Estimating Gastric Cancer Risk Using DNA Methylation and Lifestyle Data

Aberrant DNA methylation in the gastric mucosa is an important biomarker for gastric cancer. While exposure to pathogens like Helicobacter pylori can exacerbate such aberrant DNA methylation, it is unknown whether these are a direct indication of future tumor development or gastric neoplasia. Scientists from Japan and Singapore have found that integrating DNA methylation data with patients' lifestyle and clinical data improves risk stratification for predicting gastric neoplasia.

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