DEPARTMENT OF IMMUNOLOGY

Publications

I) Original paper
  1. Nigo, Y. I., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103:2286-2291 (2006).
  2. Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, M. Y., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24:611-622 (2006).
  3. Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-1120 (2008).
  4. Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11 (2008).
  5. Hirahara, K., Ghoreschi, K., Laurence, A., Yang, X. P., Kanno, Y., and O'Shea, J. J.: Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev. 21:425-434 (2010).
  6. Ghoreschi, K., Laurence, A., Yang, X. P., Hirahara, K., and O'Shea, J. J.: T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol. 32:395-401 (2011).
  7. Yang, X. P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H. W., Wei, L., Vahedi, G., Kanno, Y., O'Shea, J. J., and Laurence, A.: Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12:247-254 (2011).
  8. Hirahara, K., Vahedi, G., Ghoreschi, K., Yang, X. P., Nakayamada, S., Kanno, Y., O'Shea, J. J., and Laurence, A.: Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 134:235-245 (2011).
  9. Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K.,and O'Shea, J. J.: Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30:707-731 (2012).
  10. Laurence, A., Ghoreschi, K., Hirahara, K., Yang, X. P., and O'Shea, J. J.: Therapeutic inhibition of the Janus kinases. Inflammation and Regeneration 32:16-22 (2012).
  11. Takahashi, H., Kanno, T., Nakayamada, S., Hirahara, K., Sciumè, G., Muljo, S. A., Kuchen, S., Casellas, R., Wei, L., Kanno, Y., and O'Shea, J. J.: TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat. Immunol. 13:587-595 (2012).
  12. Hirahara, K., Ghoreschi, K., Yang, X. P., Takahashi, H., Laurence, A., Vahedi, G., Sciumè, G., Hall, A. O., Dupont, C. D., Francisco, L. M., Chen, Q., Tanaka, M., Kanno, Y., Sun, H. W., Sharpe, A. H., Hunter, C. A., and O'Shea, J. J.: Interleukin-27 priming of T cells controls Interleukin-17 production in trans via induction of the ligand PD-L1. Immunity 36:1017-1030 (2012).
  13. Sciumè, G., Hirahara, K., Takahashi, H., Laurence, A., Villarino, A. V., Singleton, K. L., Spencer, S. P., Wilhelm, C., Poholek, A. C., Vahedi, G., Kanno, Y., Belkaid, Y., and O'Shea, J. J.: Distinct requirements for T-bet in gut innate lymphoid cells. J. Exp. Med. 209:2331-2338 (2012).
  14. Vahedi, G., C. Poholek, A., Hand, T. W., Laurence, A., Kanno, Y., O'Shea, J. J., and Hirahara, K.: Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol. Rev. 252:24-40 (2013).
  15. Hirahara, K., Poholek, A., Vahedi, G., Laurence, A., Kanno, Y., Milner, J. D., and O'Shea, J. J.: Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease. J. Allergy Clin. Immunol. 131:1276-1287 (2013).
  16. Roychoudhuri, R.*, Hirahara, K.*, Mousavi, K.*, Clever, D., Klebanoff, C. A., Bonelli, M., Sciumè, G., Zare, H., Vahedi, G., Dema, B., Yu, Z., Liu, H., Takahashi, H., Rao, M., Muranski, P., Crompton, J. G., Punkosdy, G., Bedognetti, D., Wang, E., Hoffmann, V., Rivera, J., Marincola, F. M., Nakamura, A., Sartorelli, V., Kanno, Y., Gattinoni, L., Muto, A., Igarashi, K., O'Shea, J. J., and Restifo, N. P.: BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis. *These authors are contributed equally to this work. Nature 498:506-510 (2013).
  17. Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, M. V., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110:18626-18631 (2013).
  18. Nakayamada, S., Poholek, A. C., Lu, K. T., Takahashi, H., Kato, M., Iwata, S., Hirahara, K., Cannons, J. L., Schwartzberg, P. L., Vahedi, G., Sun, H. W., Kanno, Y., and O'Shea, J. J.: Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J. Immunol. 192:2156-2166 (2014).
  19. Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., Hirahara, K., Vahedi, G., Sun, H. W., Feigenbaum, L., Milner, J. D., Holland, S. M., Casellas, R., Powrie, F., and O'Shea, J. J.: A mouse model of HIES reveals pro and anti-inflammatory functions of STAT3. Blood 123:2978-2987 (2014).
  20. Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111:12829-12834 (2014).
  21. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).
  22. Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114:289-298 (2015).
  23. Hirahara, K., Onodera, A., Villario, A. V., Bonelli, M., Sciume, G., Laurence, A., Sun, H. W., Brooks, R. S., Vahedi, G., Shih, H. Y., Gtierrez-Cruz, G., Iwata, S., Suzuki, R., Mikami, Y., Okamoto, Y., Nakayama, T., Holland, S., Hunter, C. A., Kanno, Y., and O'Shea, J. J.: Asymmetric action of STAT transcription factors drive transcriptional outputs and cytokine specificity. Immunity in press.
II) Review Article and Book Chapter
  1. Villarino, A., Yang, X. P., Hirahara, K., Kanno, Y., O'Shea, J. J., and Laurence, A.: Function of JAKs and STATs in lymphocyte: bench to bedside. Springer-Verlag Wien Thomas Decker (Ed.) (2012).
  2. Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35:69-78 (2014).
  3. Bonelli, M., Shih, H. Y., Hirahara, K., Singelton, K., Laurence, A., Poholek, A., Hand, T., Mikami, Y., Vahedi, G., Kanno, Y., and O'Shea, J. J.: Helper T cell plasticity: impact of extrinsic and intrinsicsSignals on transcriptomes and epigenomes. Curr. Top. Microbiol. Immunol. 381:279-326 (2014).
  4. Shih, H. Y., Sciume, G., Poholek, A. C., Vahedi, G., Hirahara, K., Villarino, A. V., Bonelli, M., Bosselut, R., Kanno, Y., Muljo, S. A., and O'Shea, J. J.: Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol. Rev. 261:23-49 (2014).

邦文業績

（２０１４）
  1. 平原潔、中山俊憲　エピジェネティクス(Epigenetics)と呼吸器疾患　Respiratory Medical Research　先端医学社　2(2):63-65 (2014・4)
  2. 平原潔、中山俊憲　Th2細胞分化制御の新知見とアレルギー発症の新概念ー代謝・エピジェネティクスからpathogenicメモリーTh2細胞まで　実験医学　32(17):70-74 (2014・11)
（２０１３）
  1. 平原潔、中山俊憲　アレルギ−総論　免疫・アレルギ−疾患イラストレイテッド　20-27 (2013・10)
  2. 平原潔、中山俊憲　気管支喘息病態形成におけるT細胞サブセットの可塑性と多様性　実験医学増刊　病態の理解に向かうアレルギ−疾患研究　31(17):150-154 (2013・11)
  3. 平原潔、中山俊憲　ヘルパ−T細胞サブセットの多様性と気道アレルギ−性炎症の病態形成における役割　医学のあゆみ　花粉症ー研究と治療の進展　247(12,13):1203-1207 (2013・12)
（２００９）
  1. 津畑千佳子、田邊嘉也、田中淳一、朝川勝明、平原潔、手塚貴文、坂上拓郎、小屋俊之、寺田正樹、高田俊範、成田一衛、村上修一、黒田毅、長谷川隆志、鈴木栄一　メトトレキサ−トとタクロリムス使用中にニュ−モシスチス肺炎を合併した関節リウマチの1例　新潟医学会雑誌　123(11):585-589 (2009)
（２００８）
  1. 平原潔、田中純太、伊藤竜、栗山英之、田中洋史、各務博、吉澤弘久、下条文武　非小細胞肺癌に対するCisplatinとVinorelbine併用による術後補助化学療法-連続5例における安全性の検討-　癌と化学療法　35(1):109-111 (2008)
（２００５）
  1. 下畑光輝、平原潔、五十嵐修一、原賢寿、木島一己、小野寺理、田中恵子、西澤正豊、辻省次、早坂清　Charcot-Marie-Tooth disease type 4F (Periaxin変異)の1家系　臨床神経学　45:221-225 (2005)
（２００４）
  1. 平原潔、坂井邦彦、中山秀章、長谷川隆志、塚田弘樹、吉澤弘久、鈴木栄一、下条文武　診断時に進行した呼吸不全を呈していたKartagener症候群の1例　日本胸部床　63(5):473-483 (2004)
（２００３）
  1. 平原潔、高堂裕平、下畑光輝、五十嵐修一、田中恵子、辻省次　免疫グロブリン静注療法(IVIg)が奏功した糖尿病性筋萎縮症の1症例　神経治療学　20(1):81-85 (2003)

学会発表・セミナー等

（２０１５）
  1. Hirahara, K., Nakayama, T., Holland, S., Hunter, C., Kanno, Y., and O’Shea, J. J.: Asymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity. Keystone Symposia Mechanisms of Pro-Inflammatory Diseases (Z4), 2015 Apr 19-24, Olympic Valley, CA
（２０１４）
  1. Hirahara, K., Nakayama, T., Holland, S., Hunter, C.A., Kanno, Y., and O'Shea, J.J.: Asymmetry of STAT action to define specificity and redundancy of IL-27 and IL-6 signals. KEYSTONE SYMPOSIA Emerging Cytokine Networks (J3), 2014 Jan 17-22, Vancouver
  2. 平原潔　The Regulation of Immune Homeostasis via CD4 T Cells.　＜CD4T細胞から見た免疫システムの恒常性制御＞　教育講演　テニュアトラック普及事業スポンサード・セミナー（第18回大学院医学セミナー・三重大学大学院医学系研究科）2014年2月10日、三重
  3. Hirahara, K., Kanno, Y., Nakayama, T., and O'Shea, J. J.: Asymmetry of STAT action to define specificity and redundancy of IL-27 and IL-6 signals. The 2nd Symposium of International Immunological Memory and Vaccine Forum, 2014 Aug 25-26, La Jolla, USA
  4. 平原潔　CD4T細胞を介した免疫恒常性の制御およびその破綻による慢性真菌感染症について　真菌医学研究センター・Monthlyセミナー（千葉大学真菌医学研究センター）　2014年10月7日、千葉
  5. 平原潔、遠藤裕介、中山俊憲　アレルギ−性炎症の病態形成における多様なヘルパ−T細胞サブセットの役割　第10回千葉小児感染・アレルギ−懇話会　2014年11月20日、千葉
  6. Hirahara, K., Wada, T., Nakayama, T., and O'Shea, J. J.: Asymmetry of STAT action to define specificity and redundancy of IL-27 and IL-6 signals.　第43回日本免疫学会総会・学術集会　2014年12月10-12日、京都
  7. Watanabe, Y., Onodera, A., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Morimoto, Y., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: The trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.　第43回日本免疫学会総会・学術集会　2014年12月10-12日、京都
（２０１３）
  1. Hirahara, K.: Bach2 represses effector programs to stabilize Treg-mediated immune homeostasis. NIAMS IRP Retreat 2013, 2013 June 5-6, Bethesda
  2. Ito, T., Hirahara, K., Motohashi, S., Yano, I., and Nakayama, T.: Anti-tumor effect of BCG-LM via the activation of eosinophils. 第72回日本癌学会学術総会 2013年10月3-5日、横浜
  3. Hirahara, K.: Bach2 represses effector programs to stabilize Treg-mediated immune homeostasis. シンポジウム The 3rd CSI/JSI/KAI Joint Symposium on Immunology, 2013 Dec 1-3, Korea
  4. Hirahara, K.: Bach2 represses effector programs to stabilize Treg-mediated immune homeostasis. シンポジウム 第42回日本免疫学会総会学術集会 2013年12月11-13日、幕張
  5. Ito, T., Hirahara, K., Suzuki, A., Shinoda, K., Wada, T., Yano, I., and Nakayama, T.: Induction of anti-tumor effect of BCG-LM through activation of eosinophils and effector memory Th2 cells. 第42回日本免疫学会総会学術集会 2013年12月11-13日、幕張
（２０１２）
  1. Hirahara, K., Ghoreschi, K., Yang, X. P., Takahashi, H., Laurence, A., Vahedi, G., Sciumè, G., Hall, A. O., Dupont, C. D., Francisco, L. M., Chen, Q., Tanaka, M., Kanno, Y., Sun, H. W., Sharpe, A. H., Hunter, C. A., and O'Shea, J. J.: IL-27 priming of T cells controls IL-17-production in trans via induction of PD-L1. The 99th Annual Meeting of The American Association of Immunologists, Immunology 2012, 2012 May 4-8, Boston
  2. Hirahara, K., Ghoreschi, K., Yang, X. P., Takahashi, H., Laurence, A., Vahedi, G., Sciumè, G., Hall, A. O., Dupont, C. D., Francisco, L. M., Chen, Q., Tanaka, M., Kanno, Y., Sun, H. W., Sharpe, A. H., Hunter, C. A., and O'Shea, J. J.: IL-27 priming of T cells controls IL-17-production in trans via induction of PD-L1. Keystone Symposia Th17 cells in Health and Disease (Q2) Keystone CO U.S.A. Feb 5-10, USA
（２０１１）
  1. Hirahara, K., Ghoreschi, K., Yang, X. P., Laurence, A., Takahashi, H., Vahedi, G., Sun, H. W., Kanno, Y., Hunter, C. A., and O'Shea, J. J.: Activation-dependent changes in cytokine signaling during T cell differentiation. Keystone Symposia Immunoregulatory netwark (D5) Breckenridge CO U.S.A. 2011 April 1-6, USA
（２００９）
  1. Nakayama, T., Hirahara, K., and Yamashita, M.: ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. The 96th Annual Meeting of The American Association of Immunologists, Immunology 2009, 2009 May 8-12, Seattle
  2. Hirahara, K., Yamashita, M., Iwamura, C., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness.　第49回日本呼吸器学会総会　2009年6月12-14日、東京

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