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[2023] [2022] [2021] [2020] [2019] [2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001] [2000] [1999] [1998] [1997]

 

２０２３年

  • Koyama-Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., Motohashi, S., Nakayama, T.: CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes. Cancer Immunol. Res. 11(8):1085-1099(2023) .
  • Aoki, T., Motohashi, S., Koseki, H.: Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy. Inflamm. Regen. 43(1):27(2023).
  • Ogawa, K., Chiba, T., Nakamura, M., Arai, J., Zhang, J., Ma, Y., Qiang, N A., Ao, J., Yumita, S., Ishino, T., Kan, M., Iwanaga, T., Nakagawa, M., Fujiwara, K., Sakuma, T., Kanzaki, H., Koroki, K., Kusakabe, Y., Kobayashi, K., Kanogawa, N., Kiyono, S., Kondo, T., Nakagawa, R., Ogasawara, S., Muroyama, R., Nakamoto, S., Kanda, T., Maruyama, H., Kato, J., Matsumoto, S., Arai, T., Motohashi, S., Kato, N.,: Successful Identification of a Novel Therapeutic Compound for Hepatocellular Carcinoma Through Screening of ADAM9 Inhibitors. Anticancer Res. 43(3):1043-1052 (2023).

 

２０２２年

  • Ikeda, M., Ide, T., Matsushima, S., Ikeda, S., Okabe, K., Ishikita, A., Tadokoro, T., Sada, M., Abe, K., Sato, M., Hanada, A., Arai, S., Ohtani, K., Nonami, A., Mizuno, S., Morimoto, S., Motohashi, S., Akashi, K., Taniguchi, M., Tsutsui, H.: Immunomodulatory Cell Therapy Using αGalCer-Pulsed Dendritic Cells Ameliorates Heart Failure in a Murine Dilated Cardiomyopathy Model. Circ. Heart Fail. 15(12):e009366(2022) .
  • Shiina, Y., Suzuki, H., Hata, A., Kaiho, T., Matsumoto, H., Toyoda, T., Sakairi, Y., Wada, H., Motohashi, S., Yoshino, I.: Antibodies against complement component C5 prevent antibody-mediated rejection after lung transplantation in murine orthotopic models with skin-graft-induced pre-sensitization. Gen. Thorac. Cardiovasc. Surg. 70(12):1032-1041(2022).
  • Ogawa, K., Kanzaki, H., Chiba, T., Ao, J., Qiang, N., Ma, Y., Zhang, J., Yumita, S., Ishino, T., Unozawa, H., Kan, M., Iwanaga, T., Nakagawa, M., Fujiwara, K., Fujita, N., Sakuma, T., Koroki, K., Kusakabe, Y., Kobayashi, K., Kanogawa, N., Kiyono, S., Nakamura, M., Kondo, T., Saito, T., Nakagawa, R., Ogasawara, S., Suzuki, E., Nakamoto, S., Muroyama, R., Kanda, T., Maruyama, H., Mimura, N., Kato, J., Motohashi, S., and Kato, N.: Effect of Atezolizumab plus Bevacizumab in Patients with Hepatocellular Carcinoma Harboring CTNNB1 Mutation in Early Clinical Experience. J. Cancer. 13(8):2656-2661(2022).

 

２０２１年

  • Hagiya, M., Tanaka, T., Aita, K., Shiragami, R., Ihara, F., Ishii, A., Takami, M., Homma, T., Wada, Y., Motohashi, S.: Administration of α-galactosylceramide-pulsed Antigen Presenting Cells in Combination with First-line Chemotherapy for Advanced Lung Cancer. Chiba SurveyRes J. 10(1):27-33(2021).
  • Nakayama, T., Hirahara, K., Kimura, M.Y., Iwamura, C., Kiuchi, M., Kokubo, K., Onodera, A., Hashimoto, K., Motohashi, S.: CD4 + T cells in inflammatory diseases : pathogenic T-helper cells and the CD69-Myl9 system. Int Immunol. 33(12):699-704(2021).
  • Shimazaki, R., Takano, S., Satoh, M., Takada, M., Miyahara, Y., Sasaki, K., Yoshitomi, H., Kagawa, S., Furukawa, K., Takayashiki, T., Kuboki, S., Sogawa, K., Motohashi, S., Nomura, F., Miyazaki, M., Ohtsuka, M.: Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.Cell Oncol. 44(4):937-950(2021).

 

２０２０年

  • Hara, A., Koyama-Nasu, R., Takami, M., Toyoda, T., Aoki, T., Ihara, F., Kobayashi, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.: CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy. Cancer Immunol. Immunother. 70(5):1239-1254(2020).
  • Suzuki, A.S., Yagi, R., Kimura, M.Y., Iwamura, C., Shinoda, K., Onodera, A., Hirahara, K., Tumes, D. J., Koyama-Nasu, R., Iismaa, S. E., Graham, R. M., Motohashi, S., and Nakayama, T.: Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front. Immunol. 11:1536(2020).
  • Hata, A., Suzuki, H., Nakajima, T., Fujiwara, T., Shiina, Y., Kaiho, T., Toyoda, T., Inage, T., Ito, T., Sakairi, Y., Tamura, H., Wada, H., Yamada, Y., Chiyo, M., Matsusaka, K., Fukuyo, M., Shinohara, KI., Itoga, S., Motohashi, S., Matsushita, K., Kaneda, A., and Yoshino, I.: Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: a comprehensive transcriptome-based analysis.PLoS One. 15(5):e0232884(2020).
  • Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Toyoda, T., Okada, R., Hino, M., Koyama-Nasu, R., Kiuchi, M., Hirahara, K., Kimura, M.Y., Nakayama, T., Shimojo, N., and Motohashi, S.: Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner. Cancer Sci. 111(7):2223-2233(2020).
  • Ishibashi, F., Sakairi, Y., Iwata, T., Moriya, Y., Mizobuchi, T., Hoshino, H., Yoshida, S., Hanaoka, H., Yoshino, I., and Motohashi, S.: A phase I study of loco-regional immunotherapy by trans-bronchial injection of α-galactosylceramide-pulsed antigen presenting cells in patients with lung cancer. Clin. Immunol. (2020).

 

２０１９年

  • Toyoda, T., Kamata, T., Tanaka, K., Ihara, F., Takami, M., Suzuki, H., Nakajima, T., Ikeuchi, T., Kawasaki, Y., Hanaoka, H., Nakayama, T., Yoshino, I. and Motohashi, S. : Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer. J Immunother Cancer.8(1) : pii: e000316(2020).
  • Kamata, T., Yoshida, S., Takami, M., Ihara, F., Yoshizawa, H., Toyoda, T., Takeshita, Y., Nobuyama, S., Kanetsuna, Y., Sato, T., Yoshino, I. and Motohashi, S. : Immunological Features of a Lung Cancer Patient Achieving an Objective Response with Anti-PD-1 Blockade Therapy. Cancer Sci. 111(1):288-296(2019).
  • Ihara, F., Sakurai, D., Takami, M., Kamata, T., Kunii, N., Yamasaki, K., Iinuma, T., Nakayama, T., Motohashi, S. and Okamoto, Y. : Regulatory T cells induce CD4− NKT cell anergy and suppress NKT cell cytotoxic function. Cancer Immunol. Immunother. 68(12):1935-1947 (2019).
  • Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H. and Motohashi, S. : Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation. Cancer Sci. 110(3):888-902. (2019).

 

２０１８年

  • Makita, Y., Kunii, N., Sakurai, D., Ihara, F., Motohashi, S., Suzuki, A., Nakayama, T. and Okamoto, Y. : Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer. BMC Cancer. 18(1):1254. (2018).
  • Tanaka, T., Kanesaka, Y., Takami, M., Suzuki, A., Hosokawa, H., Onodera, A., Kamata, T., Nagato, K., Nakayama, T., Yoshino, I. and Motohashi, S. : Role of Leukotriene B4 12-Hydroxydehydrogenase in α-Galactosylceramide-Pulsed Dendritic Cell Therapy for Non-Small Cell Lung Cancer. Biochem Biophys Res Commun. 506(1): 27-32. (2018).
  • Mita, Y., Kimura, M.Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y., and Nakayama, T. : Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-in ltrating T cells. Int Immunol. 30(12):559-567(2018).
  • Takami, M., Cunha, C., Motohashi, S., Nakayama, T. and Iwashima, M.: TGF-β suppresses RasGRP1 expression and supports regulatory T cells resistance against p53-induced CD28-dependent T cell apoptosis. Eur J Immunol. 48(12):1938-1943 (2018).
  • Takami, M., Iwashima, M. and Motohashi, S.: Co-stimulatory Signaling Influences TGF-β-Dependent CD4+ T cell Differentiation and Its Plasticity. Chiba Survey Research Journal. 7(2): 80-87 (2018).
  • Kimura, M.Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., Endo, Y., Ogawa, S., Yagi, R., Motohashi, S., Singer, A. and Nakayama, T.: CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nat Commun. 9(1):3749 (2018).
  • Takami, M., Ihara, F. and Motohashi, S.: Clinical Application of iNKT Cell-mediated Anti-tumor Activity Against Lung Cancer and Head and Neck Cancer. Front Immunol. 9:2021 (2018).
  • Ihara, F., Sakurai, D., Yonekura, S., Iinuma, T., Yagi, R., Sakurai, T., Ito, T., Matsuura, A., Morimoto, Y., Arai, T., Suzuki, S., Katayama, K., Nakayama, T. and Okamoto, Y. : Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Allergy. 73(9):1823-1832 (2018).
  • Sakurai, D., Uchida, R., Ihara, F., Kunii, N., Nakagawa, T., Chazono, H., Hanazawa, T., Motohashi, S. and Okamoto, Y. : Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells. BMC Res Notes. 16;11(1): 479 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H. and Motohashi, S. : Invariant natural killer T infiltration in neuroblastoma with favorable outcome. Pediatr Surg Int. 34(2):195-201 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H. and Motohashi, S. : Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors. Pediatr Surg Int. 34(2):169-176 (2018).
  • Kawashima, T., Ikari, N., Watanabe, Y., Kubota, Y., Yoshio, S., Kanto, T., Motohashi, S., Shimojo, N. and Tsuji, N.M. : Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-β from Human Dendritic Cells. Front Immunol. 9:27 (2018).

 

２０１７年

  • Ihara, F., Sakurai, D., Horinaka, A., Fujisawa, A., Makita, Y., Sakurai, T., Yamasaki, K., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma. Cancer Immunol Immunother. 66(10):1275-85 (2017).
  • Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S. and Nakayama, T. : Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol Rev. 278(1):87-100 (2017).

 

２０１６年

  • Kamata, T., Suzuki, A., Mise, N., Ihara, F., Takami, M., Makita, Y., Horinaka, A., Harada, K., Kunii, N., Yoshida, S., Yoshino, I., Nakayama, T. and Motohashi, S. : Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells. Cancer Immunol Immunother. 65(12):1477-89 (2016).
  • Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y. and Nakayama, T. : Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci Immunol. 1(3):eaaf9154 (2016).
  • Aoki, T., Hino, M., Koh, K., Kyushiki, M., Kishimoto, H., Arakawa, Y., Hanada, R., Kawashima, H., Kurihara, J., Shimojo, N. and Motohashi, S. : Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers. Pediatr Blood Cancer. 63(8):1461-4 (2016).
  • Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. and Nakayama, T. : Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 7:11289 (2016).
  • Mise, N., Takami, M., Suzuki, A., Kamata, T., Harada, K., Hishiki, T., Saito, T., Terui, K., Mitsunaga, T., Nakata, M., Ikeuchi, T., Nakayama, T., Yoshida, H. and Motohashi, S. : Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant NKT cells. Cancer Sci. 107(3):233-241 (2016).
  • Horinaka, A., Sakurai, D., Ihara, F., Makita, Y., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer. Cancer Sci. 107(3):207-16 (2016).

 

２０１５年

  • Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J, Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. and Nakayama, T. : Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells. J Biol Chem. 290(21):13095-103 (2015).
  • Frigault, M. J., Lee, J., Basil, M., Carpenito, C., Motohashi, S., Scholler, J., Kawalekar, O. U., Guedan, S., McGettigan, S., Posey, A Jr., Ang, S., Cooper, L. J., Platt, J. M., Johnson, F. B., Paulos, C. M., Zhao, Y., Kalos, M., Milone, M. C. and June, C. H. : Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Cancer Immunol Res. 3(4):356-67 (2015).
  • Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y. and Nakayama, T. : The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway. Immunity 42(2):294-308 (2015).

 

２０１４年

  • Sun, Y., Furihata, T., Ishii, S., Nagai, M., Harada, M., Shimozato, O., Kamijo, T., Motohashi, S., Yoshino, I., Kamiichi, A., Kobayashi, K. and Chiba, K. : Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers: potential biomarker implications. Clin Transl Med. 3:37 (2014).
  • Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T. : Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc Natl Acad Sci U S A. 111(35):12829-34 (2014).

 

２０１３年

  • Fujii, S., Shimizu, K., Okamoto, Y., Kunii, N., Nakayama, T., Motohashi, S. and Taniguchi, M. : NKT cells as an ideal anti-tumor immunotherapeutic. Front Immunol. 4:409 (2013).
  • Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S. and Nakayama, T. : The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells. Immunity 39(5):819-32 (2013).
  • Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S. and Nakayama, T. : Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci U S A. 110(46):18626-31 (2013).

 

２０１２年

  • Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y. and Nakayama, T. : Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc Natl Acad Sci U S A. 109(42):16992-7 (2012).
  • Nagato, K., Motohashi, S., Ishibashi, F., Okita, K., Yamasaki, K., Moriya, Y., Hoshino, H., Yoshida, S., Hanaoka, H., Fujii, S., Taniguchi, M., Yoshino, I. and Nakayama, T. : Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells. J Clin Immunol. 32(5):1071-81 (2012).
  • Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V. and Nakayama, T. : The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation. Nat Immunol. 13(8):778-86 (2012).
  • Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S. and Nakayama, T. : Murine Schnurri-2 controls Natural Killer cell function and lymphoma development. Leuk Lymphoma. 53(3):479-86 (2012).
  • Nagai, M., Furihata, T., Matsumoto, S., Ishii, S., Motohashi, S., Yoshino, I., Ugajin, M., Miyajima, A., Matsumoto, S. and Chiba, K. : Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem Biophys Res Commun. 418(4):818-23 (2012).

 

２０１１年

  • Taniguchi, M., Fujii, S., Nakayama, T., Motohashi, S., Dashtsoodal, N., Watarai, H., and Harada, M. : Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Deprived NKT Cells. Natural killer T cells: Balancing the Regulation of Tumor Immunity 1-14 (2011).
  • Motohashi, S., Okamoto, Y., Yoshino, I. and Nakayama, T. : Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer. Clin Immunol. 140(2):167-76 (2011).
  • Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, S. F. and Nakayama, T. : Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71(14):4790-8 (2011).
  • Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T. and Okamoto, Y. : Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. Clin Immunol. 138(3):255-65 (2011).
  • Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A. and Okamoto, Y. : Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer. Cancer Immunol Immunother. 60(2):207-15 (2011).

 

２０１０年

  • Okita, K., Motohashi, S., Shinnakasu, R., Nagato, K., Yamasaki, K., Sato, Y., Kitamura, H., Hijikata, A., Yamashita, M., Shimizu, K., Fujii, S., Ohara, O., Taniguchi, M., Sakaida, I. and Nakayama, T. : A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci. 101(11):2333-40 (2010).
  • Ishii, Y., Motohashi, S., Shimizu, K., Nakayama, T., Taniguchi, M. and Fujii, S. : Application of NKT cells in immunotherapy. Curr Immunol Rev. 6(2):109-15 (2010).
  • Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y. and Taniguchi, M. : Adjuvant activity mediated by iNKT cells. Semin Immunol. 22(2):97-102 (2010).
  • Suzuki, M., Wada, H., Yoshino, M., Tian, L., Shigematsu, H., Suzuki, H., Alaa, M., Tamura, H., Fujiwara, T., Nagato, K., Motohashi, S., Moriya, Y., Hoshino, H., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y. and Yoshino, I. : Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling. Ann Surg Oncol. 17(3):878-88 (2010).

 

２００９年

  • Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M. and Nakayama, T. : CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 183(12):8203-15 (2009).
  • Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M. and Nakayama, T. : Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J Immunol. 183(8):5388-96 (2009).
  • Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T. and Okamoto, Y. : Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. Cancer Sci. 100(6):1092-8 (2009).
  • Motohashi, S. and Nakayama, T. : Natural killer T cell-mediated immunotherapy for malignant diseases. Front Biosci (Schol Ed). 1:108-16 (2009).
  • Alaa, M., Suzuki, M., Yoshino, M., Tian, L., Suzuki, H., Nagato, K., Fujiwara, T., Wada, H., Moriya, Y., Hoshino, H., Motohashi, S., Yoshida, S., Shibuya, K., Hiroshima, K., Nakatani, Y., Abdrabou, A., Elkholy, M., Mahfouz, T. and Yoshino, I. : Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. Int J Oncol. 34(3):805-12 (2009).
  • Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T. and Nakayama, T. : A phase I-II study of α-Galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer. J Immunol. 182(4):2492-501 (2009).
  • Motohashi, S. and Nakayama, T. : Invariant natural killer T cell-based immunotherapy for cancer. Immunotherapy. 1(1):73-82 (2009).
  • Nakayama, T., and Kimura, M. Y.: Memory Th1/Th2 cell generation controlled Schnurri-2. Memory T-cells, edited by Maurizio Zanetti, (2009).

 

２００８年

  • Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S. and Nakayama, T. : Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J Biol Chem. 283(42):28216-25 (2008).
  • Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I. and Nakayama, T. : Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int Immunol. 20(7):849-60 (2008).
  • Suzuki, M., Mohamed, S., Nakajima, T., Kubo, R., Tian, L., Fujiwara, T., Suzuki, H., Nagato, K., Chiyo, M., Motohashi, S., Yasufuku, K., Iyoda, A., Yoshida, S., Sekine, Y., Shibuya, K., Hiroshima, K., Nakatani, Y., Yoshino, I. and Fujisawa, T. : Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Int J Oncol. 33(1):113-9 (2008).
  • Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A. and Nakayama, T. : Bmi1 regulates memory CD4 T cell sirvival via repression of the Noxa gene. J Exp Med. 205(5):1109-20 (2008).
  • Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T. and Okamoto, Y. : Phase I study of α-Galactosylceramide-pulsed anitgen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. Cancer Immunol Immunother. 57(3):337-45 (2008).
  • Motohashi, S. and Nakayama, T. : Clinical applications of natural killer T cell-based immunotherapy for cancer. Cancer Sci. 99(4):638-45 (2008).

 

２００７年

  • Suzuki, M., Shigematsu, H., Nakajima, T., Kubo, R., Motohashi, S., Sekine, Y., Shibuya, K., Iizasa, T., Hiroshima, K., Nakatani, Y., Gazdar, A. F. and Fujisawa, T. : Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer. Clin Cancer Res. 13(20):6087-92 (2007).

 

２００６年

  • Hosokawa, H., Kimura, M. Y., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M. and Nakayama, T. : Regulation of Th2 development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol. 177(11):7656-7664 (2006).
  • Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T. and Nakayama, T. : A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. Clin Cancer Res. 12(20):6079-86 (2006).
  • Seino, K., Motohashi, S., Fujisawa, T., Nakayama, T. and Taniguchi, M. : Natural killer T cell-mediated antitumor immune responses and their clinical applications. Cancer Sci. 97(9):807-12 (2006).
  • Tenda, Y., Yamashita, M., Kimura, M. Y., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki N. and Nakayama, T. : Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J Allergy Clin Immunol. 118(3):725-733 (2006).
  • Sekine, Y., Yasufuku, K., Motohashi, S. and Fujisawa, T. : Triple reconstruction of pulmonary artery, superior vena cava and bronchus for lung cancer. Interact Cardiovasc Thorac Surg. 5(4):509-510 (2006).
  • Iizasa, T., Suzuki, M., Yoshida, S., Motohashi, S., Yasufuku, K., Iyoda, A., Shibuya, K., Hiroshima, K., Nakatani, Y. and Fujisawa, T. : Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann Thorac Surg. 82(1):254-60 (2006).

 

２００５年

  • Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H. and Shinnakasu, R. : Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
  • Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A. and Nakayama, T. : Dendritic cell maturation by CD11c- T cells and Vα24+ NKT cell activation by α-Galactosylceramide. Int J Cancer. 117(2):265-73 (2005).
  • Yoshino, M., Hiroshima, K., Motohashi, S., Shibuya, K., Iyoda, A., Sekine, Y. and Fujisawa, T. : Papillary carcinoma of the thymus gland. Ann Thorac Surg. 80(2):741-2 (2005).
  • Seino, K., Fuji, S., Harada, M., Motohashi, S., Nakayama, T., Fujisawa, T. and Taniguchi, M. : Vα14 NKT cell-mediated anti-tumor responses and their clinical application. Springer Semin Immunopathol. 27(1):65-74 (2005).
  • Suzuki, H., Sekine, Y., Motohashi, S., Chiyo, M., Suzuki, M., Haga, Y., Hiroshima, K., Ohwada, H., Iizasa, T., Saitoh, Y., Baba, M. and Fujisawa, T. : Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases. Surg Today. 35(3):243-6 (2005).
  • Ishikawa, A., Motohashi, S., Ishikawa, E., Fuchida, H., Higashino, K., Otsuji, M., Iizasa, T., Nakayama, T., Taniguchi, M. and Fujisawa, T. : A phase I study of α-Galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer. Clin Cancer Res. 11(5):1910-7 (2005).
  • Motohashi, S., Sekine, Y., Iizasa, T., Nakano, K., Numata, T. and Fujisawa, T. : Thyroid cancer with massive invasion into the neck and mediastinal great veins. 53(1):55-7 (2005).

 

２００４年

  • Yamaji, H., Iizasa, T., Koh, E., Suzuki, M., Otsuji, M., Chang, H., Motohashi, S., Yokoi, S., Hiroshima, K., Tagawa, M., Nakayama, T. and Fujisawa, T. : Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer. Cancer Immunol Immunother. 53(9):786-92 (2004).
  • Iizasa, T., Chang, H., Suzuki, M., Otsuji, M., Yokoi, S., Chiyo, M., Motohashi, S., Yasufuku, K., Sekine, Y., Iyoda, A., Shibuya, K., Hiroshima, K. and Fujisawa, T. : Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in non-small cell lung cancer. Clin Cancer Res. 10(16):5361-6 (2004).
  • Kobayashi, S., Kaneko, Y., Seino, K., Yamada, Y., Motohashi, S., Koike, J., Sugaya, K., Kuriyama, T., Asano, S., Tsuda, T., Wakao, H., Harada, M., Kojo, S., Nakayama, T. and Taniguchi, M. : Impaired IFN-γ production of Vα24 NKT cells in non-remitting sarcoidosis. Int Immunol. 16(2):215-22 (2004).

 

２００３年

  • Ishikawa, A., Motohashi, S., Shibuya, K., Baba, M., Toyosaki, T., Ohwada, H., Saito, N., Suzuki, K. and Fujisawa, T. : Small solitary pulmonary metastasis detected before primary sigmoid colon cancer: report of a case. Surg Today. 33(9):709-11 (2003).
  • Sekine, Y., Iwata, T., Chiyo, M., Yasufuku, K., Motohashi, S., Yoshida, S., Suzuki, M., Iizasa, T., Saitoh, Y. and Fujisawa, T. : Minimal alteration of pulmonary function after lobectomy in lung cancer patients with chronic obstructive pulmonary disease. Ann Thorac Surg. 76(2):356-61 (2003).
  • Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M. and Nakayama, T. : TH1-biased immunity induced by exposure to Antarctic winter. J Allergy Clin Immunol. 111(6):1353-1360 (2003).

 

２００２年

  • Motohashi, S., Kobayashi, S., Ito, T., Magara, K. K., Mikuni, O., Kamada, N., Iizasa, T., Nakayama, T., Fujisawa, T. and Taniguchi M. : Preserved IFN-γ production of circulating Vα24 NKT cells in primary lung cancer patients. Int J Cancer. 102(2):159-65 (2002).
  • Asai, K., Hachimura, S., Kimura, M., Toraya, T., Yamashita, M., Nakayama, T. and Kaminogawa, S. : T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. J Immunol. 169:4723-4731 (2002).
  • Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M. and Nakayama, T. : Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem. 277:42399-42408 (2002).
  • Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C. -R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N. and Nakayama, T. : Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J Immunol. 169:2134-2140 (2002).
  • Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M. and Nakayama, T. : Th1/Th2 cell differentiation of developing CD4 single-positive thymocytes. Int Immunol. 14:943-951 (2002).
  • Akutsu, Y., Nakayama, T., Harada, M., Kawano, T., Motohashi, S., Shimizu, E., Ito, T., Kamada, N., Saito, T., Matsubara, H., Miyazawa, Y., Ochiai, T. and Taniguchi, M. : Expansion of lung Vα14 NKT cells by administration of α-galactosylceramide-pulsed dendritic cells. Jpn J Cancer Res. 93(4):397-403 (2002).
  • Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H. and Ziegler, S. F. : The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol. 168:87-94 (2002).

 

２００１年

  • Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi M., Koseki, H. and Nakayama, T. : Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity. 15:275-287 (2001).
  • Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S., Kawano, T., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M. and Taniguchi, M. : Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int Immunol. 13(7):853-61 (2001).
  • Shin, T., Nakayama, T., Akutsu, Y., Motohashi, S., Shibata, Y., Harada, M., Kamada, N., Shimizu, C., Shimizu, E., Saito, T., Ochiai, T. and Taniguchi, M. : Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells. Int J Cancer. 91(4):523-8 (2001).
  • Nakayama, T., Yamashita, M., Kawano, T., Shimizu, C., Shibata, Y., Kamata, T., Kaneko, Y., Kobayashi, S., Takeda, U., Motohashi, S., Cui, J. and Taniguchi, M. : The role of α-GalCer-activated Vα14 NKT cells in the regulation of Th2 cell differentiation. Int Arch Allergy Immunol. 124(1-3):38-42 (2001).
  • Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondo, E., Kaneko, Y., Okada, S., Tokuhisa T., Yokoyama, M., Taniguchi, M., Katsura, Y. and Nakayama, T. : Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lack proximal promoter activity. Int Immunol. 13:105-117 (2001).

 

 

１９９９年

  • Kawano, T., Nakayama, T., Kamada, N., Kaneko, Y., Harada, M., Ogura, N., Akutsu, Y., Motohashi, S., Iizasa, T., Endo, H., Fujisawa, T., Shinkai, H. and Taniguchi, M. : Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells. Cancer Res. 59(20):5102-5 (1999).
  • Fujisawa, T., Iizasa, T., Saitoh, Y., Sekine, Y., Motohashi, S., Yasukawa, T., Shibuya, K., Hiroshima, K. and Ohwada, H. : Smoking before surgery predicts poor long-term survival in patients with stage I non-small-cell lung carcinomas. J Clin Oncol. 17(7):2086-91 (1999).
  • Iizasa, T., Fujisawa, T., Suzuki, M., Motohashi, S., Yasufuku, K., Yasukawa, T., Baba, M. and Shiba, M. : Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin Cancer Res. 5(1):149-53 (1999).

 

 

１９９７年

  • Ran, S., Kimura, H., Iwai, N., Yamamoto, N. and Motohashi, S. : A case of synovial sarcoma treated by adoptive immunotherapy after resection of metastatic lung tumors. Jpn J Lung Cancer. 37(7):1023-1028 (1997).
  • Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T. and Nakayama, T. : TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.350-351 (1997).