業績紹介

  1. Palikuqi B, Nguyen TD, Pellegata A, Liu Y, Gómez-Salinero MJ Geng F, Schreiner R, Zumbo P, Zhang T, Kunar B, Yokoyama M., Witherspoon M, Han T, Tedeschi MA, Scottoni, F, Lipkin S, Dow L, Elemento O, Schwartz R, XiangJ, Shido K, DeCoppi P, Rabbany YS, Rafii S. Adaptable durable human endothelial cells for organogenesis and tumorigenesis. Nature.. in press
  2. Tanaka T, Satoh F,  Ujihara M,  Midorikawa S,  Kaneko T,  Takeda T,  Suzuki A,  Sato M, Shimatsu A. A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11β-hydroxylase inhibitor, in Japanese patients with endogenous Cushing’s syndrome other than Cushing’s disease. Endcrine Journal.. in press. https://doi.org/10.1507/endocrj.EJ19-0617
  3. Kakinuma S, Beppu M, Sawai S, Nakayama A., Hirano S, Yamanaka Y, Yamamoto T, Masafumi C, Aisihaer X, Aersilan A, Gao Y, Sato K, Sakae I, Ishige T, Nishimura M, Matsushita K, Satoh M, Nomura F, Kuwabara S, Tanaka T. Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease. eNeurologicalSci.. 19:100239 2020 Apr. DOI: 10.1016/j.ensci.2020.100239
  4. Ailiken G, Kitamura K, Hoshino T, Satoh M, Tanaka N, Minamoto T, Bahityar Rahmutulla B, Kobayashi S, Kano M, Tanaka T, Kaneda A, Nomura F, Hisahiro Matsubara a, Kazuyuki Matsushita.Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer. Oncogenesis.. 9(2):26 , 2020. https://doi.org/10.1038/s41389-020-0205-4
  1. Barry D, McMillan E, Kunar B, Lis R, Zhang T, Lu T, Daniel E, Yokoyama M., Gomez Salinero J, Sureshbabu A, Cleaver O, Choi M, Xiang J, Redmond D, Rabbany S, Muthukumar T, Rafii S. Molecular determinants of kidney vascular zonation and function. Nat Commun. 10(1):5705, (2019,Dec.)  DOI: 10.1038/s41467-019-12872-5
  2. Yao Y, Nishimura M, Murayama K, Kuranobu N, Tojo S, Beppu M, Ishige T, Itoga S, Tsuchida S, Mori M, Takayanagi M, Yokoyama M, Yanagata K, Kishita Y, Okazaki Y, Nomura F, Matsushita K, Tanaka T*.. A simple method for sequencing the whole human mitochondrial genome directly from samples and its application to genetic testing. Sci Rep..9(1):17441 (2019.11) https://doi.org/10.1038/s41598-019-53449-y
  3. Hosokawa H, Romero-Wolf M, Yang Q, Motomura Y, Levanon D, Groner Y, Moro K, Tanaka T., Rothenberg V. E. Cell-type specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells. J Exp Med.. 217(1):e20190972. (2019.Oct.) DOI: 10.1084/jem.20190972
  4. Nagano H, Kono T, Saiga A, Kubota Y, Fujimoto M, Felizola S, Ishiwata K, Tamura A, Higuchi S, Sakuma I, Suzuki S, Koide H, Takeshita N, Sakamoto S, Yokote K, Nakamura Y, Ichikawa T, Uno Takashi, and Tanaka T*.. Aldosterone Reduction Rate After Saline Infusion Test May Be A Novel Prediction In Patients With Primary Aldosteronism. J Clin Endocrinol Metab.. 105(3). (2019.Oct.) doi: 10.1210/clinem/dgz092.
  5. Takekoshi K, Satoh F, Tanabe A, Okamoto T, Ichihara A,  Tsuiki M,  Katabami T,  Nomura M, Matsuda T, Imai T,  Yamada M,  Asada S, Kawata N,  Naruse M. Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study. Endocrine Journal.. Epub. (2019.Oct.)  https://doi.org/10.1507/endocrj.EJ19-0125
  6. Sasahara Y, Kubota Y, Kosaka K, Adachi N, Yamaji Y, Nagano H, Akita S, Kuroda M, Tanaka T., Bujo H, Mitsukawa N. Adipose-Derived Stem Cells (ASCs) and Ceiling Culture-Derived Preadipocytes (ccdPAs) Cultured from Subcutaneous Fat Tissue Differed in their Epigenetic Characteristics and in Osteogenic Potential. Plast Reconstr Surg.. 144(3):644-655(2019,Sep.) DOI:10.1097/PRS.0000000000005913
  7. Yokoyama M., Shimizu I, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol.. 129:105-117, 2019
  8. Yoshida T, Nakayama A, Tamura A, Higuchi S, Sakuma I, Nagano H, Saulo J.A. Felizola, Takemoto M, Tatsuno I, Koide H, Yokote K, and Tanaka T.. A case of Hashimoto’s thyroiditis with multiple drug resistance and high expression of efflux transporters. J Clin Endocrinol Metab.., 105(2):399-406 (2019.Oct.)DOI:10.1210/clinem/dgz073
  9. Fengkai L, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada O, Nishimoto Y, Muranaka Y, Nagatani N, Suzuki M, Masuda S, Tran C, Nishiuchi T, Tanaka T., Barbie D, Mukaida N, and Takahash C. RB inactivation induces a protumoral microenvironment via enhanced CCL2 secretion. Cancer Research., 79(15):3903-3915 (2019,Aug.). DOI: 10.1158/0008-5472. CAN-18-3604
  10. Hashimoto N, Nagano H, Tanaka, T.. The Role of Tumor Suppressor p53 in Metabolism and Energy Regulation, and Its Implication in Cancer and Lifestyle-related Diseases. Endocrine Journal., 66(6):485-496, (2019,Jun). doi: 10.1507/endocrj.EJ18-0565. 
  11. Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T., Barbie DA, Mukaida N, Takahashi C. Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion. Cancer Res.. 79(15):3903-3915 (2019,Aug.). doi: 10.1158/0008-5472.CAN-18-3604.
  12. Tanaka S, Ishihara N, Suzuki S, Watanabe Y, Nagayama D, Yamaguchi T, Ohira M, Saiki A, Tanaka T., and Tatsuno I. Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells. Sci Rep.. 9(1);100009 (2019,July). https://doi.org/10.1038/s41598-019-46461-9.
  13. Sakuma I, Nagano H, Yoshino I, Yokote K, Tanaka T.. Ceritinib Aggravates Glycemic Control in Insulin-treated Patients with Diabetes and Metastatic ALK-positive Lung Cancer. Intern Med.., 58(6). (2019,Mar.). doi:10.2169/internalmedicine.1870-18.
  1. Hosokawa H, Romero-Wolf M, Yui A M, Ungerbäck J, Quiloan M, Matsumoto M, Nakayama I. K, Tanaka T. Rothenberg V. E. Bcl11b defines pro-T identity by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature Immunology. 19(12):1427-144, (2018)
  2. Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi U, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T*. p53-Inducibe DPYSL4 Associates with Mitochondrial Supercomplexes and Regulates Energy Metabolism in Adipocytes and Cancer Cells. Proc. Natl. Acad. Sci. USA., 115 (33) 8370-8375, (2018)
  3. Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama I. K, Cohen M. S, Tanaka T. Rothenberg V. E. Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding. Immunity, 48(6):1119-1134. (2018)
  4. Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Komai E, Kohno T, Sakuma I, Suzuki S, Mayama T, Koide H, Yokote K, Ogawa Seishi, and Tanaka T*. Glucagonoma with necrolytic migratory erythema: metabolic profile and detection of biallelic inactivation of DAXX gene. J Clin Endocrinol Metab., 103(7):1-7. (2018)
  5. Sakuma I, Koide H, Yoshida T, Yamato A, Fujimoto M, Tamura A, Komai E, Kono T, Nagano H, Horiguchi K, Yokote K, and Tanaka T. Congestive heart failure secondary to a TSH-secreting pituitary adenoma aggravated by takotsubo cardiomyopathy in elderly patient. Endocrine Practice,, 4(2) e115-e123. (2018)
  6. Koide H, Shiga A, Komai E Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi, Yokote K, Tanaka T. Prednisolone-responsive Postpertum IgG4-related Hypophysitis. Internal Medicine., 57(3) 367-375. (2018)
  7. Takayama KI, Suzuki T, Tanaka T, Fujimura T, Takahashi S, Urano T, Ikeda K, Inoue S. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Oncogene, 37(16):2165-2180. (2018)
  8. Hosokawa H, Romero-Wolf M, Yui A M, Ungerbäck J, Quiloan M, Matsumoto M, Nakayama I. K, Tanaka T. Rothenberg V. E. Bcl11b defines pro-T identity by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature Immunology. 19(12):1427-144, (2018, Dec.) doi: 10.1038/s41590-018-0238-4
  9. Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi U, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T*. p53-Inducibe DPYSL4 Associates with Mitochondrial Supercomplexes and Regulates Energy Metabolism in Adipocytes and Cancer Cells. Proc. Natl. Acad. Sci. USA., 115 (33) 8370-8375, (2018, Aug.) http://doi.org/10.1073/pnas.1804243115.
  10. Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama I. K, Cohen M. S, Tanaka T. Rothenberg V. E. Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding. Immunity, 48(6):1119-1134. (2018) doi:10.1016/j.immuni.2018.04.024
  11. Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Komai E, Kohno T, Sakuma I, Suzuki S, Mayama T, Koide H, Yokote K, Ogawa Seishi, and Tanaka T*. Glucagonoma with necrolytic migratory erythema: metabolic profile and detection of biallelic inactivation of DAXX gene. J Clin Endocrinol Metab., 103(7):2417-2423. (2018) doi:0.1210/jc.2017-02646
  12. Sakuma I, Koide H, Yoshida T, Yamato A, Fujimoto M, Tamura A, Komai E, Kono T, Nagano H, Horiguchi K, Yokote K, and Tanaka T. Congestive heart failure secondary to a TSH-secreting pituitary adenoma aggravated by takotsubo cardiomyopathy in elderly patient. Endocrine Practice,, 4(2) e115-e123. (2018) doi:org/10.4158/EP171968.CR
  13. Koide H, Shiga A, Komai E Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi, Yokote K, Tanaka T. Prednisolone-responsive Postpertum IgG4-related Hypophysitis. Internal Medicine., 57(3) 367-375. (2018) doi:10.2169/internalmedicine.8446-16
  14. Takayama KI, Suzuki T, Tanaka T, Fujimura T, Takahashi S, Urano T, Ikeda K, Inoue S. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Oncogene, 37(16):2165-2180. (2018) doi: 10.1038/s41388-017-0095-x
  1. Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M. Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation. Oncogene, 36(41):5885-8-5896.(2017)
  2. Takiguchi T, Koide H, Nagano H, Nakayama A, Fujimoto M, Tamura A, Komai E, Shiga A, Kono T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Miyabayashi Y, Ishiwatari N, Horiguchi K, Nakatani Y, Yokote K, Tanaka T. Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report. BMC Endocrine Disorders., 2;17(1):54. (2017)
  3. Shiba S, Ikeda K, Horie-Inoue, K Nakayama A, Tanaka T, and Inoue S. Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice. Scientific Report., 7(1):7606. (2017)
  4. Nagano H, Nakagawa Y, Ishikawa N, Watanabe H, Miyabayashi Y, Nakayama A, Fujimoto M, Komai E, Shiga A, Tamura A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Yokote T, Tanaka T. Seven familial dysalbuminemic hyperthyroxinemia cases in three unrelated Japanese families and high-performance liquid chromatography analysis of the thyroxine binding profile. Endocrine Practice, 23(11):1325-1332. (2017)
  5. Ashikari D, Takayama K, Tanaka T, Suzuki Y, Obinata D, Fujimura T, Urano T, Takahashi S, Inoue S. Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer. Oncogene., 36(45):6272-6281. (2017)
  6. Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, Nishimoto Y, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M, Baebie D, Hirose O, Tanaka T, Takahashi C. The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Oncogene, 7;36(36):5145-5157. (2017)
  7. Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Hayashi N, Nishimoto Y, Nagatani N, Kohno S, Muranaka S, Nishiuchi T, Suzuki S, Nakao S, Tanaka T, Hirose O, and Takahashi C. MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6. Oncotarget., 8:13872-13885. (2017)
  8. Hashimoto N, Tanaka T*. Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus. J. Hum. Genet., 62:141-50. (2017)
  1. Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T*. Cushing syndrome due to ACTH-secreting pheochromocytoma aggravated by a glucocorticoid-driven positive-feedback loop. J Clin Endocrinol Metab., 101:841-6. (2016)
  2. Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, Nakayama T. Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. , 7: 11289. (2016)
  3. Fleseriu M, Pivonello R, Young J, Hamrahian AH, Molitch ME, Shimizu C, Tanaka T, Shimatsu A, White T, Hilliard A, Tian C, Sauter N, Biller BM, Bertagna X.Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease .Pituitary. 19(2):138-48. (2016)
  4. Yoshida M, Lee EY, Kohno T, Tanaka T, Miyazaki M, Miki T. Importance of Hepatocyte Nuclear Factor 4α in Glycerol-induced Glucose-6-phosphatase Expression in Liver. Biomed Res. 37(2):85-93. (2016)
  5. Namekawa T, Utsumi T, Kawamura K, Kamiya N, Imamoto T, Takiguchi T, Hashimoto N, Tanaka T, Naya Y, Suzuki H, Ichikawa T. Clinical predictors of prolonged postresection hypotension after laparoscopic adrenalectomy for pheochromocytoma. Surgery. 159:763-770. (2016)
  6. Namekawa T, Utsumi T, Imamoto T, Kawamura K, Oide T, Tanaka T, Nihei N, Suzuki H, Nakatani Y, Ichikawa T. Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature. Asian J Surg. 39(3):187-90. (2016)
  7. Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K. Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients. Oncotarget 7:82493-82503. (2016)
  8. Araki N, Misawa S, Shibuya K, Ota S, Oide T, Kawano A, Beppu M, Nakatani Y, Kuwabara S.POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification.Orphanet. J Rare Dis. 11:35. (2016)
  9. Sekiguchi Y, Mori M, Misawa S, Sawai S, Yuki N, Beppu M, Kuwabara S. How often and when Fisher syndrome is overlapped by Guillain-Barré syndrome or Bickerstaff brainstem encephalitis? Eur J Neurol. 23(6):1058-63. (2016)
  10. Muto T, Ohwada C, Sawai S, Beppu M, Tsukamoto S, Takeda Y, Mimura N, Takeuchi M, Sakaida E, Sogawa K, Misawa S, Shimizu N, Iseki T, Nomura F, Kuwabara S, Nakaseko C. Acutely deteriorated extravascular volume overload during peripheral blood stem cell mobilization in POEMS syndrome: A case series with cytokine analysis. Transfus Apher Sci. 54(2):276-81. (2016)
  1. 1. Eun Young L, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y and Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in InsrP1195L/+ mice fed high-fat-diet. Sci Rep., 30;5:17565. (2015)
  2. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T., and Nakayama, T. Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells. J Biol Chem., 290: 13095-103. (2015)
  3. Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T. GERMLINE DELETION OF ARMC5 IN FAMILIAL PRIMARY MACRONODULAR ADRENAL HYPERPLASIA. Endocr Pract., 21(10) 1152-60. (2015)
  4. Higuchi K, Sakamoto S, Kato H, Takahashi Y, Tanaka T, Ichikawa T. Cushing's tumor meets pheochromocytoma in one adrenal gland. Int J Urol. Jan;22(1):135-136 (2015)
  5. Utsumi T, Kawamura K, Imamoto T, Kamiya N, Nagano H, Tanaka T, Nihei N, Naya Y, Suzuki H, Ichikawa T. Assessment of postoperative changes in antihypertensive drug consumption in patients with primary aldosteronism using the defined daily dose. Asian J Surg. 37(4):190-194 (2014).
  6. Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki, Y and Nakayama, T. Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci USA. 110(46):18626-31. (2013)
  7. Hosokawa H, Tanaka T(Co-first author), Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes J D, Kanai A, Sugano S, Nakayama T. Functionally distinct Gata3/Chd4 complexes coordinately establish Th2 cell identity. Proc Natl Acad Sci USA. 110(12):4691-6. (2013)
  8. Namekawa, T., Utsumi, T., Imamoto, T., Kawamura, K., Oide, T., Tanaka, T., Nihei, N., Ichikawa, T. Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature. Asian Journal of Surgery. (2013)
  9. Utsumi, T., Kawamura, K., Imamoto, T., Nagano, H., Tanaka, T., Kamiya, N., Nihei, N., (...), Ichikawa, T. Preoperative masked renal damage in Japanese patients with primary aldosteronism: Identification of predictors for chronic kidney disease manifested after adrenalectomy. International Journal of Urology 20(7)685−691. (2013)
  10. Tatsuno, I., Terano, T., Nakamura, M., Suzuki, K., Kubota, K., Yamaguchi, J., Yoshida, T., Suzuki, S., Tanaka, T., Shozu, M. Lifestyle and osteoporosis in middle-aged and elderly women: Chiba bone survey Endocrine Journal 60(5):643-650 (2013)
  11. Higashide, T., Funabashi, N., Tanaka, T., Inoue, K., Kazama, T., Motoori, K., Nagano, H., Nakatani, Y., Ichikawa, T., Takaoka, H., Uehara, M., Yokote, K., Kobayashi, Y., Uno, T. Detection of adrenal veins on selective retrograde CT adrenal venography in comparison with digital subtraction angiography in subjects with established diagnosis of one-sided adrenal aldosterone-producing tumor confirmed by adrenal vein sampling, histopathology and clinical course. International Journal of Cardiology (2013)
  12. Higashide, T., Funabashi, N., Tanaka, T., Inoue, K., Kazama, T., Motoori, K., Nagano, H., Takaoka, H., Uehara, M., Nishiyama, A., Kato, H., Yokote, K., Kobayashi, Y., Uno, T. Utility of 320 slice mapping CT for adrenal vein sampling in subjects suspected of having primary-aldosteronism compared with digital-subtraction-angiography and selective retrograde CT adrenal venography. International Journal of Cardiology (2013)
  13. Tanaka, T. Regulation of cell metabolism by tumor suppressor p53 and its concern in cencer and lifestyle-related disease. Chiba Medical Journal 89(1)15-20. (2013)
  14. Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D.J., Kanai, A., Sugano, S., Nakayama, T. Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.Proceedings of the National Academy of Sciences of the United States of America 110(12):4691-4696. (2013)
  15. Namekawa, T., Utsumi, T., Imamoto, T., Kawamura, K., Oide, T., Tanaka, T., Nihei, N., Suzuki, H., Nakatani, Y., Ichikawa, T. Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature Asian Journal of Surgery (2013)
  16. Terano, T., Suzuki, S., Yoshida, T., Nagano, H., Hashimoto, N., Mayama, T., Koide, H., Suyama, K., Tanaka, T., Yamamoto, K., Tatsuno, I. Glycemic control and bone metabolism in postmenopausal women with type 2 diabetes mellitus Diabetology International 3(2):68-74 (2012)
  17. Utsumi, T., Kawamura, K., Imamoto, T., Kamiya, N., Komiya, A., Suzuki, S., Nagano, H., Tanaka, T., Nihei, N., Naya, Y., Suzuki, H., Tatsuno, I., Ichikawa, T. High predictive accuracy of Aldosteronoma Resolution Score in Japanese patients with aldosterone-producing adenoma Surgery 151(3):437-4743(2012)
  18. Tatsuno, I., Suzuki, S., Yoshida, T., Nagano, H., Hashimoto, N., Mayama, T., Tanaka, T., Sugiyama, T. Disease-related risk of vertebral fracture during glucocorticoid treatment of collagen vascular diseases Journal of Rheumatology. 38(10)2270-2271 (2011)
  19. Tanaka, T. Mechanisms of cellular senescence by tumor suppressor p53. Nihon rinsho Japanese journal of clinical medicine 69(10):1891-1900. (2011)
  20. Tanaka, T., Yokote, K. Epigenetic regulation and molecular mechanisms of cellular senescence by tumor suppressor p53. Japanese Journal of Geriatrics 45(2):134-137. (2011)
  21. Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., Nakayama, T. Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. Journal of Immunology 186(11):6378-6389. (2011)
  22. Sugiyama, T., Suzuki, S., Yoshida, T., Mayama, T., Hashimoto, N., Suyama, K., Tanaka, T., Sueishi, M., Tatsuno, I. Age, initial dose and dose increase are independent risk factors for symptomatic vertebral fractures in glucocorticoid-treated male patients. Internal Medicine 50(8):81797824. (2011)
  23. Toyoda, A., Yokota, A., Saito, T., Kawana, H., Higashi, M., Suzuki, Y., Tanaka, T., Kitagawa, M., Harigaya, K. Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers. International Journal of Oncology 38(1):89-96. (2011)
  24. Tanaka, T. Regulation of p53 function and promoter selectivity by posttranslational modifications. Seikagaku 82(3):200-209. (2010)
  25. Sugiyama, T., Suzuki, S., Yoshida, T., Suyama, K., Tanaka, T., Sueishi, M., Tatsuno, I. Incidence of symptomatic vertebral fractures in women of childbearing age newly treated with high-dose glucocorticoid. Gender Medicine 7(3):218-229. (2010)
  26. Suzuki S, Tanaka T(Co-first author), Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci USA 107(16):7461-6. (2010)
  27. Nagata, A., Tanaka, T., Minezawa, A., Poyurovsky, M., Mayama, T., Suzuki, S., Hashimoto, N., Yoshida, T., Suyama, K., Miyata, A., Hosokawa, H., Nakayama, T., Tatsuno, I. cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. Journal of Cellular Physiology 221(1)]75-83. (2009)
  28. Suzuki, S., Uchida, D., Koide, H., Suyama, K., Tanaka, T., Noguchi, Y., Saito, Y., Tatsuno, I.Vasopressin responders have a high prevalence of hypertension and insulin resistance in spite of a lower secretion of cortisol in subclinical Cushing's syndrome. Molecular Medicine Reports 2(1):75-83. (2009)
  29. Sugiyama, T., Tatsuno, I., Suzuki, S., Yoshida, T., Tanaka, T., Sueishi, M., Saito, Y. Incidence of symptomatic vertebral fracture with high-dose glucocorticoid treatment in the Chiba-Shimoshizu Rheumatic Cohort between 1986 and 2006. Endocrine Journal 56(4):591-599. (2009)
  30. Tatsuno, I., Sugiyama, T., Suzuki, S., Yoshida, T., Tanaka, T., Sueishi, M., Saito, Y. High prevalence and early complication of symptomatic vertebral fracture in elderly people treated with high-dose glucocorticoids. Journal of the American Geriatrics Society 57(1):188-189. (2009)
  31. Suzuki, S., Uchida, D., Koide, H., Suyama, K., Shibata, T., Yoshida, T., Tanaka, T., Noguchi, Y., Saito, Y., Tatsuno, I. A possible association between aldosterone response to vasopressin and circadian change of aldosterone in the patients with aldosterone-producing adenoma. Peptides 29(12):2225-2231. (2008)
  32. Suzuki, S., Uchida, D., Koide, H., Tanaka, T., Noguchi, Y., Saito, Y., Tatsuno, I. Hyper-responsiveness of adrenal gland to vasopressin resulting in enhanced plasma cortisol in patients with adrenal nodule(s). Peptides 29(10):1767-1772. (2008)
  33. Hosaka, H., Nagata, A., Yoshida, T., Shibata, T., Nagao, T., Tanaka, T., Saito, Y., Tatsuno, I.Pancreatic polypeptide is secreted from and controls differentiation through its specific receptors in osteoblastic MC3T3-E1 cells. Peptide 29(6):1390-1395. (2008)
  34. Miyazawa, H., Tanaka, T., Nagai, Y., Matsuoka, M., Sutani, A., Udagawa, K., Zhang, J., Hirama, T., Murayama, Y., Koyama, N., Ikebuchi, K., Nagata, M., Kanazawa, M., Nukiwa, T., Takenoshita, S., Kobayashi, K., Hagiwara, K. Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation. Cancer Science 29(3):595-600. (2008)
  35. Suyama, K., Noguchi, Y., Tanaka, T., Yoshida, T., Shibata, T., Saito, Y., Tatsuno, I. Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7.Oncology reports 18(5):1291-1298. (2007)
  36. Tanaka T, Ohkubo S, Tatsuno I, Prives C. hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130:638-50. (2007).
  37. Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S and Carol Prives. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem. 282(41): 30311-30321. (2007)
  38. Koide, H., Shibata, T., Yamada, N., Asaki, T., Nagao, T., Yoshida, T., Noguchi, Y., Tanaka, T., Saito, Y., Tatsuno, I. Tumor suppressor candidate 5 (TUSC5) is expressed in brown adipocytes. Biochemical and Biophysical Research 360(1):139-145, (2007)
  39. Shibata, T., Koide, H., Hayashi, R., Nagata, K., Takeo, C., Yoshida, T., Noguchi, Y., Tanaka, T., Saito, Y., Tatsuno, I. Molecular cloning and characterization of rat brain endothelial cell derived gene-1 (tumor suppressor candidate 5) expressing abundantly in adipose tissues. Molecular and Cellular Endocrinology 263(*):38-45. (2007)
  40. Yoshida, T., Asanuma, M., Grossmann, L., Fuse, M., Shibata, T., Yonekawa, T., Tanaka, T., Ueno, K., Yasuda, T., Saito, Y., Tatsuno, I. Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1. FEBS Letters 580(22):5203-5207. (2006)
  41. Ohkubo, S., Tanaka, T., Taya, Y., Kitazato, K., Prives, C. Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. Journal of Biological Chemistry 281(25):16943-16950. (2006)
  42. Lokshin, M., Tanaka, T., Prives, C. Transcriptional regulation by p53 and p73. Cold Spring Harbor Symposia on Quantitative Biology 70:121-128. (2005)
  43. Urist, M, Tanaka, T, Poyurovsky, M. V, and Prives, C. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes & Dev. 18, 3041-3054. (2004).
  44. Otsuka, Y., Tanaka, T., Uchida, D., Noguchi, Y., Saeki, N., Saito, Y., Tatsuno, I. Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse. Neuroscience Letters 365(3):180-185. (2004)
  45. Fuse, M., Tanaka, T., Shibata, T., Yoshida, T., Noguchi, Y., Misawa, N., Yasuda, T., Saito, Y., Kohn, L.D., Tatsuno, I. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: Involvement of both cAMP-PKA and PI3-AKT pathways. Biochemical and Biophysical Research Communications 315(4):1147-1153. (2004)
  46. Tatsuno, I., Uchida, D., Tanaka, T., Koide, H., Shigeta, A., Ichikawa, T., Sasano, H., Saito, Y. Vasopressin responsiveness of subclinical Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia. Clinical Endocrinology 60(2):192-200. (2004)
  47. Takeo, C., Nakamura, S., Tanaka, T., Uchida, D., Noguchi, Y., Nagao, T., Saito, Y., Tatsuno, I. Rat cerebral endothelial cells express trk C and are regulated by neurotrophin-3. Biochemical and Biophysical Research Communications 305(2):400-406. (2003)
  48. Tatsuno, I., Noguchi, Y., Tanaka, T., Nakamura, S., Uchida, D., Hirai, A., Saito, Y. Ninjinyouei-to (TJ-108), a Chinese medicine containing polygalae radix, increases the blood concentration of 1,5-anhydro-D-glucitol independent of that of glucose and HbA 1c in diabetic patients. Journal of the Japan Diabetes Society 45(8):583-587. (2002)
  49. Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ching Ching Ng, Taya Y, Monden M, Nakamura Y, and Taya Y. p53Dinp1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis. Molecular Cell 8:85-94. (2001).
  50. Tatsuno, I., Uchida, D., Tanaka, T., Saeki, N., Hirai, A., Saito, Y., Moro, O., Tajima, M. Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons. Brain Research 889(1-2):138-148. (2001)
  51. Oda K, Arakawa H(Co-first author), Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y and Taya Y. Isolation of a Novel Gene Encoding a Mitochondrial Protein, p53AIP1, a Potential Mediator of p53-dependent Apoptosis, and Its Regulation by Ser46-phosphorylated p53. Cell 102(15): 849-862. (2000).
  52. Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y., Hirai, A. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. Journal of Neuroscience 20(8):2852-2859. (2000)
  53. Uchida, D., Tatsuno, I., Nakamura, S., Noguchi, Y., Saito, J., Tanaka, T., Saito, Y., Saeki, N., Nishikawa, T. Glucocorticoid-dependency on GH secretion and tumor growth in a GH- producing pituitary adenoma with Cushing's syndrome. Endocrine Journal 47:S69-S71. (2000)
  54. Higuchi, Y., Saeki, N., Iuchi, T., Uchino, Y., Tatsuno, I., Uchida, D., Tanaka, T., Noguchi, Y., Nakamura, S., Yasuda, T., Yamaura, A., Sunami, K., Oka, Y., Uozumi, A. Incidence of malignant tumors in patients with acromegaly. Endocrine Journal 47:S57-S60. (2000)
  55. Suyama, K., Uchida, D., Tanaka, T., Saito, J., Noguchi, Y., Nakamura, S., Tatsuno, I., Saito, Y., Saeki, N. Octreotide improved ventricular arrhythmia in an acromegalic patient. Endocrine Journal 47:S73-S75. (2000)
  56. Terano, T., Fujishiro, S., Ban, T., Yamamoto, K., Tanaka, T., Noguchi, Y., Tamura, Y., Yazawa, K., Hirayama, T. Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids 34(6)S345-S346. (1999)
  57. Nishimura, M., Tanaka, T., Yasuda, T., Kurakata, S., Kitagawa, M., Yamada, K., Saito, Y., Hirai, A. ollagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. Kidney International 55(2):520-529. (1999)
  58. Terano, T., Tanaka, T., Tamura, Y., Kitagawa, M., Higashi, H., Saito, Y., Hirai, A. Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. Biochemical and Biophysical Research Communications 254(2):502-506. (1999)
  59. Nishimura, M., Tanaka, T., Yasuda, T., Kurakata, S., Kitagawa, M., Yamada, K., Saito, Y., Hirai, A. Effect of pravastatin on type IV collagen secretion and mesangial cell proliferation. Kidney International, Supplement 56(71):S97-S100.(1999)
  60. Terano, T., Shiina, T., Noguchi, Y., Tanaka, T., Tatsuno, I., Saito, Y., Yasuda, T., Kitagawa, M., Hirai, A. Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells. Journal of atherosclerosis and thrombosis 5(1):1-6. (1998)
  61. Uchida, D., Tatsuno, I., Tanaka, T., Hirai, A., Saito, Y., Moro, O., Tajima, M. Maxadilan is a specific agonist and its deleted peptide (M65) is a specific antagonist for PACAP type 1 receptor. Annals of the New York Academy of Sciences 865:253-258(1998)
  62. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y., Hirai, A. Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes: Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. Journal of Biological Chemistry 273(41:26772-26778. (1998)
  63. Higuchi, Y., Saeki, N., Iuchi, T., Uchino, Y., Tatsuno, I., Uchida, D., Tanaka, T., Noguchi, Y., Nakamura, S., Yasuda, T., Yamaura, A., Sunami, K., Oka, Y., Uozumi, A. Role of p27(Kip1) and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer. American Journal of Pathology 153.(2):505-513.(1998)
  64. Suyama, K., Uchida, D., Tanaka, T., Saito, J., Noguchi, Y., Nakamura, S., Tatsuno, I., Saito, Y., Saeki, N. Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates mitogen-activated protein kinase (MAPK) in cultured rat astrocytes. Brain Research 795(1-2):191-196(. 1998)
  65. Kawana, H., Tamaru, J.-I., Tanaka, T., Hirai, A., Saito, Y., Kitagawa, M., Mikata, A., Harigaya, K., Kuriyama, T. Role of p27(Kip1) and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer. American Journal of Pathology 153(2):505-513. (1998)
  66. Moroo, I., Tatsuno, I., Uchida, D., Tanaka, T., Saito, J., Saito, Y., Hirai, A. Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates mitogen-activated protein kinase (MAPK) in cultured rat astrocytes. Brain Research 795(1-2):191-196. (1998)
  67. Tatsuno, I., Tanaka, T., Oeda, T., Yasuda, T., Kitagawa, M., Saito, Y., Hirai, A. Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. Biochemical and Biophysical Research Communications 241(2):376-382. (1997)
  68. Tatsuno, I., Morio, H., Tanaka, T., Hirai, A., Tamura, Y., Saito, Y., Arimura, A. Astrocytes are one of the main target cells for pituitary adenylate cyclase-activating polypeptide in the central nervous system. Astrocytes are very heterogeneous regarding both basal movement of intracellular free calcium ([Ca 2+]i) and the [Ca 2+]i response to PACAP at a single cell level. Annals of the New York Academy of Sciences 805:613-619.(1997)
  69. Tatsuno, I., Morio, H., Tanaka, T., Uchida, D., Hirai, A., Tamura, Y., Saito, Y. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a regulator of astrocytes: PACAP stimulates proliferation and production of interleukin 6 (IL-6), but not nerve growth factor (NGF), in cultured rat astrocyte. Annals of the New York Academy of Sciences 805:482-488(1996)
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