メンバ-

木村元子 業績

英文業績

  1. *Kimura, M. Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., Endo, Y., Ogawa, S., Yagi, R., Motohashi, S., Singer, A., and Nakayama, T.: CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nat. Commun. 9:3749 (2018). *Corresponding author
  2. Mita, Y., *Kimura, M. Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y., and Nakayama, T.: Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. Int. Immunol. in press. *Corresponding author
  3. *Kimura, M. Y.: The basisof T cell development and lineage choice in the thymus. Chiba Medical Journal 94(3):19-23 (2018). *Corresponding author
  4. *Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S., and *Nakayama, T.: Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation. Immunol. Rev. 278:87-100 (2017). *Co-corresponding author
  5. *Kimura, M. Y., Thomas, J., Tai, X., Guinter, T. I., Shinzawa, M., Etzenperger, R., Li, Z., Love, P., Nakayama, T., and *Singer, A.: Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors. Nat. Immunol. 17:1415-1423 (2016). *Co-corresponding author
  6. Hayashizaki, K.,* Kimura, M. Y.,* Tokoyoda, K.,* Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y., and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. (*these authors contributed equally to this work) Sci. Immunol. 1:pp.eaaf9154 (2016).
  7. Pobezinsky, L. A., Etzensperger, R., Jeurling, S., Alag, A., Kadakia, T., McCaughtry, T. M., Kimura, M. Y., Sharrow, S. O., Guinter, T. I., Feigenbaum, L., and Singer, A.: Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nat. Immunol. 16:517-24 (2015).
  8. Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T., and Nakayama, T.: Methylation of gata3 protein at arg-261 regulates transactivation of the il5 gene in T helper 2 cells. J. Biol. Chem. 290:13095-103 (2015).
  9. Luckey, M. A., Kimura, M. Y., Waickman, A. T., Feigenbaum, L., Singer, A., and Park, J. H.: The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat. Immunol.15(7):638-45 (2014).
  10. Van Laethem, F., Tikhonova, A., Pobezinsky, L. A., Tai, X., Kimura, M. Y., Le Saout, C., Guinter, T. I., Adams, A., Sharrow, S. O., Bernhardt, G., Feigenbaum, L., and Singer, A.: Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154(6):1326-1341 (2013).
  11. Kimura, M. Y., Pobezinsky, L. A., Guinter, T. I., Thomas, J., Adams, A., Park, J. H., Tai, X., and Singer, A.: IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death. Nat. Immunol. 14(2):143-151 (2013).
  12. Tai, X., Erman, B., Alag, A., Mu, J., Kimura, M., Katz, G., Guinter, T., McCaughtry, T., Etzensperger, R., Feigenbaum, L., Singer, D. S., and Singer, A.: Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity 38(6):1116-28 (2013).
  13. Adoro, S., McCaughtry, T., Erman, B., Alag, A., Van Laethem, F., Park, J. H., Tai, X., Kimura, M., Wang, L., Grinberg, A., Kubo, M., Bosselut, R., Love, P., and Singer, A.: Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 31(2):366-377 (2012).
  14. Park, J. H., Adoro, S., Guinter, T., Erman, B., Alag, A. S., Catalfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., Kubo, M., Hennighausen, L., Feigenbaum, L., and Singer, A. l.: Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat. Immunol. 11:257-264 (2010).
  15. Suzuki, A., Iwamura, C., Shinoda, K., Tumes, D. J., Kimura, M. Y., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M., and Nakayama, T.: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. J. Immunol. 184(8):4510-4520 (2010).
  16. Nakayama, T., and Kimura, M. Y.: Memory Th1/Th2 cell generation controlled Schnurri-2. Memory T-cells, edited by Maurizio Zanetti, (2009).
  17. Kimura, M. Y., Iwamura, C., Suzuki, A., Miki, T., Hasegawa, A., Sugaya, K., Yamashita, M., Ishii, S., and Nakayama, T.: Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J. Immunol. 178(8):4926-4936 (2007).
  18. Iwamura, C., Kimura, M. Y., Shinoda, K., Endo, Y., Hasegawa, A., Yamashita, M., and Nakayama, T.: Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int. Immunol. 19(6):755-762 (2007).
  19. Kimura, M. Y., Iwamura, C., Suzuki, A., Kitajima, M., Hosokawa, H., Hasegawa, A., Yamashita, M., and Nakayama, T.: Schnurri-2 controls the generation of memory Th1 and Th2 cells. 13th International congress of Immunology pp.475-479 (2007).
  20. Kaneko, T., Hosokawa, H., Yamashita, M., Wang, C. R., Hasegawa, A., Kimura, M. Y., Kitajima, M., Kimura, F., Miyazaki, M., and Nakayama, T.: Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Mol. Immunol. 44(9):2249-2256 (2007).
  21. Hosokawa, H., Kimura, M. Y., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., and Nakayama, T.: Regulation of Th2 development by Polycomb group gene bmi-1 through the stabilization of GATA3. J. Immunol. 177(11):7656-7664 (2006).
  22. Tenda, Y., Yamashita, M., Kimura, M. Y., Hasegawa, A., Shimizu, C., Kitajima, M., Onodera, A., Suzuki, A., Seki N., and Nakayama, T.: Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J. Allergy Clin. Immunol. 118(3):725-733 (2006).
  23. Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, M. Y., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24(5):611-622 (2006).
  24. Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M. B., Shimizu, C., Hashimoto, K., Kimura, M. Y., Yamashita, M., and Nakayama, T.: Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J. Immunol. 176(4):2546-2554 (2006).
  25. Nigo, I. Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103(7):2286-2291 (2006).
  26. Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., and Shinnakasu, R.: Chromatin remodeling of the Th2 cytokine gene loci. International Congress Series 1285:137-144 (2005).
  27. Kimura, M. Y., and Nakayama, T.: Differentiation of NK1 and NK2 cells. Crit. Rev. Immunol.25(5):361-374 (2005).
  28. Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., and Nakayama, T.: Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J. Biol. Chem. 280(33):29409-29419 (2005).
  29. Miyamoto, T., Kaneko, T., Yamashita, M., Tenda, Y., Inami, M., Suzuki, A., Ishii, S., Kimura, M., Hashimoto, K., Shimada, H., Yahata, H., Ochiai, T., Saito, I., DeGregori, J., and Nakayama, T.: Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int. Immunol. 17:759-768 (2005).
  30. Kimura, M. Y., and Nakayama, T.: Differentiation of NK1 and NK2 cells. Crit. Rev. Imm. 25:361-374 (2005).
  31. Kimura, M. Y., Hosokawa, H., Yamashita, M., Hasegawa, A., Iwamura, C., Watarai, H., Taniguchi, M., Takagi, T., Ishii, S., and Nakayama, T.: Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J. Exp. Med. 201:397-408 (2005).
  32. Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M., and Nakayama, T.: STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. J. Immunol. 173:4967-4975 (2004).
  33. Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., and Nakayama, T.: Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279:39454-39464 (2004).
  34. Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., and Nakayama, T.: Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279:26983-26990 (2004).
  35. Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., and Nakayama, T.: CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing Th2 cells. J. Biol. Chem. 279:23123-23133 (2004).
  36. Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hosokawa, H., Hasegawa, A., Taniguchi, M., and Nakayama, T.: CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity 19:281-294 (2003).
  37. Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., Shinkai, H., Koseki, H., Taniguchi, M., Ziegler, S. F., and Nakayama, T.: CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int. Immunol. 8:987-992 (2003).
  38. Fukuda, K., Yoshida, H., Sato, T., Furumoto, T., Mizutani-Koseki, Y., Suzuki, Y., Saito, Y., Takemori, T., Kimura, M., Sato, H., Taniguchi, M., Nishikawa, S., Nakayama, T., and Koseki, H.: Mesenchymal expression of Fokl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Developmental Biol. 255:278-289 (2003).
  39. Sakamoto, M., Hasegawa, A., Sugaya, K., Hashimoto, K., Kimura, M., Yamashita, M., Suzuki, K., and Nakayama, T.: Destinct calcium response induced by T-cell antigen receptor stimulation in thymocytes and mature T cells. Bioimages 11:1-8 (2003).
  40. Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M., and Nakayama, T.: TH1-biased immunity induced by exposure to Antarctic winter. J. Allergy Clin. Immunol. 111:1353-1360 (2003).
  41. Asai, K., Hachimura, S., Kimura, M., Toraya, T., Yamashita, M., Nakayama, T., and Kaminogawa, S.: T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. J. Immunol. 169:4723-4731 (2002).
  42. Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C. -R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N., and Nakayama, T.: Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J. Immunol. 169:2134-2140 (2002).
  43. Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M., and Nakayama, T.: Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J. Biol. Chem. 277:42399-42408 (2002).
  44. Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M., and Nakayama, T.: Th1/Th2 cell differentiation of developing CD4 single-positive thymocytes. Int. Immunol. 14:943-951 (2002).
  45. Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H., and Ziegler, S. F.: The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168:87-94 (2002).
  46. Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi M., Koseki, H., and Nakayama, T.: Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 15:275-287 (2001).
  47. Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondo, E., Kaneko, Y., Okada, S., Tokuhisa T., Yokoyama, M., Taniguchi, M., Katsura, Y., and Nakayama, T.: Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lack proximal promoter activity. Int. Immunol. 13:105-117 (2001).
  48. Yamashita, M., Katsumata, M., Iwashima, M., Kimura, M., Shimizu, C., Kamata, T., Shin, T., Seki, N., Suzuki, S., Taniguchi, M., and Nakayama, T.: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J. Exp. Med. 191:1869-1879 (2000).
  49. Kimura, M., Yamashita, M., Kubo, M., Iwashima, M., Shimizu, C., Tokoyoda, K., Chiba, J., Taniguchi, M., Katsumata, M., and Nakayama, T.: Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells. Int. Immunol. 12:817-824 (2000).
  50. Cui, J., Watanabe, N., Kawano, T., Yamashita, Y., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M., and Nakayama, T.: Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190:783-792 (1999).
  51. Yamashita, M., Kimura, M., Kubo, M., Shimizu, C., Tada, T., Perlmutter, R. M., and Nakayama, T.: T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. USA 96:1024-1029 (1999).
  52. Shimizu, C., Li, X., Kimura, M., Hashimoto, K., Sugaya, K., Kubo, M., Suzuki, S., and Nakayama, T.: A novel immunosuppressant, FTY720, increases the efficiency of a superantigen-induced peripheral T-cell deletion whilst inhibiting negative selection in the thymus. Immunology 94:503-512 (1998).
  53. Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.: Requirement for p56lck tyrosine kinase activation in Th subset differentiation. Int. Immunol. 10:577-591 (1998).
  54. Nakayama, T., Yamashita, M., Kubo, M., Kimura, M., Shimizu, C., and Tada, T.: TCR-mediated signal transduction pathways that control helper T cell differentiation: Requirement for activation of Lck tyrosine kinase and Ras/MAPK pathway in Th2 cell differentiation. 10th International congress of Immunology pp.589-593 (1998).
  55. Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.: TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling edited by H. Yakura pp.350-351 (1997).

邦文業績

  1. 木村元子、林崎浩史、中山俊憲 気道炎症を制御するCD69-Myl9システムとその展望 臨床免疫・アレルギ-科 70(4):393-399 (2018・10)
  2. 木村元子、中山俊憲 ミオシン軽鎖9/12 アレルギ- 67(6):785-786 (2018・7)
  3. 木村元子、林崎浩史、中山俊憲 CD69-Myl9システムによるアレルギ-性気道炎症制御とその展望 アレルギ-研究最前線 医学のあゆみ 265(9):719-723 (2018・6)
  4. 木村元子 胸腺内T細胞分化制御機構 感染・炎症・免疫 47(3):50-53 (2017)
  5. 木村元子 CD8T細胞分化と胸腺での正の選択 医学のあゆみ 263(3):258-260 (2017)
  6. 木村元子 胸腺の正の選択におけるCD8陽性T細胞の分化制御機構 臨床免疫・アレルギ-科 67(5):524-531 (2017)
  7. 木村元子、林崎浩史 CD69-Myl9システムによる気道アレルギ-の制御 医学のあゆみ 261(4):325-326 (2017)
  8. 木村元子 胸腺の正の選択におけるCD8T細胞分化制御機構:如何にして分化エラ-を防ぐのか? ライフサイエンス新着論文レビュ- 2016年10月21日
  9. 木村元子、持続的なIL-7シグナルはCD8+T細胞において生存ではなく細胞死を誘導する 実験医学 2013年5月号 Vol.31 No.8 2013
  10. 木村元子、胸腺内CD4T細胞・CD8T細胞の分化決定機構 医学のあゆみ 悪性リンパ腫Update 235:369-374 (2010)
  11. 岩村千秋、木村元子、中山俊憲 NKT細胞によるTh2細胞分化と気道炎症制御 アレルギ-科21(3):294-301 (2006・3)
  12. 木村元子、中山俊憲 転写因子Schnurri-2によるTh2細胞分化制御 Molecular Medicine臨時増刊号 免疫2006 42:184-192 (2005・12)
  13. 木村元子、中山俊憲 アレルギ-疾患とヘルパ-T細胞の機能 アレルギ-・免疫別冊 11(4):32-39 (2004・4)
  14. 木村元子、中山俊憲 Th1/Th2細胞分化とポリコ-ム群遺伝子 Annual Review 免疫2004 中外医学社 9-16 (2003・12)
  15. 木村元子、中山俊憲 ポリコ-ム群遺伝子産物によるTh1/Th2細胞分化制御 蛋白質 核酸 酵素 47(16):2286-2292 (2002・12)
  16. 木村元子、中山俊憲 T細胞ー胸腺内分化とセレクションの分子機序 別冊医学のあゆみ 免疫疾患-state of arts Ver.2 9-13 (2002・3)
  17. 木村元子、中山俊憲 Th1, Th2細胞の分化とポリコ-ム群遺伝子産物 臨床免疫 36(5):694-699 (2001・11)
  18. 木村元子、中山俊憲 アレルギ-発症を制御するTh2細胞の機能分化 臨床免疫 35(6):738-745 (2001・6)
  19. 木村元子、中山俊憲 ポリコ-ム群遺伝子産物によるTh1/Th2細胞の分化調節機構 アレルギ-科 11(6):469-477 (2001)
  20. 木村元子、中山俊憲 ポリコ-ム群遺伝子産物によるTh2細胞の分化制御 医学の歩み 196(12):847-849 (2001・3)
  21. 木村元子、山下政克、中山俊憲 Th1/Th2細胞の分化制御ーサイトカイン、転写因子研究からクロマチンリモデリング研究へー アレルギ-科 10:128-134 (2000・8)
  22. 木村元子、中山俊憲 胸腺内T細胞選択機構と制御 日本臨床 57(2):267-272 (1999・2)
  23. 木村元子、中山俊憲 T細胞のシグナル伝達機構ーTh1, Th2細胞の分化と細胞内シグナル伝達ーAnnual review 呼吸器1999 pp14-22 (1998・12)
  24. 清水千織、李小康、木村元子、鈴木盛一、中山俊憲 免疫抑制剤FTY720によって調節されるT細胞のアポト-シス Organ Biology 5(4):71-80 (1998・4)

講演・シンポジウム(招待講演)

  1. Kimura, M. Y.: The role of CD69 on iNKT cell development in the thymus, NIH Thymus Symposium, Sep. 26 2018.
  2. Kimura, M. Y., Hayashizaki, K. and Nakayama, T.: CD69-Myl9 system regulates pathogenesis of inflammatory disorders. The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine", Mar. 28 2018.
  3. Kimura, M. Y., Hayashizaki, K. and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. The 5th Annual Meeting of the International Cytokine and Interferon Society 2017, Oct. 31 2017.
  4. Kimura, M. Y.: Roles of CD69 on NKT cell development. Experimental Immunology Branch, NCI/NIH, Bethesda USA, May 5 2017.
  5. Kimura, M. Y.: Timing and duration of MHC-I positive selection and CD8 lineage choice in the thymus. 5th Anniversary of the Japan Center for Health Professions Education and Research in Japan Week, Thomas Jefferson University, Philadelphia USA, May 3 2017.
  6. Kimura, M. Y.: Timing and duration of MHC-I positive selection and CD8 lineage choice in the thymus. NIH Thymus Symposium, Bethesda USA, Dec. 9 2016.
  7. Kimura, M. Y.: Timing of positive selection and CD8 lineage choice. IGMM-UMR5535-CNRS Seminar, Montpellier/ France, Apr. 8th 2015.
  8. Kimura, M. Y.: Timing of positive selection and CD8 lineage choice. Biological Sciences and bioengineering Program seminar at Sabanci University, Istanbul Turkey, Apr. 14th 2015.
  9. Kimura, M. Y. and Singer, A.: Why is signaling by both TCR and IL-7R necessary for naïve CD8 T cell survival. G-COE Symposium, Makuhari/ Chiba, Nov. 30th 2011.
  10. Kimura, M. Y.: Basis for IL-7 function as a homeostatic and pro-survival cytokine. G-COE seminar at Chiba University, Jun 11th 2009.
  11. 木村元子 アレルギ-発症に関わるTh2細胞の分化維持機構 The 6th Guest Symposium on Asthma and Allergy, 2003年2月 15日、大阪

Back