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論文発表

          2021（21） 2020（12）
2019(3) 2018(9) 2017(10) 2016(3) 2015(10) 2014(4) 2013(1)
2012(2) 2011(5) 2010(2) 2009(10) 2008(4) 2007(4) 2006(10)
2005(3) 2004(8) 2003(6) 2002(6) 2001(7) 2000(5) 1999(10)

2021年

  1. Hiroshima K, Wu D, Hamakawa S, Tsuruoka S, Ozaki D, Orikasa H, Hasegawa M, Koh E, Sekine Y, Yonemori Y, Nabeshima K, Tsuji S, Miyagi Y, Imai K. HEG1, BAP1, and MTAP are useful in cytologic diagnosis of malignant mesothelioma with effusion. Diagn Cytopathol 2021;49:622-632.      
  2. Hiroshima K, Wu D, Koh E, Sekine Y, Ozaki D, Yusa T, Nakazawa T, Tsuji S, Miyagi Y, Walts AE, Marchevsky AM, Husain AN, Imai K. Membranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas. Pathol Int 2021;71:604-613.                                          
  3. Klebe S, Nakatani Y, Dobra K, Butnor KJ, Roden AC, Nicholson AG, Marchevsky AM, Husain AN, Segal A, Walts AE, Weynand B, Michael CW, Dacic S, Godbolt D, Attanoos R, Santoni-Rugiu E, Galateau-Salle F, Hiroshima K, Moreira AL, Burn J, Nabeshima K, Gibbs AR, Churg A, Litzky LA, Brcic L, Tsao MS, Mino-Kenudson M, Rorvig SB, Tazelaar HD, Krausz T, Zhang YZ, Chirieac LR, Beasley MB, Hjerpe A. The concept of mesothelioma in situ, with consideration of its potential impact on cytology diagnosis. Pathology 2021;53:446-453.                                  
  4. Schulte JJ, Chapel DB, Attanoos R, Brcic L, Burn J, Butnor KJ, Chang N, Chen H, Dacic S, De Perrot M, Fukuoka J, Galateau-Salle F, Godschachner T, Hiroshima K, Klebe S, Krausz T, Litzky L, Marchevsky AM, Mueller J, Nabeshima K, Nicholson AG, Pal P, Roden AC, Rorvig S, Santoni-Rugiu E, Tazelaar H, Tsao MS, Walts AE, Weynand B, Zaizen Y, Zhang YZ, Husain AN. Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis. Am J Clin Pathol 2021;156:989-999.
  5. Chapel DB, Schulte JJ, Absenger G, Attanoos R, Brcic L, Butnor KJ, Chirieac L, Churg A, Galateau-Salle F, Hiroshima K, Hung YP, Kindler H, Krausz T, Marchevsky A, Mino-Kenudson M, Mueller J, Nabeshima K, Turaga K, Walts AE, Husain AN. Malignant peritoneal mesothelioma: prognostic significance of clinical and pathologic parameters and validation of a nuclear-grading system in a multi-institutional series of 225 cases. Mod Pathol 2021;34:380-395.
  6. Nguyễn TTT, Shingyoji M, Hanazono M, Zhong B, Morinaga T, Tada Y, Shimada H, Hiroshima K, Tagawa M. An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression. Cell Death Dis 2021;12:663.                                                                  
  7. Ota M, Nakatani Y, Nakajima T, Hiroshima K, Motoi N, Yoshino I, Ikeda JI. Pulmonary microinvasive small cell carcinoma with an extensive in-situ component identified after photodynamic therapy for 'squamous cell carcinoma in situ': a case report. Histopathology 2021;78:912-916.                                                                            
  8. Misono S, Mizuno K, Suetsugu T, Tanigawa K, Nohata N, Uchida A, Sanada H, Okada R, Moriya S, Inoue H, Seki N. Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target. Cancers (Basel). 2021;13:1187.                         
  9. Potluri S, Assi AS, Chin SP, Coleman JD, Pickin A, Moriya S, Seki N, Heidenreich O, Cockerill NP, Bonifer C. Isoform-Specific and Signaling-Dependent Propagation of Acute Myeloid Leukemia by Wilms Tumor 1. Cell Reports. 2021;35:109010.                                                     
  10. Oshima S, Asai S, Seki N, Minemura C, Kinoshita T, Goto Y, Kikkawa N, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K. Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2021;22:6199.         
  11. Hozaka Y, Seki N, Tanaka T, Asai S, Moriya S, Idichi T, Wada M, Tanoue K, Kawasaki Y, Mataki Y, Kurahara H, Ohtsuka T. Molecular Pathogenesis and Regulation of the miR-29-3p-Family: Involvement of ITGA6 and ITGB1 in Intra-Hepatic Cholangiocarcinoma. Cancers (Basel). 2021;13:2804.
  12. Hozaka Y, Kita Y, Yasudome R, Tanaka T, Wada M, Idichi T, Tanabe K, Asai S, Moriya S, Toda H, Mori S, Kurahara H, Ohtsuka T, Seki N. RNA-Sequencing Based microRNA Expression Signature of Colorectal Cancer: The Impact of Oncogenic Targets Regulated by miR-490-3p. Int J Mol Sci. 2021;22:9876.                                                                                 
  13. Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2021;22:9947.                                       
  14. Mizuno K, Tanigawa K, Misono S, Suetsugu T, Sanada H, Uchida A, Kawano M, Machida K, Asai S, Moriya S, Inoue H, Seki N. Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma. Biomedicines. 2021;9:1883.              
  15. Matsunaga W, Hamada K, Tagawa M, Morinaga T, Gotoh A. Cancer cell-specific transfection of hCas9 gene using Ad5F35 vector. Anticancer Res 2021;41:3731-3740.  
  16. Hiwasa T, Wang H, Goto K, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kunimatsu M, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Muto M, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Hattori A, Yamamoto M, Maezawa Y, Kobayashi K, Ishibashi R, Takemoto M, Yokote K, Takizawa H, Kishimoto T, Matsushita K, Kobayashi S, Nomura F, Arasawa T, Kagaya A, Maruyama T, Matsubara H, Tomiita M, Hamanaka S, Imai Y, Nakagawa T, Kato N, Terada J, Matsumura T, Katsumata Y, Naito A, Tanabe N, Sakao S, Tatsumi K, Ito M, Shiratori F, Sumazaki M, Yajima S, Shimada H, Shirouzu M, Yokoyama S, Kudo T, Doi H, Iwase K, Ashino H, Li SY, Kubota M, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y. Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC Medicine. 2021; 19:131. doi: 10.1186/s12916-021-02001-9. 
  17. Li SY, Yoshida Y, Kobayashi E, Kubota M, Matsutani T, Mine S, Machida T, Maezawa Y, Takemoto M, Yokote K, Kobayashi Y, Takizawa H, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kobayashi S, Matsushita K, Nomura F, Matsubara H, Sumazaki M, Ito M, Yajima S, Shimada H, Iwase K, Ashino H, Wang H, Goto K, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y, Hiwasa T. Serum anti‑AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis. Scientific Reports. 2021; 11:13450  doi: 10.1038/s41598-021-92786-9.
  18. Wang H, Lu H, Zhang XM, Goto K, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Iwadate Y, Mine S, Machida T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kamitsukasa I, Wada T, Aotsuka A, Sugimoto K, Takizawa H, Kashiwado K, Shin H, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Xu A, Hiwasa T. Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction. BMC Neurol. 2021; 21(1): 274.         
  19. 廣島健三. 胸膜中皮腫の診断.  呼吸器内科  2021;40:475-481.               
  20. 山口雅利, 福田祐樹, 鹿島田寛明, 杉山亜斗, 青木耕平, 羽藤泰, 儀賀理暁, 河野光智, 中山光男, 山崎真美, 廣島健三. 腫瘍の大部分を骨組織が占める原発性肺腺癌の1例.  肺癌  2022;62:65-66.                                                                                          
  21. 濱田賢一, 江口圭介, 枝浪元紀, 菊池勇次, 猪股研太, 別宮絵美真, 小野滋司, 浅原史卓, 瀧川穣, 和田徳昭, 長谷川博俊, 松井淳一, 大金覚, 野村武史, 佐々木文, 河合繁夫, 廣島健三：  両側肺転移をきたした軟口蓋多形腺腫の1手術例.  肺癌  2022;62:67-68.                                                                       

2020年

  1. Katsumata Y, Terada J, Matsumura T, Koshikawa K, Sakao S, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Nagashima K, Kobayashi Y, Kobayashi E, Iwadate Y, Zhang XM, Hiwasa T, Tatsumi K. Circulating anti-sorting nexins 16 antibodies as an emerging biomarker of coronary artery disease in patients with obstructive sleep apnea. Diagnostics (Basel). 2020; 10(2): 71. doi: 10.3390/diagnostics10020071. PMID: 32012743.
  2. Li, SY, Yoshida Y, Kobayashi E, Adachi A, Hirono S, Matsutani T, Mine S, Machida T, Ohno M, Nishi E, Maezawa Y, Takemoto M, Yokote K, Kitamura K, Sumazaki M, Ito M, Shimada H, Takizawa H, Kashiwado K, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Zhang XM, Wang H, Goto K, Iwadate Y, Hiwasa T. Association between serum anti‑ASXL2 antibody levels and acute ischemic stroke, acute myocardial infarction, diabetes mellitus, chronic kidney disease and digestive organ cancer, and their possible association with atherosclerosis and hypertension. Int J Mol Med. 2020; 46: 1274-1288. DOI: 10.3892/ijmm.2020.4690. PMID: 32945427.
  3. Yoshida Y, Zhang XM, Wang H, Machida T, Mine S, Kobayashi E, Adachi A, Matsutani T, Kamitsukasa I, Wada T, Aotsuka A, Iwase K, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Shin H, Akaogi Y, Shimada J, Nishi E, Ohno M, Takemoto M, Yokote K, Kitamura K, Iwadate Y, Hiwasa T. Elevated levels of autoantibodies against DNAJC2 in sera of patients with atherosclerotic diseases. Heliyon. 2020; 6(8): e04661. doi.org/10.1016/j.heliyon.2020.e04661 PMID: 32904265.
  4. Sumazaki M, Shimada H, Ito M, Shiratori F, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Iwadate Y, Mine S, Machida T, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Maezawa Y, Takemoto M, Yokote K, Takizawa H, Kashiwado K, Shin H, Kishimoto T, Matsushita K, Kobayashi S, Nakamura R, Shinmen N, Kuroda H, Zhang XM, Wang H, Goto KI, Hiwasa T. Serum anti-LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases. Cancer Sci. 2020;　111:　4453-4464. doi: 10.1111/cas.14652. PMID: 32939876.
  5. Zhong B, Shingyoji M, Hanazono M, Nguyễn T T T, Morinaga T, Tada Y, Hiroshima K, Shimada  H, and Tagawa M.: Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype. Apoptosis 25: 535-547, 2020 doi: 10.1007/s10495-020-01612-6. PMID: 32468177.                             
  6. Tada Y, Tagawa M, Yusa T, Yatomi M, Shimomura I, Suzuki T, Takeshita Y, Sato T, Shimada H, Hiroshima K.: Diffuse pleural thickening and thoracic contraction: An indistinguishable case from malignant pleural mesothelioma. SAGE Open Med. Case Rep. 8: 1-6, 2020 doi: 10.1177/2050313X20948716. PMID: 32922794;PMCID: PMC7446552.                 
  7. Hiroshima K, Yoshizawa A, Takenaka A, Haba R, Kawahara K, Minami Y, Kakinuma H, Shibuki Y, Miyake S, Kajio K, Miyamoto K, Nagatomo M, Nishimura S, Mano M, Matsubayashi J, Motoi N, Nagao T, Nakatsuka SI, Yoshida T, Satoh Y. Cytology Reporting System for Lung Cancer from the Japan Lung Cancer Society and Japanese Society of Clinical Cytology: An Interobserver Reproducibility Study and Risk of Malignancy Evaluation on Cytology Specimens. Acta Cytol. 2020;64(5):452-462. doi: 10.1159/000506431. PMID: 32222718.
  8. Ota M, Nakatani Y, Nakajima T, Hiroshima K, Motoi N, Yoshino I, Ikeda JI. Pulmonary microinvasive small cell carcinoma with an extensive in-situ component identified after photodynamic therapy for 'squamous cell carcinoma in situ': a case report. Histopathology. 2020 Nov 30. doi: 10.1111/his.14308. Online ahead of print. PMID: 33253420.
  9. Karpathiou G, Hiroshima K, Peoc'h M. Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description. Adv Anat Pathol. 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378.                                                    
  10. Galateau Salle F, Le Stang N, Tirode F, Courtiol P, Nicholson AG, Tsao MS, Tazelaar HD, Churg A, Dacic S, Roggli V, Pissaloux D, Maussion C, Moarii M, Beasley MB, Begueret H, Chapel DB, Copin MC, Gibbs AR, Klebe S, Lantuejoul S, Nabeshima K, Vignaud JM, Attanoos R, Brcic L, Capron F, Chirieac LR, Damiola F, Sequeiros R, Cazes A, Damotte D, Foulet A, Giusiano-Courcambeck S, Hiroshima K, Hofman V, Husain AN, Kerr K, Marchevsky A, Paindavoine S, Picquenot JM, Rouquette I, Sagan C, Sauter J, Thivolet F, Brevet M, Rouvier P, Travis WD, Planchard G, Weynand B, Clozel T, Wainrib G, Fernandez-Cuesta L, Pairon JC, Rusch V, Girard N. Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center. J Thorac Oncol. 2020 Jun;15(6):1037-1053. doi: 10.1016/j.jtho.2020.01.025. PMID: 32165206.
  11. Nicholson AG, Sauter JL, Nowak AK, Kindler HL, Gill RR, Remy-Jardin M, Armato SG 3rd, Fernandez-Cuesta L, Bueno R, Alcala N, Foll M, Pass H, Attanoos R, Baas P, Beasley MB, Brcic L, Butnor KJ, Chirieac LR, Churg A, Courtiol P, Dacic S, De Perrot M, Frauenfelder T, Gibbs A, Hirsch FR, Hiroshima K, Husain A, Klebe S, Lantuejoul S, Moreira A, Opitz I, Perol M, Roden A, Roggli V, Scherpereel A, Tirode F, Tazelaar H, Travis WD, Tsao MS, van Schil P, Vignaud JM, Weynand B, Lang-Lazdunski L, Cree I, Rusch VW, Girard N, Galateau-Salle F. EURACAN/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach. J Thorac Oncol. 2020 Jan;15(1):29-49. doi: 10.1016/j.jtho.2019.08.2506. PMID: 31546041.
  12. Chapel DB, Schulte JJ, Berg K, Churg A, Dacic S, Fitzpatrick C, Galateau-Salle F, Hiroshima K, Krausz T, Le Stang N, McGregor S, Nabeshima K, Husain AN. MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma. Mod Pathol. 2020 Feb;33(2):245-254. doi: 10.1038/s41379-019-0310-0. PMID: 31231127.                                                                  

2019年

  1. Naito A, Hiwasa T, Tanabe N, Jujo-Sanada T, Sugiura T, Shigeta A, Terada J, Takizawa H, Kashiwado K, Sakao S, Tatsumi K (2019) Elevated levels of autoantibodies against EXD2 and PHAX in the sera of patients with chronic thromboembolic pulmonary hypertension. PLoS One 14(2):e0211377. doi: 10.1371/journal.pone.0211377. PMID: 30759165.
  2. Taira A, Arita E, Matsumoto E, Oohira A, Iwase K, Hiwasa T, Yokote K, Shibata S, Takiguchi M (2019) Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver. Chronobiol Int 1-25. doi: 10.1080/07420528.2019.1570246. PMID: 30714432.
  3. Misono S, Seki N, Mizuno K, Yamada Y, Uchida A, Sanada H, Moriya S, Kikkawa N, Kumamoto T, Suetsugu T, Inoue H. Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma. Cancers (Basel). 2019 Apr 30;11(5):601. doi: 10.3390/cancers11050601. PMID: 31052206; PMCID: PMC6562801.
  4. Kobayashi S, Hiwasa T, Ishige T, Rahmutulla B, Kano M, Hoshino T, Minamoto T, Shimada H, Nomura F, Matsubara H, Matsushita K. Anti-FIRΔexon2, a splicing variant form of PUF60, autoantibody is detected in the sera of esophageal squamous cell carcinoma. Cancer Sci. 2019 Jun;110(6):2004-2013. doi: 10.1111/cas.14024. Epub 2019 May 20. PMID: 30980774; PMCID: PMC6549911.
  5. Sugimoto K, Mori M, Liu J, Tanaka S, Kaneko K, Oji S, Takahashi T, Uzawa A, Uchida T, Masuda H, Ohtani R, Nomura K, Hiwasa T, Kuwabara S. The accuracy of flow cytometric cell-based assay to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies determining the optimal method for positivity judgement. J Neuroimmunol. 2019 Nov 15;336:577021. doi: 10.1016/j.jneuroim.2019.577021. Epub 2019 Aug 21. PMID: 31473520.
  6. Sanada H, Seki N, Mizuno K, Misono S, Uchida A, Yamada Y, Moriya S, Kikkawa N, Machida K, Kumamoto T, Suetsugu T, Inoue H. Involvement of Dual Strands of miR-143 (miR-143-5p and miR-143-3p) and Their Target Oncogenes in the Molecular Pathogenesis of Lung Adenocarcinoma. Int J Mol Sci. 2019 Sep 11;20(18):4482. doi: 10.3390/ijms20184482. PMID: 31514295; PMCID: PMC6770575.
  7. Okada R, Koshizuka K, Yamada Y, Moriya S, Kikkawa N, Kinoshita T, Hanazawa T, Seki N. Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma. Cells. 2019 Nov 28;8(12):1535. doi: 10.3390/cells8121535. PMID: 31795200; PMCID: PMC6953126.
  8. Zhong B, Shingyoji M, Hanazono M, Nguyễn TTT, Morinaga T, Tada Y, Hiroshima K, Shimada H, Tagawa M. A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway. Am J Cancer Res. 2019 Jan 1;9(1):79-93. PMID: 30755813; PMCID: PMC6356922.
  9. Qin Y, Sekine I, Hanazono M, Morinaga T, Fan M, Takiguchi Y, Tada Y, Shingyoji M, Yamaguchi N, Tagawa M. AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression. Mol Oncol. 2019 Jun;13(6):1419-1432. doi: 10.1002/1878-0261.12496. Epub 2019 May 15. PMID: 31033201; PMCID: PMC6547620.
  10. Hong R, Lai N, Xiong E, Ouchida R, Sun J, Zhou Y, Tang Y, Hikida M, Tsubata T, Tagawa M, Wang Y, Wang JY. Distinct roles of BCNP1 in B-cell development and activation. Int Immunol. 2020 Jan 9;32(1):17-26. doi: 10.1093/intimm/dxz055. PMID: 31412363.
  11. Arimura K, Sekine Y, Hiroshima K, Shimizu S, Shibata N, Kondo M, Takeyama K, Tagaya E. PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma. BMC Pulm Med. 2019 Sep 3;19(1):169. doi: 10.1186/s12890-019-0913-8. PMID: 31481045; PMCID: PMC6724334.
  12. Kawai T, Ogata S, Nakashima H, Urabe S, Murakami I, Hiroshima K. Clinicopathologic study of deciduoid mesothelioma using SMARCB1/INI1 immunohistochemistry and fluorescence in situ hybridization. Hum Pathol. 2019 Nov;93:23-29. doi: 10.1016/j.humpath.2019.08.016. Epub 2019 Aug 22. PMID: 31445842.
  13. Haruta S, Gunji K, Kawamura T, Hiroshima K. Generalized Vascular Dissection on Pathological Examination in a Patient With Polycystic Kidney Disease and Acute Aortic Dissection. J Natl Med Assoc. 2019 Oct;111(5):563-568. doi: 10.1016/j.jnma.2019.04.008. Epub 2019 May 27. PMID: 31147097.
  14. Hamasaki M, Kinoshita Y, Yoshimura M, Matsumoto S, Kamei T, Hiroshima K, Sato A, Tsujimura T, Kawahara K, Nabeshima K. Cytoplasmic MTAP expression loss detected by immunohistochemistry correlates with 9p21 homozygous deletion detected by FISH in pleural effusion cytology of mesothelioma. Histopathology. 2019 Jul;75(1):153-155. doi: 10.1111/his.13872. Epub 2019 Jun 10. PMID: 30957899.
  15. Chapel DB, Churg A, Santoni-Rugiu E, Tsujimura T, Hiroshima K, Husain AN. Molecular pathways and diagnosis in malignant mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group. Lung Cancer. 2019 Jan;127:69-75. doi: 10.1016/j.lungcan.2018.11.032. Epub 2018 Nov 26. PMID: 30642555.

2018年

  1. 日和佐隆樹（2018）動脈硬化症の血清抗体マーカーの開発．iｎ ｓｉｌｉｃｏ創薬におけるスクリーニングの高速化・高精度化技術．(株)技術情報協会．483-491頁.
  2. Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Takizawa H, Kashiwado K, Kamitsukasa I, Shin H, Wada T, Aotsuka A, Nishi E, Ohno M, Takemoto M, Yokote K, Takahashi S, Zhang XM, Takiguchi M, Iwadate Y (2018) Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack. Oncotarget 9(10): 8836-8848. doi.org/10.18632/oncotarget.23653.
  3. Wang H, Zhang XM, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kimura R, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Yoshida Y, Kobayashi E, Matsutani M, Iwadate Y, Sugimoto K, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Machida T, Takizawa H, Kashiwado K, Shimada H, Ito M, Goto K, Iwase K, Ashino H, Taira A, Arita E, Takiguchi M, Hiwasa T (2018) Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. Oncotarget 9: 5600-5613. doi.org/10.18632/oncotarget.23789.
  4. Kobayashi S, Hiwasa T, Arasawa T, Kagaya A, Ishii S, Shimada H, Ito M, Suzuki M, Kano M, Rahmutulla B, Kitamura K, Sawabe Y, Shin H, Takiguchi M, Nomura F, Matsubara H, Matsushita K (2018) Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library. Oncotarge 9(26): 18559-18569. doi: 10.18632/oncotarget.24963. PMID: 29719626.
  5. Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Tsushima K, Sakao S, Nagashima K, Iwata Y, Ozaki T, Nagase H, Tatsumi K, Hiwasa T, Kobayashi Y (2018) Autoantibody against NBL1 in obstructive sleep apnea patients with cardiovascular disease. PLoS ONE 13(3): e0195015. doi: 10.1371/journal.pone.0195015. PMID: 29596467.
  6. Yoshioka M, Matsutani T, Hara A, Hirono S, Hiwasa T, Takiguchi M, Iwadate Y (2018) Real-time methylation-specific PCR for the evaluation of methylation status of MGMT gene in glioblastoma. Oncotarget 9(45): 27728-27735. doi: 10.18632/oncotarget.25543. PMID: 29963232.
  7. Hamanaka S, Nakagawa T, Hiwasa T, Ohta Y, Kasamatsu S, Ishigami H, Taida T, Okimoto K, Saito K, Maruoka D, Matsumura T, Takizawa H, Kashiwado K, Kobayashi S, Matsushita K, Matsubara H, Katsuno T, Arai M, Kato N (2018) Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis. J Gastroenterol Hepatol, doi: 10.1111/ jgh. 14297. PMID:29869393.
  8. Yoshida Y, Hiwasa T, Machida T, Kobayashi E, Mine S, Matsushima J, Takiguchi M, Iwadate Y (2018) Elevation of autoantibody in patients with ischemic stroke. Neurol Med Chir (Tokyo) 58(7): 303-310. doi: 10.2176/nmc.ra.2018-0022. PMID: 29848906.
  9. Sugimoto K, Hiwasa T,Shibuya K, Hirano S, Beppu M, Isose S, Arai K, Takiguchi M, Kuwabara S, Mori M (2018) Novel autoantibodies against the proteasome submit PMSA7 amyotrophic lateral sclerosis. J Neuroimmunol 325:54-60. PMID: 30390597.

2017年

  1. Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Ema R, Amata A, Sakao S, Nagashima K, Tatsumi K, Hiwasa T (2017) Circulating anti-coatomer protein complex subunit epsilon (COPE) autoantibodies as a potential biomarker for cardio- and cerebro-vascular events in patients with obstructive sleep apnea. J Clin Sleep Med 13(3): 393-400. doi: 10.5664/jcsm.6488.
  2. Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N (2017) The pluripotent stem-cell marker alkaline phosphatase is highly expressed in refractory glioblastoma with DNA hypomethylation. Neurosurgery 80(2): 248-256. doi: 10.1093/neuros/nyw026.
  3. Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H, Kudo T, Doi H, Mine S, Machida T, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Iwata Y, Harada J, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kitamura K, Takizawa H, Kashiwado K, Shimada H, Ito M, Goto K, Zhang XM, Kimura R, Wang H, Taira A, Arita E, Ashino H, Iwase K, Hiwasa T (2017) An anti-deoxyhypusine synthase antibody as a marker of atherosclerosis-related cerebral infarction, myocardial infarction, diabetes mellitus, and chronic kidney disease. SM Atheroscler J 1(1): 1001. doi: http://smjournals.com/atherosclerosis/in-press.php#x
  4. Hiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine S, Machida T, Sato E, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Kitamura K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Sunami K, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ito M, Shimada H, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Goto K, Kudo T, Doi H (2017) Serum SH3BP5-specific antibody level is a biomarker of atherosclerosis. Immunome Res 13(2), 132. doi: 10.4172/17457580.1000132
  5. Chen PM, Ohno M, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka M, Kita T, Kimura T, Nishi E (2017) Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome. Int J Cardiol 243: 1-8.  doi.org/10.1016/j.ijcard.2017.04.047. PMID: 28747015
  6. 芦野洋美、向井克之、中島宏、横浜康継 (2017) 緑藻ヒトエグサ及びミル由来脂溶性成分による鶏胚漿尿膜上血管新生の抑制. 調査研究ジャーナル, 6(1), 21-28.
  7. 日和佐隆樹（2017）動脈硬化関連疾患の血清抗体マーカー．動脈・静脈の疾患（上）．日本臨床，75巻，増刊号4，281-284頁.
  8. Sugimoto K, Tomiyoshi G, Mori M, Kuwabara S, Hirano S, Sawai S, Beppu M, Muto M, Uzawa A, Kitamura K, Takemoto M, Hattori A, Yamamoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Mine S, Machida T, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Kobayashi Y, Nakamura R, Shinmen N, Kuroda H, Wang H, Zhang XM, Hiwasa T (2017) Identification of serum anti-GADD34 antibody as a common marker of diabetes mellitus and Parkinson disease. J Alzheim Dis Parkins 7: 358. doi: 10.4172/2161-0460.1000358.
  9. Zhang XM, Wang H, Mine S, Takemoto M, Yokote K, Kitamura K, Kobayashi Y, Machida T, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Hiwasa T (2017) Association of serum anti-prolylcarboxypeptidase antibody marker with atherosclerotic diseases accompanied by hypertension. J Mol Biomark Diagn 8: 361. doi: 10.4172/2155-9929.1000361
  10. Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S (2017) Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors. Oncotarget 8(63): 106206-106221. PMID: 29290942. doi: 10.18632/oncotarget.22175.

2016年

  1. Kano M, Matsushita K, Rahmutulla B, Yamada S, Shimada H, Kubo S, Hiwasa T, Matsubara H, Nomura F (2015) Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams. Gene Ther 23(1): 50-56 .
  2. Hiwasa T, Zhang XM, Kimura R, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kamitsukasa I, Wada T, Aotsuka S, Mine S, Takizawa H, Kashiwado K, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2016) Elevated adiponectin antibody levels in sera of patients with atherosclerosis-related coronary artery disease, cerebral infarction, and diabetes mellitus. J Circ Biomark 5: 8.
  3. Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K (2016) Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients. Oncotarget 7(50): 82493-82503. doi: 10.18632/oncotarget.12696.

2015年

  1. Machida T, Kubota M, Kobayashi E, Iwadate Y, Saeki N, Yamaura A, Nomura F, Takiguchi M, Hiwasa T (2015) Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). J Translat Med 13: 71.
  2. Goto K, Sugiyama T, Matsumura R, Zhang XM, Kimura R, Taira A, Arita E, Iwase K, Kobayashi E, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Kuwabara S, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chin H, Nishi E, Machida T, Iwata Y, Mine S, Kamitsukasa I, Wada T, Aotsuka A, Katayama K, Kikkawa Y, Sunami K, Takizawa H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H, Hiwasa T(2015) Identification of cerebral infarction-specific antibody markers from autoantibodies detected in patients with systemic lupus erythematosus. J Mol Biomark Diagnos 6: 2.
  3. Shimada H, Ito M, Kagaya A, Shiratori T, Kuboshima M, Suzuki M, Liu TL, Nabeya Y, Matsubara H, Matsushita K, Nomura F, Takiguchi M, Hiwasa T(2015) Elevated serum antibody levels against cyclin L2 in patients with esophageal squamous cell carcinoma. J Cancer Sci Ther 7(2): 60-66.
  4. Kuroiwa N, Iwase K, Morii S, Takiguchi M, Hiwasa T(2015) Up-regulation of growth-inhibitory or tumor suppressive genes by overexpression of C/EBPα or C/EBPβ in ras-transformed NIH3T3 cells. Integr Mol Med 2(2): 150-157.
  5. Muto M, Mori M, Hiwasa T, Takiguchi M, Iwadate Y, Uzawa A, Uchida T, Masuda H, Sugimoto K, Kuwabara S (2015) Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies. J Neuroimmunol 284: 30-36.
  6. Hiwasa T, Iwase K, Suichi T, Hino Y, Kimura R, Shinmen N, Takiguchi M (2015) Identification of the p53-responsive element in the promoter region of the human decorin gene. Mol Biol 4: 1.
  7. Hiwasa T, Zhang XM, Kimura R, Machida T, Kitamura K, Yamazoe R, Kunimatsu M, Mine S, Kobayashi E, Iwadate Y, Saeki N, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Ohno M, Chen PM, Nishi E, Yokota M, Kamitsukasa I, Wada T, Aotsuka A, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Goto K, Matsumura R, Sugiyama T, Takizawa H, Shimada H, Ito M, Wang H, Taira A, Arita E, Iwase K, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2015) Association of serum antibody levels against TUBB2C with diabetes and cerebral infarction. Gratis J Biomed Sci 1(2): 49-63.
  8. Hiwasa T, Machida T, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Mine S, Ohno M, Chen PM, Nishi E, Kitamura K, Yamazoe R, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Kobayashi E, Matsutani T, Iwadate Y, Saeki N, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Nakayama T, Harada J, Kobayashi Y, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Sakurai K, Fujimoto M, Yokote K, Goto K, Matsumura R, Sugiyama T, Hayashi H, Hasegawa R, Shimada H, Ito M, Kudo T, Doi H, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H (2015) Elevated levels of autoantibodies against ATP2B4 and BMP-1 in sera of patients with atherosclerosis-related diseases. Immunome Res 11: 097.
  9. Hirono S, Iwadate Y, Kambe M, Hiwasa T, Takiguchi M, Nakatani Y, Saeki N (2015) Role of Evaluating MGMT Status and 1p36 Deletion in Radiosurgery-Induced Anaplastic Ependymoma That Rapidly and Completely Resolved by Temozolomide Alone: Case Report and Review of the Literature. J Neurol Surg Rep 76(1): e43-7.
  10. Dong M, Hiwasa T, Cong B, Shi QW, Wang SM, Kita K, Sugaya S, Suzuki N (2015) Protein kinase Cα-mediated cyto-toxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells. Int J Oncol 47: 1939-1944.

2014年

  1. Iwase, K., Ishihara, A., Yoshimura, S., Andoh, Y., Kato, M., Seki, N., Matsumoto, E., Hiwasa, T., Muller, D., Fukunaga, K. and Takiguchi, M. (2014) The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. J. Neurochem., 128, 233-245.
  2. Adachi-Hayama, M., Adachi, A., Shinozaki, N., Matsutani, T., Hiwasa, T., Takiguchi, M., Saeki, N. and Iwadate, Y. (2014) Circulating anti-filamin C antibody as a potential serum biomarker for low-grade gliomas. BMC Cancer 14, 452.
  3. Morii, S., Kato, M., Seki, N., Shinmen, N., Iwase, K., Takiguchi, M. and Hiwasa, T. (2014) Inhibition of Cell Growth by Nuclear Receptor COUP-TFI: possible involvement of decorin in growth inhibition. Biochem. Physiol., S4-001.
  4. 日和佐隆樹（2014）疾患抗体マーカーの開発．医学のあゆみー臨床プロテオミクス．251巻．953-957頁.

2013年

  1.  Miyauchi, O., Iwase, K., Ito, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H. and Takiguchi, M. (2013) Efficient subtractive cloning of genes activated by lipopolysaccharide and interferonγ in the primary-cultured cortical cells of newborn mice. PLoS ONE, 8, e79236.

2012年

  1. Shimada, H., Yajima, S., Oshima, Y., Hiwasa, T., Tagawa, M., Matsushita, K. and Nomura, F. Impact of serum biomarkers on esophageal squamous cell carcinoma. Esophagus 2012, 9, 131-140.
  2. Matsutani, T., Hiwasa, T., Takiguchi, M., Oide, T., Kunimatsu, M., Saeki, N. and Iwadate, Y. (2012) Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. J. Experiment. Clin. Cancer Res., 31, 85.

2011年

  1. Tumurkhuu, G., Koide, N., Hiwasa, T., Ookoshi, M., Dagvadorj, J., Noman, A.S., Iftakhar-E-Khuda, I., Naiki, Y., Komatsu, T., Yoshida, T. and Yokochi, T. (2011) ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 17(1), 97-105.
  2. Mori, M., Hosoya, M., Hiwasa, T., Hayakawa, S., Uzawa, A. and Kuwabara, S. (2011) Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica. Neurol. Sci. 32, 795-799.
  3. Nabeya, Y., Suzuki, T., Furuya, A., Koide, N., Ohkoshi, M., Takiguchi, M., Ochiai, T., Matsubara, H. and Hiwasa, T. (2011) Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells. Cancer Sci. 102(8), 1509-1515.
  4. Kagaya, A., Shimada, H., Shiratori, T., Kuboshima, M., Nakashima-Fujita, K., Yasuraoka, M., Nishimori, T., Kurei, S., Hachiya, T., Murakami, A., Tamura, Y., Nomura, F., Ochiai, T., Matsubara, H., Takiguchi, M. and Hiwasa, T. (2011) Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. Proteome Sci. 9, Article ID:31.
  5. Hiwasa, T., Utsumi, T., Yasuraoka, M., Hanamura, N., Shimada, H., Nakajima, H., Kitagawa, M., Iwadate, Y., Goto, K., Takeda, A., Ohtsuka, K., Ariga, H. and Takiguchi, M. (2011) Functional similarity of anticancer drugs by MTT bioassay. J Cancer Sci Ther, 3: 250-255.

2010年

  1. Koshida, T., Kitagawa, M., Iwase, K., Takiguchi, M. and Hiwasa, T. (2010) Stimulation of p53 transactivation ability by nicastrin in mouse fibroblasts. SRX Biology 2010, ID 606391.
  2. Matsumoto, E., Ishihara, A., Tamai, S., Nemoto, A., Iwase, K., Hiwasa, T., Shibata, S. and Takiguchi, M. (2010) Time-of-day and Nutrients in Feeding Govern Daily Expression Rhythms of the Gene for Sterol Regulatory Element-binding Protein (SREBP)-1 in the Mouse Liver. J. Biol. Chem. 285 (43), 33028-33036.

2009年

  1. Dong, M., Chen, S., Kita, K., Ichimura, Y., Guo, W., Lv, S., Sugaya, S., Hiwasa, T., Takiguchi, M., Mori, N., Kashima, A., Morimura, K., Hirota, J. and Suzuki, N. (2009) Anti-proliferative and apoptosis-inducible activity of Sarcodonin G from Sarcodon scabrosus in Hela cells. Int. J. Oncol. 34, 201-207.
  2. Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H. and Takiguchi, M. (2009) Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. Int. J. Oncol. 34, 641-648.
  3. Sugiyama, H., Kumamoto, T., Suganami, A., Nakanishi, W., Sowa, Y., Takiguchi, M., Ishikawa, T. and Tamura, Y. (2009) Insight into estrogenicity of phytoestrogens using in silico simulation. Biochem. Biophys. Res. Commun. 379, 139-144.
  4. Matsushita, K., Tomonaga, T., Kajiwara, T., Shimada, H., Itoga, S., Hiwasa, T., Kubo, S., Ochiai, T., Matsubara, H. and Nomura, F. (2009) c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy. Front. Biosci. 14, 3401-3408.
  5. Zahed, M., Suzuki, T., Suganami, A., Sugiyama, H., Harada, K., Takiguchi, M., Tamura, Y. and Suzuki, N. (2009) Screening of SMB7-binding peptides by combination of phage display and docking simulation analysis. Protein & Peptide Lett. 16, 301-305.
  6. Shimada, H., Kagaya, A., Shiratori, T., Nomura, F., Takiguchi, M., Matsubara, H. and Hiwasa, T. (2009) Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma-possible new serum marker for esophageal cancer-. J. Gastroenterology 44, 691-696.
  7. Guo, W., Sugaya, S., Satoh, M., Tomonaga, T., Nomura, F., Hiwasa, T., Takiguchi, M., Kita, K. and Suzuki, N. (2009) Nm23-H1 is responsible for SUMO-2-involved DNA synthesis induction after X-ray irradiation in human cells. Arch. Biochemi. Biophys. 486, 81-87.
  8. Shinmen, N., Koshida, T., Kumazawa, T., Sato, K., Shimada, H., Matsutani, T., Iwadate, Y., Takiguchi, M. and Hiwasa, T. (2009) Activation of NFAT signal by p53-K120R mutant. FEBS Lett. 583, 1916-1922.
  9. Shimada, H., Shiratori, T., Yasuraoka, M., Kagaya, A., Kuboshima, M., Nomura, F., Takiguchi, M., Ochiai, T., Matsubara, H. and Hiwasa, T. (2009) Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma. BMC Cancer 9, MSNo.232.
  10. Moriya, Y., Iyoda, A., Kasai, Y., Sugimoto, T., Hashida, J., Nimura, Y., Kato, M., Takiguchi, M., Fujisawa, T., Seki, N. and Yoshino, I. (2009) Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer. Lung Cancer 64, 86-91.

2008年

  1. Moriya, S., Takiguchi, M. and Seki, N. (2008) Expression of the WT1 gene-KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells. Int. J. Oncol. 32, 349-356.
  2. Iwadate, Y., Hayama, M., Adachi, A., Mausutani, T., Nagai, Y., Hiwasa, T. and Saeki, N. (2008) High serum level of plasminogen activator inhibitor-1 predicts histological grade of intracerebral gliomas. Anticancer Res. 28, 415-418.
  3. Fukasawa, S., Kino, M., Kobayashi, M., Suzuki, H., Komiya, A., Imamoto, T., Hirokawa, Y., Shiraishi, T., Takiguchi, M., Ishida, H., Shindo, T., Seki, N., and Ichikawa, T. (2008) Genetic changes in pT2 and pT3 prostate cancer detected by comparative genomic hybridization. Prostate Cancer Prostatic Dis. 11, 303-310.
  4. omizawa, M., Toyama, Y., Ito, C., Toshimori, K., Iwase, K., Takiguchi, M., Saisho, H., and Yokosuka, O. (2008) Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 333, 17-27.

2007年

  1. Shimada, H., Kuboshima, M., Shiratori, T., Nabeya, Y., Takeuchi, A., Takagi, H., Nomura, F., Takiguchi, M., Ochiai, T. and Hiwasa, T. (2007) Serum anti-myogegalin antibodies in patients with esophageal squamous cell carcinoma. Int. J. Oncol. 30, 97-103.
  2. Kumazawa, T., Hiwasa, T., Takiguchi, M., Suzuki, O. and Sato, K. (2007) Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts. Int. J. Mol. Med. 19, 765-770.
  3. Ishihara, A., Matsumoto, E., Horikawa, K., Kudo, T., Sakao, E., Nemoto, A, Iwase, K., Sugiyama, H., Tamura, Y., Shibata, S. and Takiguchi, M. (2007) Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene Spot-14 in the mouse liver. J. Biol. Rhythms 22, 324-334.
  4. Shiratori, T., Shimada, H., Kagaya, A., Kuboshima, M., Nabeya, Y., Machida, T., Goto, K., Takiguchi, M., Ochiai, T. and Hiwasa, T. (2007) Sensitization against anticancer drugs by tranfection with UBE2I variant gene into ras-NIH3T3 mouse fibroblasts. Anticancer Res. 27, 3227-3234.

2006年

  1. Kuboshima, M., Shimada, H., Liu, T.-L., Nakashima, K., Nomura, F., Takiguchi, M., Hiwasa, T. and Ochiai, T. Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. Int. J. Oncol. 28, 463-468, 2006.
  2. Kuboshima, M., Shimada, H., Liu, T.-L., Nomura, F., Takiguchi, M., Hiwasa, T. and Ochiai, T. Presence of serum TRIM21 antibodies in patients with esophageal squamous cell carcinoma. Cancer Sci., 97, 380-386, 2006.
  3. Hiwasa, T., Shimada, H., Ochiai, T. and Takiguchi, M. Serological identification of antigens by recombinant cDNA expression cloning (SEREX) using antibodies from patients with esophageal squamous cell carcinoma. In Moleculomics and Thereafter (ISBN: 81-308-0019-5), Hiwasa T. (ed.), Research Signpost, Kerala, India, pp 99-117, 2006.
  4. Hiwasa, T. DSPA, a new method for comprehensive analysis of gene function. In Moleculomics and Thereafter (ISBN: 81-308-0019-5), Hiwasa T. (ed.), Research Signpost, Kerala, India, pp 143-157, 2006.
  5. Osawa, A., Kato, M., Matsumoto, E., Iwase, K., Sugimoto, T., Matsui, T., Ishikura, H., Sugano, S., Kurosawa, H., Takiguchi, M. and Seki, N. Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells. Genomics, 88, 52-64, 2006.
  6. Liu, T.-L., Shimada, H., Ochiai, T., Shiratori, T., Lin, S.-E., Kitagawa, M., Harigaya, K., Maki, M., Oka, M., Abe, T., Takiguchi, M. and Hiwasa, T. Enhancement of chemosensitivity toward peplomycin by calpastatin-stabilized NF-κB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism. Apoptosis, 11, 1025-1037, 2006.
  7. Tonouchi, A., Ohtsuka, M., Ito, H., Kimura, F., Shimizu, H., Kato, M., Nimura, Y., Iwase, K., Hiwasa, T., Seki, N., Takiguchi, M. and Miyazaki, M. (2006) Relationship between pancreatic secretory trypsin inhibitor and early recurrence of intrahepatic cholangiocarcinoma following surgical resection. Am. J. Gastroenterol. 101, 1601-1610.
  8. Adachi-Uehara, N., Kato, M., Nimura, Y., Seki, N., Ishihara, A., Matsumoto, E., Iwase, K., Ohtsuka, S., Kodama, H., Mizota, A., Yamamoto, S., Adachi-Usami, E. and Takiguchi, M. (2006) Up-regulation of genes for oxidative phosphorylation and protein turnover in diabetic mouse retina. Exptl. Eye Res. 83, 849-857.
  9. Kai, N., Iwase, K., Imai, K., Nakahira, E., Soma, M., Ohtsuka, S., Yagi, T., Kobayashi, K., Koga, H., Takiguchi, M. and Yuasa, S. (2006) Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as reverled by laser capture microdissection and mKIAA cDNA array analysis. Brain Res. 1073-1074, 60-70.
  10. Kawakami, K., Enokida, H., Tachiwada, T., Gotanda, T., Tsuneyoshi, K., Kubo, H., Nishiyama, K., Takiguchi, M., Nakagawa, M. and Seki, N. (2006) Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling. Oncol. Rep. 16, 521-531.

2005年

  1. Shimada, H., Nakashima, K., Ochiai, T., Nabeya, Y., Takiguchi, M., Nomura, F. and Hiwasa, T. Serological identification of tumor antigens of esophageal squamous cell carcinoma. Int. J. Oncol., 26, 77-86, 2005.
  2. Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S. and Yamaura, A. Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. Int. J. Oncol., 26, 993-998, 2005.
  3. Fukuda, M. E., Iwadate, Y., Machida, T., Hiwasa, T., Nimura, Y., Nagai, Y., Takiguchi, M., Tanzawa, H., Yamaura, A. and Seki, N. Cathepsin D is a potential serum marker for poor prognosis in glioma patients. Cancer Res., 65, 5190-5194, 2005.

2004年

  1. Mori, M., Shimada, H., Gunji, Y., Matsubara, H., Hayashi, H., Nimura, Y., Kato, M., Takiguchi, M., Ochiai, T. and Seki, N. S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastasis of gastric cancer. Oncol. Rep. 11, 1287-1295, 2004.
  2. Arai, M., Yokosuka, O., Fukai, K., Imazaki, F., Chiba, T., Sumi, H., Kato, M., Takiguchi, M., Saisho, H., Muramatsu, M. and Seki, N. Gene expression profiles in liver regeneration with oval cell induction. Biochem. Biophys. Res. Commun. 317, 370-376, 2004.
  3. Ohtsuka, S., Iwase, K., Kato, M., Seki, N., Shimizu-Yabe, A., Miyauchi, O., Sakao, E., Kanazawa, M., Yamamoto, S., Kohno, Y. and Takiguchi, M. An mRNA amplification procedure with directional cDNA cloning and strand-specific cRNA synthesis for comprehensive gene expression analysis. Genomics 84, 715-729, 2004.
  4. Machida, T., Kubota, M., Saeki, N., Takiguchi, M., Yamaura, A. and Hiwasa, T. Increase in metalloproteinase activity in the plasma of smoke-extract-injected rats. Int. J. Mol. Med. 14, 659-662, 2004.
  5. Nakashima, K., Shimada, H., Ochiai, T., Kuboshima, M., Kuroiwa, N., Okazumi, S., Matsubara, H., Nomura, F., Takiguchi, M. and Hiwasa, T. Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int. J. Cancer 112, 1029-1035, 2004.
  6. Chang, H., Iizasa, T., Shibuya, K., Iyoda, A., Suzuki, M., Moriya, Y., Liu, T. -L., Hiwasa, T., Hiroshima, K. and Fujisawa, T. Increased expression of collagen XVIII and its prognostic value in nonsmall cell lung carcinoma. Cancer 100, 1665-1672, 2004.
  7. Iwadate, Y., Sakaida, T., Hiwasa, T., Nagai, Y., Ishikura, H., Takiguchi, M. and Yamaura, A. Molecular classification and survival prediction in human gliomas based on proteome analysis. Cancer Res. 64, 2496-2501, 2004.
  8. Oohira, G., Yamada, S., Ochiai, T., Matsubara, H., Okazumi, S., Ando, K., Tsujii, H., Hiwasa, T. and Shimada, H. Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transfer. Int. J. Oncol. 25, 563-569, 2004.

2003年

  1. Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A. and Hiwasa, T. Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. Int. J. Oncol. 23, 1071-1077, 2003.
  2. Hiwasa, T., Shimada, H., Sakaida, T., Kitagawa, M., Kuroiwa, N., Ochiai, T. and Takiguchi, M. Drug-sensitivity pattern analysis for study of functional relationship between gene products. FEBS Lett. 552, 177-183, 2003.
  3. Hiwasa, T. Substrates for calpain, proteasome and caspase. Recent Res. Devel. Biochem. 4, 629-642, 2003.
  4. Arai, M., Yokosuka, O., Chiba, T., Imazeki, F., Kato, M., Hashida, J., Ueda, Y., Sugano, S., Hashimoto, K., Saisho, H., Takiguchi, M. and Seki, N. Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration. J. Biol. Chem. 278, 29813-29818, 2003.
  5. Sakao, E., Ishihara, A., Horikawa, K., Akiyama, M., Arai, M., Kato, M., Seki, N., Fukunaga, K., Shimizu-Yabe, A., Iwase, K., Ohtsuka, S., Sato, T., Kohno, Y., Shibata, S. and Takiguchi, M. Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver. J. Biol. Chem. 278, 30450-30457, 2003.
  6. Suzuki, K., Nakajima, H., Ikeda, K., Tamachi, T., Hiwasa, T., Saito, Y. and Iwamoto, I. Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046. Biochem. Biophys. Res. Commun. 309, 768-773, 2003.

2002年

  1. Shimada, H., Liu, T. -L., Ochiai, T., Shimizu, T., Haupt, Y., Hamada, H., Abe, T., Oka, M., Takiguchi, M. and Hiwasa, T. Facilitation of adenoviral wild-typr p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells. Oncogene 21, 1208-1216, 2002.
  2. Hiwasa, T., Nakata, M., Nakata, M., Ohno,S., Maki, M., Suzuki, K. and Takiguchi M. Regulation of transformed state by calpastatin via PKCε in NIH3T3 mouse fibroblasts. Biochem. Biophys. Res. Commun. 250, 510-517, 2002.
  3. Hiwasa, T., Shimada, H., Ochiai, T., Liu, T. -L., Yuasa, Y., Takiguchi, M. and Ohkoshi, M. Decrease in growth factor receptors after treatment with serine protease inhibitor ONO-3403. Int. J. Oncol. 20, 797-802, 2002.
  4. Suzuki, K., Nakajima, H., Kagami, S., Suto, A., Ikeda, K., Hirose, K., Hiwasa, T., Takeda, K., Saito, Y., Akira, S. and Iwamoto, I. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J. Exp. Med. 196, 27-38, 2002.
  5. Fujita, Y., Kitagawa, M., Nakamura, S., Azuma, K., Ishii, G., Higashi, M., Kishi, H., Hiwasa, T., Koda, K., Nakajima, N. and Harigaya, K. CD44 signaling through focal adhesion kinase and its anti-apotototic effect. FEBS Lett. 528, 101-108, 2002.
  6. Akiba, T., Kuroiwa, N., Shimizu-Yabe, A., Iwase, K., Hiwasa, T., Yokoe, H., Kubosawa, H., Kageyama, R., Dahrington, G. J., Mori, M., Tanzawa, H. and Takiguchi, M. Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein α for the expression in the parotid gland. J. Biochem. 132, 621-627, 2002.

2001年

  1. Kimura, T., Chowdhury, S., Tanaka, T., Shimizu, A., Iwase, K., Oyadomari, S., Gotoh, T., Matsuzaki, H., Mori, M., Akira, S. and Takiguchi, M. CCAAT/enhancer-binding protein b is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes. FEBS Lett. 494, 105-111, 2001.
  2. Kuroiwa, N., Nakayama, M., Fukuda, T., Fukui, H., Ohwada, H., Hiwasa, T. and Fujimura, S. Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase. J. Immunol. Meth. 253, 1-11, 2001.
  3. Shimada, H., Shimizu, T., Ochiai, T., Liu, T. -L., Sashiyama, H., Nakamura, A., Matsubara, H., Gunji, Y., Kobayashi, S., Tagawa, M., Sakiyama, S. and Hiwasa, T. Preclinical study of adenoviral p53 gene therapy for esophageal cancer. Surg. Today 31, 597-604, 2001.
  4. Sugita, K., Chi, X. -J., Hiwasa, T. and Suzuki, N. Stidies on p53 and Bax protein expression in Cockayne syndrome cells after UV irradiation and interferon-α treatment. Cell Biochem. Func. 19, 221-225, 2001.
  5. Oyadomari, S., Takeda, K., Takiguchi, M., Gotoh, T., Matsumoto, M., Wada, I., Akira, S., Araki, E. and Mori, M. Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway. Proc. Natl. Acad. Sci. USA 98, 10845-10850, 2001.
  6. Sugahara, K., Iyama, K., Kimura, T., Sano, K., Darlington, G. J., Akiba, T. and Takiguchi, M. Mice lacking CCAAT/enhancer-binding protein-α show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs. Cell Tissue Res. 306, 57-63, 2001.
  7. Sugita, T., Hiwasa, T., Nomura, J., Kita, K., Hiroshima, K., Suzuki, H., Sekiya, S. and Suzuki, N. Hypermutable change of human UVr-1 cells by p53 overexpression. Biochem. Biophys. Res. Commun. 289, 756-762, 2001.

2000年

  1. Arase, Y., Hiwasa, T., Hasegawa, R., Nomura, J., Ito, H. and Suzuki, N. Prevention of v-Ha-ras-dependent apoptosis by PDGF coordinates in phosphorylation of ERK and Akt. Biochem. Biophys. Res. Commun. 267, 33-39, 2000.
  2. Hiwasa, T., Arase, Y., Kikuno, K., Hasegawa, R., Sugaya, S., Kita, K., Saido, T., Yamamori, H., Maki, M. and Suzuki, N. Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ. 7, 531-537, 2000.
  3. Kuroiwa, N., Yusa, T., Nakamura, Y., Sakiyama, S., Hiwasa, T., Lin, L., Moriyama, Y. and Fujimura, S. Regulation of the activity and polymerization status of recombinant human cytosolic thymidine kinase by thiols and ATP. Int. J. Oncol. 16, 305-313, 2000.
  4. wase, K., Miyanaka, K., Shimizu, A., Nagasaki, A., Gotoh, T., Mori, M. and Takiguchi, M. Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. J. Biol. Chem. 275, 11929-11933, 2000.
  5. Oyadomari, S., Matsuno, F., Chowdhury, S., Kimura, T., Iwase, K., Araki, E., Shichiri, M., Mori, M. and Takiguchi, M. The gene for hepatocyte nuclear factor (HNF)-4a is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver. FEBS Lett. 478, 141-146, 2000.

1999年

  1. Yanai, K., Hirota, K., Taniguchi-Yanai, K., Shigematsu, Y., Shimamoto, Y., Saito, T., Chowdhury, S., Takiguchi, M., Arakawa, M., Nibu, Y., Sugiyama, F., Yagami, K. and Fukamizu, A.,　Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. J. Biol. Chem. 274(49), 34605-34612, 1999.
  2. Sugahara, K., Sadohara, T., Sugita, M., Iyama, K. and Takiguchi, M., Differential expression of CCAAT enhancer binding protein family in rat alveolar epithelial cell proliferation and in acute lung injury. Cell & Tissue Res. 297(2), 261-270, 1999.
  3. Braissant, O., Honegger, P., Loup, M., Iwase, K., Takiguchi, M. and Bachmann, C. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neuroscience Letters. 266(2), 89-92, 1999 May 7.
  4. Zhang, W. Y., Takiguchi, M., Koshiyama, Y., Gotoh, T., Nagasaki, A., Iwase, K., Yamamoto, K., Takeshima, H., Negi, A. and Mori, M. Expression of citrulline-nitric oxide cycle in lipopolysaccharide and cytokine-stimulated rat astroglioma C6 cells. Brain Res. 849(1-2), 78-84, 1999.
  5. Fujimura, S., Sakuramoto, K., Du, M., Kuroiwa, K. and Ohmura, Y. Aspect of nitric oxide, released from gastro-carcinogenic N-alkyl-N-nitroso compounds, in gastro-carcinogenesis. In 3rd International Gastric Cancer Congress. J. -P. Kim, J. -S. Min, Y. -J. Mok (eds.) Monduzzi Editore, Bologna, Italy, pp.947-950, 1999.
  6. Hiwasa, T., Chen, Z., Nomura, J., Yamamori, H., Tashiro, T., Nakajima, N. and Suzuki N. Differential sensitivity to mitomycin C between human RSa cell line and its derivative UVr-1. Anticancer Res. 19(5B), 3915-3920, 1999.
  7. Lin, L., Islam, M. M., Du, M., Ohmura, Y., Hiwasa, T. and Fujimura, S. Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to　phosphorylation. Int. J. Oncol. 15(2), 293-299, 1999.
  8. Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umezawa, K., Ito, H. and Suzuki, N. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Lett. 444(2-3):173-6, 1999.
  9. Chi, X. J., Hiwasa, T., Maki, M., Sugaya, S., Nomura, J., Kita, K. and Suzuki, N. Suppression of okadaic acid-induced apoptosis by overexpression of calpastatin in human UVr-1 cells. FEBS Lett. 459(3), 391-394, 1999 Oct 15.
  10. Hiwasa, T., Takeda, A. and Umezawa, K. Inhibition of Thrombin and Calpain by a Ras Inhibitor, Damnacanthal. J. Biochem. Mol. Biol. & Biophys. 2, 311-316, 1999.