第3版の主な変更点

• 前浸潤性病変として、3つの病変を設けました。
  • 異形成、上皮内癌
  • 異型腺腫様過形成
  • びまん性特発性肺神経内分泌細胞過形成
• 腺癌の分類を厳密にし、亜型が混在する腫瘍は混合型腺癌としました。
• 神経内分泌腫瘍に、大細胞神経内分泌癌が加わりました。
• 肉腫様成分を含む癌を、多形、肉腫様、あるいは肉腫成分を含む癌としてまとめました。

引用文献

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2. Nakatani Y, Kitamura H, Inayama Y, Kamijo S, Nagashima Y, Shimoyama K, Nakamura N, Sano J, Ogawa N, Shibagaki T, Resl M, Mark EJ. Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms. Am. J. Surg. Pathol. 22, 399-411, 1998
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5. Hiroshima K, Shibuya K, Shimamura F, Toyozaki T, HagaY, Ohwada H, Iyoda A, Sekine Y, Iizasa T, Fujisawa T. Pulmonary large cell carcinoma with rhabdoid phenotype. Ultrastruct. Pathol. 27, 55-59, 2003
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7. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Fujisawa T, Ohwada H. Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer 91, 1992-2000, 2001
8. Iyoda A, Hiroshima K, Baba M, Saitoh Y, Ohwada H, Fujisawa T. Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors. Ann. Thorac. Surg. 73, 1049-1054, 2002
9. Iyoda A, Hiroshima K, Toyozaki T, Haga Y, Baba M, Fujisawa T, Ohwada H. Adjuvant chemotherapy for large cell carcinoma with neuroendocrine features. Cancer 92, 1108-1112, 2001
10. Travis WD, Gal AA, Colby TV, Klimstra DS, Falk R, Koss MN. Reproducibility of neuroendocrine lung tumor classification. Hum Pathol. 29, 272-279, 1998
11. Hiroshima K, Ishibashi M, Ohwada H, Kawano Y, Mizutani F, Hayashi Y. A case of adenocarcinoma of the lung with a spindle cell component. Acta Pathol. Jpn. 42, 841-846, 1992
12. Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ. Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am. J. Surg. Pathol. 28, 921-7, 2004

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