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Oral Science (Dentistry and Oral-Maxillofacial Surgery)

Overview

 Our department, which was established in 1918, is a leading oral surgery department in Japan. Dr. Kenji Nittono, who is regarded as the founder of oral surgery in Japan, Dr. Heizo Nakamura, Dr. Torakichi Kanamori, Prof. Ikichi Sato and other pioneers of the early stages of oral surgery in Japan, have acted as leaders in this field. As a result, departments of oral surgery were established at Nihon University, Tokyo Medical and Dental University, and the Health Sciences University of Hokkaido. In 1962, it was established as a course and Dr. Ikichi Sato became the first professor Chiba University under the new system. Prof. Tatsurou Horikoshi, Prof. Ken-ichi Sato, Prof. Hideki Tanzawa, and Prof. Katsuhiro Uzawa became chief professor in 1966, 1979, 1997, and 2020, respectively. We generally handle oral diseases both in clinical and research settings, but we have been studying oral cancer intensely from before, and our department has been continuing development involving many big-budget projects, like the center of excellence (COE) of research, education, and treatment of the 21st Century COE Program (2003-2008), the leaders’ class of the Educational Program for the Specialist of Cancer Treatment (2007-2012), and as a representative researcher of Japan Science and Technology (JST) seeds contracted development work.

Professor:
Katsuhiro Uzawa, D.D.S., Ph.D., FIBCSOMS

TEL: +81-43-226-2300
FAX: +81-43-226-2300
e-mail: uzawak●faculty.chiba-u.jp
URL: https://www.m.chiba-u.ac.jp/class/oral-sci/

※ Please change "●" mark to at-mark if you send emails.

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Research & Education

Characterization of oncogenes/tumor suppressor genes and investigation of the relevance in oral squamous carcinoma cell (OSCC).

Development of new anti-cancer agents for effective chemotherapy, radiotherapy, inhibition of metastasis, and drug delivery system in OSCC by molecular biology methods.
a) Mechanisms of cetuximab resistance/side effects in OSCC
b) Mechanisms of CDDP resistance in OSCC
c) Mechanisms of radioresistance in OSCC
d) Mechanisms of collagen highway/barrier, which is thought to assist/protect cancer cell metastasis, in OSCC

Development of new cell-based therapy for salivary gland transplantation for the head and neck cancer patients with radiotherapy.

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Recent Publications

  • Kawasaki K, Kasamatsu A, Ando T, Saito T, Nobuchi T, Nozaki R, Iyoda M, Uzawa K. Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway. Cancers (Basel). 2021 Dec 15;13(24):6299. doi: 10.3390/cancers13246299.
  • Uzawa K, Amelio A L, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma. Sci Rep. 2019 Aug 21;9(1):12179. doi: 10.1038/s41598-019-48717-w.
  • Kasamatsu A, Uzawa K, Hayashi F, Kita A, Okubo Y, Saito T, Kimura Y, Miyamoto I, Oka N, Shiiba M, Ito C, Toshimori K, Miki T, Yamauchi M, Tanzawa H.Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.Biochem Biophys Res Commun. 2019 Mar 21. pii: S0006-291X(19)30480-2. doi: 10.1016/j.bbrc.2019.03.091.
  • Saito T, Uzawa K, Terajima M, Shiiba M, Amelio AL, Tanzawa H, Yamauchi M.Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma.J Dent Res. 2019 Feb 20:22034519828710. doi: 10.1177/0022034519828710.