<Regulation of memory CD4 T cell (Th1/Th2/Th17) generation and maintenance>
- Endo, Y., Onodera, A., Obata-Ninomiya, K., Koyama-Nasu, R., Asou, H. K., Ito, T., Yamamoto, T., Kanno, T., Nakajima, T., Ishiwata, K., Kanuka, H., Tumes, D. J., and Nakayama, T.: Acc1 determines memory potential of indivisual CD4+ T cells by regulating de novo fatty acid biosynthesis. Nat. Metab. 1(2):261-275 (2019).
- Endo, Y., Yokote, K., and Nakayama, T.: The obesity-related pathology and Th17 cells. Cell. Mol. Life Sci. 74(7):1231-1245 (2017).
- Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 cells in health and disease. Annu. Rev. Immunol. 35:53-84 (2017).
- Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. (*these authors contributed equally to this work) Nat. Commun. 7:13683 (2016).
- Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I., and Nakayama, T.: Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat. Commun. 7:11289 (2016).
- Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, Y. M., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, I. K., Tanaka, T., and Nakayama, T.: Methylation of Gata3 at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells. J. Biol. Chem. 290(21):13095-13103 (2015).
- Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12(6):1042-1055 (2015).
- Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110(46): 18626-18631 (2013).
- Hanazawa, A., Hayashizaki, K., Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B., Radbruch, A., Tokoyoda, K., and Nakayama, T.: CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol. 91:524-531 (2013).
- Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., Tanaka, H., Ogawa, Y., Suzuki, Y., and Nakayama, T.: Genomic-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity. PLOS ONE 8(6): e66468 (2013).
- Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., Kanai, A., Sugano, S., and Nakayama, T.: Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc. Natl. Acad. Sci. USA 110(12): 4691-4696 (2013).
- Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc. Natl. Acad. Sci. USA 109(42): 16992-16997 (2012).
- Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786 (2012).
- Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., and Nakayama, T.: Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J. Immunol. 186:6378-6389 (2011).
- Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
- Nakayama, T., and Yamashita, M.: The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin. Immunol. 22:303-309 (2010).