業 績

論 文

2018

  • Watanabe, K., Hirano, S., Kojima, K., Nagashima, K., Mukai, H., Sato, T., Takemoto, M., Matsumoto, K., Iimori, T., Isose, S., Omori, S., Shibuya, K., Sekiguchi, Y., Beppu, M., Amino, H., Suichi, T., Yokote, K., Uno, T., Kuwabara, S., and Misawa, S. : Altered cerebral blood flow in the anterior cingulate cortex is associated with neuropathic pain. J Neurol Neurosurg Psychiatry. (2018) in press.
  • Morimoto, Y., Hirahara, K., Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T. : Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete Osteopontin and facilitate airway fibrosis. Immunity. 49(1):134-150 (2018).
  • Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T. : The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells. J Leukoc Biol. (2018) in press.
  • Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T. : Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation. Inflamm Regen. 20;38:10 (2018) .
  • Misawa, S., Kuwabara, S., Sato, Y., Yamaguchi, N., Nagashima, K., Katayama, K., Sekiguchi, Y., Iwai, Y., Amino, H., Suichi, T., Yokota, T., Nishida, Y., Kanouchi, T., Kohara, N., Kawamoto, M., Ishii, J., Kuwahara, M., Suzuki, H., Hirata, K., Kokubun, N., Masuda, R., Kaneko, J., Yabe, I., Sasaki, H., Kaida, KI., Takazaki, H., Suzuki, N., Suzuki, S., Nodera, H., Matsui, N., Tsuji, S., Koike, H., Yamasaki, R., and Kusunoki, S., and Japanese Eculizumab Trial for GBS (JET-GBS) Study Group. : Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial. Lancet Neurol. 17(6):519-529 (2018).
  • Kuwabara, S., Misawa, S., Mori, M., Iwai, Y., Ochi, K., Suzuki, H., Nodera, H., Tamaoka, A., Iijima, M., Toda, T., Yoshikawa, H., Kanda, T., Sakamoto, K., Kusunoki, S., Sobue, G., Kaji, R., and Glovenin-I MMN Study Group. : Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi-center, open-label, 52-week phase 3 trial. J Peripher Nerv Syst. 23(2):115-119 (2018).
  • Ohwada, C., Sakaida, E., Kawajiri-Manako, C., Nagao, Y., Oshima-Hasegawa, N., Togasaki, E., Muto, T., Tsukamoto, S., Mitsukawa, S., Takeda, Y., Mimura, N., Takeuchi, M., Shimizu, N., Misawa, S., Iseki, T., Kuwabara, S., and Nakaseko, C. : Long-term evaluation of physical improvement and survival of autologous stem cell transplantation in POEMS syndrome. Blood. 10;131(19):2173-2176 (2018).
  • Ihara, F., Sakurai, D., Yonekura, S., Iinuma, T., Yagi, R., Sakurai, T., Ito, T., Matsuura, A., Morimoto, Y., Arai, T., Suzuki, S., Katayama, K., Nakayama, T., and Okamoto, Y. : Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Allergy. doi: 10.1111/all.13436 (2018).
  • Kuroda, M., Saito, Y., Aso, M., and Yokote, K. : A novel approach to the treatment of plasma protein deficiency: Ex vivo-manipulated adipocytes for sustained secretion of therapeutic proteins. Chem Pharm Bull. 66, 217-224 (2018).
  • Iinuma, T., Okamoto, Y., Morimoto, Y., Arai, T., Sakurai, T., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T. : Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy. 73(2):479-489 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H., and Motohashi, S. : Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors. Pediatr Surg Int. 34(2):169-176 (2018).
  • Hishiki, T., Mise, N., Harada, K., Ihara, F., Takami, M., Saito, T., Terui, K., Nakata, M., Komatsu, S., Yoshida, H., and Motohashi, S. : Invariant natural killer T infiltration in neuroblastoma with favorable outcome. Pediatr Surg Int. 34(2):195-201 (2018).
  • Kawashima, T., Ikari, N., Watanabe, Y., Kubota, Y., Motohashi, S., Shimojo, N., and Tsuji, N. M. : Double-stranded RNA derived from lactic acid bacteria augments Th1 immunity via interferon-β from human dendritic cells. Front. Immunol. 23;9:27 (2018).
  • Goschl, L., Preglej, T., Hamminger, P., Bonelli, M., Andersen, L., Boucherron, N., Gulich, A., Muller, L., Saferding, V., Mufazolov, AI., Hirahara, K., Seiser, C., Matthias, P., Penz, T., Schuster, M., Bock, C., Waisman, A., Steiner, G., and Ellmeier, W. : A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun. 86:51-61 (2018).

2017

  • Furuta, S., Sugiyama, T., Umibe, T., Kaneko, Y., Amano, K., Kurasawa, K., Nakagomi, D., Hiraguri, M., Hanaoka, H., Sato, Y., Ikeda, K., and Nakajima, H. : LoVAS Trial study investigators. Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open. 7(12):e018748 (2017).
  • Yamazaki, S., Suzuki, T., Suzuki, T., Takatsuka, H., Ishikawaa, M., Hattori, N., Fujishiro, T., Miyauchi, H., Oami, T., Ariyoshi, N., Oda, S., Matsubara, H., and Ishii, I. : An extremely high bioavailability of orally administered vancomycin in a patient with severe colitis and renal insufficiency. J Infect Chemother. 23(12): 848-851 (2017).
  • Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y. : Th2 cells in health and disease. Annu Rev Immunol. 35: 53-84 (2017).
  • Ito, T., Hirahara, K., Onodera, A., Koyama-Nasu, R., Yano, I., and Nakayama, T. : Anti-tumor immunity via the superoxide-eosinophil axis induced by lipophilic component of Mycobacterium lypomannan. Int Immunol. 29(9):411-421 (2017).
  • Nakagawa, T., Matsusaka, K., Misawa, K., Ota, S., Takane, K., Fukuyo, M., Rahmutulla, B., Shinohara, KI., Kunii, N., Sakurai, D., Hanazawa, T., Matsubara, H., Nakatani, Y., Okamoto, Y., and Kaneda, A. : Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. Cancer Lett. 18;407:21-31 (2017).
  • Kuwabara, S., Mori, M., Misawa, S., Suzuki, M., Nishiyama, K., Mutoh, T., Doi, S., Kokubun, N., Kamijo, M., Yoshikawa, H., Abe, K., Nishida, Y., Okada, K., Sekiguchi, K., Sakamoto, K., Kusunoki, S., Sobue, G., Kaji, R., and Glovenin-I CIDP Study Group. : Intravenous immunoglobulin for maintenance treatment of chronic inflammatory demyelinating polyneuropathy: a multicentre, open-label, 52-week phase III trial. J Neurol Neurosurg Psychiatry 88(10):832-838 (2017).
  • Kageyama, T., Suto, A., Iwamoto, T., Tanaka, S., Suehiro, K., Yokoyama, Y., Saku, A., Furuta, S., Ikeda, K., Suzuki, K., Hirose, K., and Nakajima, H. : IL-21 Exacerbates Autoimmune Myositis by Enhancing the Accumulation of GM-CSF–Producing γδ T Cells in the Muscle. ImmunoHorizons. 1(8):176-187 (2017).
  • Ihara, F., Sakurai, D., Horinaka, A., Fujisawa, A., Makita, Y., Sakurai, T., Yamasaki, K., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma. Cancer Immunol Immunother. 66(10):1275-85(2017).
  • Kuwabara, S., Mori, M., Misawa, S., Suzuki, M., Nishiyama, K., Mutoh, T., Doi, S., Kokubun, N., Kamijo, M., Yoshikawa, H., Abe, K., Nishida, Y., Okada, K., Sekiguchi, K., Sakamoto, K., Kusunoki, S., Sobue, G. and Kaji, R. and Glovenin-I CIDP Study Group. : Intravenous immunoglobulin for maintenance treatment of chronic inflammatory demyelinating polyneuropathy: a multicentre, open-label, 52-week phase III trial. J Neurol Neurosurg Psychiatry. 88(10):832-838(2017).
  • Onodera A, Kiuchi M, Kokubo K, Kato M, Ogino T, Horiuchi S, Kanai U, Hirahara K, Nakayama T. : Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. J Immunol. 1;199(3):1153-1162 (2017).
  • Omori, S., Isose, S., Misawa, S., Watanabe, K., Sekiguchi, Y., Shibuya, K., et al. : Pain-related evoked potentials after intraepidermal electrical stimulation to Adelta and C fibers in patients with neuropathic pain. Neurosci Res. 121:43-48 (2017).
  • Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S., and Nakayama, T.: Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol Rev. 278(1):87-100 (2017).
  • Ogasawara, S., Chiba, T., Ooka, Y., Kanogawa, N., Motoyama, T., Suzuki, E., Tawada, A., Nagai, K., Nakagawa, T., Sugawara, T., Hanaoka, H., Kanai, F., and Yokosuka, O. : A Randomized Placebo-Controlled Trial of Prophylactic Dexamethasone for Transcatheter Arterial Chemoembolization. Hepatology. doi: 10.1002/hep.29403 (2017).
  • Shinoda, K., Hirahara, K., and Nakayama, T. : Maintenance of pathogenic Th2 cells in allergic disorders. Allergol. Int. 66(3):369-376 (2017).
  • Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., and Nakayama, T. : Epigenetic regulation of T helper cell differentiation, memory and plasticity in allergic asthma. Immunol Rev. 278(1):8-19 (2017).
  • Mato, N., Hirahara, K., Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T. : Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Sci Rep. 28;7(1):6805 (2017).
  • Yokota, M., Tamachi, T., Yokoyama, Y., Maezawa, Y., Takatori, H., Suto, A., Suzuki, K., Hirose, K., Takeda, K., and Nakajima, H. : IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy. 72(7):1043-1053 (2017).
  • Hosokawa, J., Suzuki, K., Meguro, K., Tanaka, S., Maezawa, Y., Suto, A., Fujimura, L., Sakamoto, A., Clevers, H., Ohara, O., and Nakajima, H. : IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2. J Allergy Clin Immunol. 140(1):288-291.e8 (2017).
  • Yonekura, S., Okamoto, Y., Sakurai, D., Sakurai, T., Iinuma, T., Yamamoto, H., Hanazawa, T., Horiguchi, S., Kurono, Y., Honda, K., Majima, Y., Masuyama, K., Takeda, N., Fujieda, S., Okano, M., Ogino, S. and Okubo, K. : Complementary and alternative medicine for allergic rhinitis in Japan. Allergol Int. 66(3):425-431 (2017).
  • Sugibayashi, K. and Ishii, I. : Thorough Discussion! What Does IPE Bring to Pharmaceutical Education?. Yakugaku Zasshi. 137(7):845 (2017).
  • Okubo, M., Takahashi, Y., Yamashita, J., Takahashi, H., Miyata, O., Suzuki, T. and Ishii, I. : In Practical Training, a Questionnaire Survey and Analysis to Pharmacy Students of the Utilization Situation of the Course Contents of Pharmacy School. Yakugaku Zasshi. 1;137(6):745-755 (2017).
  • Iwata, S., Mikami, Y., Sun, HW., Brooks, RS., Jankovic, D., Hirahara, K., Onodera, A., Shih, HY., Kawabe, T., Jiang, K., Nakayama, T., Sher, A., O’Shea, JJ., Davis, FP. and Kanno, Y. : The transcription factor T-bet limits amplification of type l IFN transcriptome and circuitry in T helper 1 cells. Immunity. 46(6):983-991.e4 (2017).
  • Yokouchi, H., Baba, T., Misawa, S., Kitahashi, M., Oshitari, T., Kuwabara, S., et al. : Changes in subfoveal choroidal thickness and reduction of serum levels of vascular endothelial growth factor in patients with POEMS syndrome. Br J Ophthalmol. 101(6):786-790 (2017).
  • Nishi, T., Ariyoshi, N., Nakayama, T., Fujimoto, Y., Sugimoto, K., Wakabayashi, S., Hanaoka, H., and Kobayashi, Y. : Impact of chronic kidney disease on platelet inhibition of clopidogrel and prasugrel in Japanese patients. J Cardiol. 69(5):752-755 (2017).
  • Iwase, T., Yokouchi, H., Misawa, S., Oshitari, T., Baba, T., Kuwabara, S., and Yamamoto, S. : Reduction of Optic Disc Oedema by Bortezomib and Dexamethasone Followed by Autologous Peripheral Blood Stem Cell Transplantation in Patient with POEMS Syndrome. Neuroophthalmology. 19;42(1):25-30 (2017).
  • Matsuki, A., Takatori, H., Makita, S., Yokota, M., Tamachi, T., Suto, A., Suzuki, K., Hirose, K., and Nakajima, H. : T-bet inhibits innate lymphoid cell-mediated eosinophilic airway inflammation by suppressing IL-9 production. J Allergy Clin Immunol. 139(4):1355-1367 (2017).
  • Natori, T., Fujiyoshi, M., Uchida, M., Abe, N.,Kanaki, T., Fukumoto, Y. and Ishii, I. : Growth Arrest of Vascular Smooth Muscle Suspension Culture Using Low-Acyl Gellan Gum. In Vitro Cell Dev Biol Anim. 53(3):191-198 (2017).
  • Brück, J., Holstein, J., Glocova, I., Seidel, U., Geisel, J., Kanno, T., Kumagai, J., Mato, N., Sudowe, S., Widmaier, K., Sinnberg, T., Yazdi, AS., Eberle, FC., Hirahara, K., Nakayama, T., Röcken, M. and Ghoreschi, K. : Nutrional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation. Sci Rep. 2017 Mar 14;7:44482. doi: 10.1038/srep44482. (2017).
  • Watanabe, E., Yamazaki, S., Setoguchi, D., Sadahiro, T., Tateishi, Y., Suzuki, T., Ishii, I. and Oda, S. : Pharmacokinetics of Standard- and Reduced-Dose Recombinant Human Soluble Thrombomodulin in Patients with Septic Disseminated Intravascular Coagulation during Continuous Hemodiafiltration. Front Med (Lausanne). 21;4:15. 00015. eCollection (2017).
  • Muto, T., Ohwada, C., Takaishi, K., Isshiki, Y., Nagao, Y., Hasegawa, N., Kawajiri-Manako, C., Togasaki, E., Shimizu, R., Tsukamoto, S., Sakai, S., Takeda, Y., Mimura, N., Takeuchi, M., Sakaida, E., Misawa, S., Shimizu, N., Iseki, T., Kuwabara, S. and Nakaseko, C. : Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome. Biol Blood Marrow Transplant. 23(2):361-3 (2017).
  • Beppu, M., Sawai, S., Misawa, S., Mori, M., Ito S, Sogawa, K., et al. : Serum cytokine and chemokine profiles in patients with juvenile muscular atrophy of distal upper extremity (Hirayama disease). J Neuroimmunol. 302:20-2 (2017).

2016

  • Kamata, T., Suzuki, A., Mise, N., Ihara, F., Takami, T., Makita, Y., Horinaka, A., Harada, K., Kunii, K., Yoshida, S., Yoshino, I., Nakayama, T. and Motohashi, S. : Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells. Cancer Immunol Immunother. 65(12):1477-1489 (2016).
  • Hirahara, K., Schwartz, D., Gadina, M., Kanno, Y. and O’Shea, JJ. : Targeting cytokine signaling in autoimmunity: back to the future and beyond. Curr Opin Immunol. 43:89-97 (2016).
  • Yamaguchi, N., Misawa, S., Sato, Y., Nagashima, K., Katayama, K., Sekiguchi, Y., Iwai, Y., Amino, H., Suichi, T., Yokota, T., Nishida, Y., Kohara, N., Hirata, K., Nishiyama, K., Yabe, I., Kaida, KI., Suzuki, N., Nodera, H., Tsuji, S., Koike, H., Kira, JI., Hanaoka, H., Kusunoki, S., Kuwabara, S. and JET-GBS Group. : A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS). JMIR Res Protoc. 5(4):e210 (2016).
  • Nishi, T., Kitahara, H., Fujimoto, Y., Nakayama, T., Sugimoto, K., Nagashima, K., Hanaoka, H. and Kobayashi, Y. : Efficacy of intravenous nicorandil for fractional flow reserve assessment: study protocol for a crossover randomised trial. BMJ Open. 6(11):e012737 (2016).
  • Poudel, BK. and Ishii, I. Hospital pharmacy service in developing nations: The case of Nepal. 12(6):1038-39 (2016).
  • Tanino, A., Okura, T., Nagao, T., Kukida, M., Enomoto, D., Miyoshi, K., Higaki, J., Kuroda, M. and Bujo, H. : A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously. CEN Case Rep. 5, 1-5 (2016).
  • Nakayama, T., Endo, Y., Shinoda, K. and Hirahara, K. : Pathogenic Th cell subsets in chronic inflammatory diseases. Cornea. 35:S8 (2016).
  • Yamaguchi, N., Misawa, S., Sato, Y., Nagashima, K., Katayama, K., Sekiguchi, Y., et al. : A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barre Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS). JMIR Res Protoc. 5(4):e210 (2016).
  • Kanogawa, Y., Fujiyoshi, M., Nakazato, Y., Watanabe, K., Kurihara, M., Takezawa, A., Uchida, M., Igarashi, K., Suzuki, T., Ariyoshi, N. and Ishii, I. : Beta-migrating very low-density lipoprotein conjugates with acrolein in high-cholesterol diet-fed rabbits and localizes to atherosclerotic lesions with macrophages. Int J Clin Expe Path. 9(11):11149-58 (2016).
  • Misawa, S., Sato, Y., Katayama, K., Nagashima, K., Aoyagi, R., Sekiguchi, Y., Sobue, G., Koike, H., Yabe, I., Sasaki, H., Watanabe, O., Takashima, H., Nishizawa, M., Kawachi, I., Kusunoki, S., Mitsui, Y., Kikuchi, S., Nakashima, I., Ikeda, S., Kohara, N., Kanda, T., Kira, J., Hanaoka, H. and Kuwabara, S. : Japanese POEMS Syndrome for Thalidomide (J-POST) Trial Study Group. Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 15(11):1129-1137 (2016).
  • Misawa, S., Sato, Y., Katayama, K., Nagashima, K., Aoyagi, R., Sekiguchi, Y., et al. : Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 15(11):1129-37 (2016).
  • Hayashizaki, K., Kimura, MY., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, DJ., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y. and Nakayama, T. : Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci. Immunol. 1(3): pp.eaaf9154 (2016).
  • Sakurai, D., Yonekura, S., Iinuma, T., Sakurai, T., Morimoto, Y., Mita, Y., Arai, T., Suzuki, S., Okuma, Y., Kaneko, S. and Okamoto, Y. : Sublingual immunotherapy for allergic rhinitis: subjective versus objective tools to evaluate its success. Rhinology. 54(3):221-30 (2016).
  • Aoki, T., Hino, M., Koh, K., Kyushiki, M., Kishimoto, H., Arakawa, Y., Hanada, R., Kawashima, H., Kurihara, J., Shimojo, N. and Motohashi. : Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers. Pediatr. Blood Cancer. 63(8):1461-4 (2016).
  • Kosaka, K., Kubota, Y., Adachi, N., Akita, S., Sasahara, Y., Kira, T., Kuroda, M., Mitsukawa, N., Bujo, H., and Satoh K. : Human Adipocytes from the Subcutaneous Superficial Layer have Greater Adipogenic Potential and Lower PPAR-γ DNA Methylation Levels than Deep Layer Adipocytes. Am J Physiol Cell Physiol. 311, C322-329 (2016).
  • Okuma, Y., Okamoto, Y., Yonekura, S., Iinuma, T., Sakurai, T., Hamasaki, S., Ohki, Y., Yamamoto, H. and Sakurai, D. : Persistent nasal symptoms and mediator release after continuous pollen exposure in an environmental challenge chamber. Ann Allergy Asthma Immunol. 117(2):150-7 (2016).
  • Yokouchi, H., Baba, T., Misawa, S., Sawai, S., Kitahashi, M., Oshitari, T., et al. : Correlation between peripapillary retinal thickness and serum level of vascular endothelial growth factor in patients with POEMS syndrome. Br J Ophthalmol. 100(7):897-901 (2016).
  • Iwai, Y., Shibuya, K., Misawa, S., Sekiguchi, Y., Watanabe, K., Amino, H., et al. : Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis. PLoS One. 11(7):e0158596 (2016).
  • Poudel, BK. and Ishii I. : Assessment of physical premises of selected pharmacies of Nepal. SAGE Open Med. eCollection Res Social Adm Pharm. (2016).
  • Suzuki, T., Okamoto, Y., Yonekura, S., Okuma, Y., Sakurai, T. and Sakurai, D. : Characteristics of laryngeal symptoms induced in patients with allergic rhinitis in an environmental challenge chamber. Ann Allergy Asthma Immunol. 116(6):491-6 (2016).
  • Sekiguchi, Y., Mori, M., Misawa, S., Sawai, S., Yuki, N., Beppu, M., et al. : How often and when Fisher syndrome is overlapped by Guillain-Barre syndrome or Bickerstaff brainstem encephalitis?. Eur J Neurol. 23(6):1058-63 (2016).
  • Tanemura, N., Uyama, Y., Nagashima, K., Suzuki, T., Asahina, Y., Kobayashi, Y., Iyo, M., Yokote, Y. and Hanaoka, H. : Comparison of Drug Use Between Clinical Practice and Regulatory Approval: Results in Older Japanese Patients With Rheumatoid Arthritis, Diabetes, High Blood Pressure, or Depression. Ther Innov Regul Sci. 50(6): 743-750 (2016).
  • Yoshinaga, N., Matsuki, S., Niitsu, T., Sato, Y., Tanaka, M., Ibuki, H., Takanashi, R., Ohshiro, K., Ohshima, F., Asano, K., Kobori, O., Yoshimura, K., Hirano, Y., Sawaguchi, K., Koshizaka, M., Hanaoka, H., Nakagawa, A., Nakazato, M., Iyo, M. and Shimizu, E. : Cognitive Behavioral Therapy for Patients with Social Anxiety Disorder Who Remain Symptomatic following Antidepressant Treatment: A Randomized, Assessor-Blinded, Controlled Trial. Psychother Psychosom. 85(4):208-217 (2016).
  • 黒田正幸、武城英明、麻生雅是、齋藤康、横手幸太郎. 疾患治療用タンパク質分泌加工脂肪細胞の創薬開発と難病治療. 薬学雑誌-Symposium Review- 136; 705-709 (2016).
  • Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A., Sugaya, K., Tumes, DJ., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y. and Nakayama, T. : Thy1+IL-7+ lymphatic endthelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc Natl Acad Sci U S A. 113(20):E2842-E2851 (2016).
  • Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. and Nakayama, T. : Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 7:11289 (2016).
  • Hirahara, K. and Nakayama, T. : CD4+ T cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol. 28(4):163-71 (2016).
  • Eberle, FC., Bruck, J., Holstein, J., Hirahara, K. and Ghoreschi, K. : Recent advances in understanding prosiasis. F1000Res, 2016 Apr 28;5. Pii: F1000 Faculty Rev-770 (2016)
  • Bonelli, M., Goschl, L., Bluml, S., Karonitsch, T., Hirahara, K., Ferner, E., Steiner, CW., Steiner, G., Smolen, JS. and Scheinecker, C. : Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford). 55(4):710-20 (2016).
  • Muto, T., Ohwada, C., Sawai, S., Beppu, M., Tsukamoto, S., Takeda, Y., Mimura, N., Takeuchi, M., Sakaida, E., Sogawa, K., Misawa, S., Shimizu, N., Iseki, T., Nomura, F., Kuwabara, S. and Nakaseko, C. : Acutely deteriorated extravascular volume overload during peripheral blood stem cell mobilization in POEMS syndrome: A case series with cytokine analysis. Transfus Apher Sci. 54(2):276-81 (2016).
  • Araki, N., Misawa, S., Shibuya, K., Ota, S., Oide, T., Kawano, A., et al. : POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification. Orphanet J Rare Dis. 11:35 (2016).
  • Horinaka, A., Sakurai, D., Ihara, F., Makita, Y., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer. Cancer Sci. 107(3):207-16 (2016).
  • Mise, N., Takami, M., Suzuki, A., Kamata, T., Harada, K., Hishiki, T., Saito, T., Terui, K., Mitsunaga, T., Nakata, M., Ikeuchi, T., Nakayama, T., Yoshida, H. and Motohashi, S. : Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant NKT cells. Cancer Sci. 107(3):233-41 (2016).
  • Meguro, K., Nakagomi, D., Suzuki, K., Hosokawa, J., Fukuta, T., Yokota, M., Maezawa, Y., Suto, A. and Nakajima, H. SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production. J Invest Dermatol. 136:649-57 (2016).
  • Mitsuhashi, A., Sato, Y., Kiyokawa, T., Koshizaka, M., Hanaoka, H. and Shozu, M. Phase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer. Ann Oncol. 27(2):262-266 (2016).
  • Masuyama, K., Goto, M., Takeno, S., Ohta, N., Okano, M., Kamijo, A., Suzuki, M., Terada, T., Sakurai, D., Horiguchi, S., Honda, K., Matsune, S., Yamada, T., Sakashita, M., Yuta, A., Fuchiwaki, T., Miyanohara, I., Nakayama, T., Okamoto, Y. and Fujieda, S. : Guiding principles of sublingual immunotherapy for allergic rhinitis in Japanese patients. Auris Nasus Larynx. 43(1):1-9 (2016).
  • Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, WM., Sukumar, S., Haines, CJ., Sadekova, S., McClanahan, TK., McGeachy, MJ., O’Shea, JJ., Cua, DJ. Interleukin-23-Induced Transcription Factor Blimp-1 Promotes pathogenicity of T Helper 17 Cells. Immunity. 19;44(1):131-42 (2016).
  • Uchida, M., Suzuki, S., Suzuki, T. and Ishii, I. : p27(Kip1) and p21(Cip1)-independent proliferative inhibition of vascular smooth muscle cells cultured in type-I collagen matrix honeycombs. Microvasc Res. 103:36-40 (2016).

2015

  • Miasma, S., Sato, Y., Katayama, K., et al. : Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study. BMJ Open. 5(11):e009157 (2015).
  • Suto, A., Tanaka, S. and Nakajima, H. : Sox5 and Th17 cell differentiation. Oncotarget. 6(24):19952-3 (2015).
  • Hirahara, K., Onodera, A., Villario, AV., Bonelli, M., Sciumè, G., Laurence, A., Sun, HW., Brooks, RS., Vahedi, G., Shih, HY., Gutierrez-Cruz, G., Iwata, S., Suzuki, R., Miami, Y., Okamoto, Y., Wakayama, T., Holland, S., Hunter, CA., Kanno, Y. and O’Shea, JJ. : Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity. 42(5):877-89 (2015).
  • Frigault, M. J., Lee, J., Basil, M., Carpenito, C., Motohashi, S., Scholler, J., Kawalekar, O. U., Guedan, S., McGettigan, S., Posey, A Jr., Ang, S., Cooper, L. J., Platt, J., Johnson, F. B., Paulos, C. M., Zhao, Y., Kalos, M., Milone, M. and June, C. H. : Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Cancer Immunol Res. 3(4):356-367 (2015).
  • Ishii, I. and Uchida, M. : Three-Dimensional “Honeycomb” Culture System that Helps to Maintain the Contractile Phenotype of Vascular Smooth Muscle Cells. Muscle Cell and Tissue", book edited by Kunihiro Sakuma, ISBN 978-953-51-2156-5 (2015).
  • Matsumoto, J., Ariyoshi, N., Sakakibara, M., Nakanishi, T., Okubo, Y., Shiina, N., Fujisaki, K., Nagashima, T., Nakanishi, Y., Tamai, I., Yamada, H., Takeda, H. and Ishii, I. : Organic anion transporting polypeptide 2B1 expression vcorrelates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells. Drug Metab Pharmacokinet. 30(2):133-41 (2015).
  • Horinaka, A., Sakurai, D., Ihara, F., Makita, Y., Kunii, N., Motohashi, S., Nakayama, T. and Okamoto, Y. : Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer. Cancer Sci. 107(3):207-16 (2015).
  • Katayama, K., Misawa, S., Sato, Y., et al. : Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial. BMJ Open. 5(1):e007330 (2015).

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