Bioinformatics
Overview
The Department of Bioinformatics was established on January 1, 2006, with the basic philosophy of “For the smiles of patients and their families”.
Dr. Kenichi Fukui, a Nobel prize laureate in Chemistry who had created fundamental insights into chemical reactivity, was trying to say, “With the development of computers, large computational theories were introduced into the research field of chemistry, which helped us to understand empirical facts in a non-empirical way. However, theory has only half the advantage if you must do all the calculations to understand it. Theory must continually generate concepts that will help drive experimental chemistry forward”.
Therefore, we are addressing the question “What is life?” by using mathematical sciences to develop basic medicine and enhance clinical medicine.
Associate Professor:
Yutaka Tamura, DOM. PhD.
TEL: +81-43-222-7171（ex70490）
e-mail: yutaka_tamura●faculty.chiba-u.jp
URL: https://www.m.chiba-u.ac.jp/class/bioinfor/e/index.html
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Research & Education
- Bioinformatics: Sequence Analysis and Genome Annotation
Precision medicine by the gene expression analytical technique using the next-generation sequencer - Bioinformatics: Structural Biology
Computer simulations (molecular dynamics, electrostastic complementary, shape complementary, and quantum chemistry) to approach the elucidation of life phenomena - Molecular Target Drug Discovery
・ Antibody Drugs: Construction of Immunoadhesins by molecular biology
・ Peptide Drugs: Construction of Peptide Mimetics by "in silico molecular evolution method"
・Small molecule drugs: Searched for functional control molecules by high-throughput screening using a super computing system - Photoimmunotherapy: Non-Invasive Medicine
Attempt to improve QOL and prolong survival of patients by combining LP-iDOPE, a clinically applicable fluorescent nanoparticle, with a near-infrared fluorescence irradiation system
Recent Publications
- “15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling.” Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. J Biol Chem.2020 Sep 18;295(38):13338-13352.
- “Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.” Hirano KI, Suganami A, Tamura Y, Yagita H, Habu S, Kitagawa M, Sato T, Hozumi K. Elife.2020 Jan 16;9:e50979.
- “Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.” Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y. Int J Pharm. 2015 Oct 23. pii: S0378-5173(15)30271-4.