業績

Win NN, Kanda T, Nakamoto S, Yokosuka O, Shirasawa H. Hepatitis C virus genotypes in Myanmar. World J Gastroenterol. 2016;22:6095-9.

Wu S, Kanda T, Nakamoto S, Jiang X, Nakamura M, Sasaki R, Haga Y, Shirasawa H, Yokosuka O. Cooperative effects of hepatitis B virus and TNF may play important roles in the activation of metabolic pathways through the activation of NF-κB. Int J Mol Med. 2016;38:475-81.

Sasaki R, Kanda T, Nakamura M, Nakamoto S, Haga Y, Wu S, Shirasawa H, Yokosuka O. Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells. PLoS One. 2016;11:e0146314.

小野亮平、山内かづ代、Daniel Salcedo、白澤 浩、朝比奈真由美 千葉大学医学部における医学留学制度の利用 -6年間の留学の軌跡と留学を志望する医学生の方々へ- 医学教育 2016;47:11-6.

Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y. Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection. Int J Pharm. 2015;496:401-6.

Kanda T, Sasaki R, Nakamoto S, Haga Y, Nakamura M, Shirasawa H, Okamoto H, Yokosuka O. The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity. Biochem Biophys Res Commun. 2015;4466:567-71.

Nakamoto S, Imazeki F, Arai M, Yasui S, Nakamura M, Haga Y, Sasaki R, Kanda T, Shirasawa H, Yokosuka O. Effect of Hepatitis C Virus Genotype 1b Core and NS5A Mutations on Response to Peginterferon Plus Ribavirin Combination Therapy. Int J Mol Sci. 2015;16:21177-90.

Takenouchi A, Saito K, Saito E, Saito T, Hishiki T, Matsunaga T, Isegawa N, Yoshida H, Ohnuma N, Shirasawa H. Oncolytic viral therapy for neuroblastoma cells with Sindbis virus AR339 strain. Pediatr Surg Int. 2015;31:1151-9.

Sasaki R, Kanda T, Wu S, Nakamoto S, Haga Y, Jiang X, Nakamura M, Shirasawa H, Yokosuka O. Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver. Biochem Biophys Res Commun. 2015;464:1192-5.

Yi R, Saito K, Isegawa N, Shirasawa H. Alteration of cell cycle progression by Sindbis virus infection. Biochem Biophys Res Commun. 2015;462:426-32.

Nakamoto S, Kanda T, Shirasawa H, Yokosuka O. Antiviral therapies for chronic hepatitis C virus infection with cirrhosis. World J Hepatol. 2015;7:1133-41.

Jiang X, Kanda T, Nakamoto S, Saito K, Nakamura M, Wu S, Haga Y, Sasaki R, Sakamoto N, Shirasawa H, Okamoto H, Yokosuka O. The JAK2 inhibitor AZD1480 inhibits hepatitis A virus replication in Huh7 cells. Biochem Biophys Res Commun. 2015;458:908-912.

Nakamoto S, Kanda T, Nakaseko C, Sakaida E, Ohwada C, Takeuchi M, Takeda Y, Mimura N, Iseki T, Wu S, Arai M, Imazeki F, Saito K, Shirasawa H, Yokosuka O. Reactivation of Hepatitis B Virus in Hematopoietic Stem Cell Transplant Recipients in Japan: Efficacy of Nucleos(t)ide Analogues for Prevention and Treatment. Int J Mol Sci. 2014;15:21455-67.

Jiang X, Kanda T, Wu S, Nakamoto S, Wakita T, Shirasawa H, Yokosuka O. Hepatitis C Virus Nonstructural Protein 5A Inhibits Thapsigargin-Induced Apoptosis. PLoS One. 2014;10:e0131973.


Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O. Suppression of La antigen exerts potential antiviral effects against hepatitis A virus. PLoS One. 2014;9:e101993.


Nakamoto S, Kanda T, Wu S, Shirasawa H, Yokosuka O., Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J Gastroenterol. 2014;20:2902-12.

Wu S, Nakamoto S, Kanda T, Jiang X, Nakamura M, Miyamura T, Shirasawa H, Sugiura N, Takahashi-Nakaguchi A, Gonoi T, Yokosuka O. Ultra-deep sequencing analysis of the hepatitis A virus 5'-untranslated region among cases of the same outbreak from a single source. Int J Med Sci. 2013;11:60-4.

Kohji Mori, Yukinao Hayashi, Tetsuya Akiba, Miyuki Nagano, Tatsuya Tanaka, Mitsugu Hosaka, Akiko Nakama, Akemi Kai, Kengo Saito, Hiroshi Shirasawa. Multiplex real-time PCR assays for the detection of group C rotavirus, astrovirus, and Subgenus F adenovirus in stool specimens. J. Virol. Methods. 191: 141-147, 2013.

Suganami A, Toyota T, Okazaki S, Saito K, Miyamoto K, Akutsu Y, Kawahira H, Aoki A, Muraki Y, Madono T, Hayashi H, Matsubara H, Omatsu T,Shirasawa H, Tamura Y. Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe. Bioorg Med Chem Lett. 22:7481-7485, 2012.

Uehara E, Shiiba M, Shinozuka K, Saito K, Kouzu Y, Koike H, Kasamatsu A, Sakamoto Y, Ogawara K, Uzawa K, Tanzawa H.Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.Int J Oncol. 2012 May;40(5):1414-22.

Wu S, Kanda T, Imazeki F, Nakamoto S, Tanaka T, Arai M, Roger T, Shirasawa H, Nomura F, Yokosuka O. Hepatitis B virus e antigen physically associates with receptor-interacting serine/threonine protein kinase 2 and regulates IL-6 gene expression. J Infect Dis. 206:415-420, 2012.

Wu S, Kanda T, Imazeki F, Nakamoto S, Shirasawa H, Yokosuka O. Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines. Cancer Lett. 312, 33-42, 2011

Tamura R, Kanda T, Imazeki F, Wu S, Nakamoto S, Tanaka T, Arai M, Fujiwara K, Saito K, Roger T, Wakita T, Shirasawa H, Yokosuka O. Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4. J Infect. Dis. 204, 793-801, 2011.

田邊 政裕、朝比奈真由美、伊藤 彰一、前田 崇、野口 穂高、白澤 浩、田川まさみ (2011) 千葉大学医学部における学習成果基盤型教育(Outcome-based Education)の実質化 –順次性のあるカリキュラム編成の工夫-. 医学教育 42、263-269.

指山 浩志、辻中 康伸、浜畑 幸弘、堤 修、赤木 一成、星野 敏彦、南 有紀子、角田 祥之、松尾 恵五、中島 康雄、高瀬 康雄、新井 建広、北山 大祐、金 忠日、齋藤 謙吾、白澤 浩 (2011) 肛門部尖圭コンジローマ症例のHPVタイプについての検討(第二報)-HIV陽性症例におけるハイリスク型HPVの関与-.日本大腸肛門病学会雑誌 64、11-16.

Kanda T, Imazeki F, Yonemitsu Y, Mikami S, Takada N, Nishino T, Takashi M, Tsubota A, Kato K, Sugiura N, Tawada A, Wu S, Tanaka T, Nakamoto S, Mikata R, Tada M, Chiba T, Kurihara T, Arai M, Fujiwara K, Kanai F, Yokosuka O. Quantification of hepatitis C virus in patients treated with peginterferon-alfa 2a plus ribavirin treatment by COBAS TaqMan? HCV test. J Viral Hepat. 2010.

Wu S, Kanda T, Imazeki F, Arai M, Yonemitsu Y, Nakamoto S, Fujiwara K, Fukai K, Nomura F, Yokosuka O. Hepatitis B virus e antigen downregulates cytokine production in human hepatoma cell lines. Viral Immunol. 2010; 23: 467-476.

Kanda T, Imazeki F, Nakamoto S, Okitsu K, Fujiwara K, Yokosuka O. Internal ribosomal entry-site activities of clinical isolate-derived hepatitis A virus and inhibitory effects of amantadine. Hepatol Res. 2010; 40:415-423.

Nakamoto S, Imazeki F, Fukai K, Fujiwara K, Arai M, Kanda T, Yonemitsu Y, Yokosuka O. Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development. J Hepatol. 2010; 52 :72-78.

Kanda T, Gauss-Müller V, Cordes S, Tamura R, Okitsu K, Shuang W, Nakamoto S, Fujiwara K, Imazeki F, Yokosuka O. Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein. J Viral Hepat. 2010; 17 :618-623.

中本晋吾, 今関文夫, 神田達郎, 横須賀收. 肝癌発生の危険因子と高危険群の設定(2)C型慢性肝炎・肝硬変に発生する肝癌.. 臨床消化器内科2010; 25(4):413-21.

Shiiba M, Nomura H, Shinozuka K, Saito K, Kouzu Y, Kasamatsu A, Sakamoto Y, Murano A, Ono K, Ogawara K, Uzawa K, Tanzawa H. Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas. Oncol Rep. 2010; 24 :241-249.

Saito K, Shirasawa H, Isegawa N, Shiiba M, Uzawa K, Tanzawa H. Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent viruses. Oral Oncol. 2009;45:1021-1027.

Saito K, Uzawa K, Kasamatsu A, Shinozuka K, Sakuma K, Yamatoji M, Shiiba M, Shino Y, Shirasawa H, Tanzawa H. Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells. Br J Cancer. 2009;101:684-890.

Stefanie J. Klug, Meike Ressing, Jochem Koenig, Martin C Abba, Theodoros Agorastos, Sylvia MF Brenna, Marco Ciotti, BR Das, Annarosa Del-Mistro, Aleksandra Dybikowska, Anna R Giuliano, Zivile Gudleviciene, Ulf Gyllensten, Andrea LF Haws, Aslaug Helland, Simon C Herrington, Alan Hildesheim, Olivier Humbey, Sun H Jee, Jae W Kim, Margaret M Madeleine, Joseph Menczer, Hextan YS Ngan, Akira Nishikawa, Yoshimitsu Niwa, Rosemary Pegoraro, MR Pillai, Gulielmina Ranzani, Giovanni Rezza, Adam N Rosenthal, Susanta Roychoudhury, Dhananjaya Saranath, Virginia M Schmitt, Sharmila Sengupta, Wannapa Settheetham-Ishida, Hiroshi Shirasawa, Peter JF Snijders, Mark H Stoler, Angel E Suarez-Rincon, Krisztina Szarka, Ruth Tachezy, Masatsugu Ueda, Ate GJ van der Zee, Magnus von Knebel Doeberitz, Ming-Tsang Wu, Tsuyoshi Yamashita, Ingeborg Zehbe, Maria Blettner. TP53 codon 72 polymorphism and cervical cancer: pooled analysis of individual data of 15 834 women from 49 studies. Lancet Oncology, 10, 772-784, 2009.

Yamano Y, Uzawa K, Saito K, Nakashima D, Kasamatsu A, Koike H, Kouzu Y, Shinozuka K, Nakatani K, Negoro K, Fujita S, Tanzawa H. Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma. Int J Cancer. 126:437-449, 2009.

Negoro K, Yamano Y, Nakashima D, Saito K, Nakatani K, Shiiba M, Bukawa H, Yokoe H, Uzawa K, Wada T, Tanzawa H, Fujita S. Cross-resistance of platinum derivatives in H-1R, a cisplatin-resistant cell line. Oncol Rep.;21:443-449, 2009.

Nakamoto S, Sakai Y, Kasanuki J, Kondo F, Ooka Y, Kato K, Arai M, Suzuki T, Matsumura T, Bekku D, Ito K, Tanaka T, Yokosuka O. Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection. Endoscopy. 2009;41:746-750.

Iesato, K., Tatsumi, K., Saito, K., Ogasawara, T., Sakao, S., Tada, Y., Kasahara, Y., Kurosu, K., Tanabe, N., Takiguchi, Y., Kuriyama, T., Shirasawa, H. (2008) Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells. Respiration, 76, 434-441.

Hiroshi Shirasawa. (2008) Human papillomavirus vaccine. Virus Report, 5, 40-48.

Hayashi, Y., Shino, Y., Saito, K., Tanzawa, H., Shirasawa, H. (2008) c-Jun-mediated repression and transactivation of fibronectin. Molecular Medicine Reports, 1, 99-103.

Ishigami T, Uzawa K, Fushimi K, Saito K, Kato Y, Nakashima D, Higo M, Kouzu Y, Bukawa H, Kawata T, Ito H, Tanzawa H. Inhibition of ICAM2 induces radiosensitization in oral squamous cell carcinoma cells. British Journal of Cancer. 2008;8:1357-65.

Kono, M., Tatsumi, K., Imai, AM, Saito, K., Kuriyama, T., Shirasawa, H. Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK. (2007) Antiviral Research, 77, 150-152.

Koda M, Kamada T, Hashimoto M, Murakami M, Shirasawa H, Sakao S, Ino H, Yoshinaga K, Koshizuka S, Moriya H, Yamazaki M. (2007) Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord. Eur Spine J. 16, 2206-2214.

白澤 浩(2007)インフルエンザの特徴と予防、小学保健ニュース 2007年11月8日第830号、少年写真新聞(東京).

白澤 浩(2007) HPVの生物学.ヒト乳頭腫ウイルス(HPV)と子宮頸癌:総説、臨床検査 51(8) 別冊、医学書院(東京).

Tomita, Y., Literak, I., Ogawa, T., Jin, Z., Shirasawa, H. (2007) Complete genomes and phylogenetic positions of bovine papillomavirus type 8 and a variant type from a European bison. Virus Genes 35, 243-249.

Ogawa T, Tomita Y, Okada M, Shirasawa H. (2007) Complete genome and phylogenetic position of bovine papillomavirus type 7. J Gen Virol. 88, 1934-1938.

Watanabe TS, Ohtori S, Koda M, Aoki Y, Doya H, Shirasawa H, Yamazaki M, Moriya H, Takahashi K, Yamashita T. (2006) Adenoviral gene transfer in the peripheral nervous system. J Orthop Sci. 11, 64-69.

Tomita, Y., Ogawa, T., Jin, Z., Shirasawa, H. (2006) Genus Specific Features of Bovine Papillomavirus E6, E7, E5 and E8 Proteins. Virus Research 24, 231-236.

Literak, I., Tomita, Y., Ogawa, T., Sirasawa, H., Smid, B., Novotny, L., Adamec, M., (2006) Papillomatosis in a European bison. J Wild Dis. 42, 149-53.

Unno, Y., Shino, Y., Kondo, F., Igarashi, N., Wang, G., Shimura, R., Yamaguchi, T., Asano, T., Saisho, H., Sekiya, S., Shirasawa, H. (2005) Oncolytic viral therapy for cervical and Ovarian cells by sindbis virus AR339 strain. Clin Cancer Res 11, 4553-4560

Terui, E., Matsunaga, T., Yoshida, H., Kouchi, K., Kuroda, H., Hishiki, T., Saito, T., Yamada, S., Shirasawa, H., Ohnuma, N. (2005) Shc family expression in neuroblastoma: High expression of shcC is associated with a poor prognosis in advanced neuroblastoma. Clin Cancer Res 11, 3280-3287

Kumahara, K., Nagata, H., Watanabe, K., Shimizu, N., Arimoto, Y., Isoyama, K., Okamoto, Y., and Shirasawa, H. (2005) Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in murine nasal mucosa. Acta Oto-laryngologica 125, 1301-1306.

白澤 浩 (2005) ウイルス検出法とその意義 「そこが知りたい小児臨床検査のポイント」  小児内科, 37増刊号, 571-575.

白澤 浩 (2005) 人類の脅威となりうる非(低)病原性ウイルスのサーベイランス. 千葉医学, 81, 301-304.

Isoyama, K., Nagata, H., Shino, Y., Isegawa, N., Arimoto, Y., Kumahara, K., Koda, M., Okamoto, Y., Shirasawa, H. (2004) Effects of adenoviral vecto-mediated BDNF expression on the bulbectomy-induced apoptosis of olfactory receptor neurons. Molecular Brain Reserch 129, 88-95.

Ogawa, T., Tomita, Y., Okada, M., Shinozaki, K., Kuboyama, H., Kaiho, I., Shirasawa, H. (2004) Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin. Journal of General Virology 85, 2191-2197. 

Koda, M., Hashimoto, M., Murakami, M., Yoshinaga, K., Ikeda, O., Yamazaki, M., Koshizuka, S., Kamada, T., Moriya, H., Shirasawa, H., Sakao, S., Ino H. (2004) Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. J Neurotrauma. 21, 329-337.

Saito, T., Shinozaki, K., Matsunaga, T., Ogawa, T., Etoh, T., Muramatsu, T., Kawamura, K., Yoshida, H., Ohnuma, N., and Shirasawa, H. (2004) Lack of evidence for reovirus infection in tissues from patients with biliary atresia and congenital dilatation of the bile duct. Journal of Hepatology 40, 203-211.

Kanda T, Yokosuka O, Imazeki F, Tanaka M, Shino Y, Shimada H, Tomonaga T, Nomura F, Nagao K, Ochiai T, Saisho H. (2004) Inhibition of subgenomic hepatitis C virus RNA in Huh-7 cells: ribavirin induces mutagenesis in HCV RNA. J Virol Hepat 11, 479-487.

Ilić D, Kovacic B, Johkura K, Schlaepfer DD, Tomasević N, Han Q, Kim JB, Howerton K, Baumbusch C, Ogiwara N, Streblow DN, Nelson JA, Dazin P, Shino Y, Sasaki K, Damsky CH. (2004) FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci 117, 177-187.

白澤 浩 (2004) SARSウイルスはどこから来たのか. 千葉医学,80,21-25.

Chigira, S., Sugita, K., Kita, K., Sugaya, S., Arase, Y., Ichinose, M., Shirasawa, H., Suzuki, N. (2003) Increased expression of the Huntingtin interacting protein-1 gene in cells from Hutchinson Gilford Syndrome (Progeria) patients and aged donors. J Gerontol A Biol A Sci Med Sci. 58, B873-878.

Asano, K., Sameshima, T., Shirasawa, H., Hisamitsu, T. (2003) Attenuating effect of mexiletine hydrochloride on herpetic pair in mice infected with herpes simplex virus. J Pharm Pharmacol 55, 1365-1370.

Okamoto, H., Shino, Y., Hashimoto, K., Kumakiri, C., Shimizu, E., Shirasawa, H., M. Iyo. (2003) Dynamic changes in AP-1 transcription factor DNA binding activity in rat brain following administration of antidepressant amitriptyline and brain-derived neurotrophic factor. Neuropharmacology 45, 251-259.

Sakao S, Tatsumi K, Hashimoto T, Igari H, Shino Y, Shirasawa H, Kuriyama T. Vascular endothelial growth factor and the risk of smoking-related COPD. (2003) Chest. 124, 323-327.

Okutomi, Y., Shino, Y., Komoda, F., Hirano, T., Ishihara, T., Yamaguchi, T., Saisho, H., Shirasawa, H. (2003) Survival regulation in pancreatic cancer cells by c-Jun. Int J Clin Oncol 23, 1127-1134.

Okamoto H, Shino Y, Hashimoto K, Kumakiri C, Shimizu E, Shirasawa H, Iyo M. Dynamic changes in AP-1 transcription factor DNA binding activity in rat brain following administration of antidepressant amitriptyline and brain-derived neurotrophic factor. Neuropharmacology. 2003 45, 251-259.

Sakao, S., Takiguchi, Y., Nemoto, K., Tatsumi, K., Tanabe, N., Kurosu, K., Ooiwa, T., Shirasawa, H., Kuriyama, T. (2002) Thermoradiotherapy for local control of chest wall invasion in patients with advanced non-small cell lung cancer. Int J Clin Oncol 7, 343-348.

Arimoto, Y., Nagata, H., Isegawa, N., Kumahara, K., Isoyama, K., Konno, A., Shirasawa, H. (2002) In vivoexpression of adenovirusmediated lacZ gene in murine nasal mucosa. Acta Otolaryngol 122, 627-633.

Arase, Y., Sugita, K., Hiwasa, T., Shirasawa, H., Agematsu, K., Ito, H., Suzuki, N. (2002) Effects of increased telomerase activity on radiosensitive human SCID cells. International Congress Series 1236, 335-339.

Sakao, S., Hashimoto, T., Shino, Y., Saito, T., Kado, S., Sashiyama, H., Tatsumi, K., Kuriyama, T., and Shirasawa, H. (2002) Expression of the potential novel gene E6DG1 downregulated by the E6 protein of human papillomavirus type 16 is correlated with anchorage-independent growth. Int. J. Oncol. 21, 237-279.

Komoda, F., Shino, Y., Hirano, T., Okutomi, Y., Okamoto, H., Hayashi, Y., Suyama, T., Ebara, M., Saisho, H., and Shirasawa, H. (2002) MEKK1 induces c-Jun complexes that act as negative regulators for cell survival and proliferation of HCC cells. Int. J. Oncol. 21, 553-559.

Kawamata, Y., Mitsuhashi, A., Unno, Y., Kado, S., Shino, Y., Usugi, K., Eguchi, O., Ishii, J., Seki, K., Sekiya, S., and Shirasawa, H. (2002) HPV 16-E6-mediated degradation of intrinsic p53 is compensated by upregulation of p53 gene expression in normal cervical keratinocytes. Int. J. Oncol. 21, 561-567.

Hirano, T., Shino, Y., Saito, T., Komoda, F., Okutomi, Y., Takeda, A., Ishihara, T., Yamaguchi, T., Saisho, H., and Shirasawa, H. (2002) Dominant negative MEKK1 inhibits survival of pancreatic cancer cells. Oncogene 21, 5923-5928.

Sakao, S., Tatsumi, K., Igari, H., Watanabe, R., Shino, Y., Shirasawa, H., and Kuriyama, T. (2002) Association of tumor necrosis factor- gene promoter polymorphism with low attenuation areas on high-resolution CT in patients with COPD. Chest 122, 416-420.

浅野和仁、鮫島達夫、白澤 浩、江口一之、江黒 剛、久光 正 (2002) 帯状疱疹痛モデルマウスにおける塩酸メキシレチンの疼痛抑制作用. ペインクリニック 9、1259-1264.

白澤 浩 (2002) 私はなぜ現在の科目を選んだか-微生物学. 月間Junior 416、36.

Sashiyama, H., Shino, Y., Sakao, S., Shimada, H., Kobayashi, S., Ochiai, T., and Shirasawa, H. (2001) Alteration of integrin expression relates to malignant progression of human papillomavirus-immortalized esophageal kerationocytes. Cancer Letters, 1777, 21-28.

Sashiyama, H., Shino, Y., Kawamata, Y., Tomita, Y., Ogawa, N., Shimada, H., Kobayashi, S., Asano, T., Ochiai, T., and Shirasawa, H. (2001) Immortalization of human esophageal kerationocytes by E6 and E7 of human papillomavirus type 16. Int. J. Oncol. 19, 97-103.

Kado, S., Kawamata, Y., Shino, Y., Kasai, T., Kubota, K., Iwasaki, H., Fukazawa, I., Takano, H., Nunoyama, T., Mitsuhashi, A., Sekiya, S., and Shirasawa, H. (2001) Detection of human papillomaviruses in cervical neoplasias using multiple sets of generic polymerase chain reaction primers. Gynecologic Oncology 81, 47-52.

Sakao, S., Tatsumi, K., Igari, H., Shino, Y., Shirasawa, H., Kuriyama, T., and the Association of non-univsersity-affiliated pulmonary specialist physicians of Chiba University School of Medicine. (2001) Association of tumor necrosis factor gene promoter polymorphism with the presence of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163, 420-422.

Matsunaga, T., Shirasawa, H., Hishiki, T., Yoshida, H., Kouch, K., Ohtsuka, Y., Kawamura, K., Etoh, T., and Ohnuma, N. (2000) Enhanced Expression of N-myc Messenger RNA in Neuroblastomas Found by Mass Screening. Clinical Cancer Research 6, 3199-3204.

Yamazawa, K., Matsui, H., Seki, K., Mitsuhashi, A., Kawamata, Y., Shirasawa, H., and Sekiya, S. (2000) Human papillomavirus-positive well-defferentiated villoglandular adenocarcinoma of the uterine cervix: A case report and review of the literature. Gynecol Oncol 77, 473-477.

Hiroshima, K., Toyozaki, T., Iyoda, A., Ohwada, H., Kado, S., Shirasawa, H., Fujisawa, T. (1999) Ultrastructural study of intranuclear inclusion bodies of pulmonary adenocarcinoma. Ultrastructural Pathology 23, 383-389.

Kobayashi, S., Shirasawa, H., Sashiyama, H., Kawahira, H., Kaneko, K., Asano T., and Ochiai, T. (1999) p16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation. Clinical Cancer Research 5, 4182-4185.

Kumakiri, C., Kodama, K., Shimizu, E., Yamanouchi, N., Okada, S., Noda, S., Okamoto, H., Sato, T., and Shirasawa, H. (1999) Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neuroscience Letters 263, 205-207.

清水栄司、児玉和宏、佐藤甫夫、白澤 浩(1999) フェンシクリジン投与後のラット大脳皮質におけるグルタミン酸デヒドロゲナーゼmRNA発現の時間的変化. 脳と精神の医学 10、185-189.

Murata, M., Tagawa, M., Kimura, H., Kakisawa, K., Shirasawa, H., and Fujisawa, T. (1998) Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients. Int. J. Oncol. 12, 577-581.

Matsunaga, T., Shirasawa, H., Enomoto, H., Yoshida, H., Iwai, J., Tanabe, M., Kawamura, K., Etoh, T., and Ohnuma, N. (1998) Neuronal src and trk A protooncogene expression in neuroblastomas and patient prognosis. Int. J. Cancer 79, 226-231.

Mitsuhashi, A., Tanaka, H., Tanaka, N., Sugita, M., Shirasawa, H., Tokita, H., Eda, H., Sekiya, S. (1998) Establishment and characterization of a new HPV-negative squamous cell carcinoma cell line (Yumoto) from the human uterine cervix. Gynecologic Oncology 70, 339- 347.

Teifke, J.P., Lohr CV., and Shirasawa, H. (1998) Detection of canine oral papillomavirus-DNA in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and non-radioactive in situ hybridization. Veterinary Microbiology 60, 119-130.

Tomita, Y., Asano, Y., and Shirasawa, H. (1998) Trans-activating activity of the E6 proteins of the human papillomavirus (HPV) type-11 and -16 on the pE1^E4 promoter of HPV-11 in C33A cells. Int. J. Oncol. 13, 1253-1258.

Matsunaga, T., Shirasawa, H., Hishiki, T., Enomoto, H., Kouchi, K., Ohtsuka, Y., Iwai, J., Yoshida, H., Tanabe, M., Kobayashi, S., Asano, T., Etoh, T., Nishi, Y., and Ohnuma, N. (1998) Expression of MRP and cMOAT in childhood neuroblastomas and malignant liver tumors and its relevance to clinical behavior. Jpn. J. Cancer Res. 89, 1276-1283.

白澤 浩 (1998) パピローマウルス. ウイルス, 48, 27-37.

Shimizu, E., Shirasawa, H., Kodama, K., Kuroyanagi, H., Shirasawa, T., Sato, T. and Simizu, B. (1997) Glutamate dehydrogenase mRNA is immediately induced after phencyclidine treatment in the rat brain. Schizophr. Res. 25, 251-258.

Shino, Y., Shirasawa, H., Kinoshita, T., and Simizu, B. (1997) Human papillomavirus type 16 E6 protein transcriptionally modulates fibronectin gene expression by induction of protein complexes binding to the cAMP response element. J. Virol. 71, 4310-4318. 1997

Shiga, T., Shirasawa, H., Shimizu, K., Dezawa, M., Masuda, Y., and Simizu, B. (1997) Normal human fibroblasts can be immortalized by introduction of human papillomavirus type 16 (HPV-16) E6-E7 genes. Microbiology and Immunology, 41, 313-319.

Kinoshita, T., Shirasawa, H., Shino, Y., Moriya, H., Desbarats, L., Eilers, M., and Simizu, B. (1997) Transactivation of prothymosin-α and c-myc promoters by human papillomavirus type 16 E6 protein. Virology, 232, 53-61.

白澤 浩、清水文七、第26章 ヒトパピローマウイルス 「がん遺伝子研究の展望II」 野田 亮 編、東京化学同人、東京、1997。

白澤 浩 (1997) 腫瘍ウイルスの戦略 -発癌パラダイムの変遷-. 千葉医学, 73, 259-262.

白澤 浩 (1997) HPVと子宮頚癌. 産科と婦人科, 41, 1677-1682.

清水英司、児玉和宏、佐藤甫夫(1997)フェンシクリジン投与後のラット大脳皮質におけるグルタミン酸デヒドロキナーゼ. 脳と精神の医学 10, 185-189.

白澤 浩、HPVの基礎と癌化の機構、産婦人科の実際、45, 263-268, (1996).

Kinoshita, T., Shirasawa, H., Shino, Y., Shimizu, K., Moriya, H., and Simizu, B. (1996) Human papillomavirus type 16 E6 protein up-regulates the expression of the high mobility group protein HMG-I(Y) gene in mouse 10T1/2 cells. Virus Research, 42, 119-125.

Akutsu, N., Shirasawa, H., Asano, T., Isono, K., and B. Simizu. (1996) p53-dependent and -independent trans-activation by the E6 protein of human papillomavirus type 16. J. Gen. Virology, 77, 459-463.

Shimizu, E., Shirasawa, H., Kodama, K., Sato, T., and B. Simizu. (1996) Expression, regulation and polymorphism of the mxi1 genes. Gene, 176, 45-48.

Shinozaki, K., Yamanaka, T., Tokieda, M., Shirasawa, H., and Simizu, B. Isolation and serial propagation of human group C rotaviruses in a cell line (CaCo?-2). J. Med. Virol., 48, 48-52, (1996).

Takano, H., Harigaya, K., Ishii, G., Sugaya, Y., Soeta, S., Nunoyama, T., Shirasawa, H., Shimizu, K., Tokita, H., Simizu, B., Mikata, A., and Sekiya, S. Interleukin-6 (IL-6) production in carcinoma of the cervix. Arch Gynecol Obstet 258:25-33 (1996).

Shimizu, E., Shirasawa, H., Kodama, K., Koseki, K., Sato, T., and Simizu, B. Cloning and sequencing of the murine Mxi1 cDNA. Gene 152, 283-284, (1995).

Akutsu, N., Shirasawa, H., Nakano, K., Tanzawa, H., Asano, T., Kobayashi, S., Isono, K., and Simizu, B. Rare association of human papillomavirus DNA with esophageal cancer in Japan. J. Infect. Dis. 171, 425-428, (1995).

Isegawa, N., Ohta, M., Shirasawa, H., Tokita, H., Yamaura, A., and Simizu, B. Nucleotide sequence of a canine oral papillomavirus containing a long noncoding region. Int. J. Oncology, 7, 155-159, (1995).

Yamanaka, T., Shirasawa, H., and Yoshizawa, S. Isolation of influenza A and B viruses in HeLa? cells. Microbiol. Immunol. 39, 361-363, (1995).

Shirasawa, H., Kinoshita, T., Shino, Y., Mori, K., Shimizu, K., and Simizu, B. Cloning and sequencing of the murine farnesyltransferase (-encoding cDNA from a cell line which expresses the human papillomavirus type-16 E6 gene. Gene, 164, 373-374, (1995).

Suzuki, T., Tomita, Y., Nakano, K., Shirasawa, H., and Simizu, B. Deletion in the L1 open reading frame of human papillomavirus type 6a genomes associated with recurrent laryngeal papilloma. J. Med. Virol., 47, 191-197, (1995).

白澤 浩、清水文七、ウイルスによる腫瘍化機構、「微生物学・免疫学」緒方幸雄、内山竹彦、伊藤正彦編、医学教育出版社, 1995.

白澤 浩、ポックスウイルス、「微生物学・免疫学」緒方幸雄、内山竹彦、伊藤正彦編、医学教育出版社, 1995.

白澤 浩、アデノウイルス、「微生物学・免疫学」緒方幸雄、内山竹彦、伊藤正彦編、医学教育出版社, 1995.

白澤 浩、パポバウイルス、「微生物学・免疫学」緒方幸雄、内山竹彦、伊藤正彦編、医学教育出版社, 1995.

白澤 浩、清水文七、ウイルス検査法 - パピローマウイルス, 臨床とウイルス、23、355-361, (1995).

白澤 浩、関谷宗英、子宮頚癌とヒトパピローマウイルス、産婦人科治療、70, 394-398, (1995).

計良恵治、岩崎秀昭、清水久美子、田口明美、石川 明、白澤 浩、清水文七、子宮頚部におけるHuman papillomavirus 58型感染症例の臨床経過、産婦人科の実際、43、73-80、1994.

Shimizu, K., Shirasawa, H., Jin, M., Inaba, N., Sekiya, S. and Simizu, B. Alternative splicing of human papillomavirus type-16 E6-mRNA in mouse and monkey cell lines. Int. J. Oncology, 4, 971-976, (1994).

Suzuki, H., Sato, N., Kodama, T., Okano, T., Isaka, S., Shirasawa, H., Simizu, B., and Shimazaki, J. Detection of human papillomavirus DNA and state of p53 gene in Japanese penile cancer. Jpn. J. Clin. Oncol. 24, 1-6, (1994).

Shirasawa, H., Jin, M., Shimizu, K., Akutsu, N., Shino, Y., and Simizu, B. Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16. Virology 203, 36-42, (1994).

Matsunaga, T., Shirasawa, H., Tanabe, M., Ohnuma, N., Kawamura, K., Etoh, T., Takahashi, H., and Simizu, B. Expression of neuronal src mRNA as a favorable marker and inverse correlation to N-myc gene amplification in human neuroblastomas. Int. J. Cancer 58, 793-798, (1994).

Isegawa, N., Nakano, K., Ohta, M., Shirasawa, H., Tokita, H., and Simizu, B. Cloning and sequencing of the L1 gene of canine oral papillomavirus. Gene 146, 261-265, (1994).

Tadashi Matsunaga, Hiroshi Shirasawa, Masahiro Tanabe, Naomi Ohnuma, Hideyo Takahashi, and Bunsiti Simizu, Expression of Alternatively spliced src messenger RNAs related to neuronal differentiation in human neuroblastomas, Cancer Research 53, 3179-3185, 1993.

清水文七、白澤 浩、圷 尚武、仲野公一、布山隆史、食道癌とパピローマウイルス、21世紀を目指し羽ばたく消化器病学、原田 尚編、日本医学館、1993.

Matsunaga, T., Takahashi, H., Ohnuma, N., Tanabe, M., Yoshida, H., Enomoto, H., Horie, H. Shirasawa, H., and Simizu, B: Paratesticular neuroblastoma with N-myc activation. J. Ped. Surg. 28, 1612-1614, 1993.

Shirasawa, H., Typing of human papillomavirus, Japanese Archives of Sexually Transmitted Diseases, 2, 63-67, 1992.

岩崎秀昭、稲葉憲之、深沢一雄、白澤 浩、布山隆、武田 敏、高見澤裕吉、計良恵治、河西十九三、久保田浩一: HPV感染例のprospectiveな検索 - Vira TypeTMを用いて. 医学と薬学、27, 55-60, 1992.

S. Sekiya, T. Nunoyama, H. Shirasawa, H. Kimura, M. Kawata, N. Iijima, Y. Sugimoto, T. Tsuruo, and H. Takamizawa, Expression of a human multidrug resistance gene in human ovarian carcinoma cell lines, Arch Gynecol Obstet, 251, 79-86, 1992.

堀内文男、大木昌二、武田 敏、米満 博、計良恵治、白澤 浩、冨田善身、清水文七、岩崎秀昭、高見澤裕吉:子宮頚部病変におけるHPV-DNAの局在と組織学的所見、日本臨床細胞学会、31、444-449、1992.

Yuzo Furuya, Hiroshi Shirasawa, Naohide Sato, Yoshio Watabe, Bunsiti Simizu and Jun Shimazaki, Loss of androgen dependency with preservation of functional androgen receptors in androgen-dependent mouse tumor (Shionogi carcinoma 115), The Journal of Steroid Biochemistry and Molecular Biology, 42, 569-574, 1992.

計良恵治、岩崎秀昭、深沢一雄、高見澤裕吉、白澤 浩、清水文七:子宮頚部組織におけるIn situ hybridization法によるHuman papillomavirus DNA 検出例のProspective, Retrospectiveな検索、産婦人科の世界、41, 839-847, 1992.

Hideaki Iwasaki, Ichio Fukazawa, Takafumi Nunoyama, Noriyuki Inabaa, Souei Sekiya, Hiroyoshi Takamizawa, Keiji Kera, Hiroshi Shirasawa, Detection, typing and localization of human papillomavirus by in situ hybridization, J. Clin. Electron Microscopy 25, 5-6, 1992.

Takafumi Nunoyama, Souei Sekiya, Hiroshi Shirasawa and Hiroyoshi Takamizawa : Transforming activity of human papillomavirus 16 DNA. Acta Obst Gynaec Jpn, 43, 38-44, 1991.

Yoshimi Tomita, Akira Fuse, Hiromasa Sekine, Hiroshi Shirasawa, Bunsiti Simizu, Masanobu Sugimoto, and Shinichi Funahashi. Human papillomavirus type 6 and 11 E4 gene products in condyloma acuminata. J. gen. Virol., 72, 731-734, 1991.

Haruhito Tsuchiya, Yoshimi Tomita, Hiroshi Shirasawa, Hideki Tanzawa, Kenichi Sato, and Bunsiti Simizu. Detection of human papillomavirus in head and neck tumors using DNA-hybridization and immunohistochemical analysis. Oral surgery Oral medicine Oral pathology, 71, 721-725, 1991.

Tadashi Matsunaga, Hideyo Takahashi, Naomi Ohnuma, Masahiro Tanabe, Hideo Yoshida, Jun Iwai, Hiroshi Shirasawa, and Bunsiti Simizu. Expression of N-myc and c-src proto-oncogenes correlating to the undifferentiated phenotype and prognosis of primary neuroblastomas. Cancer Research, 51, 3148-3152, 1991.

白澤 浩. ヒトパピローマウイルス同定とその意義. Oncology & Chemotherapy, 7, 9-15, 1991.

Hiroshi Shirasawa, Hideki Tanzawa, Tadashi Matsunaga, and Bunsiti Simizu. Quantitative detection of spliced E6-E7 transcripts of human papillomavirus type 16 in cervical premalignant lesions. Virology, 184, 795-798, 1991.

高見澤 裕吉、稲葉憲之、白澤 浩.  DNA診断の現状と今後の展望. 産婦人科の実際、40、583-586,1991.

岩崎秀昭、稲葉憲之、深沢一雄、布山隆史、武田 敏、高見澤裕吉、白澤 浩、計良恵治. ViraPapTM, ViraTypeTM法によるヒトパピローマウイルス診断. 産婦人科の実際、40、633-640, 1991.

計良恵治、岩崎秀昭、武田 敏、稲葉憲之、高見澤裕吉、白澤 浩、冨田善身、清水文七、堀内文男、藤田秀雄. In situハイブリダイゼーション法による泌尿生殖器尖圭コンジローマ組織中のHuman Papillomavirus DNAの検出と局在、臨床とウイルス19、264-272, 1991.

計良恵治、岩崎秀昭、武田 敏、高見澤裕吉、堀内文男、田口明美、石川 明、白澤 浩、清水文七: 子宮頚部生検組織における in situ hybridization法によるヒトパピローマウイルスDNAの検出と型同定: Southern blot hybridization法との比較. 日本臨床細胞学会誌 30、1055-1062、1991.

角田治美、白澤 浩、岩崎秀昭、深沢一雄、久保田浩一、河西十九三、稲葉憲之、高見澤裕吉、清水文七: 子宮頚部前癌病変におけるヒトパピローマウイルスのlow stringent hybridizationによる検索。医学のあゆみ、152、119-120, 1990.

Hideki Tanzawa, Hiroshi Shirasawa, Kenichi Sato, and Bunsiti Simizu : Transformation of mouse C3H/10T1/2 cells induced by human papillomavirus type 16 DNA. Chiba Medical Journal, 66, 327-333, 1990.

白澤 浩、岩崎秀昭、高見澤裕吉 : HPVの発癌因子としての可能性。日本婦人科病理コルポスコピー学会誌、7, 56-67, 1989.

岩崎秀昭、白澤 浩、深沢一雄、稲葉憲之、武田 敏、高見澤裕吉、河西十九三、久保田浩一: 内膜の前癌病変の診断。癌と化学療法、16, 1605-1611, 1989.

Hiroshi Shirasawa, Yoshimi Tomita, Akira Fuse, Tomoko Yamamoto, Hideki Tanzawa, Souei Sekiya, Hiroyoshi Takamizawa, Bunsiti Simizu. Structure and expression of an integrated human papillomavirus type 16 genome amplified in a cervical carcinoma cell line. J. gen. Virol, Vol. 70, 1913-1919, 1989.

斎藤 督、堤 正好、西郷貴史、引地一昌、塚田 裕、高橋正宣、中村春次、宇津野博、石 和久、白澤 浩、清水文七: ViraPapTMを用いたヒトパピローマウイルス(HPV)の検出について。臨床とウイルス、17、169-172, 1989.

白澤 浩、関根大正、清水文七: ヒトパピローマウイルス, 82-92, 1989.先端技術を用いたSTDの臨床検査、高橋正宣、武田 敏編、文光堂。

Hiroshi Shirasawa, Yoshimi Tomita, Koichi Kubota, Tokuzo Kasai, Souei Sekiya, Hiroyoshi Takamizawa, and Bunsiti Simizu. Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas. Journal of Virology,62, 1022-1027, 1988.

岩崎秀昭、 稲葉憲之、白澤 浩、深沢一雄、武田 敏、高見澤裕吉、清水文七、河西十九三、久保田浩一、守谷和人、計良恵治、石川明 : Human Papilloma Virus に対する新しい簡易検出法の基礎的、臨床的検討。産婦人科の世界、40, 841-846, 1988.

Shirasawa,H., Tomita,Y., Sekiya, S., Takamizawa, H., and Simizu, B., Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas, J. gen. Virol. 68, 583-591, 1987.

白澤 浩、関谷宗英:ヒトパピローマウイルスと子宮頚癌 - 分子生物学によるアプローチ。千葉医学, 63, 239-245, 1987.

Tomita,Y., Shirasawa,H., Sekine,H. and Simizu,B., Department of Microbiology, School of Medicine, Chiba University, Expression of the human papillomavirus type 6b L2 open reading frame in Escherichia coli: L2-β-galactosidase fusion proteins and their antigenic properties, Virology, 158, 8-14, 1987.

Tomita,Y., Shirasawa,H. and Simizu,B., Department of Microbiology, School of Medicine, Chiba University, Expression of human papillomavirus type 6b and 16 L1-open reading frames in Escherichia coli: detection of a 56K-dalton polypeptide containing genus-specific antigens, J. Virol., 61, 2389-2394, 1987.

Shirasawa, H., Tomita,Y., Kubota,K., Kasai,T., Sekiya,S., Takamizawa, H., and Simizu. B. Detection of human papillomavirus type 16 DNA and evidence for integration into the cell DNA in cervical dysplasia, J. gen. Virol. 67, 2011-2015,1986.

関谷宗英、白澤 浩、久保田浩一、河西十九三、武田 敏、高見澤裕吉: 子宮頚癌とヒトパピローマウイルス。産婦人科の世界、38, 759-767, 1986。

白澤 浩、福田耕一、増淵一正、金田浩一: 血中TA-4の臨床的意義。産婦人科の世界、36、 479-482, 1984。

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