DEPARTMENT OF IMMUNOLOGY

Original paper

  1. Nassenstein, C., Kutschker, J., Tumes, D., and Braun, A.: Neuro-immune interaction in allergic asthma: role of neurotrophins. Biochem. Soc. Trans. 34:591-593 (2006).
  2. Tumes, D. J., Cormie, J., Calvert, M. G., Stewart, K., Nassenstein, C., Braun, A., Foster, P. S., and Dent, L. A.: Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils. J. Leukoc. Biol. 81:1362-1373 (2007).
  3. Giancomin, P. R., Cava, M., Tumes, D. J., Gauld, A. D., Iddawela, D. R., McColl, S. R., Parsons, J. C., Gordon, D. L., and Dent, L. A.: Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis. Parasite Immunol. 30:435-445 (2008).
  4. Tumes, D. J., Wong, A. C., Sewell, W. A., McColl, S. R., Connolly, A., and Dent, L. A.: Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice. Mol. Immunol. 45:3609-3617 (2008).
  5. Tumes, D. J., Connolly, A., and Dent, L. A.: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. Int. Immunol. 21:633-644 (2009).
  6. Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M., and Nakayama, T.: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J. Immunol. 184:4510-4520 (2010).
  7. Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
  8. Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745 (2011).
  9. Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., and Nakayama, T.: Murine Schnurri-2 controls Natural Killer cell function and lymphoma development. Leuk. Lymphoma 53:479-486 (2012).
  10. Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D. J., Radbruch, A., and Nakayama, T.: Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. USA 109:7409-7414 (2012).
  11. Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786 (2012).
  12. Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc. Natl. Acad. Sci. USA 109:16992-16997 (2012).
  13. Onodera, A., Tumes, D. J., and Nakayama, T.: Too much of a good thing. Nat. Immunol. 14:112-114 (2013).
  14. Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., Kanai, A., Sugano, S., and Nakayama, T.: Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc. Natl. Acad. Sci. USA 110:4691-4696 (2013).
  15. Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.: The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells. Immunity 39:819-832 (2013).
  16. Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35:69-78 (2014).
  17. Onodera, A., Tumes, D. J., and Nakayama, T.: Epigenetic control of immune T cell memory. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. 367-382 (2014).
  18. Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111:12829-12834 (2014).
  19. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).
  20. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T., and Nakayama, T.: Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells. J. Biol. Chem. in press.

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