DEPARTMENT OF IMMUNOLOGY

I) Original paper

  1. Kawano, T., Nakayama, T., Kamada, N., Kaneko, Y., Harada, M., Ogura, N., Akutsu, Y., Motohashi, S., Iizasa, T., Endo, H., Fujisawa, T., Shinkai, H., and Taniguchi, M.: Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells. Cancer Res. 59:5102-5105 (1999). (8.302)
  2. Iizasa, T., Fujisawa, T., Suzuki, M., Motohashi, S., Yasufuku, K., Yasukawa, T., Baba, M., and Shiba, M.: Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin. Cancer Res. 5(1):149-153 (1999). (5.076)
  3. Fujisawa, T., Iizasa, T., Saitoh, Y., Sekine, Y., Motohashi, S., Yasukawa, T., Shibuya, K., Hiroshima, K., and Ohwada, H.: Smoking before surgery predicts poor long-term survival in patients with stage I non-small-cell lung carcinomas. J. Clin. Oncol. 17(7):2086-2091 (1999). (8.530)
  4. Shin, T., Nakayama, T., Akutsu, Y., Motohashi, S., Shibata, Y., Harada, M., Kamada, N., Shimizu, C., Shimizu, E., Saito, T., Ochiai, T., and Taniguchi, M.: Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells. Int. J. Cancer 91:523-528 (2001). (4.233)
  5. Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S., Kawano, T., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M., and Taniguchi, M.: Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int. Immunol. 13:853-861 (2001). (3.611)
  6. Akutsu, Y., Nakayama, T., Harada, M., Kawano, T., Motohashi, S., Shimizu, E., Ito, T., Kamada, N., Saito, T., Matsubara, H., Miyazawa, Y., Ochiai, T., and Taniguchi, M.: Expansion of lung Vα14 NKT cells by administration of α-galactosylceramide-pulsed dendritic cells. Jpn. J. Can. Res. 93:397-403 (2002). (1.918)
  7. Motohashi, S., Kobayashi, S., Ito, T., Magara, K. K., Mikuni, O., Kamada, N., Iizasa, T., Nakayama, T., Fujisawa, T., and Taniguchi, M.: Preserved IFN-γ production of circulating Vα24 NKT cells in primary lung cancer patients. Int. J. Cancer 102:159-165 (2002). (4.233)
  8. Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M., and Nakayama, T.: TH1-biased immunity induced by exposure to Antarctic winter. J. Allergy Clin. Immunol. 111:1353-1360 (2003). (6.831)
  9. Ishikawa, A., Motohashi, S., Shibuya, K., Baba, M., Toyosaki, T., Ohwada, H., Saito, N., Suzuki, K., and Fujisawa, T.: Small solitary pulmonary metastasis detected before primary sigmoid colon cancer: report of a case. Surg. Today 33(9):709-711 (2003). (0.528)
  10. Sekine, Y., Iwata, T., Chiyo, M., Yasufuku, K., Motohashi, S., Yoshida, S., Suzuki, M., Iizasa, T., Saitoh, Y., and Fujisawa, T.: Minimal alteration of pulmonary function after lobectomy in lung cancer patients with chronic obstructive pulmonary disease. Ann. Thorac. Surg. 76(2):356-361 (2003). (2.041)
  11. Kobayashi, S., Kaneko, Y., Seino, K., Yamada, Y., Motohashi, S., Koike, J., Sugaya, K., Kuriyama, T., Asano, S., Tsuda, T., Wakao, H., Harada, M., Kojo, S., Nakayama, T., and Taniguchi, M.: Impaired IFN-γ production of Vα24 NKT cells in non-remitting sarcoidosis. Int. Immunol. 16:215-222 (2004). (3.69)
  12. Yamaji, H., Iizasa, T., Koh, E., Suzuki, M., Otsuji, M., Chang, H., Motohashi, S., Yokoi, S., Hiroshima, K., Tagawa, M., Nakayama, T., and Fujisawa, T.: Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer. Cancer Immunol. Immunother. 53(9):786-792 (2004). (3.13)
  13. Iizasa, T., Chang, H., Suzuki, M., Otsuji, M., Yokoi, S., Chiyo, M., Motohashi, S., Yasufuku, K., Sekine, Y., Iyoda, A., Shibuya, K., Hiroshima, K., and Fujisawa, T.: Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in non-small cell lung cancer. Clin. Cancer Res. 10(16):5361-5366 (2004). (6.511)
  14. Ishikawa, A., Motohashi, S., Ishikawa, E., Fuchida, H., Higashino, K., Otsuji, M., Iizasa, T., Nakayama, T., Taniguchi, M., and Fujisawa, T.: A phase I study of α-Galactosyl ceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer. Clin. Cancer Res. 11:1910-1917 (2005). (6.511)
  15. Motohashi, S., Sekine, Y., Iizasa, T., Nakano, K., Numata, T., and Fujisawa, T.: Thyroid cancer with massive invasion into the neck and mediastinal great veins. Jpn. J. Thorac. Cardiovasc Surg. 53:55-57 (2005). (3.319)
  16. Suzuki, H., Sekine, Y., Motohashi, S., Chiyo, M., Suzuki, M., Haga, Y., Hiroshima, K., Ohwada, H., Iizasa, T., Saitoh, Y., Baba, M., and Fujisawa, T.: Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases. Surg. Today 35:243-246 (2005). (0.528)
  17. Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A., and Nakayama, T.: Dendritic cell maturation by CD11c+ T cells and Vα24+ NKT cell activation by α-Galactosylceramide. Int. J. Cancer 117:265-273 (2005). (4.375)
  18. Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., and Shinnakasu, R.: Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
  19. Yoshino, M., Hiroshima, K., Motohashi, S., Shibuya, K., Iyoda, A., Sekine, Y., and Fujisawa, T.: Papillary carcinoma of the thymus gland. Ann. Thorac. Surg. 80:741-742 (2005).
  20. Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T., and Nakayama, T.: A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. Clin. Can. Res. 12:6079-6086 (2006). (5.715)
  21. Sekine, Y., Yasufuku, K., Motohashi, S., and Fujisawa, T.: Triple reconstruction of pulmonary artery, superior vena cava and bronchus for lung cancer. Interact. Cardiovasc Thorac. Surg. 5:509-510 (2006).
  22. Iizasa, T., Suzuki, M., Yoshida, S., Motohashi, S., Yasufuku, K., Iyoda, A., Shibuya, K., Hiroshima, K., Nakatani, Y., and Fujisawa, T.: Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann. Thorac. Surg. 82:254-260 (2006).
  23. Suzuki, M., Shigematsu, H., Nakajima, T., Kubo, R., Motohashi, S., Sekine, Y., Shibuya, K., Iizasa, T., Hiroshima, K., Nakatani, Y., Gazdar, A. F., and Fujisawa, T.: Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer. Clin. Cancer Res. 13:6087-6092 (2007).
  24. Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T., and Okamoto, Y.: Phase I study of α-Galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. Cancer Immunol. Immunother. 57:337-345 (2008).
  25. Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-1120 (2008).
  26. Suzuki, M., Mohamed, S., Nakajima, T., Kubo, R., Tian, L., Fujiwara, T., Suzuki, H., Nagato, K., Chiyo, M., Motohashi, S., Yasufuku, K., Iyoda, A., Yoshida, S., Sekine, Y., Shibuya, K., Hiroshima, K., Nakatani, Y., Yoshino, I., and Fujisawa, T.: Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Int. J. Oncol. 33:113-119 (2008).
  27. Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., and Nakayama, T.: Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int. Immunol. 20:849-860 (2008).
  28. Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., and Nakayama, T.: Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J. Biol. Chem. 283:28216-28225 (2008).
  29. Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T., and Nakayama, T.: A phase I-II study of α-Galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer. J. Immunol. 182:2492-2501 (2009).
  30. Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., and Okamoto, Y.: Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. Cancer Sci. 100:1092-1098 (2009).
  31. Alaa, M., Suzuki, M., Yoshino, M., Tian, L., Suzuki, H., Nagato, K., Fujiwara, T., Wada, H., Moriya, Y., Hoshino, H., Motohashi, S., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y., Abdrabou, A., Elkholy, M., Mahfouz, T., and Yoshino, I.: Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. Int. J. Oncol. 34:805-812 (2009).
  32. Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., and Nakayama, T.: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J. Immunol. 183:5388-5396 (2009).
  33. Miki-Hosokawa, T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., and Nakayama, T.: CD69 controls the pathogenesis of allergic airway inflammation. J. Immunol. 183:8203-8215 (2009).
  34. Suzuki, M., Wada, H., Yoshino, M., Tian, L., Shigematsu, H., Suzuki, H., Alaa, M., Tamura, H., Fujiwara, T., Nagato, K., Motohashi, S., Moriya, Y., Hoshino, H., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y., and Yoshino, I.: Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling. Ann. Surg. Oncol. 17:878-888 (2010).
  35. Okita, K., Motohashi, S., Shinnakasu, R., Nagato, K., Yamasaki, K., Sato, Y., Kitamura, H., Hijikata, A., Yamashita, M., Shimizu, K., Fujii, S., Ohara, O., Taniguchi, M., Sakaida, I., and Nakayama, T.: A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.Cancer Sci. 101:2333-2340 (2010).
  36. Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., and Okamoto, Y.: Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer. Cancer Immunol. Immunother. 60:207-215 (2011).
  37. Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T., and Okamoto, Y.: Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. Clin. Immunol. 138:255-265 (2011).
  38. Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
  39. Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., and Nakayama, T.: Murine Schnurri-2 controls Natural Killer cell function and lymphoma development. Leuk. Lymphoma 53:479-486 (2012).
  40. Nagai, M., Furihata, T., Matsumoto, S., Ishii, S., Motohashi, S., Yoshino, I., Ugajin, M., Miyajima, A., Matsumoto, S., and Chiba, K.: Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem. Biophys. Res. Commun. 418:818-823 (2012).
  41. Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat. Immunol. 13:778-786 (2012).
  42. Nagato, K., Motohashi, S., Ishibashi, F., Okita, K., Yamasaki, K., Moriya, Y., Hoshino, H., Yoshida, S., Hanaoka, H., Fujii, S., Taniguchi, M., Yoshino, I., and Nakayama, T.: Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells. J. Clin. Immunol. 32:1071-1081 (2012).
  43. Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc. Natl. Acad. Sci. USA 109:16992-16997 (2012).
  44. Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110:18626-18631 (2013).
  45. Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.: The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells. Immunity 39:819-832 (2013).
  46. Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111:12829-12834 (2014).
  47. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).
  48. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T., and Nakayama, T.: Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells. J. Biol. Chem. in press.

II) Review Article and Book Chapter

  1. Nakayama, T., Yamashita, M., Kawano, T., Shimizu, C., Shibata, Y., Kamata, T., Kaneko, Y., Kobayashi, S., Takeda, U., Motohashi, S., Cui, J., and Taniguchi, M.: The role of α-GalCer-activated Vα14 NKT cells in the regulation of Th2 cell differentiation. Int. Arch. Allergy Immunol. 124:38-42 (2001). (2.164)
  2. Seino, K., Fuji, S., Harada, M., Motohashi, S., Nakayama, T., Fujisawa, T., and Taniguchi, M.: Vα14 NKT cell-mediated anti-tumor responses and their clinical application. Springer Semin. Immunopathol. 27:65-74 (2005). (0.918)
  3. Seino, K., Motohashi, S., Fujisawa, T., Nakayama, T., and Taniguchi, M.: Natural killer T cell-mediated antitumor immune responses and their clinical applications. Cancer Sci. 97:807-812 (2006). (3.829)
  4. Motohashi, S., and Nakayama, T.: Clinical applications of natural killer T cell-based immunotherapy for cancer. Cancer Sci. 99:638-645 (2008).
  5. Motohashi, S., and Nakayama, T.: Natural killer T cell-mediated immunotherapy for malignant diseases. Front. Biosci. S1:108-116 (2009).
  6. Motohashi, S., and Nakayama, T.: Invariant natural killer T cell-based immunotherapy for cancer. Immunotherapy 1:73-82 (2009).
  7. Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y., and Taniguchi, M.: Adjuvant activity mediated by iNKT cells. Semin. Immunol. 22:97-102 (2010).
  8. Ishii, Y., Motohashi, S., Shimizu, K., Nakayama, T., Taniguchi, M., and Fujii, S.: Application of NKT cells in immunotherapy. Curr. Immunol. Rev. 6:109-115 (2010).
  9. Motohashi, S., Okamoto, Y., Yoshino, I., and Nakayama, T.: Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer. Clin. Immunol. 140:167-176 (2011).
  10. Motohashi, S., Okamoto, Y., and Nakayama, T.: Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer. Natural killer T cells: Balancing the Regulation of Tumor Immunity. 185-198 (2011).
  11. Taniguchi, M., Fujii, S., Nakayama, T., Motohashi, S., Dashtsoodal, N., Watarai, H., and Harada, M.: Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Deprived NKT Cells. Natural killer T cells: Balancing the Regulation of Tumor Immunity. 1-14 (2011).
  12. Fujii, S., Shimizu, K., Okamoto, Y., Kunii, N., Nakayama, T., Motohashi, S., and Taniguchi, M.: NKT cells as an ideal anti-tumor immunotherapeutic. Front. Immunol. 4:409 (2013).

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