Antitumor Mechanism in Tumor Immunity
Description of your research and your dream!
There are many types of cells related to tumor immunity in tumor microenvironment. These cells establish a system to eliminate cancer cells through expression of various types of genes and secretion of chemokines and cytokines. However, the details of the mechanism remain unknown. We have revealed the anti-tumor effect induced by memory Th2 cells and also that coadministration of the drug in tumor microenvironment could amplify its anti-tumor effect.
Now, we face a new question: what kind of immune system is actually working in the tumor microenvironment? In tumor microenvironment, we can find many types of cells such as CD4T cells, dendritic cells, NK cells, and eosinophils. Also, various factors responsible for immunity, including cytokines such as IL-4, or chemokine such as RANTES, are recognized playing a role. I am hoping that we can take a further step to new cancer treatment and prevention by clarifying these immune mechanisms. If you are interested, please visit us to join our quest!
- Department of Industrial Chemistry, College of Science and Technology, Nihon University
- Technical Associate, Division of Immunology, Environmental Epidemiology Center, Department of Medicine, Chiba University
- Technical Associate, Division of Molecular Immunology, Center for Neurobiology and Molecular Immunology, Department of Medicine, Chiba University
- Technical Specialist, Department of Immunology, Graduate School of Medicine, Chiba University
- Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., and Nakayama, T.: Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int. Immunol. 20:849-860 (2008).
- Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K., and Nakayama, T.: Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses. Clin. Immunol. 139:267-276 (2011).
- Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
- Yamashita, J., Iwamura, C., Ito, T., Narita, M., Hara, Y., Sasaki, T., Masuda, D., Takahashi, M., Tsuchiya, M., Hada, K., Ishikawa, M., Matsuo, T., Ohno, Y., Tanaka, H., Maruyama, H., Ogawa, Y., and Nakayama, T.: Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells. J. Immunol. 191:949-960 (2013).
- Nakamura, T., Fukiage, M., Higuchi, M., Nakaya, A., Yano, I., Miyazaki, J., Nishiyama, H., Akaza, H., Ito, T., Hosokawa, H., Nakayama, T., and Harashima, H.: Nanoparticulation of BCG-CWS for application to bladder cancer therapy. J. Control. Release 176:44-53 (2013).
Japanese Society for Immunology,
Japanese Cancer Association