DEPARTMENT OF IMMUNOLOGY, GRADUATE SCHOOL OF MEDICINE, CHIBA UNIVERSITY

<Pathogenic Th cell regulation of chronic airway inflammation in mouse and human system>

  1. Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.: CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells. *These authors contributed equally to this work. Nat. Immunol. in press.
  2. Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.: Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology. Front. Immunol. 10:570 (2019).
  3. Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.: CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 115(42):E9849-E9858 (2018).
  4. Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat. Commun. 9(1):4231 (2018).
  5. Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T.: The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells. J. Leukoc. Biol. 104(5):895-901 (2018).
  6. Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T.: Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. Immunity 49(1):134-150 (2018).
  7. Mato, N., Hirahara, K., Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T.: Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Sci. Rep. 7(1):6805 (2017).
  8. Nakayama, T.: Introduction to “allergic inflammation”. Immunol. Rev. 278(1):5-7 (2017).
  9. Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 cells in health and disease. Annu. Rev. Immunol. 35:53-84 (2017).
  10. Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation 401-415 (2016).
  11. Hirahara, K., and Nakayama, T.: CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int. Immunol. 28(4):163-171 (2016).
  12. Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.: Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA 113(20):E2842-51 (2016).
  13. Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114(4):289-298 (2015).
  14. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, K. H., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42(2):294-308 (2015).
  15. Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35(2): 69-78 (2014).
  16. Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745 (2011).
  17. Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A., and Nakayama, T.: Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergology International 59:67-73 (2010).
  18. Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R. M., Shirai, M., and Nakayama, T.: Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in mouse asthma model. J Allergy Clin. Immunol. 125:461-468.e6 (2010).
  19. Iwamura, C., and Nakayama, T.: Role of NKT cells in allergic asthma. Curr. Opin. Immunol. 22:807-813 (2010).