I) Original paper

1. Asano, Y., Nakayama, T., Kubo, M., Nakanishi, K., Hodes, R. J., and Tada, T.: Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. I. MHC-restricted activation of B cells by an IL 2-dependent pathway. J. Immunol. 138:667-673 (1987).
2. Iwashima, M., Nakayama, T., Kubo, M., Asano, Y., and Tada, T.: Alterations in the proliferative responses of T cells from aged and chimeric mice. Int. Arch. Allergy Appl. Immunol. 83:129-137 (1987).
3. Nakayama, T., Kubo, M., Gomi, H., Asano, Y., and Tada, T.: Major histocompatibility complex-restricted augmenting T cells induced by in vitro cultivation of antigen-primed T cells. J. Immunol. 139:3935-3941 (1987).
4. Asano, Y., Nakayama, T., Kubo, M., Yagi, J., and Tada, T.: Epitopes associated with MHC restriction site of T cells. III. I-J epitope on MHC-restricted T helper cells. J. Exp. Med. 166:1613-1626 (1987).
5. Asano, Y., Nakayama, T., Kubo, M., Fujisawa, I., Karasuyama, H., Singer, A., Hodes, R. J., and Tada, T.: Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. II. T helper cell secretion of interleukin 4 selectively inhibits antigen-specific B cell activation by cognate, but not noncognate, interactions with T cells. J. Immunol. 140:419-426 (1988).
6. Nakayama, T., Kubo, R. T., Kubo, M., Fujisawa, I., Kishimoto, H., Asano, Y., and Tada, T.: Epitopes associated with major histocompatibility complex (MHC) restriction site of T cells. IV. I-J epitopes on MHC-restricted cloned T cells. Eur. J. Immunol. 18:761-765 (1988).
7. Nakayama, T., Kubo, R. T., Kishimoto, H., Asano, Y., and Tada, T.: Biochemical identification of I-J as a novel dimeric surface molecule on mouse helper and suppressor T cell clones. Int. Immunol. 1:50-58 (1989).
8. Nakayama, T., Asano, Y., and Tada, T.: I-J and mechanism of immunosuppression. Immunol. suppl. 2:16-19 (1989).
9. Furutani, M., Yanagi, Y., Fujisawa, I., Nakayama, T., Kishimoto, H., Kuida, K., Asano, Y., and Tada, T.: Post-transcriptional allelic exclusion of two functionally rearrenged T cell receptor α genes. Int. Immunol. 1:281-288 (1989).
10. Nakayama, T., Singer, A., Hsi, E. D., and Samelson, L. E.: Intrathymic signalling in immature CD4⁺CD8⁺ thymocytes results in tyrosine phosphorylation of the T-cell receptor ζ chain. Nature 341:651-654 (1989).
11. Bonifacino, J. S., McCarthy, S. A., Maguire, J. E., Nakayama, T., Singer, D. S., Klausner, R. D., and Singer, A.: Novel post-translational regulation of TCR expression in CD4⁺CD8⁺ thymocytes influenced by CD4. Nature 344:247-251 (1990).
12. Nakayama, T., June, C. H., Munitz, T. I., Sheard, M., McCarthy, S. A., Sharrow, S. O., Samelson, L. E., and Singer, A.: Inhibition of T cell receptor expression and function in immature CD4⁺8⁺ cells by CD4-mediated signals. Science 249:1558-1561 (1990).
13. Nakayama, T., Samelson, L. E., Nakayama, Y., Munitz, T. I., Sheard, M., June, C. H., and Singer, A.: Ligand-stimulated signaling events in immature CD4⁺CD8⁺ thymocytes expressing competent T-cell receptor complexes. Proc. Natl. Acad. Sci. USA 88:9949-9953 (1991).
14. Nakayama, T., Ueda, Y., Yamada, H., Shores, E. W., Singer, A., and June, C. H.: In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands. Science 257:96-99 (1992).
15. Anderson, S. J., Abraham, K. M., Nakayama, T., Singer, A., and Perlmutter, R. M.: Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56^lck. EMBO Journal 11:4877-4886 (1992).
16. Nagasawa, T., Sano, K., Ike, F., Kishimoto, H., Nakayama, T., Asano, Y., Ishikawa, I., and Tada, T.: Negative selection of thymus-dependent CD4⁺8⁺ intestinal intraepithelial lymphocytes by internal superantigens. Cell. Immunol. 147:158-166 (1993).
17. Shores, E. W., Nakayama, T., Wiest, D. L., Takahama, Y., Sharrow, S., and Singer, A.: Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCRβ transgene. J. Immunol. 150:1263-1275 (1993).
18. Yamashita, I., Nagata, T., Tada, T., and Nakayama, T.: CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 5:1139-1150 (1993).
19. Nakayama, T., Wiest, D. L., Abraham, K. M., Munitz, T. I., Perlmutter, R. M., and Singer, A.: Decreased signaling competence as a result of receptor overexpression: Overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4⁺CD8⁺ thymocytes. Proc. Natl. Acad. Sci. USA 90:10534-10538 (1993).
20. Kubo, S., Nakayama, T., Furutani-Seiki, M., Kishimoto, H., Hashimoto, K., Bae, M.-J., Yokochi, T., Takeda, N., Aizawa, S., Asano, Y., and Tada, T.: A novel form of self tolerance dictated in the thymus of transgenic mice with autoreactive T cell receptor α and β chain genes. Int. Immunol. 6:593-602 (1994).
21. Benveniste, P., Takahama, Y., Wiest, D. L., Nakayama, T., Sharrow, S. O., and Singer, A.: Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4⁺CD8⁺ thymocytes into mature T cells. Proc. Natl. Acad. Sci. USA 91:6933-6937 (1994).
22. Kearse, K. P., Roberts, J. L., Munitz, T. I., Wiest, D. L., Nakayama, T., and Singer, A.: Developmental regulation of αβ T cell antigen receptor expression results from differential stability of nascent TCRα proteins within the endoplasmic reticulum of immature and mature T cells. EMBO Journal 13:4504-4514 (1994).
23. Wang, C.-R., Hashimoto, K., Kubo, S., Yokochi, T., Kubo, M., Suzuki, M., Suzuki, K., Tada, T., and Nakayama, T.: T cell receptor-mediated signaling events in CD4⁺CD8⁺ thymocytes undergoing thymic selection: Requirement of calcineurin activation for thymic positive selection but not negative selection. J. Exp. Med. 181:927-941 (1995).
24. Kishimoto, H., Kubo, R. T., Yorifuji, H., Nakayama, T., Asano, Y., and Tada, T.: Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. J. Exp. Med. 182:1997-2006 (1995).
25. Hashimoto, K., Sohn, S. J., Levin, S. D., Tada, T., Perlmutter, R. M., and Nakayama, T.: Requirement for p56^lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. Med. 184:931-943 (1996).
26. Kubo, M., Ransom, J., Webb, D., Hashimoto, Y., Tada, T., and Nakayama, T.: T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO Journal 16:4007-4020 (1997).
27. Kubo, S., Hasegawa, A., Hashimoto, K., Shimizu, C., Kubo, M., Tada, T., and Nakayama, T.: CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRVβ11⁺ cells in the periphery. Immunology 92:437-446 (1997).
28. Hasegawa, A., Ueno, Y., Yamashita, M., Nakayama, T., and Tada, T.: Regulation of T cell autoreactivity to MHC class II by controlling CD80 (B7-1) expression on B cells. Int. Immunol. 10:147-158 (1998).
29. Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.: Requirement for p56^lck tyrosine kinase activation in T_h subset differentiation. Int. Immunol. 10:577-591 (1998).
30. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Sato, H., Kondo, E., Harada, M., Koseki, H., Nakayama, T., Tanaka, Y., and Taniguchi, M.: Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells. Proc. Natl. Acad. Sci. USA 95:5690-5693 (1998).
31. Shimizu, C., Li, X., Kimura, M., Hashimoto, K., Sugaya, K., Kubo, M., Suzuki, S., and Nakayama, T.: A novel immunosuppressant, FTY720, increases the efficiency of a superantigen-induced peripheral T-cell deletion whilst inhibitting negative selection in the thymus. Immunology 94:503-512 (1998).
32. Yamashita, M., Kimura, M., Kubo, M., Shimizu, C., Tada, T., Perlmutter, R. M., and Nakayama, T.: T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. USA 96:1024-1029 (1999).
33. Kawano, T., Tanaka, Y., Shimizu, E., Kaneko, Y., Kamata, N., Sato, H., Osada, H., Sekiya, S., Nakayama, T., and Taniguchi, M.: A novel recognition motif of human NKT antigen receptor for a glycolipid ligand. Int. Immunol. 11:881-887 (1999).
34. Sato, H., Nakayama, T., Tanaka, Y., Yamashita, M., Shibata, Y., Kondo, E., Saito, Y., and Taniguchi, M.: Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 96:7439-7444 (1999).
35. Toura, I., Kawano, T., Akutsu, Y., Nakayama, T., Ochiai, T., and Taniguchi, M.: Inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide. J. Immunol. 163:2387-2391 (1999).
36. Kubo, M., Yamashita, M., Abe, R., Tada, T., Okumura, K., Ransom, J. T., and Nakayama, T.: CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation. J. Immunol. 163:2432-2442 (1999).
37. Cui, J., Watanabe, N., Kawano, T., Yamashita, M., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M., and Nakayama, T.: Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 NKT cells. J. Exp. Med. 190:783-792 (1999).
38. Kawano, T., Nakayama, T., Kamada, N., Kaneko, Y., Harada, M., Ogura, N., Akutsu, Y., Motohashi, S., Iizasa, T., Endo, H., Fujisawa, T., Shinkai, H., and Taniguchi, M.: Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells. Cancer Res. 59:5102-5105 (1999).
39. Hammond, K. J. L., Pelikan, S. B., Crowe, N. Y., Randle-Barrett, E., Nakayama, T., Taniguchi, M., Smyth, M. J., van Driel, I. R., Scollay, R., Baxter, A. G., and Godfrey, D. I.: NKT cells are phenotypically and functionally diverse. Eur. J. Immunol. 29:3768-3781 (1999).
40. Shimamura, Y., Huang, Y.-Y., Suda, Y., Kusumoto, S., Sato, K., Grusby, M. J., Sato, H., Nakayama, T., and Taniguchi, M.: Positive selection of NKT cells by CD1⁺, CD11c⁺ non-lymphoid cells residing in the extrathymic organs. Eur. J. Immunol. 29:3962-3970 (1999).
41. Kaneko, Y., Harada, M., Kawano, T., Yamashita, M., Shibata, Y., Gejyo, F., Nakayama, T., and Taniguchi, M.: Augmentation of Vα14NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105-114 (2000).
42. Adachi, T., Wakabayashi, C., Nakayama, T., Yakura, H., and Tsubata, T.: CD72 negatively regulates signaling through the antigen receptor of B cells. J. Immunol. 164:1223-1229 (2000).
43. Ito, K., Karasawa, M., Kawano, T., Akasaka, T., Koseki, H., Akutsu, Y., Kondo, E., Sekiya, S., Sekikawa, K., Harada, M., Yamashita, M., Nakayama, T., and Taniguchi, M.: Involvement of decidual Vα14 NKT cells in abortion. Proc. Natl. Acad. Sci. USA 97:740-744 (2000).
44. Tokoyoda, K., Takemoto, Y., Nakayama, T., Arai, T., and Kubo, M.: Synergism between the calmodulin-binding and autoinhibitory domains on calcineurin is essential for the induction of their phosphatase activity. J. Biol. Chem. 275:11728-34 (2000).
45. Honma, N., Koseki, H., Akasaka, T., Nakayama, T., Taniguchi, M., Serizawa, I., Akahori, H., Osawa, M., and Mikayama, T.: Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia. Immunology 100:84-90 (2000).
46. Kimura, M., Yamashita, M., Kubo, M., Iwashima, M., Shimizu, C., Tokoyoda, K., Chiba, J., Taniguchi, M., Katsumata, M., and Nakayama, T.: Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int. Immunol. 12:817-824 (2000).
47. Ikehara, Y., Yasunami, Y., Kodama, S., Maki, T., Nakano, M., Nakayama, T., Taniguchi, M., and Ikeda, S.: CD4⁺ Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J. Clin. Invest. 105:1761-1767 (2000).
48. Gonzalez-Aseguinolaza, G., de Oliveira, C., Tomaska, M., Hong, S., Bruna-Romero, O., Nakayama, T., Taniguchi, M., Bendelac, A., Van Kaer, L., Koezuka, Y., and Tsuji, M.: α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. USA 97:8461-8466 (2000).
49. Yamashita, M., Katsumata, M., Iwashima, M., Kimura, M., Shimizu, C., Kamata, T., Shin, T., Seki, N., Suzuki, S., Taniguchi, M., and Nakayama, T.: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J. Exp. Med. 191:1869-1879 (2000).
50. Ishikawa, H., Hisaeda, H., Taniguchi, M., Nakayama, T., Sakai, T., Maekawa, Y., Nakano, Y., Zhang, M., Zhang, T., Nishitani, M., Takashima, M., and Himeno, K.: CD4⁺ Vα14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major. Int. Immunol. 12:1267-1274 (2000).
51. Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., and Kronenberg, M.: Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:741-754 (2000).
52. Andrews, K. J., Ribas, A., Butterfield, L. H., Vollmer, C. M., Eilber, F. C., Dissette, V. B., Nelson, S. D., Shintaku, P., Mekhoubad, S., Nakayama, T., Taniguchi, M., Glaspy, J. A., McBride, W. H., and Economou, J. S.: Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells. Cancer Res. 60:6457-6464 (2000).
53. Maki, T., Yasunami, Y., Ikehara, Y., Kodama, S., Nakano, M., Nakayama, T., Taniguchi, M., and Ikeda, S.: Prolongation of rat islet xenograft survival in the liver of IFN-γ-deficient mice. J. Surg. Res. 93:101-107 (2000).
54. Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y., and Nakayama, K.: Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. Immunity 13:561-571 (2000).
55. Kawakami, K., Kinjo, Y., Yara, S., Koguchi, Y., Uezu, K., Nakayama, T., Taniguchi, M., and Saito, A.: Activation of Vα14⁺ natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with cryptococcus neoformans. Infect. Immun. 69:213-220 (2001).
56. Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondou, E., Kaneko, Y., Okada, S., Tokuhisa, T., Yokoyama, M,, Taniguchi, M., Katsura, Y., and Nakayama, T.: Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int. Immunol. 13:105-117 (2001).
57. Shin, T., Nakayama, T., Akutsu, Y., Motohashi, S., Shibata, Y., Harada, M., Kamada, N., Shimizu, C., Shimizu, E., Saito, T., Ochiai, T., and Taniguchi, M.: Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells. Int. J. Cancer 91:523-528 (2001).
58. Seino, K., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H., and Okumura, K.: Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 98:2577-2581 (2001).
59. Yamasaki, M., Sasho, T., Moriya, H., Kanno, M., Harada, M., Kamada, N., Shimizu, E., Nakayama, T., and Taniguchi, M.: Extrathymic development of Vα11 T cells in placenta during pregnancy and their possible physiological role. J. Immunol. 166:7244-7249 (2001).
60. Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S., Kawano, T., Tanaka, Y., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M., and Taniguchi, M.: Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells. Int. Immunol. 13:853-861 (2001).
61. Sharif, S., Arreaza, G. A., Zucker, P., Mi, Q.-S., Sondhi, J., Naidenko, O. V., Kronenberg, M., Koezuka, Y., Delovitch, T. L., Gombert, J.-M., Leite-De-Moraes, M., Gouarin, C., Zhu, R., Hameg, A., Nakayama, T., Taniguchi, M., Lepault, F., Lehuen, A., Bach, J.-F., and Herbelin, A.: Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 7:1057-1062 (2001).
62. Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi, M., Koseki, H., and Nakayama, T.: Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 15:275-287 (2001).
63. Kawakami, K., Kinjo, Y., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Nakayama, T., Taniguchi, M., and Saito, A.: Monocyte chemoattractant protein-1-dependent increase of Vα14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. J. Immunol. 167:6525-6532 (2001).
64. Duthie, M. S., Wleklinski-Lee, M., Smith, S., Nakayama, T., Taniguchi, M., and Kahn, S. J.: During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect. Immun. 70:36-48 (2002).
65. Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H., and Ziegler, S. F.: The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168:87-94 (2002).
66. Suto, A., Nakajima, H., Ikeda, K., Kubo, S., Nakayama, T., Taniguchi, M., Saito, Y., and Iwamoto, I.: CD4⁺ CD25⁺ T-cell development is regulated by at least 2 distinct mechanisms. Blood 99:555-560 (2002).
67. Gonzalez-Aseguinolaza, G., Van Kaer, L., Bergmann, C. C., Wilson, J. M., Schmieg, J., Kronenberg, M., Nakayama, T., Taniguchi, M., Koezuka, Y., and Tsuji, M.: Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 195:617-624 (2002).
68. Akutsu, Y., Nakayama, T., Harada, M., Kawano, T., Motohashi, S., Shimizu, E., Ito, T., Kamada, N., Saito, T., Matsubara, H., Miyazawa, Y., Ochiai, T., and Taniguchi, M.: Expansion of lung Vα14 NKT cells by administration of α-galactosylceramide-pulsed dendritic cells. Jpn. J. Can. Res. 93:397-403 (2002).
69. Kawakami, K., Kinjo, Y., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Nakayama, T., Taniguchi, M., and Saito, A.: Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice. Microbiol. Immunol. 46:207-210 (2002).
70. Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C.-R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N., and Nakayama, T.: Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J. Immunol. 169:2134-2140 (2002).
71. Sfondrini, L., Besusso, D., Zoia, M. T., Rodolfo, M., Invernizzi, A. M., Taniguchi, M., Nakayama, T., Colombo, M. P., Menard, S., and Balsari, A.: Absence of the CD1 molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in mice. J. Immunol. 169:151-158 (2002).
72. Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M., and Nakayama, T.: T_h1/T_h2 cell differentiation of developing CD4 single-positive thymocytes. Int. Immunol. 14:943-951 (2002).
73. Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M., and Nakayama, T.: Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J. Biol. Chem. 277:42399-42408 (2002).
74. Motohashi, S., Kobayashi, S., Ito, T., Magara, K. K., Mikuni, O., Kamada, N., Iizasa, T., Nakayama, T., Fujisawa, T., and Taniguchi, M.: Preserved IFN-α production of circulating Vα24 NKT cells in primary lung cancer patients. Int. J. Cancer 102:159-165 (2002).
75. Asai, K., Hachimura, S., Kimura, M., Toraya, T., Yamashita, M., Nakayama, T., and Kaminogawa, S.: T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27^kip1 degradation. J. Immunol. 169:4723-4731 (2002).
76. Sugawara, I., Yamada, H., Mizuno, S., Li, C. Y., Nakayama, T., and Taniguchi, M.: Mycobacterial infection in natural killer T cell knockout mice. Tuberculosis 82:97-104 (2002).
77. Kamata, T., Yamashita, M., Kimura, M., Murata, K., Inami, M., Shimizu, C., Sugaya, K., Wang, C.-R., Taniguchi, M., and Nakayama, T.: src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J. Clin. Invest. 111:109-119 (2003).
78. Kubo, S., Nakayama, T., Matsuoka, K., Yonekawa, H., and Karasuyama, H.: Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J. Immunol. 170:775-780 (2003).
79. Kondo, E., Wakao, H., Koseki, H., Takemori, T., Kojo, S., Harada, M., Takahashi, M., Sakata, S., Shimizu, C., Ito, T., Nakayama, T., and Taniguchi, M.: Expression of recombination-activating gene in mature peripheral T cells in Peyer's Patch. Int. Immunol. 15:393-402 (2003).
80. Akbari, O., Stock, P., Meyer, E., Kronenberg, M., Sidobre, S., Nakayama, T., Taniguchi, M., Grusby, M. J., DeKruyff, R. H., and Umetsu, D. T.: Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat. Med. 9:582-588 (2003).
81. Fukuda, K., Yoshida, H., Sato, T., Furumoto, T., Mizutani-Koseki, Y., Suzuki, Y., Saito, Y., Takemori, T., Kimura, M., Sato, H., Taniguchi, M., Nishikawa, S., Nakayama, T., and Koseki, H.: Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev. Biol. 255:278-289 (2003).
82. Ashcroft, G. S., Mills, S. J., Lei, K., Gibbons, L., Jeong, M.-J., Taniguchi, M., Burow, M., Horan, M. A., Wahl, S. M., and Nakayama, T.: Estrogen modulates cutaneous wound healing by down-regulating macrophage migration inhibitory factor. J. Clin. Invest. 111:1309-1318 (2003).
83. Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M., and Nakayama, T.: T_H1-biased immunity induced by exposure to Antarctic winter. J. Allergy Clin. Immunol. 111:1353-1360 (2003).
84. Nakamura, Y., Yasunami, Y., Satoh, M., Hirakawa, E., Katsuta, H., Ono, J., Kamada, M., Todo, S., Nakayama, T., Taniguchi, M., and Ikeda, S.: Acceptance of islet allografts in the liver of mice by blockade of an inducible costimulator. Transplantation 75:1115-1118 (2003).
85. Shimonaka, M., Katagiri, K., Nakayama, T., Fujita, N., Tsuruo, T., Yoshie, O., and Kinashi, T.: Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J. Cell Biol. 161:417-427 (2003).
86. Shimizu, T., Abe, R., Nishihara, J., Shibaki, A., Watanabe, H., Nakayama, T., Taniguchi, M., Ishibashi, T., and Shimizu, H.: Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice. Eur. J. Immunol. 33:1478-1487 (2003).
87. Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hosokawa, H., Hasegawa, A., Taniguchi, M., and Nakayama, T.: CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity 19:281-294 (2003).
88. Zhang, G., Nichols, R. D., Taniguchi, M., Nakayama, T., and Parmely, M. J.: Gamma interferon production by hepatic NK T cells during Escherichia coli infection is resistant to the inhibitory effects of oxidative stress. Infect. Immun. 71:2468-2477 (2003).
89. Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., Shinkai, H., Koseki, H., Taniguchi, M., Ziegler, S. F., and Nakayama, T.: CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int. Immunol. 15:987-992 (2003).
90. Sakamoto, M., Hasegawa, A., Sugaya, K., Hashimoto, K., Kimura, M., Yamashita, M., Suzuki, K., and Nakayama, T.: Destinct calcium response induced by T-cell antigen receptor stimulation in thymocytes and mature T cells. Bioimages. 11:1-8 (2003).
91. Nishikawa, H., Kato, T., Tanida, K., Hiasa, A., Tawara, I., Ikeda, H., Ikarashi, Y., Wakasugi, H., Kronenberg, M., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L. J., and Shiku, H.: CD4⁺ CD25⁺ T cells responding to serologically defined autoantigens suppress antitumor immune responses. Proc. Natl. Acad. Sci. USA 100:10902-10906 (2003).
92. Ito, H., Ando, K., Nakayama, T., Taniguchi, M., Ezaki, T., Saito, K., Takemura, M., Sekikawa, K., Imawari, M., Seishima, M., and Moriwaki, H.: Role of Vα14 NKT cells in the development of impaired liver regeneration in vivo. Hepatology 38:1116-1124 (2003).
93. Kawakami, K., Yamamoto, N., Kinjo, Y., Miyagi, K., Nakasone, C., Uezu, K., Kinjo, T., Nakayama, T., Taniguchi, M., and Saito, A.: Critical role of Vα14⁺ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection. Eur. J. Immunol. 33:3322-3330 (2003).
94. Koike, J., Wakao, H., Ishizuka, Y., Sato, T., Hamaoki, M., Seino, K., Koseki, H., Nakayama, T., and Taniguchi, M.: Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. J. Exp. Med. 199:137-144 (2004).
95. Watanabe, H., Shimizu, T., Nishihara, J., Abe, R., Nakayama, T., Taniguchi, M., Sabe, H., Ishibashi, T., and Shimizu, H.: Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts. J. Biol. Chem. 279:1676-1683 (2004).
96. Hasegawa, A., Cheng, X., Kajino, K., Berezov, A., Murata, K., Nakayama, T., Yagita, H., Murali, R., and Greene, M. I.: Fas-disabling small exocyclic peptide mimetecs limit apoptosis by an unexpected mechanism. Proc. Natl. Acad. Sci. USA 101:6599-6604 (2004).
97. Kobayashi, S., Kaneko, Y., Seino, K., Yamada, Y., Motohashi, S., Koike, J., Sugaya, K., Kuriyama, T., Asano, S., Tsuda, T., Wakao, H., Harada, M., Kojo, S., Nakayama, T., and Taniguchi, M.: Impaired IFN-γ production of Vα24 NKT cells in non-remitting sarcoidosis. Int. Immunol. 16:215-222 (2004).
98. Harada, M., Seino, K., Wakao, H., Sakata, S., Ishizuka, Y., Ito, T., Kojo, S., Nakayama, T., and Taniguchi, M.: Down-regulation of the invariant Vα14 antigen receptor in NKT cells upon activation. Int. Immunol. 16:241-247 (2004).
99. Hiroshima, K., Iyoda, A., Shibuya, K., Haga, Y., Toyozaki, T., Iizasa, T., Nakayama, T., Fujisawa, T., and Ohwada, H.: Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. Cancer 100:1190-1198 (2004).
100. Kondo, N., Ishii, Y., Son, A., Sakakura-Nishiyama, J., Kwon, Y,-W., Tanito, M., Nishinaka, Y., Matsuo, Y., Nakayama, T., Taniguchi, M., and Yodoi, J.: Cysteine-dependent immune regulation by TRX and MIF/GIF family proteins. Immunol. Lett. 92:143-147 (2004).
101. Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., and Nakayama, T.: CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing Th2 cells. J. Biol. Chem. 279:23123-23133 (2004).
102. Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., and Nakayama, T.: Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279:26983-26990 (2004).
103. Shimizu, E., Koike, J., Wakao, H., Seino, K., Koseki, H., Kakiuchi, T., Nakayama, T., and Taniguchi, M.: Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice. Blood 104:781-783 (2004).
104. Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., and Nakayama, T.: Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279:39454-39464 (2004).
105. Nakai, Y., Iwabuchi, K., Fujii, S., Ishimori, N., Dashtsoodol, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Bezbradica, J. S., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., and Onoe, K.: Natural killer T cells accelerate atherogenesis in mice. Blood 104:2051-2059 (2004).
106. Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Maeda, M., Hamuro, J., Nakayama, T., Taniguchi, M., Yagita, H., Van Kaer, L., Onoe, K., Denhardt, D., Rittling, S., and Uede, T.: Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity 21:539-550 (2004).
107. Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M., and Nakayama, T.: STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. J. Immunol. 173:4967-4975 (2004).
108. Yamaji, H., Iizasa, T., Koh, E., Suzuki, M., Otsuji, M., Chang, H., Motohashi, S., Yokoi, S., Hiroshima, K., Tagawa, M., Nakayama, T., and Fujisawa, T.: Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer. Cancer Immunol. Immunother. 53:786-792 (2004).
109. Ichiyama, H., Onodera, S., Nishihira, J., Ishibashi, T., Nakayama, T., Minami, A., Yasuda, K., and Tohyama, H.: Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody/lipopolysaccharide (LPS)-induced arthritis in mice due to deletion of macrophage migration inhibitory factor (MIF). Cytokine 26:187-194 (2004).
110. Kimura, Y. M., Hosokawa, H., Yamashita, M., Hasegawa, A., Iwamura, C., Watarai, H., Taniguchi, M., Takagi, T., Ishii, S., and Nakayama, T.: Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J. Exp. Med. 201:397-408 (2005).
111. Ishikawa, A., Motohashi, S., Ishikawa, E., Fuchida, H., Higashino, K., Otsuji, M., Iizasa, T., Nakayama, T., Taniguchi, M., and Fujisawa, T.: A phase I study of α-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer. Clin. Can. Res. 11:1910-1917 (2005).
112. Nishikawa, H., Kato, T., Tawara, I., Takemitsu, T., Saito, K., Wang, L., Ikarashi, Y., Wakasugi, H., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L.-J., and Shiku, H.: Accelerated chemically induced tumor development mediated by CD4⁺ CD25⁺ regulatory T cells in wild-type hosts. Proc. Natl. Acad. Sci. USA 102:9253-9257 (2005).
113. Miyamoto, T., Kaneko, T., Yamashita, M., Tenda, Y., Inami, M., Suzuki, A., Ishii, S., Kimura, M., Hashimoto, K., Shimada, H., Yahata, H., Ochiai, T., Saito, I., DeGregori, J., and Nakayama, T.: Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int. Immunol. 17:759-768 (2005).
114. Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A., and Nakayama, T.: Dendritic cell maturation by CD11c- T cells and Vα24⁺ natural killer T-cell activation by α-Galactosylceramide. Int. J. Cancer 117:265-273 (2005).
115. Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., and Nakayama, T.: Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J. Biol. Chem. 280:29409-29419 (2005).
116. Kojo, S., Seino, K., Harada, M., Watarai, H., Wakao, H., Uchida, T., Nakayama, T., and Taniguchi, M.: Induction of regulatory properties in dendritic cells by Vα14 NKT cells. J. Immunol. 175:3648-3655 (2005).
117. Koda, M., Okada, S., Nakayama, T., Koshizuka, S., Kamada, T., Nishio, Y., Someya, Y., Yoshinaga, K., Okawa, A., Moriya, H., and Yamazaki, M.: Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. Neuroreport 16:1763-1767 (2005).
118. Watarai, H., Hinohara, A., Nagafune, J., Nakayama, T., Taniguchi, M., and Yamaguchi, Y.: Plasma membrane-focused proteomics: Dramatic changes in surface expression during the maturation of human dendritic cells. Proteomics 5:4001-4011 (2005).
119. Hardman, M. J., Waite, A., Zeef, L., Burow, M., Nakayama, T., and Ashcroft, G. S.: Macrophage migration inhibitory factor: a central regulator of wound healing. Am. J. Pathol. 167:1561-1574 (2005).
120. Toyofuku, A., Yasunami, Y., Nabeyama, K., Nakano, M., Satoh, M., Matsuoka, N., Ono, J., Nakayama, T., Taniguchi, M., Tanaka, M., and Ikeda, S.: Natural killer T-cells participate in rejection of islet allografts in the liver of mice. Diabetes 55:34-39 (2006).
121. Hasegawa, A., Miki, T., Hosokawa, H., Hossain, H. B., Shimizu, C., Hashimoto, K., Kimura, Y. M., Yamashita, M., and Nakayama, T.: Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J. Immunol. 176:2546-2554 (2006).
122. Nigo, I. Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103:2286-2291 (2006).
123. Meyer, E. H., Goya, S., Akbari, O., Berry, G. J., Savage, P. B., Kronenberg, M., Nakayama, T., DeKruyff, R. H., and Umetsu, D. T.: Glycolipid activation of invariant T cell receptor⁺ NKT cells is sufficient to induce airway hyperreactivity independent of conventional CD4⁺ T cells. Proc. Natl. Acad. Sci. USA 103:2782-2787 (2006).
124. Kunisaki, Y., Tanaka, Y., Sanui, T., Inayoshi, A., Noda, M., Nakayama, T., Harada, M., Taniguchi, M., Sasazuki, T., and Fukui, Y.: DOCK2 is required in T cell precursors for development of Vα14 natural killer T (NKT) cells. J. Immunol. 176:4640-4645 (2006).
125. Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y. M., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24:611-622 (2006).
126. Tenda, Y., Yamashita, M., Kimura, Y. M., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki, N., and Nakayama, T.: Hyperresponsive T_H2 cells with enhanced nuclear factor-κB activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J. Allergy Clin. Immunol. 118:725-733 (2006).
127. Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T., and Nakayama, T.: A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. Clin. Cancer Res. 12:6079-6086 (2006).
128. Shinnakasu, R., Yamashita, M., Shinoda, K., Endo, Y., Hosokawa, H., Hasegawa, A., Ikemizu, S., and Nakayama, T.: Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. J. Immunol. 177:5801-5810 (2006).
129. Kinjo, T., Nakamatsu, M., Nakasone, C., Yamamoto, N., Kinjo, Y., Miyagi, K., Uezu, K., Nakamura, K., Higa, F., Tateyama, M., Takeda, K., Nakayama, T., Taniguchi, M., Kaku, M., Fujita, J., and Kawakami, K.: NKT cells play a limited role in the neutrophilic inflammatory responses and host defense to pulmonary infection with Pseudomonas aeruginosa. Microbes Infect. 8:2679-2685 (2006).
130. Hosokawa, H., Kimura, Y. M., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., and Nakayama, T.: Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177:7656-7664 (2006).
131. Harada, M., Magara, K. K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W. C., Akira, S., Kitamura, H., Ohara, O., Seino, K., and Taniguchi, M.: IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses. J. Exp. Med. 203:2929-2937 (2006).
132. Ohkawara, T., Takeda, H., Miyashita, K., Nishiwaki, M., Nakayama, T., Taniguchi, M., Yoshiki, T., Tanaka, J., Imamura, M., Sugiyama, T., Asaka, M., and Nishihira, J.: Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor. Histochem. Cell Biol. 125:575-582 (2006).
133. Nagao. T., Matsumura, M., Mabuchi, A., Ishida-Okawara, A., Koshio, O., Nakayama, T., Minamitani, H., and Suzuki, K.: Up-regulation of adhesion molecule expression in glomerular endothelial cells by anti-myeloperoxidase antibody. Nephrol. Dial. Transplant. 22:77-87 (2007).
134. Kaneko, T., Hosokawa, H., Yamashita, M., Wang, C. R., Hasegawa, A., Kimura, Y. M., Kitajima, M., Kimura, F., Miyazaki, M., and Nakayama, T.: Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol. Immunol. 44:2249-2256 (2007).
135. Nakamatsu, M., Yamamoto, N., Hatta, M., Nakasone, C., Kinjo, T., Miyagi, K., Uezu, K., Nakamura, K., Nakayama, T., Taniguchi, M., Iwakura, Y., Kaku, M., Fujita, J., and Kawakami, K.: Role of interferon-γ in Vα14⁺ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs. Microbes Infect. 9:364-374 (2007).
136. Kimura, Y. M., Iwamura, C., Suzuki, A., Miki, T., Hasegawa, A., Sugaya, K., Yamashita, M., Ishii, S., and Nakayama, T.: Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J. Immunol. 178:4926-4936 (2007).
137. Iwamura, C., Kimura, Y. M., Shinoda, K., Endo, Y., Hasegawa, A., Yamashita, M., and Nakayama, T.: Schnurri-2 regulates T_h2-dependent airway inflammation and airway hyperresponsiveness. Int. Immunol. 19:755-762 (2007).
138. Usui, T., Yamagami, S., Kishimoto, S., Seiich, Y., Nakayama, T., and Amano, S.: Role of macrophage migration inhibitory factor in corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 48:3545-3550 (2007).
139. Masuda, K., Kakugawa, K., Nakayama, T., Minato, N., Katsura, Y., and Kawamoto, H.: T cell lineage determination precedes the initiation of TCRβ gene rearrangement. J. Immunol. 179:3699-3706 (2007).
140. Yamamoto, H., Okamoto, Y., Horiguchi, S., Kunii, N., Yonekura, S., and Nakayama, T.: Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis. Allergy 62:1451-1455 (2007).
141. Morita, M., Fujino, M., Li, X-K., Kimura, H., Nakayama, T., Taniguchi, M., and Sugioka, A.: Spontaneous tolerance involving natural killer T cells after hepatic grafting in mice. Transpl. Immunol. 18:142-145 (2007).
142. Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T., and Okamoto, Y.: Phase I study of α-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. Cancer Immunol. Immunother. 57:337-345 (2008).
143. Kitajima, M., Abe, T., Miyano, K. N., Taniguchi, M., Nakayama, T., and Takaku, H.: Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. Mol. Ther. 16:261-268 (2008).
144. Funeshima, F. N., Fujino, M., Kimura, H., Takahara, S., Nakayama, T., Ezaki, T., and Li, X.-K.: Survival of skin allografts is prolonged in mice with a dominant-negative H-Ras. Transpl. Immunol. 18:302-306 (2008).
145. Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205:1109-1120 (2008).
146. Hoshino, A., Nagao, T., Nagi, M. N., Ohno, N., Yasuhara, M., Yamamoto, K., Nakayama, T., and Suzuki, K.: MPO-ANCA induces IL-17 production by activated neutrophils in vitro via classical complement pathway-dependent manner. J. Autoimmun. 31:79-89 (2008).
147. Ito, H., Ando, K., Ishikawa, T., Nakayama, T., Taniguchi, M., Saito, K., Imawari, M., Moriwaki, H., Yokochi, T., Kakumu, S., and Seishima, M.: Role of Vα14⁺ NKT cells in the development of hepatitis B virus specific CTL: Activation of Vα14⁺ NKT cells promote the breakage of CTL tolerance. Int. Immunol. 20:869-870 (2008).
148. Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., and Nakayama, T.: Human T_h1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. Int. Immunol. 20:849-860 (2008).
149. Suto, A., Kashiwakuma, D., Kagami, S., Hirose, K., Watanabe, N., Yokote, K., Saito, Y., Nakayama, T., Grusby, J. M., Iwamoto, I., and Nakajima, H.: Development and characterization of IL-21-producing CD4⁺ T cells. J. Exp. Med. 205:1369-1379 (2008).
150. Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: Repressor of GATA regulates T_H2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122:512-520.e11 (2008).
151. Hossain, M. B., Hosokawa, H., Hasegawa, A., Watarai, H., Taniguchi, M., Yamashita, M., and Nakayama, T.: Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells. Immunology 125:377-386 (2008).
152. Kawamura, T., Murakami, K., Bujo, H., Unoki, H., Jiang, M., Nakayama, T., and Saito, Y.: Matrix metalloproteinase-3 enhances the free fatty acids-induced VEGF expression in adipocytes through toll-like receptor 2. Exp. Biol. Med. 233:1213-1221 (2008).
153. Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., and Nakayama, T.: Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. J. Biol. Chem. 283:28216-28225 (2008).
154. Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T., and Taniguchi, M.: A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J. Exp. Med. 205:2727-2733 (2008).
155. Gilliver, S. C., Ruckshanthi, J. P., Hardman, M. J., Nakayama, T., and Ashcroft, G. S.: Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor. Endocrinology 149:5747-5757 (2008).
156. Hayakawa, K., Tateda, K., Fuse, E. T., Matsumoto, T., Akasaka, Y., Ishii, T., Nakayama, T., Taniguchi, M., Kaku, M., Standiford, T. J., and Yamaguchi, K.: Paradoxically high resistance of natural killer T (NKT) cell-deficient mice to Legionella pneumophila: another aspect of NKT cells for modulation of host responses. J. Med. Microbiol. 57:1340-1348 (2008).
157. Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T., and Nakayama, T.: A phase I-II study of α-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer. J. Immunol. 182:2492-2501 (2009).
158. Kaga, C., Nomura, S., Okochi, M., Nozu, T., Nagao, T., Nagai, A., Nakayama, T., Suzuki, K., and Honda, H.: Screening of epithelial cell-adhesive peptides from fibronectin loop region and its cell specificity. J. Chem. Eng. Japan 42:298-302 (2009).
159. Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., and Okamoto, Y.: Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. Cancer Sci. 100:1092-1098 (2009).
160. Nagata, A., Tanaka, T., Minezawa, A., Poyurovsky, M., Mayama, T., Suzuki, S., Hashimoto, N., Yoshida, T., Suyama, K., Miyata, A., Hosokawa, H., Nakayama, T., and Tatsuno, I.: cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. J. Cell. Physiol. 221:75-83 (2009).
161. Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., and Nakayama, T.: Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. J. Immunol. 183:5388-5396 (2009).
162. Kohu, K., Ohmori, H., Wong, W. F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M., and Satake, M.: The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J. Immunol. 183:7817-7824 (2009).
163. Miki-Hosokawa, T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., and Nakayama, T.: CD69 controls the pathogenesis of allergic airway inflammation. J. Immunol. 183:8203-8215 (2009).
164. Hoshino, A., Hanada, S., Manabe, N., Nakayama, T., and Yamamoto, K.: Immune response induced by fluorescent nanocrystal quantum dots in vitro and in vivo. IEEE Trans. Nanobioscience 8:51-57 (2009).
165. Iwata, A., Watanabe, N., Oya, Y., Owada, T., Ikeda, K., Suto, A., Kagami, S., Hirose, K., Kanari, H., Kawashima, S., Nakayama, T., Taniguchi, M., Iwamoto, I., and Nakajima, H.: Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis. J. Immunol. 184:127-133 (2010).
166. Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R. M., Shirai, M., and Nakayama, T.: Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model. J. Allergy Clin. Immunol. 125:461-468.e6 (2010).
167. Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A., and Nakayama, T.: Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol. Int. 59:67-73 (2010).
168. Tokoyoda, K., Hauser, A. E., Nakayama, T., and Radbruch, A.: Organization of immunological memory by bone marrow stroma. Nat. Rev. Immunol. 10:193-200 (2010).
169. Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M., and Nakayama, T.: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J. Immunol. 184:4510-4520 (2010).
170. Suzuki, S., Tanaka, T., Poyurovsky, V. M., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., Sugano, S., Sato, E., Nagao, T., Yokote, K., Tatsuno, I., and Prives, C.: Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc. Natl. Acad. Sci. USA 107:7461-7466 (2010).
171. Tomizawa, K., Nagao, T., Kusunoki, R., Saiga, K., Oshima, M., Kobayashi, K., Nakayama, T., Tanokura, M., and Suzuki, K.: Reduction of MPO-ANCA epitopes in SCG/Kj mice by 15-deoxyspergualin treatment restricted by IgG2b associated with crescentic glomerulonephritis. Rheumatology 49:1245-1256 (2010).
172. Fujimura, T., Yonekura, S., Taniguchi, Y., Horiguchi, S., Saito, A., Yasueda, H., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M., and Okamoto, Y.: The induced regulatory T cell level, defined as the proportion of IL10⁺Foxp3⁺ cells among CD25⁺CD4⁺ leukocytes, is a potential therapeutic biomarker for sublingual immunotherapy: A preliminary report. Int. Arch. Allergy Immunol. 153:378-387 (2010).
173. Ichiyanagi, T., Imai, T., Kajiwara, C., Mizukami, S., Nakai, A., Nakayama, T., and Udono, H.: Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. J. Immunol. 185:2693-2700 (2010).
174. Kobayashi, K., Tanaka, Y., Horiguchi, S., Yamamoto, S., Nakayama, T., Sugimoto, A., and Okamoto, Y.: The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer. Cancer Immunol. Immunother. 59:1503-1509 (2010).
175. Igari, H., Segawa, S., Watanabe, A., Suzuki, A., Watanabe, M., Sakurai, T., Kuroda, F., Watanabe, M., Tatsumi, K., Nakayama, M., Nakayama, T., Suzuki, K., and Sato, T.: Immunogenicity of a monovalent pandemic influenza AH1N1 vaccine in health-care workers of a university hospital in Japan. Microbiol. Immunol. 54:618-624 (2010).
176. Okita, K., Motohashi, S., Shinnakasu, R., Nagato, K., Yamasaki, K., Sato, Y., Kitamura, H., Hijikata, A., Yamashita, M., Shimizu, K., Fujii, S., Ohara, O., Taniguchi, M., Sakaida, I., and Nakayama, T.: A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy. Cancer Sci. 101:2333-2340 (2010).
177. Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Kanai, A., Suzuki, Y., and Nakayama, T.: STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207:2493-2506 (2010).
178. Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., and Okamoto, Y.: Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer. Cancer Immunol. Immunother. 60:207-215 (2011).
179. Phung, T. T. B., Luong, S. T., Kawachi, S., Nunoi, H., Nguyen, L. T., Nakayama, T., and Suzuki, K.: Interleukin 12 and myeloperoxidase (MPO) in Vietnamese children with acute respiratory distress syndrome due to Avian influenza (H5N1) infection. J. Infect. 62:104-106 (2011).
180. Aoyagi, T., Yamamoto, N., Hatta, M., Tanno, D., Miyazato, A., Ishii, K., Suzuki, K., Nakayama, T., Taniguchi, M., Kunishima, H., Hirakata, Y., Kaku, M., and Kawakami, K.: Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1⁺ monocytes. Int. Immunol. 23:97-108 (2011).
181. Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T., and Okamoto, Y.: Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. Clin. Immunol. 138:255-265 (2011).
182. Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K., and Nakayama, T.: ApolipoproteinA-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function. J. Immunol. 186:3410-3420 (2011).
183. Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M., and Okamoto, Y.: Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in two-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis. Clin. Immunol. 139:65-74 (2011).
184. Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K., and Nakayama, T.: Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses. Clin. Immunol. 139:267-276 (2011).
185. Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., Suzuki, Y., and Nakayama, T.: Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J. Immunol. 186:6378-6389 (2011).
186. Kitajima, M., Lee, H.-C., Nakayama, T., and Ziegler, S. F.: TSLP enhances the function of helper type2 cells. Eur. J. Immunol. 41:1862-1871 (2011).
187. Asada, S., Kuroda, M., Aoyagi, Y., Fukaya, Y., Tanaka, S., Konno, S., Tanio, M., Aso, M., Satoh, K., Okamoto, Y., Nakayama, T., Saito, Y., and Bujo, H.: Ceiling culture-derived proliferative adipocytes retain high adipogenic potential suitable for use as a vehicle for gene transduction therapy. Am. J. Physiol. Cell Physiol. 301: C181-185 (2011).
188. Fujii, H., Ato, M., Takahashi, Y., Otake, K., Hashimoto, S., Kaji, T., Tsunetsugu-Yokota, Y., Fujita, M., Adachi, A., Nakayama, T., Taniguchi, M., Koyasu, S., and Takemori, T.: HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice. Int. Immunol. 23:433-441 (2011).
189. Kitajima, M., Ito, T., Tumes, D. J., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S., and Nakayama, T.: Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. Cancer Res. 71:4790-4798 (2011).
190. Nagao, T., Suzuki, K., Utsunomiya, K., Matsumura, M., Saiga, K., Wang, P.-C., Minamitani, H., Aratani, Y., Nakayama, T., and Suzuki, K.: Direct activation of glomerular endothelial cells by anti-moesin activity of anti-myeloperoxidase antibody. Nephrol. Dial. Transplant. 26:2752-2760 (2011).
191. Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T., and Tatsumi, K.: Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir. Res. 12:131 (2011).
192. Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauld, J.-C., Iwamoto, I., Nakayama, T., and Nakajima, H.: IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. J. Allergy Clin. Immunol. 128:1067-1076 (2011).
193. Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, S., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., and Tatsumi, K.: Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice. J. Recept. Sig. Transduct. Res. 31:434-439 (2011).
194. Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, D. J., Tokoyoda, K., Hosokawa, H., Yamashita, M., and Nakayama, T.: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35:733-745 (2011).
195. Kidoya, H., Kunii, N., Naito, H., Muramatsu, T., Okamoto, Y., Nakayama, T., and Takakura, N.: The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy. Oncogene 31:3254-3264 (2011).
196. Phung, T. T. B., Sugamata, R., Uno, K., Aratani, Y., Ozato, K., Kawachi, S., Nguyen, L. T., Nakayama, T., and Suzuki, K.: Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells. Microbiol. Immunol. 55:874-884 (2011).
197. Aoyagi, Y., Kuroda, M., Asada, S., Tanaka, S., Konno, S., Tanio, M., Aso, M., Okamoto, Y., Nakayama, T., Saito, Y., and Bujo, H.: Fibrin glue is a candidate scaffold for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro. Exp. Cell Res. 318:8-15 (2012).
198. Satoh, M., Andoh, Y., Clingan, S. C., Ogura, H., Fujii, S., Eshima, K., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K., and Iwabuchi, K.: Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS ONE 7:e30568 (2012).
199. Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., and Nakayama, T.: Murine Schnurri-2 controls Natural Killer cell function and lymphoma development. Leuk. Lymphoma 53:479-486 (2012).
200. Sugamata, R., Dobashi, H., Nagao, T., Yamamoto, K., Nakajima, N., Sato, Y., Aratani, Y., Oshima, M., Sata, T., Kobayashi, K., Kawachi, S., Nakayama, T., and Suzuki, K.: Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection. Microbiol. Immunol. 56:171-182 (2012).
201. Miyasaka, T., Aoyagi, T., Uchiyama, B., Oishi, K., Nakayama, T., Kinjo, Y., Miyazaki, Y., Kunishima, H., Hirakata, Y., Kaku, M., and Kawakami, K.: A possible relationship of natural killer T cells with humoral immune response to 23-valent pneumococcal polysaccharide vaccine in clinical settings. Vaccine 30:3304-3310 (2012).
202. Inamine, A., Sakurai, D., Horiguchi, S., Yonekura, S., Hanazawa, T., Hosokawa, H., Matuura-Suzuki, A., Nakayama, T., and Okamoto, Y.: Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells. Clin. Immunol. 143:170-179 (2012).
203. Ishizaki, S., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Yamauchi, K., Matsunaga, H., Iwamura, C., Nakayama, T., and Tatsumi, K.: Role of CD69 in acute lung injury. Life Sciences 90:657-665 (2012).
204. Tofukuji, S., Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., and Yamashita, M.: Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFβ. J. Immunol. 188:4846-4857 (2012).
205. Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D. J., Radbruch, A., and Nakayama, T.: Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. USA 109:7409-7414 (2012).
206. Radulovic, K., Manta, C., Rossini, V., Holzmann, K., Kestler, H. A., Wegenka, U. M., Nakayama, T., and Niess, J. H.: CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol. 188:2001-2013 (2012).
207. Lavial, F., Bessonnard, S., Ohnishi, Y., Tsumura, A., Chandrashekran, A., Fenwick, M., Tomaz, R. A., Hosokawa, H., Nakayama, T., Chambers, I., Hiiragi, T., Chazaud, C., and Azuara, V.: Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes Dev. 26:1445-1458 (2012).
208. Watanabe, M., Nakajima, S., Ohnuki, K., Ogawa, S., Yamashita, M., Nakayama, T., Murakami, Y., Tanabe, K., and Abe, R.: AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur. J. Immunol. 42:1850-1862 (2012).
209. Fukaya, Y., Kuroda, M., Aoyagi, Y., Asada, S., Kubota, Y., Okamoto, Y., Nakayama, T., Saito, Y., Satoh, K., and Bujo, H.: Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system. Exp. Mol. Med. 44:330-339 (2012).
210. Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation. Nat. Immunol. 13:778-786 (2012).
211. Nagato, K., Motohashi, S., Ishibashi, F., Okita, K., Yamasaki, K., Moriya, Y., Hoshino, H., Yoshida, S., Hanaoka, H., Fujii, S., Taniguchi, M., Yoshino, I., and Nakayama, T.: Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells. J. Clin. Immunol. 32:1071-1081 (2012).
212. Sobirin, M. A., Kinugawa, S., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Hirabayashi, K., Suga, T., Azalia, P., Takada, S., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K., and Tsutsui, H.: Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice. Circ. Res. 111:1037-1047 (2012).
213. Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, D. J., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.: Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. Proc. Natl. Acad. Sci. USA 109:16992-16997 (2012).
214. Sawant, D. V., Sehra, S., Nguyen, E. T., Jadhav, R., Englert, K., Shinnakasu, R., Hangoc, G., Broxmeyer, H. E., Nakayama, T., Perumal, N. B., Kaplan, M. H., and Dent, A. L.: Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J. Immunol. 189:4759-4769 (2012).
215. Mucida, D., Husain, M. M., Muroi, S., van Wijk, F., Shinnakasu, R., Naoe, Y., Reis, B. S., Huang, Y., Lambolez, F., Docherty, M., Attinger, A., Shui, J. W., Kim, G., Lena, J. C., Sakaguchi, S., Miyamoto, C., Wang, P., Atarashi, K., Park, Y., Nakayama, T., Honda, K., Ellmeier, W., Kronenberg, M., Taniuchi, I., and Cheroutre, H.: Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocyets. Nat. Immunol. 14:281-289 (2013).
216. Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., Kanai, A., Sugano, S., and Nakayama, T.: Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc. Natl. Acad. Sci. USA 110:4691-4696 (2013).
217. Suzuki, J., Kuwahara, M., Tofukuji, S., Imamura, M., Kato, F., Nakayama, T., Ohara, O., and Yamashita, M.: A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLOS ONE 8(4):e61785 (2013).
218. Jabara, H. H., Ohsumi, T., Chou, J., Massaad, M. J., Benson, H., Megarbane, A., Chouery, E., Mikhael, R., Gorka, O., Gewies, A., Portales, P., Nakayama, T., Hosokawa, H., Revy, P., Herrod, H., Le Deist, F., Lefranc, G., Ruland, J., and Geha, R. S.: A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J. Allergy Clin. Immunol. 132:151-158 (2013).
219. Hasegawa, A., Iwamura, C., Kitajima, M., Hashimoto, K., Otsuyama, K., Ogino, H., Nakayama, T., and Shirai, M.: Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis. PLOS ONE 8:e65494 (2013).
220. Yamashita, J., Iwamura, C., Ito, T., Narita, M., Hara, Y., Sasaki, T., Masuda, D., Takahashi, M., Tsuchiya, M., Hada, K., Ishikawa, M., Matsuo, T., Ohno, Y., Tanaka, H., Maruyama, H., Ogawa, Y., and Nakayama, T.: Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells. J. Immunol. 191:949-960 (2013).
221. Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., Tanaka, H., Ogawa, Y., Suzuki, Y., and Nakayama, T.: Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity. PLOS ONE 8:e66468 (2013).
222. Homma, T., Kinugawa, S., Takahashi, M., Sobirin, M. A., Saito, A., Fukushima, A., Suga, T., Takada, S., Kadoguchi, T., Masaki, Y., Furihata, T., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K., and Tsutsui, H.: Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice. J. Mol. Cell. Cardiol. 62:179-188 (2013).
223. Hanazawa, A., Hayashizaki, K., Shinoda, K., Yagita, H., Okumura, K., Lohning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B., Radbruch, A., Tokoyoda, K., and Nakayama, T.: CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol. 91:524-531 (2013).
224. Nagao, T., Kusunoki, R., Iwamura, C., Kobayashi, S., Yumura, W., Kameoka, Y., Nakayama, T., and Suzuki, K.: Correlation of Interleukin-6 and monocyte chemotactic protein-1 concentrations with crescent formation and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody titer in SCG/Kj mice by treatment with anti-interleukin-6 receptor antibody or Mizoribine. Microbiol. Immunol. 57:640-650 (2013).
225. Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, V. M., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110:18626-18631 (2013).
226. Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.: The polycomb protein Ezh2 regulates differentiation and plasticity of CD4⁺ T helper type-1 and type-2 cells. Immunity 39:819-832 (2013).
227. Nakamura, T., Fukiage, M., Higuchi, M., Nakaya, A., Yano, I., Miyazaki, J., Nishiyama, H., Akaza, H., Ito, T., Hosokawa, H., Nakayama, T., and Harashima, H.: Nanoparticulation of BCG-CWS for application to bladder cancer therapy. J. Control. Release 176:44-53 (2013).
228. Shiga, Y., Sugamata, R., Iwamura, C., Nagao, T., Zao, J., Kawakami, K., Kawachi, S., Nakayama, T., and Suzuki, K.: Effect of invariant natural killer T cells with IL-5 and activated IL-6 receptor in ventilator-associated lung injury in mice. Exp. Lung Res. 40:1-11 (2014).
229. Iwata, A., Kawashima, S., Kobayashi, M., Okubo, A., Kawashima, H., Suto, A., Hirose, K., Nakayama, T., and Nakajima, H.: Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int. Immunol. 26:103-114 (2014).
230. Yagi, R., Zhong, C., Northrup, D. L., Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., Belkaid, Y., Zhao, K., and Zhu, J.: The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells. Immunity 40:378-388 (2014).
231. Sugamata, R., Sugawara, A., Nagao, T., Suzuki, K., Hirose, T., Yamamoto, K., Oshima, M., Kobayashi, K., Sunazuka, T., Akagawa, S., Omura, S., Nakayama, T., and Suzuki, K.: Leucomycin A₃, a 16-memberd macrolide antibiotic, inhibits Influenza A virus infection and disease progression. J. Antibiotics 67:213-222 (2014).
232. Beaulieu, A. M., Zawislak, C. L., Nakayama, T., and Sun, J. C.: The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection. Nat. Immunol. 15:546-553 (2014).
233. Suzuki, K., Nagao, T., Itabashi, M., Hamano, Y., Sugamata, R., Yamazaki, Y., Yumura, W., Tsukita, S., Wang, P. C., Nakayama, T., and Suzuki, K.: A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis. Nephrol. Dial. Transplant. 29:1168-1177 (2014).
234. Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., and Yamashita, M.: The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat. Commun. 5:3555 (2014).
235. Sakurai, T., Inamine, A., Iinuma, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hanazawa, T., Nakayama, T., Ishii, Y., and Okamoto, Y.: Activation of invariant natural killer T cells in regional lymph nodes as new antigen-specific immunotherapy via induction of interleukinL-21 and interferon-γ. Clin. Exp. Immunol. 178:65-74 (2014).
236. Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111:12829-12834 (2014).
237. Tanaka, S., Suto, A., Iwamoto, T., Kashiwakuma, D., Kagami, S., Suzuki, K., Takatori, H., Tamachi, T., Hirose, K., Onodera, A., Suzuki, J., Ohara, O., Yamashita, M., Nakayama, T., and Nakajima, H.: Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. J. Exp. Med. 211:1857-1874 (2014).
238. Mishima, Y., Wang, C., Miyagi, S., Saraya, A., Hosokawa, H., Mochizuki, K. M., Nakajima, T. Y., Koide, S., Negishi, M., Sashida, G., Naito, T., Ishikura, T., Onodera, A., Nakayama, T., Tenen, D., Yamaguchi, N., Koseki, H., Taniuchi, I., and Iwama, A.: Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development. Nat. Commun. 5:5872 (2014).
239. Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42:294-308 (2015).
240. Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114:289-298 (2015).
241. Nakagomi, D., Suzuki, K., Meguro, K., Hosokawa, J., Tamachi, T., Takatori, H., Suto, A., Matsue, H., Ohara, O., Nakayama, T., Shimada, S., and Nakajima, H.: Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity. J. Allergy Clin. Immunol. 135:1397-1400 (2015).
242. Hirahara, K., Onodera, A., Villario, A. V., Bonelli, M., Sciume, G., Laurence, A., Sun, H. W., Brooks, S. R., Vahedi, G., Shih, H. Y., Gtierrez-Cruz, G., Iwata, S., Suzuki, R., Mikami, Y., Okamoto, Y., Nakayama, T., Holland, S. M., Hunter, C. A., Kanno, Y., and O'Shea, J. J.: Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity 42:877-889 (2015).
243. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, Y. M., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, I. K., Tanaka, T., and Nakayama, T.: Methylation of Gata3 at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells. J. Biol. Chem. 290:13095-13103 (2015).
244. Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12:1042-1055 (2015).
245. Onodera, A., Tumes, D. J., Watanabe, Y., Hirahara, K., Kaneda, A., Sugiyama, F., Suzuki, Y., and Nakayama, T.: Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes. Mol. Cell. Biol. 35:3841-3853 (2015).
246. Horinaka, A., Sakurai, D., Ihara, F., Makita, Y., Kunii, N., Motohashi, S., Nakayama, T., and Okamoto, Y.: Invariant NKT cells are resistant to circulating CD15⁺ myeloid-derived suppressor cells in patients with head and neck cancer. Cancer Sci. 107:207-216 (2016).
247. Mise, N., Takami, M., Suzuki, A., Kamata, T., Harada, K., Hishiki, T., Saito, T., Terui, K., Mitsunaga, T., Nakata, M., Ikeuchi, T., Nakayama, T., Yoshida, H., and Motohashi, S.: Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T cells. Cancer Sci. 107:233-241 (2016).
248. Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I., and Nakayama, T.: Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat. Commun. 7:11289 (2016).
249. Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.: Thy1⁺IL-7⁺ lymphatic endthelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA 113:E2842-51 (2016).
250. Kuwahara, M., Ise, W., Ochi, M., Suzuki, J., Kometani, K., Maruyama, S., Izumoto, M., Matsumoto, A., Takemori, N., Takemori, A., Shinoda, K., Nakayama, T., Ohara, O., Yasukawa, M., Sawasaki, T., Kurosaki, T., and Yamashita, M.: Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. Nat. Commun. 7:12596 (2016).
251. Nakano, M., Kamada, N., Suehiro, K., Oikawa, A., Shibata, C., Nakamura, Y., Matsue, H., Sasahara, Y., Hosokawa, H., Nakayama, T., Nonaka, K., and Ohara, O.: Establishment of a new three-dimensional human epidermal model reconstructed from plucked hair follicle-derived keratinocytes. Exp. Dermatol. 25:903-906 (2016). (2.675)
252. Kimura, M. Y., Thomas, J., Tai, X., Guinter, T. I., Shinzawa, M., Etzenperger, R., Li, Z., Love, P., Nakayama, T., and Singer, A.: Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors. Nat. Immunol. 17:1415-1423 (2016).
253. Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Fatty acid metabolic reprogramming via mTOR-mediated induction of PPARγ directs early activation of T cells. (*these authors contributed equally to this work) Nat. Commun. 7:13683 (2016).
254. Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, S. R., Masumoto, T., Fujisawa, M., Chikaishi, T., Komeda, J., Itoh, J., Umemura, M., Kyusai, A., Tomura, M., Nakayama, T., Woodland, D. L., Kohlmeler, J. E., and Miyazawa, M.: Specific niches for lung-resident memory CD8⁺ T cells at the site of tissue regeneration enable CD69-independent maintenance. J. Exp. Med. 213:3057-3073 (2016).
255. Hayashizaki, K.,* Kimura, M. Y.,* Tokoyoda, K.,* Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y., and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. (*these authors contributed equally to this work) Sci. Immunol. 1:pp.eaaf9154 (2016).
256. Kamata, T., Suzuki, A., Mise, N., Ihara, F., Takami, M., Makita, Y., Horinaka, A., Harada, K., Kunii, N., Yoshida, S., Yoshino, I., Nakayama, T., and Motohashi, S.: Blockade of programmed death-1/programmed death ligand pathway enhances the antitumor immunity of human invariant natural killer T cells. Cancer Immunol. Immunother. 65:1477-1489 (2016).
257. Brück, J., Holstein, J., Glocova, I., Seidel, U., Geisel, J., Kanno, T., Kumagai, J., Mato, N., Sudowe, S., Widmaier, K., Sinnberg, T., Yazdi, A. S., Eberle, F. C., Hirahara, K., Nakayama, T., Röcken, M., and Ghoreschi, K.: Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation. Sci. Rep. 7:44482 (2017).
258. Iwata, S., Mikami, Y., Sun, H.-W., Brooks, S. R., Jankovic, D., Hirahara, K., Onodera, A., Shih, H.-Y., Kawabe, T., Jiang, K., Nakayama, T., Sher, A., O'Shea, J. J., Davis, F. P., and Kanno, Y.: The transcription factor T-bet limits amplification of type I IFN transcriptome and circuitry in T helper 1 cells. Immunity 46:983-991 (2017).
259. Shinoda, K., Hirahara, K., and Nakayama, T.: Maintenance of pathogenic Th2 cells in allergic disorders. Allergol. Int. 66:369-376 (2017).
260. Onodera, A., Kiuchi, M., Kokubo, K., Kato, M., Ogino, T., Horiuchi, S., Kanai, U., Hirahara, K., and Nakayama, T.: Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. J. Immunol. 199:1153-1162 (2017).
261. Mato, N., Hirahara, K., Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T.: Memory-type ST2⁺CD4⁺ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Sci. Rep. 7:6805 (2017).
262. Ihara, F., Sakurai, D., Horinaka, A., Makita, Y., Fujikawa, A., Sakurai, T., Yamasaki, K., Kunii, N., Motohashi, S., Nakayama, T., and Okamoto, Y.: CD45RA^-Foxp3^high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma. Cancer Immunol. Immunother. 66:1275-1285 (2017).
263. Kameoka, Y., Koura, M., Matsuda, J., Suzuki, O., Ohno, N., Sugamata, R., Nakayama, T., and Suzuki, K.: Establishment of a library having 204 effective clones of recombinant single chain fragment of variable region (hScFv) of IgG for vasculitis treatment. ADC Letters for Infectious Disease control 4:44-47 (2017).
264. Ito, T., Hirahara, K., Onodera, A., Koyama-Nasu, R., Yano, I., and Nakayama, T.: Anti-tumor immunity via the superoxide-eosinophil axis induced by a lipophilic component of Mycobacterium lipomannan. Int. Immunol. 29:411-421 (2017).
265. Lian, S. L., Mihi, B., Koyanagi, M., Nakayama, T., and Bix, M.: A SNP uncoupling Mina expression from the TGFβ signaling pathway. Immun. Inflamm. Dis. 6:58-71 (2018).
266. Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T.: Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete Osteopontin and facilitate airway fibrosis. Immunity 49:134-150 (2018).
267. Kimura, M. Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., Endo, Y., Ogawa, S., Yagi, R., Motohashi, S., Singer, A., and Nakayama, T.: CD69 prevents PLZF^hi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nat. Commun. 9:3749 (2018).
268. Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.: CXCR6⁺ST2⁺ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 115:E9849-E9858 (2018).
269. Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.: DUSP10 constrains IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells. Nat. Commun. 9:4231 (2018).
270. Mita, Y., Kimura, M. Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y., and Nakayama, T.: Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. Int. Immunol. 30:559-567 (2018).
271. Tanaka, K., Kanesaka, Y., Takami, M., Suzuki, A., Hosokawa, H., Onodera, A., Kamata, T., Nagato, K., Nakayama, T., Yoshino, I., and Motohashi, S.: Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer. Biochem. Biophys. Res. Commun. 506:27-32 (2018).
272. Takami, M., Cunha, C., Motohashi, S., Nakayama, T., and Iwashima, M.: TGF-β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis. Eur. J. Immunol. 48:1938-1943 (2018).
273. Ihara, F., Sakurai, D., Yonekura, S., Iinuma, T., Yagi, R., Sakurai, T., Ito, T., Matsuura, A., Morimoto, Y., Arai, T., Suzuki, S., Katayama, K., Nakayama, T., and Okamoto, Y.: Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Allergy 73:1823-1832 (2018).
274. Iinuma, T., Okamoto, Y., Morimoto, Y., Arai, T., Sakurai, T., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy 73(2):479-489 (2018).
275. Wada, T., Hirahara, K., Aoki, A., Morimoto, Y., Kiuchi, M., Kumagai, J., Okano, M., Kokubo, K., Kato, M., Fukano, C., Ohashi-Doi, K., and Nakayama, T.: An Optimized protocol for the analysis of house dust mite (Dermatophagoides farinae)-induced neutrophil-dominant airway inflammation. J. Immunol. Methods 465:53-60 (2019).
276. Kameoka, Y., Kishi, F., Koura, M., Yamakawa, Y., Nagasawa, R., Ito, F., Matsuda, J., Suzuki, O., Nakayama, T., and Suzuki, K.: Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis. Drug Des. Devel. Ther. 13:555-568 (2019).
277. Endo, Y., Onodera, A., Obata-Ninomiya, K., Koyama-Nasu, R., Asou, H. K., Ito, T., Yamamoto, T., Kanno, T., Nakajima, T., Ishiwata, K., Kanuka, H., Tumes, D. J., and Nakayama, T.: Acc1 determines memory potential of indivisual CD4⁺ T cells by regulating de novo fatty acid biosynthesis. Nat. Metab. 1:261-275 (2019).
278. Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., and Motohashi, S.: Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation. Cancer Sci. 110:888-902 (2019).
279. Pillai, M. R., Mihi, B., Ishiwata, K., Nakamura, K., Sakuragi, N., Finkelstein, D. B., McGargill, M. A., Nakayama, T., Ayabe, T., Coleman, M. L., and Bix, M.: Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway. PLoS ONE 14:e0211244 (2019).
280. Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Yip, K. H., Pant, H., Kokubo, K., Kiuchi, M., Aoki, A., Obata-Ninomiya, K., Tokoyoda, K., Endo, Y., Kimura, M. Y., and Nakayama, T.: Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology. J. Allergy Clin. Immunol. 144(2):549-560.e10 (2019).
281. Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D. J., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.: CD103^hi T_reg cells constrain lung fibrosis induced by CD103^lo tissue-resident pathogenic CD4 T cells. (*these authors contributed equally to this work) Nat. Immunol. 20:1469-1480 (2019).
282. Ihara, F., Sakurai, D., Takami, M., Kamata, T., Kunii, N., Yamasaki, K., Iinuma, T., Nakayama, T., Motohashi, S., and Okamoto, Y.: Regulatory T cells induce CD4- NKT cell anergy and suppress NKT cell cytotoxic function. Cancer Immunol. Immunother. 68:1934-1947 (2019).
283. Nakayama, Y., Fujiu, K., Yuki, R., Oishi, Y., Morioka, M. S., Isagawa, T., Matsuda, J., Oshima, T., Matsubara, T., Sugita, J., Kudo, F., Kaneda, A., Endo, Y., Nakayama, T., Nagai, R., Komuro, I., and Manabe, I.: A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. Proc. Natl. Acad. Sci. USA 117:14365-14375 (2020).
284. Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Toyoda, T., Okada, R., Hino, M., Koyama-Nasu, R., Kiuchi, M., Hirahara, K., Kimura, M. Y., Nakayama, T., Shimojo, N., and Motohashi, S.: Activated invariant natural killer T cells directly recognize leukemia cells in CD1d-independent manner. Cancer Sci. 111(7):2223-2233 (2020).
285. Suzuki, A. S., Yagi, R., Kimura, M., Iwamura, C., Shinoda, K., Onodera, A., Hirahara, K., Tumes, D. J., Koyama-Nasu, R., Iismaa, S. E., Graham, R. M., Motohashi, S., and Nakayama, T.: Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front. Immunol. 11:1536 (2020).
286. Kiuchi, M., Onodera, A., Kokubo, K., Ichikawa, T., Morimoto, Y., Kawakami, E., Takayama, N., Eto, K., Koseki, H., Hirahara, K., and Nakayama, T.: The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4⁺ T cell differentiation. J. Exp. Med. 218(4):e20201690 (2021).
287. Takasato, Y., Kurashima, Y., Kiuchi, M., Hirahara, K., Murasaki, S., Arai, F., Izawa, K., Kaitani, A., Shimada, K., Saito, Y., Toyoshima, S., Nakamura, M., Fujisawa, K., Okayama, Y., Kunishima, J., Kubo, M., Takemura, N., Uematsu, S., Akira, S., Kitaura, J., Takahashi, T., Nakayama, T., and Kiyono, H.: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14(3):640-651 (2021).
288. Hara, A., Koyama-Nasu, R., Takami, M., Toyoda, T., Aoki, T., Ihara, F., Kobayashi, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., and Motohashi, S.: CD1d expression in glioblastoma is a promisingtarget for NKT cell-based cancer immunotherapy. Cancer Immunol. Immunother. 70(5):1239-1254 (2021).
289. Yokoyama, M., Kimura, M. Y., Ito, T., Hayashizaki, K., Endo, Y., Wang, Y., Yagi, R., Nakagawa, T., Kato, N., Matsubara, H., and Nakayama, T.: Myosin light chain 9/12 regulates the pathogenesis of inflammatory bowel disease. Front. Immunol. 11:594297 (2021).
290. Onodera, A., Gonzalez-Avalos, E., Lio, C.-W., Georges, R. O., Bellacosa, A., Nakayama, T., and Rao, A.: Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells. Genome Biol. 22(1):186 (2021).
291. Kanno, T., Nakajima, T., Yokoyama, S., Asou, H. K., Sasamoto, S., Kamii, Y., Hayashizaki, K., Ouchi, Y., Onodera, T., Takahashi, Y., Ikeda, K., Hasegawa, Y., Kinjo, Y., Ohara, O., Nakayama, T., and Endo, Y.: SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4⁺ T cells. Commun. Biol. 4(1):820 (2021).
292. Hosokawa, H., Koizumi, M., Masuhara, K., Romeo-Wolf, M., Tanaka, T., Nakayama, T., and Rothenberg, E.: Stage-specific adtion of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells. J. Exp. Med. 218(8):e20202648 (2021).
293. Kageyama, T., Ikeda, K., Tanaka, S., Taniguchi, T., Igari, H., Onouchi, Y., Kaneda, A., Matsushita, K., Hanaoka, H., Nakada, T., Ohtori, S., Yoshino, I., Matsubara, H., Nakayama, T., Yokote, K., and Nakajima, H.: Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan. Clin. Microbiol. Infect. 27(12):1861.e1-1861.e5 (2021).
294. Nakajima, T., Kanno, T., Yokoyama, S., Sasamoto, S., Asou, H. K., Tumes, D. J., Ohara, O., Nakayama, T., and Endo, Y.: ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. J. Exp. Med. 218(12):e20210639 (2021).
295. Kanno, T., Nakajima, T., Kawashima, Y., Yokoyama, S., Asou, H. K., Sasamoto, S., Hayashizaki, K., Kinjo, Y., Ohara, O., Nakayama, T., and Endo, Y.: Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis. Cell Rep. 37(6):109921 (2021).
296. Sarkar, M. H., Yagi, R., Endo, Y., Koyama-Nasu, R., Wang, Y., Hasegawa, I., Ito, T., Junttila, I. S., Zhu, J., Kimura, M. Y., and Nakayama, T.: IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. PLoS One 26(11):e0260204 (2021).
297. Shinoda, K.,* Choe, A.,* Hirahara, K.,* Kiuchi, M., Kokubo, K., Ichikawa, T., Hoki, J. S., Suzuki, A. S., Bose, N., Appleton, J. A., Aroian, R. V., Schroeder, F. C., Sternberg, P. W., and Nakayama, T.: Nematode ascarosides attenuate mammalian type 2 inflammatory responses. (*These authors contributed equally to this work) Proc. Natl. Acad. Sci. 119(1):e2108686119 (2022).
298. Wakai, K., Azuma, K., Iwamura, C., Maimaiti, M., Mikami, K., Yoneda, K., Sakamoto, S., Ikehara, S., Yamaguchi, T., Hirahara, K., Ichikawa, T., Nakayama, T., and Ikehara, Y.: The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice. Sci. Rep. 12(1):9046 (2022).
299. Kanno, T., Miyako, K., Nakajima, T., Yokoyama, S., Sasamoto, S., Asou, H. K., Ohara, O., Nakayama, T., and Endo, Y.: SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells. Front. Immunol. 13:904875 (2022).
300. Iwamura, C., Hirahara, K., Kiuchi, M., Ikehara, S., Azuma, K., Shimada, T., Kuriyama, S., Ohki, S., Yamamoto, E., Inaba, Y., Shiko, Y., Aoki, A., Kokubo, K., Hirasawa, R., Hishiya, T., Tsuji, K., Nagaoka, T., Ishikawa, A., Kojima, A., Mito, H., Hase, R., Kasahara, Y., Kuriyama, N., Tsukamoto, T., Nakamura, S., Urushibara, T., Kaneda, S., Sakao, S., Tobiume, M., Suzuki, Y., Tsujiwaki, M., Kubo, T., Hasegawa, T., Nakase, H., Nishida, O., Takahashi, K., Baba, K., Iizumi, Y., Okazaki, T., Kimura, M. Y., Yoshino, I., Igari, H., Nakajima, H., Suzuki, T., Hanaoka, H., Nakada, T., Ikehara, Y., Yokote, K., and Nakayama, T.: Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proc. Natl. Acad. Sci. USA 119(33):e2203437119 (2022).
301. Shinoda, K., Suganami, A., Moriya, Y., Yamashita, M., Tanaka, T., Suzuki, A. S., Suito, H., Akutsu, Y., Saito, K., Shinozaki, Y., Isojima, K., Nakamura, N., Miyachi, Y., Shirasawa, H., Matsubara, H., Okamoto, Y., Nakayama, T., and Tamura, Y.: Indocyanine green conjugated phototheranostic nanoparticle for photodiagnosis and photodynamic therapy. Photodiagnosis Photodyn. Ther. 39:103041 (2022).
302. Iinuma, T.,* Kiuchi, M.,* Hirahara, K., Kurita, J., Kokubo, K., Yagyu, H., Yoneda, R., Arai, T., Sonobe, Y., Fukuyo, M., Kaneda, A., Yonekura, S., Nakayama, T., Okamoto, Y., and Hanazawa, T.: Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion. (*These authors contributed equally to this work) J. Allergy Clin. Immunol. 150(4):850-860.e5 (2022).
303. Fujimoto, M., Yokoyama, M., Kiuchi, M., Hosokawa, H., Nakayama, A., Hashimoto, N., Sakuma, I., Nagano, H., Yamagata, K., Kudo, F., Manabe, I., Lee, E., Hatano, R., Onodera, A., Hirahara, K., Yokote, K., Miki, T., Nakayama, T., and Tanaka, T.: Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis. Nat. Commun. 13:5408 (2022).
304. Okano, M., Hirahara, K., Kiuchi, M., Onoue, M., Iwamura, C., Kokubo, K., Hishiya, T., Morimoto, Y., Ikehara, Y., Murakami, A., Ebihara, N., and Nakayama, T.: Inetrleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity 55(12):2352-2368.e7 (2022).
305. Tsuji, K., Aoki, A., Onodera, A., Kiuchi, M., Kokubo, K., Morimoto, Y., Iinuma, T., Hanazawa, T., Nakayama, T., and Hirahara, K.: Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients. Allergol. Int. 72(2):335-338 (2023).
306. Kokubo, K., Hirahara, K., Kiuchi, M., Tsuji, K., Shimada, Y., Sonobe, Y., Shinmi, R., Hishiya, T., Iwamura, C., Onodera, A., and Nakayama, T.: Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Proc. Natl. Acad. Sci. USA 120(2):e2218345120 (2023).
307. Kobayashi, H., Kimura, M. Y., Hasegawa, I., Suganuma, E., Ikehara, Y., Azuma, K., Ito, T., Ebata, R., Kurashima, Y., Kawasaki, Y., Shiko, Y., Saito, N., Iwase, H., Lee, Y., Noval Rivas, M., Arditi, M., Zuka, M., Hamada, H., and Nakayama, T.: Increased Myosin Light 9 expression during Kawasaki disease vasculitis. Front. Immunol. 13:1036672 (2023).
308. Koyama-Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., Motohashi, S., and Nakayama, T.: CD69 imposes tumor-specific CD8⁺ T-cell fate in tumor-draining lymph nodes. Cancer Immunol. Res. 11(8):1085-1099 (2023).
309. Maezawa, Y., Endo, Y., Kono, S., Ohno, T., Nakamura, Y., Teramoto, N., Yamaguchi, A., Aono, K., Minamizuka, T., Kato, H., Ishikawa, T., Koshizaka, M., Takemoto, M., Nakayama, T., and Yokote, K.: Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events. J. Diabetes Investig. 14(9):1136-1139 (2023).

1. Tada, T., Asano, Y., Nakayama, T., and Fujisawa, I.: I-J: an inducible isomorphic receptor involved in the H-2-restricted cell interaction and inhibition. In: H-2 Antigens. Edited by C. S. David, Plenum Publishing Co., New York. pp.435-440 (1987).
2. Tada, T., Nakayama, T., Kishimoto, H., and Asano, Y.: I-J as a second T cell receptor for self involved in the suppressive signal transduction. In: Cellular Basis of Immune Modulation Alan R Liss, New York. pp.341-351 (1989).
3. Tada, T., Nakayama, T., Asano, Y., Kishimoto, H., and Sano, K.: I-J as a second T cell receptor for self. Molecular polymorphism and the role in suppressive signal transduction In: Immune system and Cancer ed.by T. Hamaoka et al., Japan sci. soc. press, Tokyo, pp.227-235 (1989).
4. Tada, T., Kubo, S., and Nakayama, T.: Self Tolerance: Multiple strategies for peripheral unresponsiveness of T cell. in: New Trends in Allergy IV. Ring, J., Behrendt, H. and Vieluf, D. (Eds.) Springer-Verlag, Heidelberg, pp.359-364 (1997).
5. Nakayama, T.: T cell development in the thymus. Handbook of Experimental Immunology. (5th ed.) Edited by L. Herzenberg, Blackwell Scientific Publications. 107.1-107.5 (1997).
6. Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.: TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.350-351 (1997).
7. Hashimoto, K., Hasegawa, A., Yamashita, M., Kubo, M., Tada, T., and Nakayama, T.: CD69-mediated signaling events involved in T cell differentiation in the thymus. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.352 (1997).
8. Kubo, M., Yamashita, M., Tokoyoda, K., Tada, T., and Nakayama, T.: Impairment of IL-4 receptor-mediated signaling determines T cell subset-specific expression of IL-4 gene. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.353 (1997).
9. Taniguchi, M., and Nakayama, T.: Recognition and function of Vα14 NKT cells. Semin. Immunol. 12:543-550 (2000).
10. Nakayama, T., Yamashita, M., Kawano, T., Shimizu, C., Shibata, Y., Kamata, T., Kaneko, Y., Kobayashi, S., Takeda, U., Motohashi, S., Cui, J., and Taniguchi, M.: The role of α-galactosylceramide-activated Vα14 natural killer T cells in the regulation of Th2 cell differentiation. Int. Arch. Allergy Immunol. 124:38-42 (2001).
11. Taniguchi, M., Harada, M., Kojo, S., Nakayama, T., and Wakao, H.: The regulatory role of Vα14 NKT cells in innate and acquired immune response. Ann. Rev. Immunol. 21:483-513 (2003).
12. Taniguchi, M., Seino, K., and Nakayama, T.: The NKT cell system: bridging innate and acquired immunity. Nat. Immunol. 4:1164-1165 (2003).
13. Seino, K., Fujii, S., Harada, M., Motohashi, S., Nakayama, T., Fujisawa, T., and Taniguchi, M.: Vα14 NKT cell-mediated anti-tumor responses and their clinical application. Springer Semin. Immunopathol. 27:65-74 (2005).
14. Kimura, Y. M., and Nakayama, T.: Differentiation of NK1 and NK2 cells. Crit. Rev. Immunol. 25:361-374 (2005).
15. Seino, K., Motohashi, S., Fujisawa, T., Nakayama, T., and Taniguchi, M.: Natural killer T cell-mediated antitumor immune responses and their clinical applications. Cancer Sci. 97:807-812 (2006).
16. Iwamura, C., and Nakayama, T.: Role of α-galactosylceramide-activated Vα14 natural killer T cells in the regulation of allergic diseases. Allergol. Int. 56:1-6 (2007).
17. Yamashita, M., Onodera, A., and Nakayama, T.: Immune mechanisms of allergic airway diseases: Regulation by transcription factors. Crit. Rev. Immunol. 27:539-546 (2007).
18. Yamashita, M., and Nakayama, T.: Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function. J. Pharmacol. Sci. 106:332-335 (2008).
19. Motohashi, S., and Nakayama, T.: Clinical applications of natural killer T cell-based immunotherapy for cancer. Cancer Sci. 99:638-645 (2008).
20. Nakayama, T., and Yamashita, M.: Initiation and maintenance of Th2 cell identity. Truncated title: Regulation of Th2 responses. Curr. Opin. Immunol. 20:265-271 (2008).
21. Iwamura, C., and Nakayama, T.: Toll-like receptors in the respiratory system: their roles in inflammation. Curr. Allergy Asthma Rep. 8:7-13 (2008).
22. Motohashi, S., and Nakayama, T.: Natural killer T cell-mediated immunotherapy for malignant diseases. Front. Biosci. S1:108-116 (2009).
23. Motohashi, S., and Nakayama, T.: Invariant natural killer T cell-based immunotherapy for cancer. Immunotherapy 1:73-82 (2009).
24. Nakayama, T., and Yamashita, M.: Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. Semin. Immunol. 21:78-83 (2009).
25. Nakayama, T., and Kimura, Y. M.: Memory Th1/Th2 cell generation controlled by schnurri-2. Memory T-Cells, edited by Maurizio Zanetti. (2009).
26. Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y., and Taniguchi, M.: Adjuvant activity mediated by iNKT cells. Semin. Immunol. 22:97-102 (2010).
27. Nakayama, T., and Yamashita, M.: The TCR-mediated signaling pathways that control the direction of helper T cell differentiation. Semin. Immunol. 22:303-309 (2010).
28. Ishii, Y., Motohashi, S., Shimizu, K., Nakayama, T., Taniguchi, M., and Fujii, S.: Application of NKT cells in immunotherapy. Curr. Immunol. Rev. 6:109-115 (2010).
29. Nakayama, T., and Kimura, M. Y.: Memory Th1/Th2 cell generation controlled Schnurri-2. Adv. Exp. Med. Biol. 684:1-10 (2010).
30. Iwamura, C., and Nakayama, T.: Role of NKT cells in allergic asthma. Curr. Opin. Immunol. 22:807-813 (2010).
31. Exley, M. A., and Nakayama, T.: NKT-cell-based immunotherapies in clinical trials. Clin. Immunol. 140:117-118 (2011).
32. Motohashi, S., Okamoto, Y., Yoshino, I., and Nakayama, T.: Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer. Clin. Immunol. 140:167-176 (2011).
33. Motohashi, S., Okamoto, Y., and Nakayama, T.: Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer. Natural killer T cells: Balancing the Regulation of Tumor Immunity. 185-198 (2011).
34. Taniguchi, M., Fujii, S., Nakayama, T., Motohashi, S., Dashtsoodal, N., Watarai, H., and Harada, M.: Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Deprived NKT Cells. Natural killer T cells: Balancing the Regulation of Tumor Immunity. 1-14 (2011).
35. Onodera, A., Tumes, D. J., and Nakayama, T.: Too much of a good thing. Nat. Immunol. 14:112-114 (2013).
36. Suzuki, K., Suzuki, K., Nagao, T., and Nakayama, T.: Proposal of anti-moesin as a novel biomarker for ANCA-associated vasculitis. Clin. Exp. Nephrol. 17:638-641 (2013).
37. Fujii, S., Shimizu, K., Okamoto, Y., Kunii, N., Nakayama, T., Motohashi, S., and Taniguchi, M.: NKT cells as an ideal anti-tumor immunotherapeutic. Front. Immunol. 4:409 (2013).
38. Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35:69-78 (2014).
39. Onodera, A., Tumes, D. J., and Nakayama, T.: Epigenetic control of immune T cell memory. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. 367-382 (2014).
40. Onodera, A., and Nakayama, T.: Epigenetics of T cells regulated by Polycomb/Trithorax molecules. Trends Mol. Med. 21:330-340 (2015).
41. Endo, Y., and Nakayama, T.: Pathogenic Th2 (Tpath2) cells in airway inflammation. Oncotarget 6:32303-32304 (2015).
42. Hirahara, K., and Nakayama, T.: CD4⁺ T-cell subsets in inflammatory diseases: beyond the T_h1/T_h2 paradigm. Int. Immunol. 28:163-171 (2016).
43. Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation 401-415 (2016).
44. Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 Cells in Health and Disease. Annu. Rev. Immunol. 35:53-84 (2017).
45. Endo, Y., Yokote, K., and Nakayama, T.: The obesity-related pathology and Th17 cells. Cell. Mol. Life Sci. 74:1231-1245 (2017).
46. Nakayama, T.: Introduction to "allergic inflammation". Immunol. Rev. 278:5-7 (2017).
47. Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., and Nakayama, T.: Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma. Immunol. Rev. 278:8-19 (2017).
48. Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S., and Nakayama, T.: Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol. Rev. 278:87-100 (2017).
49. Kurashima, Y., Yamamoto, D., Nelson, S., Uematsu, S., Ernst, P. B., Nakayama, T., and Kiyono, H.: Mucosal mesenchymal cells: Secondary barrier and peripheral educator for the gut Immune system. Front. Immunol. 8:1787 (2017).
50. Onodera, A., Kokubo, K., and Nakayama, T.: The interplay between transcription factors and epigenetic modifications in Th2 cells. Gene Expression and Regulation in Mammalian Cells -Transcription from General Aspects Edited by Fumiaki Uchiumi 191-211 (2018).
51. Iwamura, C., and Nakayama, T.: Role of CD1d- and MR1-restricted T cells in asthma. Front. Immunol. 9:1942(2018).
52. Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T.: The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2⁺CD4⁺ T cells. J. Leukoc. Biol. 104:895-901 (2018).
53. Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T.: Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic inflammation. Inflamm. Regen. 38:10 (2018).
54. Onodera, A., Kokubo, K., and Nakayama, T.: Epigenetic and transcriptional regulation in the induction, maintenance, heterogeneity, and recall-response of effector and memory Th2 cells. Front. Immunol. 9:2929 (2018).
55. Tokuhara, D., Kurashima, Y., Kamioka, M., Nakayama, T., Ernst, P., and Kiyono, H.: A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol. Int. 68:17-25 (2019).
56. Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.: Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology. Front. Immunol. 10:570 (2019).
57. Hirahara, K., Aoki, A., Morimoto, Y., Kiuchi, M., Okano, M., and Nakayama, T.: The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin. Semin. Immunopathol. 41(3):339-348 (2019).
58. Kimura, M. Y., Koyama-Nasu, R., Yagi, R., and Nakayama, T.: Anew therapeutic target: the CD69-Myl9 system in immune responses. Semin. Immunopathol. 41(3):349-358 (2019).
59. Hirahara, K., and Nakayama, T.: Induction and regulation of mucosal memory T cell response. Mucosal Vaccines (Second Edition) 133-142 (2019).
60. Aoki, A., Hirahara, K., Kiuchi, M., and Nakayama, T.: Eosinophils: Cells known for over 140 years with broad and new functions. Allergol. Int. 70(1):3-8 (2021).
61. Hirahara, K., Aoki, A., and Nakayama, T.: Pathogenic helper T (Tpath) cells. Allergol. Int. 70(2):169-173 (2021).
62. Hirahara, K., Kokubo, K., Aoki, A., Kiuchi, M., and Nakayama, T.: The role of CD4⁺ resident memory T cells in local immunity in the mucosal tissue - protection versus pathology -. Front. Immunol. 12:616309 (2021).
63. Hirahara, K., Aoki, A., Kiuchi, M., and Nakayama, T.: Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation. J. Allergy Clin. Immunol. 147(6):2063-2066 (2021).
64. Nakayama, T., Hirahara, K., Kimura, M. Y., Iwamura, C., Kiuchi, M., Kokubo, K., Onodera, A., Hashimoto, K., and Motohashi, S.: CD4⁺ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system. Int. Immunol. 33:(12):699-704 (2021).
65. Onodera, A., Kiuchi, M., Kokubo, K., and Nakayama, T.: Epigenetic regulation of inflammation by CxxC domain-containing proteins. Immunol. Rev. 305(1):137-151 (2022).
66. Koyama-Nasu, R., Wang, Y., Hasegawa, I., Endo, Y., Nakayama, T., and Kimura, M. Y.: The cellular and molecular basis of CD69 function in anti-tumor immunity. Int. Immunol. 34(11):555-561 (2022).
67. Kokubo, K., Onodera, A., Kiuchi, M., Tsuji, K., Hirahara, K., and Nakayama, T.: Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. Front. Immunol. 13:945063 (2022).
68. Onodera, A., Kokubo, K., Okano, M., Onoue, M., Kiuchi, M., Iwamura, C., Iinuma, T., Kimura, M. Y., Ebihara, N., Hanazawa, T., Nakayama, T., and Hirahara, K.: Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol. Ther 247:108445 (2023).

III) Proceedings

1. Tada, T., Asano, Y., Fujisawa, I., Yagi, J., Sano, K., Tsuji, M., and Nakayama, T.: Adaptive construction of the immune circuit. Progress in Immunology VI. pp.427-437 (1986).
2. Nakayama, T., Yamashita, M., Kubo, M., Kimura, M., Shimizu, C., and Tada, T.: TCR-mediated signal transduction pathways that control helper T cell differentiation: Requirement for activation of Lck tyrosine kinase and Ras/MAPK pathway in Th2 cell differentiation. 10th International congress of in Immunology International Proceedings Division Co., Bologna, Italy. pp.589-593 (1998).
3. Kubo, M., Nakayama, T., and Tada, T.: Involvement of JAK-STAT signaling cascade in T cell subset-specific expression of IL-4 gene. 10th International congress of in Immunology International Proceedings Division Co., Bologna, Italy. pp.443-446 (1998).
4. Hachimura, S., Kaji, T., Asai, K., Ise, W., Nakayama, T., and Kaminogawa, S.: Hyperesponsiveness of CD4 T cells induced in oral tolerance is maintained by a selective impairment in the TCR-induced calcium/NFAT signaling pathway resulting from caspase activation. Ann. NY Acad. Sci. 1029:344-345 (2004).
5. Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., and Shinnakasu, R.: Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
6. Umetsu, D. T., Nakayama, T., Taniguchi, M., Kronenberg, M., DeKruyff, R. H., and Akbari, O.: NKT cells regulate the development of asthma. International Congress Series 1285:184-188 (2005).
7. Kimura, Y. M., Iwamura, C., Suzuki, A., Kitajima, M., Hosokawa, H., Hasegawa, A., Yamashita, M., and Nakayama, T.: Schnurri-2 controls the generation of memory Th1 and Th2 cells.13th International congress of Immunology pp.475-479 (2007).
8. Yamashita, M., and Nakayama, T.: Bmi1 regulates memory Th cell survival via repression of the Noxa gene. Proceedings of the 2nd European Congress of Immunology 157-159 (2009).