Research area

Immunology and Parasitology

Description of your research and your dream!

In recent years, more than one-third of the population in developed countries including Japan suffers from some type of allergic disease. However, the establishment of radical treatment for them remains out of reach. Therefore, symptomatic treatment, which only alleviates symptoms, is used for most allergic diseases. In my research on immune memory T cells which reportedly are related to allergic diseases, I would like to reveal the onset mechanism of allergic diseases. I hope my research will further the establishment of new treatments and drug development.

Education

2000-2004

School of Pharmacy and Pharmaceutical Science, Hoshi Unviersity

2004-2006

Master Course, Department of Bio-Environmental Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

2006-2009

Doctoral Course, Department of Bio-Environmental Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

Experience

2008-2010

Research Fellow of the Japan Society for the Promotion (DC2) (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

2010-2013

Research Fellow of the Japan Society for the Promotion (PD) (Department of International Environmental Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

2013

Project Researcher, Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

2014-2016

Project Assistant Professor, Department of Immunology, Graduate School of Medicine, Chiba University

2016-present

Project Associate Professor, Department of Advanced Allergology of the Airway, Graduate School of Medicine, Chiba University

Selected Publications

1. Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110: 913-920 (2007).
2. Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada T.: Nonredundant roles of basophils in immunity. Annual Review of Immunology 29:45-69 (2010).
3. Obata-Ninomiya, K., Ishiwata, K., Tsutsui, H., Nei, Y., Yoshikawa, S., Kawano, Y., Minegishi, Y., Ohta, N., Watanabe, N., Kanuka, H., and Karasuyama, H.: The skin is an important bulwark of acquired immunity against intestinal helminthes. J. Exp. Med. 210(12): 2583-95 (2013).
4. Obata-Ninomiya, K., Nei, Y., Tsutsui, H., Ishiwata, K., Miyasaka, M., Matsumoto, K., Nakae, S., Kanuka, H., Inase, N., and Karasuyama, H.: GATA-1 regulates the generation and function of basophils. Proc. Natl. Acad. Sci. USA. 110(46):18620-5 (2013). (O.-N. K. and N.Y. contributed equally to this study)
5. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).

Award

2009

The 3rd Best Presentation Award, Japanese Society of Parasitology

2014

Young Scientist Award, Japanese Society of Parasitology

Society Membership

Japanese Society of Allergology,
Japanese Society for Immunology,
Japanese Society of Parasitology