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Orthopaedic Surgery

Overview

We are conducting research into regenerative medicine concerning the articular cartilage and spinal cord using stem cells and cytokines, molecular biological research into the developmental mechanism of low back pain and its desensitization, and the development and research of knee joint prostheses with good durability. Both our basic and clinical research into enthesopathy using shock waves is globally accepted. We have started a voluntary clinical trial of the administration of granulocyte colony-stimulating factor (G-CSF) to spinal cord injury patients, based on the basic data indicating that G-CSF is effective for spinal cord injuries in animal model.

Professor:
Seiji Ohtori, M.D., PhD.

URL: http://www.chiba-orthopaedics.com/

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Research & Education

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  1. Pathomechanism of low back pain, osteoporosis, and sarcopenia
  2. Regeneration therapy for spinal cord injury
  3. Molecular mechanisms of shock wave therapy
  4. Cartilage regeneration
  5. Pathogenesis of ossification of posterior longitudinal ligament
  6. Pathogenesis of osteoarthritis of the knee joint
  7. Pathogenesis of osteoarthritis of the hip joint
  8. Sports medicine
  9. MRI imaging of the bone and joint
  10. Pathogenesis and treatment of trauma and injury of the bone and joint
  11. Orthopedic biomechanics
  12. Pathogenesis of disorders of the upper extremity and the hand

Recent Publications

  1. Bone union-promoting effect of romosozumab in a rat posterolateral lumbar fusion model. Kim G, Inage K, Shiga Y, Mukaihata T, Tajiri I, Eguchi Y, Suzuki-Narita M, Takaoka H, Hozumi T, Mizuki N, Tsuchiya R, Otagiri T, Hishiya T, Arai, Toshi N, Furuya T, Maki S, Nakamura J, Hagiwara S, Aoki Y, Koda M, Takahashi H, Akazawa T, Ohtori S, Orita S. J Orthop Res. 2022 Jan 27. doi: 10.1002/jor.25287. Online ahead of print. PMID: 35088447
  2. Anatomical Implications Regarding Femoral Nerve Palsy During a Direct Anterior Approach to Total Hip Arthroplasty: A Cadaveric Study. Yoshino K, Nakamura J, Hagiwara S, Suzuki T, Kawasaki Y, Ohtori S. J Bone Joint Surg Am. 2020 Jan 15;102(2):137-142. doi: 10.2106/JBJS.19.00667. PMID: 31725124
  3. Establishment and Characterization of NCC-MFS5-C1: A Novel Patient-Derived Cell Line of Myxofibrosarcoma. Tsuchiya R, Yoshimatsu Y, Noguchi R, Sin Y, Ono T, Akiyama T, Sugaya J, Kobayashi E, Kojima N, Yoshida A, Ohtori S, Kawai A, Kondo T. Cells. 2022 Jan 8;11(2):207. doi: 10.3390/cells11020207. PMID: 35053323 Free PMC article.