M., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, I. K., Tanaka, T., and Nakayama, T.: Methylation of Gata3 at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells. J. Biol. Chem. 290(21):13095-13103 (2015).
  7. Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12(6):1042-1055 (2015).
  8. Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110(46): 18626-18631 (2013).
  9. Hanazawa, A., Hayashizaki, K., Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B., Radbruch, A., Tokoyoda, K., and Nakayama, T.: CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol. 91:524-531 (2013).
  10. Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., Tanaka, H., Ogawa, Y., Suzuki, Y., and Nakayama, T.: Genomic-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity. PLOS ONE 8(6): e66468 (2013).
  11. Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., Kanai, A., Sugano, S., and Nakayama, T.: Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc. Natl. Acad. Sci. USA 110(12): 4691-4696 (2013).
  12. Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc. Natl. Acad. Sci. USA 109(42): 16992-16997 (2012).
  13. Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786 (2012).
  14. Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., and Nakayama, T.: Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J. Immunol. 186:6378-6389 (2011).
  15. Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
  16. Nakayama, T., and Yamashita, M.: The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin. Immunol. 22:303-309 (2010).