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Endocrinology, Hematology and Gerontology

Overview

Department of Endocrinology, Hematology and Gerontology aims at patient-centered care in complex disorders based on the highest standards of academic medicine. We provide the best possible treatment with common to relatively rare diseases through a team-based approach. We carry out the basic science and clinical studies covering a broad range of areas in diabetes, metabolism, endocrinology, gerontology and hematology to develop novel therapeutic strategies for currently untreatable diseases. Through our integrated research, education, community-outreached programs and global collaboration, we are dedicated to pursue the cutting edge of medical science.

Professor:
Koutaro Yokote, MD, PhD, MBA

TEL: +81-43-226-2092
FAX: +81-43-226-2095
e-mail: ninai●office.chiba-u.jp
URL: http://www.m.chiba-u.jp/class/clin-cellbiol/

※　Please change "●" mark to at-mark if you send emails.

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Research & Education

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Diabetes, Metabolism, Endocrinology and Gerontology

  1. Pathogenesis and treatment of type 2 diabetes.
  2. Molecular mechanism of diabetic complications: the role of transcription factors.
  3. Insulin action in the liver, adipose tissue and brain.
  4. Obesity research: from molecular mechanisms to clinical trials.
  5. Dyslipidemia and atherosclerosis.
  6. Intracellular signaling in regulation of proliferation and apoptosis of endocrine cells.
  7. Advanced research for osteoporosis and bone metabolism.
  8. Generation of endocrine cells from ES/iPS cells.
  9. Molecular pathogenesis and treatment of adrenal diseases.
  10. Molecular mechanism of aging: pathogenesis and treatment of progeroid Werner syndrome.


Hematology

  1. POEMS (Crow-Fukase) syndrome.
    - Pathogenesis of POEMS syndrome.
    - Clinical trial with autologous peripheral blood transplantation.
  2. Clinical trials in hematopoietic stem cell transplantation.
  3. Mechanism of leukemogenesis by MLL-ELL fusion gene.
  4. Mechanism of chronis myeloproliferative disorders (CMPD) development.
    - Analysis of newly-identified TEL-Lyn fusion gene in idiopathic myelofibrosis.

Recent Publications

  1. Takeda K, Ono H et al. Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats. BMJ Open Diabetes Res Care. 2021;9:e002104.
  2. Ishiwata K, Koide H et al. Characteristics of benign adrenocortical adenomas with 18F-FDG PET accumulation. Eur J Endocrinol. 2021:185:155-165.
  3. Ide S, Maezawa Y et al. Transcription factor 21 is required for branching morphogenesis and regulates the GDNF-axis in kidney development. J Am Soc Nephrol. 2018;29:2795-2808.
  4. Mishina T, Sakaida E et al. Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort. Br J Haematol. 2021;195(5):731-742.
  5. Wilding JPH, Yokote K et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021:384:989-1002.zz