EN
ページタイトル画像

Pharmacology

Overview

Pharmacotherapy occupies an essential part of medicine, where transporters have been established as a key drug target molecule in various diseases, such as hypertension, hyperuricemia, diabetes, depression, cancers, and cerebral ischemic injury. In order to seek a new opportunity toward innovative drug development, we are working on a variety of research aiming at clarification of physiological as well as pathophysiological roles of transporters expressed in various tissues. In addition, we also conduct a research to clarify the regulatory mechanisms of food intake and water intake by using physiological and pathophysiological model animals with molecular and biological techniques.

Professor:
Naohiko Anzai, M.D., Ph.D.

TEL:+81-43-226-2050
FAX:+81-43-226-2052
e-mail:afga5078●faculty.gs.chiba-u.jp
URL: https://www.m.chiba-u.ac.jp/class/pharmacology/

※　Please change "●" mark to at-mark if you send emails.

09.jpg

Research & Education

09図.jpg
  1. Characterization of clinico-pathological and pharmacological roles of transporters, including L-type amino acid transporters, in various tissues and cancers.

  2. Development of new anti-cancer agents/strategy targeting to cancer-associated transporter gene products and their functions.

  3. Development of new non-invasive diagnostic methods for determination of serum metabolites, which are substrates of transporters.

  4. Roles of neuropeptides in regulation of food intake and water intake in physiology and pathophysiology.

  5. Roles of monocarboxylate transporters (MCTs) in cerebral ischemic injury.

Recent Publications

  • Hirayama Y, Anzai N, Koizumi S. Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance. Glia. 2021; 69: 2100-2110.

  • Kaneko M, Reien Y, Morio H, Fukuuchi T, Kaneko K, Hirayama Y, Hashimoto H, Kuwata N, Mitsuya H, Anzai N. Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters. J Pharmacol Sci. 2021; 146: 82-7.

  • Morio H, Reien Y, Hirayama Y, Hashimoto H, Anzai N. Protein kinase C activation upregulates human L-type amino acid transporter 2 function. J Physiol Sci. 2021; 71:11.