Member

Member

Lecturer

Yusuke endo

Research area

Identification of induction mechanism of memory Th2 cell pathogenicity and their rolls in clinical conditions

Description of your research and your dream!

The function of immune response is usually thought of as a way to protect your body from viruses and pathogens. Memory CD4 T cells serve as a control tower of immunological memory, which is central to biological defense. However, recent studies showed that memory CD4 T (Th) cells could be a major factor of chronic allergic diseases such as asthma, while functioning as a mainstay of immune memory. Our team named these cells as pathogenic memory Th2 cell and is working on the clarification of their mechanism.
The goal is to define the features and properties of pathogenic memory Th2 cell by analyzing them at the individual level (through mouse and human samples), the cell level, and molecular level (genes and epigenetics). The research is to determine how and what type of external signals and/or internal factors make these cells to be “pathogenic". Furthermore, we hope to discover the therapeutic applications targeting functional molecules that leads to chronicity of clinical conditions. Our team members enjoy this challenging research!
Although I originally focused on chemistry, I have a strong interest in the biological field such as metabolism and obesity. Therefore, I would like to connect this field to the field directly linked to the clinical conditions under study. I am hoping my study will contribute to our society by connecting basic research and clinical application♪

Education

2001-2005
Department of Science and Technology, Keio University
2005-2007
Master Course, Graduate School of Medicine, Chiba University
2007-2011
Doctoral Course, Life Sciences, Graduate School of Medicine and Pharmaceutical Sciences, Chiba University

Experience

2011-2012
Project Researcher, Graduate School of Medicine, Chiba University
2012-2013
Project Assistant Professor, Graduate School of Medicine, Chiba Univesity
2013-Present
Project Lecturer, Graduate School of Medicine, Chiba University

Selected Publications

  1. Endo, Y., Yokote, K., and Nakayama, T.: The obesity-related pathology and Th17 cells. Cell. Mol. Life Sci. 74:1231-1245 (2017).
  2. Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells. (*these authors contributed equally to this work) Nat. Commun. 7:13683 (2016).
  3. Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation 401-415 (2016).
  4. Endo, Y., and Nakayama, T.: Pathogenic Th2 (Tpath2) cells in airway inflammation. Oncotarget 6:32303-32304 (2015).
  5. Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12:1042-1055 (2015).
  6. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).
  7. Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35:69-78 (2014).
  8. Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745 (2011).

Award

2010
Best Poster Award, Global COE Retreat
2010
Annual Best Research Award, Global COE
2011
Dean Award, Graduate School of Medical and Pharmaceutical Science, Chiba University
2015
Featured Poster Award, The 64th Meeting of Japanese Society of Allergology
2015
Best Presentation Award, The 44th Annual Meeting of The Japanese Society for Immunology
2016
The 11th JSI Young Investigator Award

Society Membership

The Japanese Society for Immunology (JSI),

The Molecular Biology Society of Japan (MBSJ),

Japanese Society of Allergology (JSA)