DEPARTMENT OF IMMUNOLOGY

<Regulation of Th2-driven Inflammation: Molecular studies in mouse models>

  1. Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A., and Nakayama, T.: Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol. Int. 59:67-73 (2010).
  2. Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., and Nakayama, T.: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J. Immunol. 183:5388-5396 (2009).
  3. Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., and Nakayama, T.: CD69 controls the pathogenesis of allergic airway inflammation. J. Immunol. 183:8203-8215 (2009).
  4. Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11 (2008).
  5. Yamashita, M., Onodera, A., and Nakayama, T.: Immune mechanisms of allergic airway diseases: Regulation by transcription factors. Crit. Rev. Immunol. 27:539-546 (2007).
  6. Iwamura, C., Kimura, Y. M., Shinoda, K., Endo, Y., Hasegawa, A., Yamashita, M., and Nakayama, T.: Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int. Immunol. 19:755-762 (2007).
  7. Iwamura, C., and Nakayama, T.: Role of α-galactosylceramide-activated Vα14 natural killer T cells in the regulation of allergic diseases. Allergol. Int. 56:1-6 (2007).
  8. Tenda, Y., Yamashita, M., Kimura, Y. M., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki, N., and Nakayama, T.: Hyperresponsive TH2 cells with enhanced nuclear factor-κB activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J. Allergy Clin. Immunol. 118:725-733 (2006)
  9. Nigo, I. Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103:2286-2291 (2006).
  10. Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M. B., Shimizu, C., Hashimoto, K., Kimura, Y. M., Yamashita, M., and Nakayama, T.: Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J. Immunol. 176:2546-2554 (2006).