DEPARTMENT OF IMMUNOLOGY, GRADUATE SCHOOL OF MEDICINE, CHIBA UNIVERSITY

<Role for CD69/CD69L (Myl9) in the pathogenesis of inflammatory diseases and cancer in mouse and human system>

  1. Mita, Y., Kimura, M. Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y., and Nakayama, T.: Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. Int. Immunol. 30(12):559-567 (2018).
  2. Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S., and Nakayama, T.: Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol. Rev. 278(1):87-100 (2017).
  3. Hayashizaki, K.,* Kimura, M. Y.,* Tokoyoda, K.,* Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y., and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. (*these authors contributed equally to this work) Sci. Immunol. 1(3):pp. eaaf9154 (2016).
  4. Hasegawa, A., Iwamura, C., Kitajima, M., Hashimoto, K., Otsuyama, K., Ogino, H., Nakayama, T., and Shirai, M.: Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis. PLOS ONE 8(6): e65494 (2013).
  5. Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D. J., Radbruch, A., and Nakayama, T.: Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. USA 109:7409-7414 (2012).