【2024年】 【2023年】 【2022年】 【2021年】 【2020年】 【2019年】 【2018年】
【2017年】 【2016年】 【2015年】 【2014年】 【2013年】 【2012年】 【2011年】
【2010年】 【2008年】 【2006年】

【2024年】

• Aoki, A.,* Iwamura, C.,* Kiuchi, M., Tsuji, K., Sasaki, A., Hishiya, T., Hirasawa, R., Kokubo, K., Kuriyama, S., Onodera, A., Shimada, T., Nagaoka, T., Ishikawa, S., Kojima, A., Mito, H., Hase, R., Kasahara, Y., Kuriyama, N., Nakamura, S., Urushibara, T., Kaneda, S., Sakao, S., Nishida, O., Takahashi, K., Kimura, M. Y., Motohashi, S., Igari, H., Ikehara, Y., Nakajima, H., Suzuki, T., Hanaoka, H., Nakada, T., Kikuchi, T., Nakayama, T., Yokote, K., and Hirahara, K.: Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Petients. (*These authors contributed equally to this work) J. Clin. Immunol. 44:104 (2024).


• Hatano, R., Lee, E., Sato, H., Kiuchi, M., Hirahara, K., Nakagawa, Y., Shimano, H., Nakayama, T., Tanaka, T., and Miki, T.: Hepatic ketone body regulatioon of renal gluconeogenesis. Mol. Metab. 84:101934 (2024).


• Tanaka, S., Yamamoto, T., Iwata, A., Kiuchi, M., Kokubo, K., Iinuma, T., Sugiyama, T., Hanazawa, T., Hirahara, K., Ikeda, K., and Nakajima, H.: Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease. Arthritis Res. Ther. 26(1):55 (2024).

【2023年】

• Kumagai, J., Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji, K., Nagahata, K., Sasaki, A., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Iinuma, T., Yonekura, S., Shinga, J., Hanazawa, T., Koseki, H., Nakayama, T., Yokote, K., and Hirahara, K.: The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. Proc. Natl. Acad. Sci. USA 120(49):e2302903120 (2023).


• Suga,K., Kiuchi, M., Kageyama, T., Kokubo, K., Tanaka, S., Iwata, A., Suzuki, K., Hirahara, K., and Nakajima, H.: Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab. Allergol. Int. 72(4):610-613 (2023).


• Koyama-Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., Motohashi, S., and Nakayama, T.: CD69 imposes tumor-specific CD8⁺ T-cell fate in tumor-draining lymph nodes. Cancer Immunol. Res. 11(8):1085-1099 (2023).


• Iinuma T., Yonekura, S., Hirahara, K., Kurita, J., Yoneda, R., Arai, T., Sonobe, Y., Shinmi, R., Okamoto, Y., and Hanazawa, T.: Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype. Allergol. Int. 72(4):564-572 (2023).


• Onodera, A., Kokubo, K., Okano, M., Onoue, M., Kiuchi, M., Iwamura, C., Iinuma, T., Kimura, M. Y., Ebihara, N., Hanazawa, T., Nakayama, T., and Hirahara, K.: Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol. Ther. 247:108445 (2023).


• Sato, Y., Silina, K., van den Broek, M., Hirahara, K., and Yanagita, M.: The roles of tertiary lymphoid structures in chronic diseases. Nat. Rev. Nephrol. 19:525-537 (2023).


• Tsuji, K., Aoki, A., Onodera, A., Kiuchi, M., Kokubo, K., Morimoto, Y., Iinuma, T., Hanazawa, T., Nakayama, T., and Hirahara, K.: Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients. Allergol. Int. 72(2):335-338 (2023).


• Kokubo, K., Hirahara, K., Kiuchi, M., Tsuji, K., Shimada, Y., Sonobe, Y., Shinmi, R., Hishiya, T., Iwamura, C., Onodera, A., and Nakayama, T.: Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Proc. Natl. Acad. Sci. USA 120(2):e2218345120 (2023).

【2022年】

• Okano, M., Hirahara, K., Kiuchi, M., Onoue, M., Iwamura, C., Kokubo, K., Hishiya, T., Morimoto, Y., Ikehara, Y., Murakami, A., Ebihara, N., and Nakayama, T.: Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity 55(12):2352-2368.e7 (2022).


• Fujimoto, M., Yokoyama, M., Kiuchi, M., Hosokawa, H., Nakayama, A., Hashimoto, N., Sakuma, I., Nagano, H., Yamagata, K., Kudo, F., Manabe, I., Lee, E., Hatano, R., Onodera, A., Hirahara, K., Yokote, K., Miki, T., Nakayama, T., and Tanaka, T.: Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis. Nat. Commun. 13:5408 (2022).


• Iinuma, T.,* Kiuchi, M.,* Hirahara, K., Kurita, J., Kokubo, K., Yagyu, H., Yoneda, R., Arai, T., Sonobe, Y., Fukuyo, M., Kaneda, A., Yonekura, S., Nakayama, T., Okamoto, Y., and Hanazawa, T.: Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic T_H2 cells and clonal conversion. (*These authors contributed equally to this work) J. Allergy Clin. Immunol. 150(4):850-860.e5 (2022).


• Kokubo, K., Onodera, A., Kiuchi, M., Tsuji, K., Hirahara, K., and Nakayama, T.: Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. Front. Immunol. 13:945063 (2022).


• Iwamura, C., Hirahara, K., Kiuchi, M., Ikehara, S., Azuma, K., Shimada, T., Kuriyama, S., Ohki, S., Yamamoto, E., Inaba, Y., Shiko, Y., Aoki, A., Kokubo, K., Hirasawa, R., Hishiya, T., Tsuji, K., Nagaoka, T., Ishikawa, S., Kojima, A., Mito, H., Hase, R., Kasahara, Y., Kuriyama, N., Tsukamoto, T., Nakamura, S., Urushibara, T., Kaneda, S., Sakao, S., Tobiume, M., Suzuki, Y., Tsujiwaki, M., Kubo, T., Hasegawa, T., Nakase, H., Nishida, O., Takahashi, K., Baba, K., Iizumi, Y., Okaszaki, T., Kimura, M. Y., Yoshino, I., Igari, H., Nakajima, H., Suzuki, T., Hanaoka, H., Nakada, T., Ikehara, Y., Yokote, K., and Nakayama, T.: Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proc. Natl. Acad. Sci. USA 119(33):e2203437119 (2022).


• Wakai, K., Azuma, K., Iwamura, C., Maimaiti, M., Mikami, K., Yoneda, K., Sakamoto, S., Ikehara, S., Yamaguchi, T., Hirahara, K., Ichikawa, T., Nakayama, T., and Ikehara, Y.: The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice. Sci. Rep. 12(1):9046 (2022).


• Shinoda, K.,* Choe, A.,* Hirahara, K.,* Kiuchi, M., Kokubo, K., Ichikawa, T., Hoki, J. S., Suzuki, A. S., Bose, N., Appleton, J. A., Aroian, R. V., Schroeder, F. C., Sternberg, P. W., and Nakayama, T.: Nematode ascarosides attenuate mammalian type 2 inflammatory responses. (*These authors contributed equally to this work) Proc. Natl. Acad. Sci. USA 119(9):e2108686119 (2022).

【2021年】

• Kiuchi, M., Onodera, A., Kokubo, K., Ichikawa, T., Morimoto, Y., Kawakami, E., Takayama, N., Eto, K., Koseki, H., Hirahara, K., and Nakayama, T.: The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4⁺ T cell differentiation. J. Exp. Med. 218(4):e20201690 (2021).


• Takasato, Y., Kurashima, Y., Kiuchi, M., Hirahara, K., Murasaki, S., Arai, F., Izawa, K., Kaitai, A., Shimada, K., Saito, Y., Toyoshima, S., Nakamura, M., Fujisawa, K., Okayama, Y., Kunisawa, J., Kubo, M., Takemura, N., Uematsu, S., Akira, S., Kitaura, J., Takahashi, T., Nakayama, T., and Kiyono, H.: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14(3):640-651 (2021).


• Nakayama, T., Hirahara, K., Kimura, M., Iwamura, C., Kiuchi, M., Kokubo, K., Onodera, A., Hashimoto, K., and Motohashi, S.: CD4⁺ T cells in inflammatory diseases: Pathogenic T-helper cells and the CD69-Myl9 system. Int. Immunol. 33(12):699-704 (2021).


• Hirahara, K., Kokubo, K., Aoki, A., Kiuchi, M., and Nakayama T.: The role of CD4⁺ resident memory T cells in local immunity in the mucosal tissue - Protection versus Pathology. Front. Immunol. 12:616309 (2021).


• Hirahara, K., Aoki, A., and Nakayama, T.: Pathogenic helper T (Tpath) cells. Allergol. Int. 70(2):169-173 (2021).


• Hirahara, K., Aoki, A., Kiuchi, M., and Nakayama, T.: Memory-type pathogenic Th2 cells and ILC2s in type 2 allergic inflammation. J. Allergy Clin. Immunol. 147(6):2063-2066 (2021).


• Aoki, A.,* Hirahara, K.,* Kiuchi, M., and Nakayama, T.: Eosinophils: Cells known for 140 years with broad and new function. (*These authors are contributed equally to this work) Allergol. Int. 70(1):3-8 (2021).

【2020年】

• Sciumè, G., Mikami, Y., Jankovic, D., Nagashima, H., Villarino, A. V., Morrison, T., Signorella, S., Yao, C., Sun, H. W., Brooks, S. R., Fang, D., Sartorelli, V., Nakayamada, S., Hirahara, K., Zitti, B., Davis, F. P., Kanno, Y., O'Shea, J. J., and Shih, H. Y.: Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells. Immunity 53(4):745-758.e4 (2020).


• Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Toyoda, T., Okada, R., Hino, M., Koyama-Nasu, R., Kiuchi, M., Hirahara, K., Kimura, M. Y., Nakayama, T., Shimojo, N., and Motohashi, S.: Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner. Cancer Sci. 111(7):2223-2233 (2020).


• Suzuki, A. S., Yagi, R., Kimura, M. Y., Iwamura, C., Shinoda, K., Onodera, A., Hirahara, K., Tumes, D. J., Koyama-Nasu, R., Iismaa, S. E., Graham, R. M., Motohashi, S., and Nakayama, T.: Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front. Immunol. 11:1536 (2020).


• Göschl, L., Preglej, T., Boucheron, N., Saferding, V., Müller, L., Platzer, A., Hirahara, K., Han-Yu, S., Backlund, J., Matthias, P., Niederreiter, B., Hladik, A., Kugler, M., Gualdoni, G., Scheinecker, C., Knapp, S., Seiser, C., Holmdahl, R., Tillmann, K., Plasenzotti, R., Podesser, B., Aletaha, D., Smolen Karonitsch, T. J., Steiner, G., Ellmeier, W., and Bonelli, M.: Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J. Autoimmun. 108:102379 (2020).

【2019年】

• Ichikawa, T.,* Hirahara, K.,* Kokubo, K.,* Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D. J., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.: CD103^hi T_reg cells constrain lung fibrosis induced by CD103^lo tissue-resident pathogenic CD4 T cells. (*These authors contributed equally to this work) Nat. Immunol. 20(11):1469-1480 (2019).


• Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Yip, K. H., Pant, H., Kokubo, K., Kiuchi, M., Aoki, A., Obata-Ninomiya, K., Tokoyoda, K., Endo, Y., Kimura, M. Y., and Nakayama, T.: Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology. J. Allergy Clin. Immunol. 144(2):549-560.e10 (2019).


• Wada, T.,* Hirahara, K.,* Aoki, A., Morimoto, Y., Kiuchi, M., Kumagai, J., Okano, M., Kokubo, K., Kato, M., Fukano, C., Ohashi-Doi, K., and Nakayama, T.: An optimized protocol for the analysis of house dust mites (Dermatophagoides farinae)-induced neutrophil-dominant airway inflammation. (*These authors contributed equally to this work) J. Immunol. Methods 465:53-60 (2019).


• Hirahara, K., and Nakayama, T.: Induction and regulation of mucosal memory T cell response. MUCOSAL VACCINES Second Edition ed. Hiroshi Kiyono, David W. Pascual, CA: Academic Press Inc., 133-140 (2019).


• Hirahara, K.,* Aoki, A.,* Morimoto, Y., Kiuchi, M., Okano, M., and Nakayama, T.: The immunopathology of lung fibrosis: Amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin. (*These authors contributed equally to this work) Semin. Immunopathol. 41(3):339-348 (2019).


• Hirahara, K.: Pathogenicity of acquired immunity in human diseases. Semin. Immunopathol. 41(3):279-281 (2019).


• Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.: Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology. Front. Immunol. 10:570 (2019).

【2018年】

• Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.: DUSP10 constrains innate IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells. Nat. Commun. 9(1):4231 (2018).


• Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.: CXCR6⁺ST2⁺ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 115(42):E9849-E9858 (2018).


• Morimoto, Y.,* Hirahara, K.,* Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T.: Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. (*These authors contributed equally to this work) Immunity 49(1):134-150.e6 (2018).


• Iinuma, T., Okamoto, Y., Morimoto, Y., Arai, T., Sakurai, T., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy 73(2):479-489 (2018).


• Goschl, L., Preglej, T., Hamminger, P., Bonelli, M., Andersen, L., Boucherron, N., Gulich, A. F., Muller, L., Saferding, V., Mufazolov, I. A., Hirahara, K., Seiser, C., Matthias, P., Penz, T., Schuster, M., Bock, C., Waisman, A., Steiner, G., and Ellmeier, W.: A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J. Autoimmun. 86:51-61 (2018).


• Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T.: The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2⁺CD4⁺ T cells. J. Leukoc. Biol. 104(5):895-901 (2018).


• Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T.: Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation. Inflamm. Regen. 38:10 (2018).

【2017年】

• Ito, T., Hirahara, K., Onodera, A., Koyama-Nasu, R., Yano, I., and Nakayama, T.: Anti-tumor immunity via the superoxide-eosinophil axis induced by lipophilic component of Mycobacterium lipomannan. Int. Immunol. 29(9):411-421 (2017).


• Onodera, A., Kiuchi, M., Kokubo, K., Kato, M., Ogino, T., Horiuchi, S., Kanai, U., Hirahara, K., and Nakayama, T.: Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. J. Immunol. 199(3):1153-1162 (2017).


• Mato, N.,* Hirahara, K.,* Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T.: Memory-type ST2⁺CD4⁺ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. (*These authors contributed equally to this work) Sci. Rep. 7(1):6805 (2017).


• Iwata, S., Mikami, Y., Sun, H. W., Brooks, R. S., Jankovic, D., Hirahara, K., Onodera, A., Shih, H. Y., Kawabe, T., Jiang, K., Nakayama, T., Sher, A., O'Shea, J. J., Davis, F. P., and Kanno, Y.: The transcription factor T-bet limits amplification of type l IFN transcriptome and circuitry in T helper 1 cells. Immunity 46(6):983-991.e4 (2017).


• Brück, J., Holstein, J., Glocova, I., Seidel, U., Geisel, J., Kanno, T., Kumagai, J., Mato, N., Sudowe, S., Widmaier, K., Sinnberg, T., Yazdi, A. S., Eberle, F. C., Hirahara, K., Nakayama, T., Röcken, M., and Ghoreschi, K.: Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation. Sci. Rep. 14(7):44482 (2017).


• Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., and Nakayama, T.: Epigenetic regulation of T helper cell differentiation, memory and plasticity in allergic asthma. Immunol. Rev. 278(1):8-19 (2017).


• Shinoda, K., Hirahara, K., and Nakayama, T.: Maintenance of pathogenic Th2 cells in allergic disorders. Allergol. Int. 66(3):369-376 (2017).


• Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 cells in health and disease. Annu. Rev. Immunol. 26(35):53-84 (2017).

【2016年】

• Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y., and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci. Immunol. 1(3):eaaf9154 (2016).


• Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.: Thy1⁺IL-7⁺ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA 113(20):E2842-E2851 (2016).


• Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., McClanahan, T. K., McGeachy, M. J., O'Shea, J. J., and Cua, D. J.: Interleukin-23-induced transcription factor Blimp-1 promotes pathogenicity of T helper 17 cells. Immunity 44(1):131-42 (2016).


• Bonelli, M., Goschl, L., Bluml, S., Karonitsch, T., Hirahara, K., Ferner, E., Steiner, C. W., Steiner, G., Smolen, J. S., and Scheinecker, C.: Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford) 55(4):710-20 (2016).


• Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation ed. Masayuki Miyasaka, Kiyoshi Takatsu, CA: Wien Heidelberg New York Dordrecht London: Springer, 401-415 (2016).


• Hirahara, K., Schwartz, D., Gadina, M., Kanno, Y., and O'Shea, J. J.: Targeting cytokine signaling in autoimmunity: back to the future and beyond. Curr. Opin. Immunol. 43:89-97 (2016).>


• Nakayama, T., Endo, Y., Shinoda, K., and Hirahara, K.: Pathogenic memory Th2 cells in airway inflammation. Cornea 35:S8 (2016).


• Hirahara, K., and Nakayama, T.: CD4⁺ T-cell subsets in inflammatory diseases: beyond the T_h1/T_h2 paradigm. Int. Immunol. 28(4):163-171 (2016).


• Eberle, F. C., Bruck, J., Holstein, J., Hirahara, K., and Ghoreschi, K.: Recent advances in understanding psoriasis. F1000Res. 5:F1000 Faculty Rev-770 (2016).

【2015年】

• Onodera, A., Tumes, D. J., Watanabe, Y., Hirahara, K., Kaneda, A., Sugiyama, F., Suzuki,. Y, and Nakayama, T.: Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes. Mol. Cell. Biol. 35 (22):3841-53 (2015).


• Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12(6):1042-1055 (2015).


• Yang, X. P., Jiang, K., Hirahara, K., Vahedi, G., Afzali, B., Sciume, G., Boneli, M., Sun, H. W., Jankovic, D., Kanno, Y., Sartorelli, V., O'Shea, J. J., and Laurence, A.: EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion. Sci. Rep. 5:10643 (2015).


• Hirahara, K., Onodera, A., Villario, A. V., Bonelli, M., Sciumè, G., Laurence, A., Sun, H. W., Brooks, R. S., Vahedi, G.,Shih, H. Y., Gtierrez-Cruz, G., Iwata, S., Suzuki, R., Mikami, Y., Okamoto, Y., Nakayama, T., Holland, S., Hunter, C. A., Kanno, Y., and O'Shea, J. J.: Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity 42(5):877-889 (2015).


• Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: IL-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114(4):289-298 (2015).


• Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper-2 cell pathogenicity in the airway. Immunity 42(2):294-308 (2015).

【2014年】

• Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111(35):12829-12834 (2014).


• Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., Hirahara, K., Vahedi, G., Sun, H. W., Feigenbaum, L., Milner, J. D., Holland, S. M., Casellas, R., Powrie, F., and O'Shea, J. J.: A mouse model of HIES reveals pro-and anti-inflammatory functions of STAT3. Blood 123(19):2978-2987 (2014).


• Nakayamada, S., Poholek, A. C., Lu, K. T., Takahashi, H., Kato, M., Iwata, S., Hirahara, K., Cannons, J. L., Schwartzberg, P. L., Vahedi, G., Sun, H. W., Kanno, Y., and O'Shea, J. J.: Type I IFN Induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J. Immunol. 192(5):2156-2166 (2014).


• Shih, H. Y., Sciumè, G., Poholek, A., Vahedi, G., Hirahara, K., Villarino, A. V., Bonelli, M., Bosselut, R., Kanno, Y., Muljo, S. A., and O'Shea, J. J.: Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol. Rev. 261(1):23-49 (2014).


• Bonelli, M., Shih, H. Y., Hirahara, K., Singelton, K., Laurence, A., Poholek, A., Hand, T., Mikami, Y., Vahedi, G., Kanno, Y., and O'Shea, J. J.: Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr. Top. Microbiol. Immunol. 381:279-326 (2014).


• Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35(2):69-78 (2014).

【2013年】

• Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, M. V., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110(46):18626-18631 (2013).


• Roychoudhuri, R.,* Hirahara, K.,* Mousavi, K.,* Clever, D., Klebanoff, C. A., Bonelli, M., Sciume, G., Zare, H., Vahedi, G., Dema, B., Yu, Z., Liu, H., Takahashi, H., Rao, M., Muranski, P., Crompton, J. G., Punkosdy, G., Bedognetti, D., Wang, E., Hoffmann, V., Rivera, J., Marincola, F. M., Nakamura, A., Sartorelli, V., Kanno, Y., Gattinoni, L., Muto, A., Igarashi, K., O'Shea, J. J., and Restifo, N. P.: BACH2 represses effector programs to stabilize T_reg-mediated immune homeostasis. (*These authors are contributed equally to this work) Nature 498(7455):506-510 (2013).


• Hirahara, K., Poholek, A., Vahedi, G., Laurence, A., Kanno, Y., Milner, J. D., and O'Shea, J. J.: Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J. Allergy Clin. Immunol. 131(5):1276-1287 (2013).


• Vahedi, G., Poholek A. C., Hand, T. W., Laurence, A., Kanno, Y., O'Shea, J. J., and Hirahara, K.: Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol. Rev. 252(1):24-40 (2013).

【2012年】

• Sciumè, G., Hirahara, K., Takahashi, H., Laurence, A., Villarino, A. V., Singleton, K. L., Spencer, S. P., Wilhelm, C., Poholek, A. C., Vahedi, G., Kanno, Y., Belkaid, Y., and O'Shea, J. J.: Distinct requirements for T-bet in gut innate lymphoid cells. J. Exp. Med. 209(13):2331-2338 (2012).


• Hirahara, K.,* Ghoreschi, K.,* Yang, X. P., Takahashi, H., Laurence, A., Vahedi, G., Sciumè, G., Hall, A. O., Dupont, C. D., Francisco, L. M., Chen, Q., Tanaka, M., Kanno, Y., Sun, H. W., Sharpe, A. H., Hunter, C. A., and O'Shea, J. J.: Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. (*These authors contributed equally to this work) Immunity 36(6):1017-1030 (2012).


• Takahashi, H., Kanno, T., Nakayamada, S., Hirahara, K., Sciumè, G., Muljo, S. A., Kuchen, S., Casellas, R., Wei, L., Kanno, Y., and O'Shea, J. J.: TGF-𝛃 and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat. Immunol. 13(6):587-595 (2012).


• Villarino, A., Yang, X. P., Hirahara, K., Kanno, Y., O'Shea, J. J., and Laurence, A.: Function of JAKs and STATs in lymphocyte: bench to bedside. Jak-Stat Signaling: From Basics to Disease ed. Thomas Decker, CA: Wien Heidelberg New York Dordrecht London: Springer, 205-237 (2012).


• Laurence, A., Ghoreschi, K., Hirahara, K., Yang, X. P., and O'Shea, J. J.: Therapeutic inhibition of the Janus kinases. Inflammation and Regeneration 32(1):16-22 (2012).


• Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., and O'Shea, J. J.: Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30:707-731 (2012).

【2011年】

• Yang, X. P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H. W., Wei, L., Vahedi, G., Kanno, Y., O'Shea, J. J., and Laurence, A.: Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12(3):247-254 (2011).


• Hirahara, K., Vahedi, G., Ghoreschi, K., Yang, X. P., Nakayamada, S., Kanno, Y., O'Shes, J. J., and Laurence, A.: Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 134(3):235-245 (2011).


• Ghoreschi, K., Laurence, A., Yang, X. P., Hirahara, K., and O'Shea, J. J.: T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol. 32(9):395-401 (2011).

【2010年】

• Hirahara, K., Ghoreschi, K., Laurence, A., Yang, X. P., Kanno, Y., and O'Shea, J. J.: Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev. 21(6):425-434 (2010).

【2008年】

• Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122(3):512-520 (2008).


• Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205(5):1109-1120 (2008).

【2006年】

• Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, M. Y., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24(5):611-622 (2006).


• Nigo, Y. I., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103(7):2286-2291 (2006).